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The map label for this gene is sdhA [H]

Identifier: 150009793

GI number: 150009793

Start: 3885607

End: 3887550

Strand: Reverse

Name: sdhA [H]

Synonym: BDI_3209

Alternate gene names: 150009793

Gene position: 3887550-3885607 (Counterclockwise)

Preceding gene: 150009794

Following gene: 150009792

Centisome position: 80.8

GC content: 48.87

Gene sequence:

>1944_bases
ATGTCTGAAATAAATTCTAAAATACCTCAAGGCCCGTTGGCTGAGAAGTGGACTAATTATAAAAATCACCAGAAATTGGT
GAACCCCGCTAACAAGCGTCGTTTGGATGTTATCGTAGTCGGTACAGGTTTGGCCGGAGCTTCCGCTGCCGCATCTTTGG
CAGAGATGGGATTCAACGTATTGAACTTCTGTATCCAAGATTCTCCCCGCCGTGCGCACTCTATCGCCGCTCAAGGTGGT
ATCAACGCCGCTAAGAACTACCAGAATGATGGTGACTCTGTTTACCGTTTGTTCTACGATACGATCAAAGGTGGTGACTA
CCGTGCTCGTGAGGCTAACGTTTATCGTTTGGCTGAGGTTTCTAACTCAATCATCGACCAGTGCGTGGCTCAAGGCGTTC
CTTTCGCTCGCGAATATGGTGGTTTGTTGGATAACCGTTCATTCGGTGGCGCTCAGGTATCGCGTACGTTCTACGCCCGT
GGCCAGACGGGTCAGCAGCTTTTGTTAGGCGCTTATTCAGCGTTGAGCCGTCAGATCGGTTTGGGTAAGGTTAAGATGTA
CACTCGTCATGAGATGTTGGATGTAGTTAAGGTAGACGGTCGTGCTCGTGGTATCATCGCCCGCAACTTGATTACAGGTA
AGATCGAGCGTTACGCCGCTCACGCTGTAGTTGTAGCTACGGGTGGTTACGTTAATACGTTCTTCTTGTCAACCAACGCT
ATGGCATCTAACGGTTCCGCCGCATGGCAATGCTACAAGAAAGGCGCTTACTTCGCTAATCCTTGTATGGTTCAGATCCA
CCCGACTTGCGTACCGGTGAAAGGTGACTTCCAATCTAAATTGACTTTGATGTCCGAATCCTTGCGTAACGACGGCCGTA
TCTGGGTTCCGAAGAAACTGGAAGACGCTAAAGCTCTACAGGCCGGAACGAAGAAAGGTAAAGATATTCCCGAGGCAGAC
CGTGATTATTATTTGGAGCGTCGTTATCCGGCATTCGGAAACTTGGTTCCTCGCGACGTGGCTTCTCGTGCCGCTAAAGA
GCGTTGCGACGCAGGTTTCGGCGTGAACAGCACGGGCTTGGCCGTATTCTTGGATTTCTCCGACGCGATCAATCGCTTGG
GTAAAGAGGTCGTTAAGCAGAAATACGGTAACTTGTTCGATATGTACGAAGAGATCACGAACGATAATCCATACGAGACT
CCGATGATGATCTACCCGGCATTGCACTACTCAATGGGTGGATTGTGGGTTGACTATGAGTTGATGACCTCCATTCCGGG
TCTGTTCGCTATCGGTGAGGCAAACTTCTCCGATCACGGAGCGAACCGTTTAGGTGCTTCCGCTTTGATGCAGGGATTGG
CCGATGGTTATTTCGTATTACCATACACGATCCAGAACTATTTGTCCGACCAAATCCAAGTTCCTCGCTTCAGCACGGAT
CTGCCGGAGTTCGTCGAGGCAGAAAAGGCCATCAAGGATCGTATCCAAAAATTGATGAACGTCAAGGGTAAAGAAACCGT
AGACACTATCCACCGCAAACTAGGTCATATCATGTGGGAACATATCGGTATGGCACGCGACGCAAAAGGTTTGCAAGAAG
CTATCCAGATGCTGAAAGACTTGAAGAAAGAGTTCTGGAGCAACGTATTCATCCCAGGCAACGCAGACAACTTGAATACC
GAGTTAGAGAAAGCATTACGTGTAGCCGACTTTATCGAGATCGGTACATTGATGGCACACGATGCTTTGGACCGCGCTGA
GTCTTGTGGTGGTCACTTCCGTACGGAGCACCAGACAGAAGAAGGTGAGGCCTTGCGTCATGACGATAAGTTCATGTACG
TATCTTGCTGGGAGTACCAAGGCGAGGACAAAGATCCTGTCATGTTGAAAGAGGATTTGAACTATGAGTTCGTTGTTCCT
CAAACACGTAACTACAAGAAGTAA

