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The map label for this gene is aslA [H]

Identifier: 150008924

GI number: 150008924

Start: 2727241

End: 2728620

Strand: Reverse

Name: aslA [H]

Synonym: BDI_2320

Alternate gene names: 150008924

Gene position: 2728620-2727241 (Counterclockwise)

Preceding gene: 150008925

Following gene: 150008923

Centisome position: 56.71

GC content: 47.68

Gene sequence:

>1380_bases
ATGAAAACACTGAAATCATTGTCTGTTTTAACAGCGGCGGTATTATCGAACAGCTTGAGCTTGAACGCTGCCTCGGATGC
GGCCAATAAGCCTAATTTTGTAATCATATTCTGTGACGATATGGGATATGGGGATTTGAGTTGCTATGGGAATCCCACGA
TCCGCACACCGAATATAGACCGTATGGCTTGTGAAGGAATGAAGCTGACCCAGTTTTATGTGGGGGCCGGAGTTTCTACG
CCAAGTCGGGCCGCGTTAATGACCGGACGTTTGCCGGTTCGAAATGGATTATATGGAGATCGGGTAGCCGTACTTTTCCC
TAACTCAAAGGCTGGGTTAGGACAAGATGAGGTCACGATCGCCAAGGTTTTACAACAAAGTGGGTATGCGACCGGCTGTG
TAGGCAAATGGCATTTAGGAGCGTTCTCTCCCTATTTACCGACGGATCATGGTTTTGATACCTATTTCGGCATACCTTAT
TCCAATGATATGAGCCCCGTTCAGAATAAAGGCGCGCATGCCCGGAATTTTCCACCGACTCCATTGATAGTGGATGGTAA
GCAAATCGAATCGGAACCGGATCAGGGAGAATTAACCCGTCGCTATACGGAGAAAGCGGTATCGTTCATCAAGAATCATT
CAAAGGAGCCTTTCTTCCTTTATTTCGCTCATACCTTCCCGCATATCCCATTGTACACGAATGCCCGTTTCGAGGGAACG
AGCAAACGAGGCCTGTACGGAGATGTGGTTGAGGAAATAGACTGGAGCGTTGGTGAAGTGTTGAAGGCTCTGCGTGAAAA
TGGCTTGGACGAGAATACGTTTGTTATTTTTACCAGCGATAACGGCCCTTGGCTGACGGAGCATGAGAATGGCGGTTCCG
CAGGTCCGTTGAAGGATGGCAAGGGTACTTGGTGGGAAGGTGGCTTCCGGGTTCCGGCCATTTGTTGGATGCCGGGAAAA
ATCAATCCGGCGATCAACGATGAGATTATGACCTCGATGGATTTATATCCGACTTTCCTCTCGATGGCGGGTATCGAGCA
ACCGAAAGATCTTGTATTGGATGGCGTGAATCAAACCGGATTATTGTTTGAGGAAAAGCATTCCGCCCGTGATGAGGTTT
ATTATTGGTGGGGCAGTGAGTTGATGGCGATCCGTAAAGGGGAGTGGAAGTATTATTTTAAGACGATCAAGGACCAATAT
CTGCGAACCTGTAAGATCGAGACTCCGGCAGAACCCTTGTTGTATAACGTGGAGACAGATATCTCAGAGCGATTCAATCT
GGCGGATAAGCATCCGGAGATCGTGAAATTACTGATCGAGGCCGGTGAGAAACATAAGAAAGGAATGAAGATCAAGCCTT
CCGTATGTGATATGATGTAA

Upstream 100 bases:

>100_bases
TAGTGATATGGGAGATTGGGGATATGAAGGCCGGAACCAGCGTCCTGCCGGTATTATAGATGAACCTTTTCCCCGTTTAC
TTAAATAAAAAGATACGCAT

Downstream 100 bases:

>100_bases
TGGGACATTTAAAAACACTAGATTAGATGAATAAATATATACTAACAGCGGCTTGCGGATTGGCTTTTTCCGCAGCTTCC
GCACAAACAAAGGCTTTGCC

Product: arylsulfatase A

Products: NA

Alternate protein names: AS; Aryl-sulfate sulphohydrolase [H]

Number of amino acids: Translated: 459; Mature: 459

Protein sequence:

