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The map label for this gene is aslA [H]

Identifier: 150008925

GI number: 150008925

Start: 2728633

End: 2730039

Strand: Reverse

Name: aslA [H]

Synonym: BDI_2321

Alternate gene names: 150008925

Gene position: 2730039-2728633 (Counterclockwise)

Preceding gene: 150008926

Following gene: 150008924

Centisome position: 56.74

GC content: 46.06

Gene sequence:

>1407_bases
ATGAAACTTATATCTAACATAATATCGGTATTAGCCTTTTCAGGAGCGGCCGTGGCTACTCAAGCGGCGGAAAGGCCAAA
TGTGATCATCGTATTTATCGATGATTTCGGATATGGGGATTTAGGTTGTTACGGGAGTACGAAGCATCGTACTCCCCATA
TCGACCAGATGGCTAAAGAGGGAATACGACTGACCGATTTTTATGTGGGTTCGAGCGTGAGCACACCTTCCAGATCGGCT
TTATTGACAGGGTGTTATCCAAGGCGAGTCTCCATGCATGTAAATGCGGACCCTACACCTTTGATGTCCAAAGGGAGGCA
AGTGCTATTTCCAGCTTCGCATAAAGGCTTGAATCCCGGTGAGATAACGATCGCCGAGTTGATGAAGGAGCAGGGATATG
CGACGGCTTGTATCGGGAAATGGCATCTAGGGGATCAATTGCCATTTCTTCCTACCCGGCAGGGTTTCGACTACTATTAT
GGTATTCCTTATAGTAACGATATGGATCGTCCGTATTGTCCGTTACCCTTGATGGAACAGGAGGAGGTAATAGTGGCTCC
TGTCGGTCATGATTCCTTGACGATTCGTTATACCAATAAGACTGTGGAGTTTATAAAGTCTCATAAGGAATCTCCGTTCT
TTATTTACTTGTGCCATAATATGACTCATAATCCGTTAGCGGCTTCTCCCGCTTTCAAGGGAAAGTCTCAGAACGGACTC
TATGGAGATGCGACCGAGGAATTGGATTGGTCGATGGGAGTCTTGCTTGAGACTTTAAAGGAGGAAGGATTGGATCAAAA
TACCTTGATTATCTTTACTTCCGATAATGGTGCGGATGAACACTTCGGTGGTACGAACCGTCCGTTGAGAGGCCAAAAGG
GTACGACGTATGAAGGTGGGTTCAGGGTGCCTTGTATAATGAGATGGCCCGCTAAAATACCGGCGGGACAGGAGACTGAT
AATCTGGTGACTTCGATGGATTTCTTACCGACATTGGCGCATTATTGCAGTTATGCGGTTCCTTCCGACCGGGTGATAGA
TGGGCATAATGTGTCTGGAATCTTGGAGGGAGAATCGATGGCATCGCCCACGGAGACTTTCTATTATTACCAGAAACAAC
AATTACAGGCGGTACGTTGGGGAAACTGGAAGTATCATTTACCTTTGAAGGAACGTATCAAAGGCCCTCACTTCCCGGAT
ACGGAAGTCGGTGAAGCTCGTTTATATAATTTGGCGAATGATTTGTCGGAAACAACCAATGTCATCGATAAACATCCCGA
AGTAGTGACGAAGATGAATCAATGGATCGAACAGGTTCGTAGTGATATGGGAGATTGGGGATATGAAGGCCGGAACCAGC
GTCCTGCCGGTATTATAGATGAACCTTTTCCCCGTTTACTTAAATAA

Upstream 100 bases:

>100_bases
AATATTACGATTTATTACCGATTCCTGATAGCGAGCGTTCTTTGAATCCGAATTTGGATCAGAATCCGGGTTGGTAATGT
GCAACTAAAAGAAAAATGAA

Downstream 100 bases:

>100_bases
AAAGATACGCATATGAAAACACTGAAATCATTGTCTGTTTTAACAGCGGCGGTATTATCGAACAGCTTGAGCTTGAACGC
TGCCTCGGATGCGGCCAATA

Product: arylsulfatase A

Products: NA

Alternate protein names: AS; Aryl-sulfate sulphohydrolase [H]

Number of amino acids: Translated: 468; Mature: 468

Protein sequence:

>468_residues
MKLISNIISVLAFSGAAVATQAAERPNVIIVFIDDFGYGDLGCYGSTKHRTPHIDQMAKEGIRLTDFYVGSSVSTPSRSA
LLTGCYPRRVSMHVNADPTPLMSKGRQVLFPASHKGLNPGEITIAELMKEQGYATACIGKWHLGDQLPFLPTRQGFDYYY
GIPYSNDMDRPYCPLPLMEQEEVIVAPVGHDSLTIRYTNKTVEFIKSHKESPFFIYLCHNMTHNPLAASPAFKGKSQNGL
YGDATEELDWSMGVLLETLKEEGLDQNTLIIFTSDNGADEHFGGTNRPLRGQKGTTYEGGFRVPCIMRWPAKIPAGQETD
NLVTSMDFLPTLAHYCSYAVPSDRVIDGHNVSGILEGESMASPTETFYYYQKQQLQAVRWGNWKYHLPLKERIKGPHFPD
TEVGEARLYNLANDLSETTNVIDKHPEVVTKMNQWIEQVRSDMGDWGYEGRNQRPAGIIDEPFPRLLK

Sequences:

>Translated_468_residues
MKLISNIISVLAFSGAAVATQAAERPNVIIVFIDDFGYGDLGCYGSTKHRTPHIDQMAKEGIRLTDFYVGSSVSTPSRSA
LLTGCYPRRVSMHVNADPTPLMSKGRQVLFPASHKGLNPGEITIAELMKEQGYATACIGKWHLGDQLPFLPTRQGFDYYY
GIPYSNDMDRPYCPLPLMEQEEVIVAPVGHDSLTIRYTNKTVEFIKSHKESPFFIYLCHNMTHNPLAASPAFKGKSQNGL
YGDATEELDWSMGVLLETLKEEGLDQNTLIIFTSDNGADEHFGGTNRPLRGQKGTTYEGGFRVPCIMRWPAKIPAGQETD
NLVTSMDFLPTLAHYCSYAVPSDRVIDGHNVSGILEGESMASPTETFYYYQKQQLQAVRWGNWKYHLPLKERIKGPHFPD
TEVGEARLYNLANDLSETTNVIDKHPEVVTKMNQWIEQVRSDMGDWGYEGRNQRPAGIIDEPFPRLLK
>Mature_468_residues
MKLISNIISVLAFSGAAVATQAAERPNVIIVFIDDFGYGDLGCYGSTKHRTPHIDQMAKEGIRLTDFYVGSSVSTPSRSA
LLTGCYPRRVSMHVNADPTPLMSKGRQVLFPASHKGLNPGEITIAELMKEQGYATACIGKWHLGDQLPFLPTRQGFDYYY
GIPYSNDMDRPYCPLPLMEQEEVIVAPVGHDSLTIRYTNKTVEFIKSHKESPFFIYLCHNMTHNPLAASPAFKGKSQNGL
YGDATEELDWSMGVLLETLKEEGLDQNTLIIFTSDNGADEHFGGTNRPLRGQKGTTYEGGFRVPCIMRWPAKIPAGQETD
NLVTSMDFLPTLAHYCSYAVPSDRVIDGHNVSGILEGESMASPTETFYYYQKQQLQAVRWGNWKYHLPLKERIKGPHFPD
TEVGEARLYNLANDLSETTNVIDKHPEVVTKMNQWIEQVRSDMGDWGYEGRNQRPAGIIDEPFPRLLK

Specific function: Unknown

COG id: COG3119

COG function: function code P; Arylsulfatase A and related enzymes

Gene ontology:

Cell location: Periplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sulfatase family [H]

Homologues:

Organism=Homo sapiens, GI146229331, Length=441, Percent_Identity=35.827664399093, Blast_Score=243, Evalue=3e-64,
Organism=Homo sapiens, GI146229329, Length=441, Percent_Identity=35.827664399093, Blast_Score=243, Evalue=3e-64,
Organism=Homo sapiens, GI6005990, Length=441, Percent_Identity=35.827664399093, Blast_Score=243, Evalue=3e-64,
Organism=Homo sapiens, GI146229324, Length=441, Percent_Identity=35.827664399093, Blast_Score=243, Evalue=3e-64,
Organism=Homo sapiens, GI4503899, Length=402, Percent_Identity=36.318407960199, Blast_Score=229, Evalue=4e-60,
Organism=Homo sapiens, GI45430057, Length=448, Percent_Identity=30.3571428571429, Blast_Score=197, Evalue=2e-50,
Organism=Homo sapiens, GI53831991, Length=212, Percent_Identity=42.9245283018868, Blast_Score=176, Evalue=5e-44,
Organism=Homo sapiens, GI146229327, Length=359, Percent_Identity=33.1476323119777, Blast_Score=166, Evalue=5e-41,
Organism=Homo sapiens, GI38569405, Length=473, Percent_Identity=28.7526427061311, Blast_Score=160, Evalue=2e-39,
Organism=Homo sapiens, GI38569407, Length=351, Percent_Identity=31.6239316239316, Blast_Score=158, Evalue=1e-38,
Organism=Homo sapiens, GI109389362, Length=472, Percent_Identity=26.6949152542373, Blast_Score=150, Evalue=3e-36,
Organism=Homo sapiens, GI59797060, Length=353, Percent_Identity=30.5949008498584, Blast_Score=147, Evalue=3e-35,
Organism=Homo sapiens, GI71852584, Length=224, Percent_Identity=37.0535714285714, Blast_Score=135, Evalue=7e-32,
Organism=Homo sapiens, GI157266309, Length=234, Percent_Identity=34.1880341880342, Blast_Score=130, Evalue=2e-30,
Organism=Homo sapiens, GI31742482, Length=150, Percent_Identity=46, Blast_Score=129, Evalue=7e-30,
Organism=Homo sapiens, GI58743319, Length=224, Percent_Identity=34.8214285714286, Blast_Score=128, Evalue=1e-29,
Organism=Homo sapiens, GI71852586, Length=159, Percent_Identity=41.5094339622642, Blast_Score=120, Evalue=2e-27,
Organism=Escherichia coli, GI1790233, Length=420, Percent_Identity=29.5238095238095, Blast_Score=154, Evalue=1e-38,
Organism=Escherichia coli, GI87081924, Length=496, Percent_Identity=26.4112903225806, Blast_Score=136, Evalue=2e-33,
Organism=Escherichia coli, GI1790112, Length=488, Percent_Identity=22.5409836065574, Blast_Score=88, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI115533416, Length=450, Percent_Identity=28.6666666666667, Blast_Score=159, Evalue=3e-39,
Organism=Caenorhabditis elegans, GI115533418, Length=438, Percent_Identity=28.5388127853881, Blast_Score=147, Evalue=1e-35,
Organism=Caenorhabditis elegans, GI17559078, Length=261, Percent_Identity=30.6513409961686, Blast_Score=123, Evalue=2e-28,
Organism=Drosophila melanogaster, GI24666175, Length=419, Percent_Identity=29.1169451073986, Blast_Score=149, Evalue=6e-36,
Organism=Drosophila melanogaster, GI24666109, Length=403, Percent_Identity=31.7617866004963, Blast_Score=147, Evalue=2e-35,
Organism=Drosophila melanogaster, GI281366397, Length=387, Percent_Identity=30.4909560723514, Blast_Score=144, Evalue=2e-34,
Organism=Drosophila melanogaster, GI281366395, Length=387, Percent_Identity=30.4909560723514, Blast_Score=144, Evalue=2e-34,
Organism=Drosophila melanogaster, GI24666163, Length=387, Percent_Identity=30.4909560723514, Blast_Score=144, Evalue=2e-34,
Organism=Drosophila melanogaster, GI281363223, Length=361, Percent_Identity=29.6398891966759, Blast_Score=143, Evalue=3e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017849
- InterPro:   IPR017850
- InterPro:   IPR000917 [H]