Upstream 100 bases:

>100_bases
ACTTTTCGCGATCATTACTATCATCTTCTTCCTAAACGGAGTAGGTGCTTAATTGCAAGCTACAGGTTTTATAATTAAGA
ACTTTTGAAATTAAATCATT

Downstream 100 bases:

>100_bases
TAATCATCAATCTCAGAAAAAATTAGAATCATGGATAAAGATATAAGTGTAACACTTAAGGTTTGGCGTCAGAGAGGTCC
GAAGGAGAAAGGACAGTTCG

Product: succinate dehydrogenase flavoprotein subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 647; Mature: 646

Protein sequence:

>647_residues
MSEINSKIPQGPLAEKWTNYKNHQKLVNPANKRRLDVIVVGTGLAGASAAASLAEMGFNVLNFCIQDSPRRAHSIAAQGG
INAAKNYQNDGDSVYRLFYDTIKGGDYRAREANVYRLAEVSNSIIDQCVAQGVPFAREYGGLLDNRSFGGAQVSRTFYAR
GQTGQQLLLGAYSALSRQIGLGKVKMYTRHEMLDVVKVDGRARGIIARNLITGKIERYAAHAVVVATGGYVNTFFLSTNA
MASNGSAAWQCYKKGAYFANPCMVQIHPTCVPVKGDFQSKLTLMSESLRNDGRIWVPKKLEDAKALQAGTKKGKDIPEAD
RDYYLERRYPAFGNLVPRDVASRAAKERCDAGFGVNSTGLAVFLDFSDAINRLGKEVVKQKYGNLFDMYEEITNDNPYET
PMMIYPALHYSMGGLWVDYELMTSIPGLFAIGEANFSDHGANRLGASALMQGLADGYFVLPYTIQNYLSDQIQVPRFSTD
LPEFVEAEKAIKDRIQKLMNVKGKETVDTIHRKLGHIMWEHIGMARDAKGLQEAIQMLKDLKKEFWSNVFIPGNADNLNT
ELEKALRVADFIEIGTLMAHDALDRAESCGGHFRTEHQTEEGEALRHDDKFMYVSCWEYQGEDKDPVMLKEDLNYEFVVP
QTRNYKK

Sequences:

>Translated_647_residues
MSEINSKIPQGPLAEKWTNYKNHQKLVNPANKRRLDVIVVGTGLAGASAAASLAEMGFNVLNFCIQDSPRRAHSIAAQGG
INAAKNYQNDGDSVYRLFYDTIKGGDYRAREANVYRLAEVSNSIIDQCVAQGVPFAREYGGLLDNRSFGGAQVSRTFYAR
GQTGQQLLLGAYSALSRQIGLGKVKMYTRHEMLDVVKVDGRARGIIARNLITGKIERYAAHAVVVATGGYVNTFFLSTNA
MASNGSAAWQCYKKGAYFANPCMVQIHPTCVPVKGDFQSKLTLMSESLRNDGRIWVPKKLEDAKALQAGTKKGKDIPEAD
RDYYLERRYPAFGNLVPRDVASRAAKERCDAGFGVNSTGLAVFLDFSDAINRLGKEVVKQKYGNLFDMYEEITNDNPYET
PMMIYPALHYSMGGLWVDYELMTSIPGLFAIGEANFSDHGANRLGASALMQGLADGYFVLPYTIQNYLSDQIQVPRFSTD
LPEFVEAEKAIKDRIQKLMNVKGKETVDTIHRKLGHIMWEHIGMARDAKGLQEAIQMLKDLKKEFWSNVFIPGNADNLNT
ELEKALRVADFIEIGTLMAHDALDRAESCGGHFRTEHQTEEGEALRHDDKFMYVSCWEYQGEDKDPVMLKEDLNYEFVVP
QTRNYKK
>Mature_646_residues
SEINSKIPQGPLAEKWTNYKNHQKLVNPANKRRLDVIVVGTGLAGASAAASLAEMGFNVLNFCIQDSPRRAHSIAAQGGI
NAAKNYQNDGDSVYRLFYDTIKGGDYRAREANVYRLAEVSNSIIDQCVAQGVPFAREYGGLLDNRSFGGAQVSRTFYARG
QTGQQLLLGAYSALSRQIGLGKVKMYTRHEMLDVVKVDGRARGIIARNLITGKIERYAAHAVVVATGGYVNTFFLSTNAM
ASNGSAAWQCYKKGAYFANPCMVQIHPTCVPVKGDFQSKLTLMSESLRNDGRIWVPKKLEDAKALQAGTKKGKDIPEADR
DYYLERRYPAFGNLVPRDVASRAAKERCDAGFGVNSTGLAVFLDFSDAINRLGKEVVKQKYGNLFDMYEEITNDNPYETP
MMIYPALHYSMGGLWVDYELMTSIPGLFAIGEANFSDHGANRLGASALMQGLADGYFVLPYTIQNYLSDQIQVPRFSTDL
PEFVEAEKAIKDRIQKLMNVKGKETVDTIHRKLGHIMWEHIGMARDAKGLQEAIQMLKDLKKEFWSNVFIPGNADNLNTE
LEKALRVADFIEIGTLMAHDALDRAESCGGHFRTEHQTEEGEALRHDDKFMYVSCWEYQGEDKDPVMLKEDLNYEFVVPQ
TRNYKK