>459_residues
MKTLKSLSVLTAAVLSNSLSLNAASDAANKPNFVIIFCDDMGYGDLSCYGNPTIRTPNIDRMACEGMKLTQFYVGAGVST
PSRAALMTGRLPVRNGLYGDRVAVLFPNSKAGLGQDEVTIAKVLQQSGYATGCVGKWHLGAFSPYLPTDHGFDTYFGIPY
SNDMSPVQNKGAHARNFPPTPLIVDGKQIESEPDQGELTRRYTEKAVSFIKNHSKEPFFLYFAHTFPHIPLYTNARFEGT
SKRGLYGDVVEEIDWSVGEVLKALRENGLDENTFVIFTSDNGPWLTEHENGGSAGPLKDGKGTWWEGGFRVPAICWMPGK
INPAINDEIMTSMDLYPTFLSMAGIEQPKDLVLDGVNQTGLLFEEKHSARDEVYYWWGSELMAIRKGEWKYYFKTIKDQY
LRTCKIETPAEPLLYNVETDISERFNLADKHPEIVKLLIEAGEKHKKGMKIKPSVCDMM

Sequences:

>Translated_459_residues
MKTLKSLSVLTAAVLSNSLSLNAASDAANKPNFVIIFCDDMGYGDLSCYGNPTIRTPNIDRMACEGMKLTQFYVGAGVST
PSRAALMTGRLPVRNGLYGDRVAVLFPNSKAGLGQDEVTIAKVLQQSGYATGCVGKWHLGAFSPYLPTDHGFDTYFGIPY
SNDMSPVQNKGAHARNFPPTPLIVDGKQIESEPDQGELTRRYTEKAVSFIKNHSKEPFFLYFAHTFPHIPLYTNARFEGT
SKRGLYGDVVEEIDWSVGEVLKALRENGLDENTFVIFTSDNGPWLTEHENGGSAGPLKDGKGTWWEGGFRVPAICWMPGK
INPAINDEIMTSMDLYPTFLSMAGIEQPKDLVLDGVNQTGLLFEEKHSARDEVYYWWGSELMAIRKGEWKYYFKTIKDQY
LRTCKIETPAEPLLYNVETDISERFNLADKHPEIVKLLIEAGEKHKKGMKIKPSVCDMM
>Mature_459_residues
MKTLKSLSVLTAAVLSNSLSLNAASDAANKPNFVIIFCDDMGYGDLSCYGNPTIRTPNIDRMACEGMKLTQFYVGAGVST
PSRAALMTGRLPVRNGLYGDRVAVLFPNSKAGLGQDEVTIAKVLQQSGYATGCVGKWHLGAFSPYLPTDHGFDTYFGIPY
SNDMSPVQNKGAHARNFPPTPLIVDGKQIESEPDQGELTRRYTEKAVSFIKNHSKEPFFLYFAHTFPHIPLYTNARFEGT
SKRGLYGDVVEEIDWSVGEVLKALRENGLDENTFVIFTSDNGPWLTEHENGGSAGPLKDGKGTWWEGGFRVPAICWMPGK
INPAINDEIMTSMDLYPTFLSMAGIEQPKDLVLDGVNQTGLLFEEKHSARDEVYYWWGSELMAIRKGEWKYYFKTIKDQY
LRTCKIETPAEPLLYNVETDISERFNLADKHPEIVKLLIEAGEKHKKGMKIKPSVCDMM

Specific function: Unknown

COG id: COG3119

COG function: function code P; Arylsulfatase A and related enzymes

Gene ontology:

Cell location: Periplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sulfatase family [H]

Homologues:

Organism=Homo sapiens, GI146229331, Length=437, Percent_Identity=39.5881006864989, Blast_Score=295, Evalue=6e-80,
Organism=Homo sapiens, GI146229329, Length=437, Percent_Identity=39.5881006864989, Blast_Score=295, Evalue=6e-80,
Organism=Homo sapiens, GI6005990, Length=437, Percent_Identity=39.5881006864989, Blast_Score=295, Evalue=6e-80,
Organism=Homo sapiens, GI146229324, Length=437, Percent_Identity=39.5881006864989, Blast_Score=295, Evalue=6e-80,
Organism=Homo sapiens, GI4503899, Length=480, Percent_Identity=36.4583333333333, Blast_Score=272, Evalue=6e-73,
Organism=Homo sapiens, GI45430057, Length=460, Percent_Identity=34.7826086956522, Blast_Score=243, Evalue=3e-64,
Organism=Homo sapiens, GI146229327, Length=364, Percent_Identity=35.989010989011, Blast_Score=207, Evalue=2e-53,
Organism=Homo sapiens, GI59797060, Length=468, Percent_Identity=30.7692307692308, Blast_Score=170, Evalue=2e-42,
Organism=Homo sapiens, GI109389362, Length=469, Percent_Identity=27.7185501066098, Blast_Score=164, Evalue=1e-40,
Organism=Homo sapiens, GI38569405, Length=485, Percent_Identity=29.0721649484536, Blast_Score=158, Evalue=8e-39,
Organism=Homo sapiens, GI38569407, Length=365, Percent_Identity=31.7808219178082, Blast_Score=155, Evalue=1e-37,
Organism=Homo sapiens, GI157266309, Length=165, Percent_Identity=46.6666666666667, Blast_Score=144, Evalue=2e-34,
Organism=Homo sapiens, GI53831991, Length=148, Percent_Identity=49.3243243243243, Blast_Score=142, Evalue=5e-34,
Organism=Homo sapiens, GI58743319, Length=140, Percent_Identity=46.4285714285714, Blast_Score=136, Evalue=4e-32,
Organism=Homo sapiens, GI71852586, Length=149, Percent_Identity=46.3087248322148, Blast_Score=136, Evalue=5e-32,
Organism=Homo sapiens, GI71852584, Length=149, Percent_Identity=46.3087248322148, Blast_Score=135, Evalue=1e-31,
Organism=Homo sapiens, GI31742482, Length=158, Percent_Identity=42.4050632911392, Blast_Score=134, Evalue=2e-31,
Organism=Homo sapiens, GI4557659, Length=239, Percent_Identity=26.3598326359833, Blast_Score=71, Evalue=2e-12,
Organism=Homo sapiens, GI5360208, Length=239, Percent_Identity=26.3598326359833, Blast_Score=70, Evalue=5e-12,
Organism=Escherichia coli, GI1790233, Length=453, Percent_Identity=30.0220750551876, Blast_Score=175, Evalue=6e-45,
Organism=Escherichia coli, GI87081924, Length=484, Percent_Identity=28.5123966942149, Blast_Score=162, Evalue=3e-41,
Organism=Escherichia coli, GI1790112, Length=377, Percent_Identity=24.6684350132626, Blast_Score=95, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI17559078, Length=248, Percent_Identity=35.8870967741936, Blast_Score=145, Evalue=6e-35,
Organism=Caenorhabditis elegans, GI115533416, Length=445, Percent_Identity=28.7640449438202, Blast_Score=141, Evalue=7e-34,
Organism=Caenorhabditis elegans, GI115533418, Length=434, Percent_Identity=28.3410138248848, Blast_Score=131, Evalue=7e-31,
Organism=Drosophila melanogaster, GI24666175, Length=379, Percent_Identity=33.509234828496, Blast_Score=185, Evalue=6e-47,
Organism=Drosophila melanogaster, GI281366397, Length=411, Percent_Identity=32.360097323601, Blast_Score=178, Evalue=7e-45,
Organism=Drosophila melanogaster, GI281366395, Length=411, Percent_Identity=32.360097323601, Blast_Score=178, Evalue=7e-45,
Organism=Drosophila melanogaster, GI24666163, Length=411, Percent_Identity=32.360097323601, Blast_Score=178, Evalue=7e-45,
Organism=Drosophila melanogaster, GI281363223, Length=391, Percent_Identity=33.5038363171356, Blast_Score=174, Evalue=8e-44,
Organism=Drosophila melanogaster, GI24666109, Length=399, Percent_Identity=32.5814536340852, Blast_Score=162, Evalue=5e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017849
- InterPro:   IPR017850
- InterPro:   IPR000917 [H]

Pfam domain/function: PF00884 Sulfatase [H]

EC number: =3.1.6.1 [H]