Pfam domain/function: PF00884 Sulfatase [H]

EC number: =3.1.6.1 [H]

Molecular weight: Translated: 52443; Mature: 52443

Theoretical pI: Translated: 6.12; Mature: 6.12

Prosite motif: PS00523 SULFATASE_1 ; PS00149 SULFATASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLISNIISVLAFSGAAVATQAAERPNVIIVFIDDFGYGDLGCYGSTKHRTPHIDQMAKE
CHHHHHHHHHHHCCCCHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCHHHHHHC
GIRLTDFYVGSSVSTPSRSALLTGCYPRRVSMHVNADPTPLMSKGRQVLFPASHKGLNPG
CCEEEEEEECCCCCCCCCCEEEECCCCCEEEEEECCCCCHHHHCCCEEEECCCCCCCCCC
EITIAELMKEQGYATACIGKWHLGDQLPFLPTRQGFDYYYGIPYSNDMDRPYCPLPLMEQ
CCHHHHHHHHCCCEEEEEEEECCCCCCCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCC
EEVIVAPVGHDSLTIRYTNKTVEFIKSHKESPFFIYLCHNMTHNPLAASPAFKGKSQNGL
CCEEEEECCCCEEEEEECCHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCC
YGDATEELDWSMGVLLETLKEEGLDQNTLIIFTSDNGADEHFGGTNRPLRGQKGTTYEGG
CCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCC
FRVPCIMRWPAKIPAGQETDNLVTSMDFLPTLAHYCSYAVPSDRVIDGHNVSGILEGESM
EECCEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCEECCCCCCEEECCCCC
ASPTETFYYYQKQQLQAVRWGNWKYHLPLKERIKGPHFPDTEVGEARLYNLANDLSETTN
CCCHHHHHHHHHHHHHHEECCCEEEECCHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHH
VIDKHPEVVTKMNQWIEQVRSDMGDWGYEGRNQRPAGIIDEPFPRLLK
HHHCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHCC
>Mature Secondary Structure
MKLISNIISVLAFSGAAVATQAAERPNVIIVFIDDFGYGDLGCYGSTKHRTPHIDQMAKE
CHHHHHHHHHHHCCCCHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCHHHHHHC
GIRLTDFYVGSSVSTPSRSALLTGCYPRRVSMHVNADPTPLMSKGRQVLFPASHKGLNPG
CCEEEEEEECCCCCCCCCCEEEECCCCCEEEEEECCCCCHHHHCCCEEEECCCCCCCCCC
EITIAELMKEQGYATACIGKWHLGDQLPFLPTRQGFDYYYGIPYSNDMDRPYCPLPLMEQ
CCHHHHHHHHCCCEEEEEEEECCCCCCCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCC
EEVIVAPVGHDSLTIRYTNKTVEFIKSHKESPFFIYLCHNMTHNPLAASPAFKGKSQNGL
CCEEEEECCCCEEEEEECCHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCC
YGDATEELDWSMGVLLETLKEEGLDQNTLIIFTSDNGADEHFGGTNRPLRGQKGTTYEGG
CCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCC
FRVPCIMRWPAKIPAGQETDNLVTSMDFLPTLAHYCSYAVPSDRVIDGHNVSGILEGESM
EECCEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCEECCCCCCEEECCCCC
ASPTETFYYYQKQQLQAVRWGNWKYHLPLKERIKGPHFPDTEVGEARLYNLANDLSETTN
CCCHHHHHHHHHHHHHHEECCCEEEECCHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHH
VIDKHPEVVTKMNQWIEQVRSDMGDWGYEGRNQRPAGIIDEPFPRLLK
HHHCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1379743; 9278503 [H]