Specific function: Two Distinct, Membrane-Bound, FAD-Containing Enzymes Are Responsible For The Catalysis Of Fumarate And Succinate Interconversion; The Fumarate Reductase Is Used In Anaerobic Growth, And The Succinate Dehydrogenase Is Used In Aerobic Growth. [C]

COG id: COG1053

COG function: function code C; Succinate dehydrogenase/fumarate reductase, flavoprotein subunit

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein; Cytoplasmic side [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily [H]

Homologues:

Organism=Homo sapiens, GI156416003, Length=566, Percent_Identity=26.3250883392226, Blast_Score=153, Evalue=4e-37,
Organism=Escherichia coli, GI1790597, Length=551, Percent_Identity=28.3121597096189, Blast_Score=193, Evalue=3e-50,
Organism=Escherichia coli, GI1786942, Length=553, Percent_Identity=25.3164556962025, Blast_Score=136, Evalue=4e-33,
Organism=Escherichia coli, GI1788928, Length=588, Percent_Identity=24.4897959183673, Blast_Score=121, Evalue=1e-28,
Organism=Caenorhabditis elegans, GI17505833, Length=549, Percent_Identity=27.3224043715847, Blast_Score=169, Evalue=5e-42,
Organism=Caenorhabditis elegans, GI17550100, Length=547, Percent_Identity=27.2394881170018, Blast_Score=156, Evalue=4e-38,
Organism=Saccharomyces cerevisiae, GI6322701, Length=633, Percent_Identity=27.172195892575, Blast_Score=182, Evalue=1e-46,
Organism=Saccharomyces cerevisiae, GI6322416, Length=628, Percent_Identity=26.4331210191083, Blast_Score=174, Evalue=6e-44,
Organism=Drosophila melanogaster, GI17137288, Length=595, Percent_Identity=26.5546218487395, Blast_Score=164, Evalue=1e-40,
Organism=Drosophila melanogaster, GI24655642, Length=595, Percent_Identity=26.5546218487395, Blast_Score=164, Evalue=1e-40,
Organism=Drosophila melanogaster, GI24655647, Length=595, Percent_Identity=26.5546218487395, Blast_Score=164, Evalue=1e-40,
Organism=Drosophila melanogaster, GI24663005, Length=596, Percent_Identity=25.6711409395973, Blast_Score=144, Evalue=2e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003953
- InterPro:   IPR013027
- InterPro:   IPR003952
- InterPro:   IPR015939
- InterPro:   IPR004112
- InterPro:   IPR011280 [H]

Pfam domain/function: PF00890 FAD_binding_2; PF02910 Succ_DH_flav_C [H]

EC number: =1.3.99.1 [H]

