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The map label for this gene is fkpA [H]

Identifier: 150009303

GI number: 150009303

Start: 3212687

End: 3213397

Strand: Reverse

Name: fkpA [H]

Synonym: BDI_2705

Alternate gene names: 150009303

Gene position: 3213397-3212687 (Counterclockwise)

Preceding gene: 150009304

Following gene: 150009302

Centisome position: 66.79

GC content: 46.98

Gene sequence:

>711_bases
ATGAAAAAGTTAAGTGTATTAGTCGCTACAGTGATTGTAGCAATGGGCGCATCTTTCACCTCTTGCGGTGATTCTCACAA
AAGCGCGAGCTTGAAGACTTCCATCGATAGCGCAAGCTACGCTATTGGTATCAGCACAGGTGCCGGTTATAAGGAAAACT
TAAAGACTTTGCCGGGTGGCGAGGCTAACGTAGATGATTTGATCGCTGGTTTTATCCAAGCTATCAAAGGGGATTCTTCT
GCGATGAAGATGAATCCGCAACAGGCTCAACAATATTTGCAGACTTACTTCGTAGAGGCTCAGGCTCGCGAGGCTAAGAA
GACAAAAGAAGAGGGTGATAAGTTCTTGGCGGAGAATAAGACAAAAGAAGGCGTTATCACGACTGAGAGCGGCTTGCAAT
ATAAGGTAGAGAAAGAAGGTACAGGCGCGAAGCCAACCGCTACCGATAAGGTAAAAGTTCATTATACCGGAACTCTATTG
GACGGTACTAAGTTTGATAGCTCCGTGGATCGTGGCGAGCCGGCTGAGTTCGGTGTTGGCCAAGTAATCAAGGGCTGGAC
TGAGGGCTTGCAGATCATGCCGGTCGGTTCTAAATATATCTTCTGGATCCCGGCTGAGTTGGCTTATGGCGAACGTGGCG
CAGGACAAGATATCAAACCGAACAGCGTATTGAAGTTCGAGGTTGAGTTGCTTGACATCGTAAAAGAATAA

Upstream 100 bases:

>100_bases
GCGAGCGTGGGGCAGGTGAGGCTATCGAGCCGAATAGTACATTGATCTTCGACGTTGAGTTATTAGATATCGAAAAATAA
TATATAAGAGTTAAAGAAAA

Downstream 100 bases:

>100_bases
GTAGCGAAGAAATAGAAACGGAACGTTTGTAAGATAATAGGCGGGCAAATTATGCTAAAAAGCATTTTTTGCCCGCTTTT
ATTATTTATTGATTACTTTT

Product: FKBP-type peptidyl-prolyl cis-trans isomerase

Products: NA

Alternate protein names: PPIase; Rotamase [H]

Number of amino acids: Translated: 236; Mature: 236

Protein sequence:

>236_residues
MKKLSVLVATVIVAMGASFTSCGDSHKSASLKTSIDSASYAIGISTGAGYKENLKTLPGGEANVDDLIAGFIQAIKGDSS
AMKMNPQQAQQYLQTYFVEAQAREAKKTKEEGDKFLAENKTKEGVITTESGLQYKVEKEGTGAKPTATDKVKVHYTGTLL
DGTKFDSSVDRGEPAEFGVGQVIKGWTEGLQIMPVGSKYIFWIPAELAYGERGAGQDIKPNSVLKFEVELLDIVKE

Sequences:

>Translated_236_residues
MKKLSVLVATVIVAMGASFTSCGDSHKSASLKTSIDSASYAIGISTGAGYKENLKTLPGGEANVDDLIAGFIQAIKGDSS
AMKMNPQQAQQYLQTYFVEAQAREAKKTKEEGDKFLAENKTKEGVITTESGLQYKVEKEGTGAKPTATDKVKVHYTGTLL
DGTKFDSSVDRGEPAEFGVGQVIKGWTEGLQIMPVGSKYIFWIPAELAYGERGAGQDIKPNSVLKFEVELLDIVKE
>Mature_236_residues
MKKLSVLVATVIVAMGASFTSCGDSHKSASLKTSIDSASYAIGISTGAGYKENLKTLPGGEANVDDLIAGFIQAIKGDSS
AMKMNPQQAQQYLQTYFVEAQAREAKKTKEEGDKFLAENKTKEGVITTESGLQYKVEKEGTGAKPTATDKVKVHYTGTLL
DGTKFDSSVDRGEPAEFGVGQVIKGWTEGLQIMPVGSKYIFWIPAELAYGERGAGQDIKPNSVLKFEVELLDIVKE

Specific function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. FkpA probably acts in the folding of extracytoplasmic proteins [H]

COG id: COG0545

COG function: function code O; FKBP-type peptidyl-prolyl cis-trans isomerases 1

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase FKBP-type domain [H]

Homologues:

Organism=Homo sapiens, GI4503729, Length=117, Percent_Identity=44.4444444444444, Blast_Score=87, Evalue=1e-17,
Organism=Homo sapiens, GI206725530, Length=87, Percent_Identity=54.0229885057471, Blast_Score=86, Evalue=3e-17,
Organism=Homo sapiens, GI17149844, Length=87, Percent_Identity=54.0229885057471, Blast_Score=86, Evalue=3e-17,
Organism=Homo sapiens, GI17149842, Length=87, Percent_Identity=54.0229885057471, Blast_Score=86, Evalue=3e-17,
Organism=Homo sapiens, GI224809329, Length=101, Percent_Identity=46.5346534653465, Blast_Score=78, Evalue=6e-15,
Organism=Homo sapiens, GI224809327, Length=101, Percent_Identity=46.5346534653465, Blast_Score=78, Evalue=6e-15,
Organism=Homo sapiens, GI4758384, Length=101, Percent_Identity=46.5346534653465, Blast_Score=78, Evalue=6e-15,
Organism=Homo sapiens, GI224809331, Length=108, Percent_Identity=44.4444444444444, Blast_Score=76, Evalue=2e-14,
Organism=Homo sapiens, GI33469985, Length=89, Percent_Identity=48.314606741573, Blast_Score=75, Evalue=4e-14,
Organism=Homo sapiens, GI17149836, Length=106, Percent_Identity=42.4528301886792, Blast_Score=75, Evalue=6e-14,
Organism=Homo sapiens, GI4503725, Length=106, Percent_Identity=42.4528301886792, Blast_Score=75, Evalue=6e-14,
Organism=Homo sapiens, GI4758380, Length=83, Percent_Identity=45.7831325301205, Blast_Score=72, Evalue=4e-13,
Organism=Homo sapiens, GI4503727, Length=99, Percent_Identity=44.4444444444444, Blast_Score=72, Evalue=4e-13,
Organism=Homo sapiens, GI192448443, Length=87, Percent_Identity=45.9770114942529, Blast_Score=70, Evalue=1e-12,
Organism=Escherichia coli, GI87082390, Length=199, Percent_Identity=48.7437185929648, Blast_Score=171, Evalue=3e-44,
Organism=Escherichia coli, GI1789745, Length=249, Percent_Identity=38.1526104417671, Blast_Score=124, Evalue=5e-30,
Organism=Caenorhabditis elegans, GI17540882, Length=109, Percent_Identity=52.2935779816514, Blast_Score=100, Evalue=7e-22,
Organism=Caenorhabditis elegans, GI17561782, Length=100, Percent_Identity=48, Blast_Score=80, Evalue=6e-16,
Organism=Caenorhabditis elegans, GI71993519, Length=92, Percent_Identity=48.9130434782609, Blast_Score=80, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6320727, Length=108, Percent_Identity=50.9259259259259, Blast_Score=97, Evalue=2e-21,
Organism=Saccharomyces cerevisiae, GI6324194, Length=97, Percent_Identity=54.639175257732, Blast_Score=94, Evalue=2e-20,
Organism=Drosophila melanogaster, GI281363946, Length=88, Percent_Identity=54.5454545454545, Blast_Score=94, Evalue=1e-19,
Organism=Drosophila melanogaster, GI17352457, Length=88, Percent_Identity=54.5454545454545, Blast_Score=94, Evalue=1e-19,
Organism=Drosophila melanogaster, GI24655568, Length=91, Percent_Identity=51.6483516483517, Blast_Score=89, Evalue=3e-18,
Organism=Drosophila melanogaster, GI24583150, Length=109, Percent_Identity=40.3669724770642, Blast_Score=80, Evalue=8e-16,
Organism=Drosophila melanogaster, GI24647110, Length=93, Percent_Identity=44.0860215053763, Blast_Score=72, Evalue=3e-13,
Organism=Drosophila melanogaster, GI21356629, Length=106, Percent_Identity=44.3396226415094, Blast_Score=71, Evalue=6e-13,

Paralogues:

None

Copy number: 340 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001179
- InterPro:   IPR000774 [H]

Pfam domain/function: PF00254 FKBP_C; PF01346 FKBP_N [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 25343; Mature: 25343

Theoretical pI: Translated: 5.45; Mature: 5.45

Prosite motif: PS00013 PROKAR_LIPOPROTEIN ; PS50059 FKBP_PPIASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKLSVLVATVIVAMGASFTSCGDSHKSASLKTSIDSASYAIGISTGAGYKENLKTLPGG
CCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEECCCCCEEEEEECCCCCCHHCCCCCCCC
EANVDDLIAGFIQAIKGDSSAMKMNPQQAQQYLQTYFVEAQAREAKKTKEEGDKFLAENK
CCCHHHHHHHHHHHHCCCCCCEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
TKEGVITTESGLQYKVEKEGTGAKPTATDKVKVHYTGTLLDGTKFDSSVDRGEPAEFGVG
CCCCEEEECCCCEEEEECCCCCCCCCCCCEEEEEEEEEEECCCCCCCCCCCCCCCCCCHH
QVIKGWTEGLQIMPVGSKYIFWIPAELAYGERGAGQDIKPNSVLKFEVELLDIVKE
HHHHHHHCCEEEEECCCEEEEEEEEECCCCCCCCCCCCCCCCEEEEEHHHHHHHCC
>Mature Secondary Structure
MKKLSVLVATVIVAMGASFTSCGDSHKSASLKTSIDSASYAIGISTGAGYKENLKTLPGG
CCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEECCCCCEEEEEECCCCCCHHCCCCCCCC
EANVDDLIAGFIQAIKGDSSAMKMNPQQAQQYLQTYFVEAQAREAKKTKEEGDKFLAENK
CCCHHHHHHHHHHHHCCCCCCEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
TKEGVITTESGLQYKVEKEGTGAKPTATDKVKVHYTGTLLDGTKFDSSVDRGEPAEFGVG
CCCCEEEECCCCEEEEECCCCCCCCCCCCEEEEEEEEEEECCCCCCCCCCCCCCCCCCHH
QVIKGWTEGLQIMPVGSKYIFWIPAELAYGERGAGQDIKPNSVLKFEVELLDIVKE
HHHHHHHCCEEEEECCCEEEEEEEEECCCCCCCCCCCCCCCCEEEEEHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9171380 [H]