Molecular weight: Translated: 51181; Mature: 51181

Theoretical pI: Translated: 6.03; Mature: 6.03

Prosite motif: PS00523 SULFATASE_1 ; PS00149 SULFATASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTLKSLSVLTAAVLSNSLSLNAASDAANKPNFVIIFCDDMGYGDLSCYGNPTIRTPNID
CCCHHHHHHHHHHHHHCCCCEECCCCCCCCCCEEEEEECCCCCCCEEECCCCEECCCCCH
RMACEGMKLTQFYVGAGVSTPSRAALMTGRLPVRNGLYGDRVAVLFPNSKAGLGQDEVTI
HHHHCCCEEEEEEEECCCCCCCCCEEEECCCCCCCCCCCCEEEEEECCCCCCCCCCHHHH
AKVLQQSGYATGCVGKWHLGAFSPYLPTDHGFDTYFGIPYSNDMSPVQNKGAHARNFPPT
HHHHHHCCCEECCCCCCCCCCCCCCCCCCCCCCCEECCCCCCCCCHHHCCCCCCCCCCCC
PLIVDGKQIESEPDQGELTRRYTEKAVSFIKNHSKEPFFLYFAHTFPHIPLYTNARFEGT
CEEECCHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCEEECCEECCC
SKRGLYGDVVEEIDWSVGEVLKALRENGLDENTFVIFTSDNGPWLTEHENGGSAGPLKDG
CCCCCHHHHHHHHCCCHHHHHHHHHHCCCCCCEEEEEECCCCCEEEECCCCCCCCCCCCC
KGTWWEGGFRVPAICWMPGKINPAINDEIMTSMDLYPTFLSMAGIEQPKDLVLDGVNQTG
CCCCCCCCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHCCCCCCC
LLFEEKHSARDEVYYWWGSELMAIRKGEWKYYFKTIKDQYLRTCKIETPAEPLLYNVETD
CEEECCCCCCCCEEEEECCEEEEEECCCHHHHHHHHHHHHHHEEECCCCCCCEEEECCCC
ISERFNLADKHPEIVKLLIEAGEKHKKGMKIKPSVCDMM
HHHHCCCCCCCHHHHHHHHHHCHHHCCCCEECCHHHCCC
>Mature Secondary Structure
MKTLKSLSVLTAAVLSNSLSLNAASDAANKPNFVIIFCDDMGYGDLSCYGNPTIRTPNID
CCCHHHHHHHHHHHHHCCCCEECCCCCCCCCCEEEEEECCCCCCCEEECCCCEECCCCCH
RMACEGMKLTQFYVGAGVSTPSRAALMTGRLPVRNGLYGDRVAVLFPNSKAGLGQDEVTI
HHHHCCCEEEEEEEECCCCCCCCCEEEECCCCCCCCCCCCEEEEEECCCCCCCCCCHHHH
AKVLQQSGYATGCVGKWHLGAFSPYLPTDHGFDTYFGIPYSNDMSPVQNKGAHARNFPPT
HHHHHHCCCEECCCCCCCCCCCCCCCCCCCCCCCEECCCCCCCCCHHHCCCCCCCCCCCC
PLIVDGKQIESEPDQGELTRRYTEKAVSFIKNHSKEPFFLYFAHTFPHIPLYTNARFEGT
CEEECCHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCEEECCEECCC
SKRGLYGDVVEEIDWSVGEVLKALRENGLDENTFVIFTSDNGPWLTEHENGGSAGPLKDG
CCCCCHHHHHHHHCCCHHHHHHHHHHCCCCCCEEEEEECCCCCEEEECCCCCCCCCCCCC
KGTWWEGGFRVPAICWMPGKINPAINDEIMTSMDLYPTFLSMAGIEQPKDLVLDGVNQTG
CCCCCCCCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHCCCCCCC
LLFEEKHSARDEVYYWWGSELMAIRKGEWKYYFKTIKDQYLRTCKIETPAEPLLYNVETD
CEEECCCCCCCCEEEEECCEEEEEECCCHHHHHHHHHHHHHHEEECCCCCCCEEEECCCC
ISERFNLADKHPEIVKLLIEAGEKHKKGMKIKPSVCDMM
HHHHCCCCCCCHHHHHHHHHHCHHHCCCCEECCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1379743; 9278503 [H]