Molecular weight: Translated: 72245; Mature: 72114

Theoretical pI: Translated: 7.59; Mature: 7.59

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEINSKIPQGPLAEKWTNYKNHQKLVNPANKRRLDVIVVGTGLAGASAAASLAEMGFNV
CCCCCCCCCCCCCHHHHCCCCCHHHHCCCCCCCEEEEEEEECCCCCHHHHHHHHHHHHHH
LNFCIQDSPRRAHSIAAQGGINAAKNYQNDGDSVYRLFYDTIKGGDYRAREANVYRLAEV
HHHHHCCCCHHHHHHHHHCCCCHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHH
SNSIIDQCVAQGVPFAREYGGLLDNRSFGGAQVSRTFYARGQTGQQLLLGAYSALSRQIG
HHHHHHHHHHCCCCCHHHHCCCCCCCCCCCHHHHHHHEECCCCCHHHHHHHHHHHHHHCC
LGKVKMYTRHEMLDVVKVDGRARGIIARNLITGKIERYAAHAVVVATGGYVNTFFLSTNA
CCCEEHHHHHHHHHHHEECCCCCCHHHHHHHHHHHHHHHCEEEEEEECCCEEEEEEECCC
MASNGSAAWQCYKKGAYFANPCMVQIHPTCVPVKGDFQSKLTLMSESLRNDGRIWVPKKL
CCCCCCHHHHHHHCCCEECCCEEEEECCEEEECCCCHHHHHHHHHHHHCCCCEEECCCCC
EDAKALQAGTKKGKDIPEADRDYYLERRYPAFGNLVPRDVASRAAKERCDAGFGVNSTGL
HHHHHHHHHCCCCCCCCCCCHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCE
AVFLDFSDAINRLGKEVVKQKYGNLFDMYEEITNDNPYETPMMIYPALHYSMGGLWVDYE
EEEEECHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCCCEEEEHHHHHHCCCEEEEHH
LMTSIPGLFAIGEANFSDHGANRLGASALMQGLADGYFVLPYTIQNYLSDQIQVPRFSTD
HHHCCCCEEEECCCCCCCCCCHHHHHHHHHHHHCCCEEEEHHHHHHHHHCCEECCCCCCC
LPEFVEAEKAIKDRIQKLMNVKGKETVDTIHRKLGHIMWEHIGMARDAKGLQEAIQMLKD
CHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
LKKEFWSNVFIPGNADNLNTELEKALRVADFIEIGTLMAHDALDRAESCGGHFRTEHQTE
HHHHHHCCEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
EGEALRHDDKFMYVSCWEYQGEDKDPVMLKEDLNYEFVVPQTRNYKK
CCCHHHCCCCEEEEEEEECCCCCCCCEEEECCCCEEEECCCCCCCCC
>Mature Secondary Structure 
SEINSKIPQGPLAEKWTNYKNHQKLVNPANKRRLDVIVVGTGLAGASAAASLAEMGFNV
CCCCCCCCCCCCHHHHCCCCCHHHHCCCCCCCEEEEEEEECCCCCHHHHHHHHHHHHHH
LNFCIQDSPRRAHSIAAQGGINAAKNYQNDGDSVYRLFYDTIKGGDYRAREANVYRLAEV
HHHHHCCCCHHHHHHHHHCCCCHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHH
SNSIIDQCVAQGVPFAREYGGLLDNRSFGGAQVSRTFYARGQTGQQLLLGAYSALSRQIG
HHHHHHHHHHCCCCCHHHHCCCCCCCCCCCHHHHHHHEECCCCCHHHHHHHHHHHHHHCC
LGKVKMYTRHEMLDVVKVDGRARGIIARNLITGKIERYAAHAVVVATGGYVNTFFLSTNA
CCCEEHHHHHHHHHHHEECCCCCCHHHHHHHHHHHHHHHCEEEEEEECCCEEEEEEECCC
MASNGSAAWQCYKKGAYFANPCMVQIHPTCVPVKGDFQSKLTLMSESLRNDGRIWVPKKL
CCCCCCHHHHHHHCCCEECCCEEEEECCEEEECCCCHHHHHHHHHHHHCCCCEEECCCCC
EDAKALQAGTKKGKDIPEADRDYYLERRYPAFGNLVPRDVASRAAKERCDAGFGVNSTGL
HHHHHHHHHCCCCCCCCCCCHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCE
AVFLDFSDAINRLGKEVVKQKYGNLFDMYEEITNDNPYETPMMIYPALHYSMGGLWVDYE
EEEEECHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCCCEEEEHHHHHHCCCEEEEHH
LMTSIPGLFAIGEANFSDHGANRLGASALMQGLADGYFVLPYTIQNYLSDQIQVPRFSTD
HHHCCCCEEEECCCCCCCCCCHHHHHHHHHHHHCCCEEEEHHHHHHHHHCCEECCCCCCC
LPEFVEAEKAIKDRIQKLMNVKGKETVDTIHRKLGHIMWEHIGMARDAKGLQEAIQMLKD
CHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
LKKEFWSNVFIPGNADNLNTELEKALRVADFIEIGTLMAHDALDRAESCGGHFRTEHQTE
HHHHHHCCEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
EGEALRHDDKFMYVSCWEYQGEDKDPVMLKEDLNYEFVVPQTRNYKK
CCCHHHCCCCEEEEEEEECCCCCCCCEEEECCCCEEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3027051; 8969504; 9384377; 3086287; 3021212 [H]