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The map label for this gene is mutA [H]

Identifier: 150008908

GI number: 150008908

Start: 2698793

End: 2700652

Strand: Reverse

Name: mutA [H]

Synonym: BDI_2303

Alternate gene names: 150008908

Gene position: 2700652-2698793 (Counterclockwise)

Preceding gene: 150008912

Following gene: 150008907

Centisome position: 56.13

GC content: 47.63

Gene sequence:

>1860_bases
ATGGCAGAACTTAAAGAAAAACTTTTCTCAGAATTCGCACCTGTGTCTACTGAAGAGTGGATGGCGAAGATAACGGCCGA
CCTGAAAGGGGTACCGTTTGAGAAAAAGCTTGTTTGGAAGACAGGCGAAGGATTTAATGTAAATCCTTTCTATCGTGCAG
AAGACATCGAGGGTTTAAAGACTACAGAGTCTCTTCCCGGTGAATTCCCTTATGTTCGTGGAACGAAGAAAGACAACGAT
TGGAAGGTACGCCAGAACATTGAAGTTTGCTGCTTCAAGGGTGCTAACGAGAAAGCACTAGACCTTTTGACGAAAGGTGT
TACTTCTCTTGGGTTCATCATCAAAGGTGATGAGGTGAACGAGGAGAACATAGCTACTTTATTAGAGGGTATTTGTCCGG
CTTCCGTAGAATTGAACTTCAACACTTGCAACTGCAAAGCGGAGAAGTTGATCGGTATCTTGGCTGACTACTTCAAAGGC
AAGGGTGTCGACGCAGAGAAGTGCTACGGTTCTGTAAACTATGACGCTTTCAAGAAACCTTTAGTAAAAGGTAAAGAAAA
CAGTGAGTGGGTAGAAGGTGCCGCAGCTGTGCTCAAAGCTGGACAGGCTTTGCCTAACTACCGTGTATTGGCTGTAAATG
CGTTCCTTTTCAACAATGCTGGCGCTTACATTTCTCAGGAATTAGGTTACGCCTTGGCTTGGGGTAACGAATTGATGGCA
AAACTAACCGAGGCTGGTTTCACCGCTGACGAGGTTGCCAAGAAGATCAAATTCAATTTTGGTATCAGCTCTAACTACTT
CATGGAAATCGCTAAGTTCCGTGCGGCTCGTTGGTTGTGGGCCGAGATCGTAGCCGCTTATAAGCCGGCCTGCGAATGCG
CTTGCAAGATGGTTGCTCACGCACAGACTTCAGAGTGGAACATGACGGTTTACGATGCTCACGTAAACTTGCTTCGTTCT
CAAACTGAGGCTATGTCTGCCGCTCTTGCTGGCGTAGACTCTATCACGGTTCGCCCGTTTGATAAGATTTACCAGACTCC
GGACGATTTCTCCGAGCGTATCGCACGTAACCAACAATTATTATTGAAGGAAGAGTGCCACTTGGATAAGGTCGTTGACC
CGTCTGCCGGTTCTTATTATGTAGAGGTATTGACGAATTCCTTGGCCGATGTCGCTTGGAAGTTGTTCTTGGAGGTTGAG
GAAAAAGGAGGATTCTCCGTTGCCGTGAACGCAGGTGAGATCCAAAATGCCGTTAACGCTTCGAATGTAGTTCGTAAGAA
AGCGGTTGCTACCCGTCGTGAGATCCTGTTGGGTTCTAACCAGTATCCTAACTTCACGGAAGTAGCTGCCGATAAGATTC
AGGAAAAAGGTTCTTGCTGTTGTGGCGGTGGTCATTGCGGCGAGGCAACGATCCCGGCTCTTGATTTCTCTCGCGGCGCT
TCCGAATTCGAGGCTTTGCGTATGGCGACAGAGAAGAGTGGCAAGACTCCGAAGGTATTCATGTTGACGATCGGTAACTT
GGCGATGCGTTTGGCTCGTTCACAGTTCTCCGCTAACTTCTTCGCTTGTGCCGGATATAAGATAATTGATAACTTAGGCT
TCGATACGGTTGAGGCTGGTGTTGAGGCTGCAGTCAAGGCGGGTGCTGAGATAGTGGTTCTTTGCTCTAGTGATGACGAG
TATGCTGAATTCGCTCCTGCTGCTTACAAGGCTTTGGCCGGACGTGCCGAATTCGTTGTAGCCGGAGCTCCTGCTTGCGC
GGACGACTTGAAGGCTCAAGGTATCGACCAGTTCGTAAATGTAAAGAGCAATGTGCTTGAGACATTGAAAGCATTCAACG
CTAAATTAGGAATCGCTTAA

Upstream 100 bases:

>100_bases
TTCATTGTCGGTACTGTTTATTTATTCTACCTTTGCCATCTGTAATTGAACAAAATAGTATTGAACATTACTAATACCAG
TTTAATAAACAACTAATATT

Downstream 100 bases:

>100_bases
GTATAAACAATTATGAGACCAAATTTTAAAAACATAGATATAAAGAATGCCGGATTCGCAGCTACAAACGCTGCCGAATG
GGCAAAAGCCAATGGTATCG

Product: methylmalonyl-CoA mutase, small subunit

Products: NA

Alternate protein names: MCM-beta [H]

Number of amino acids: Translated: 619; Mature: 618

Protein sequence:

>619_residues
MAELKEKLFSEFAPVSTEEWMAKITADLKGVPFEKKLVWKTGEGFNVNPFYRAEDIEGLKTTESLPGEFPYVRGTKKDND
WKVRQNIEVCCFKGANEKALDLLTKGVTSLGFIIKGDEVNEENIATLLEGICPASVELNFNTCNCKAEKLIGILADYFKG
KGVDAEKCYGSVNYDAFKKPLVKGKENSEWVEGAAAVLKAGQALPNYRVLAVNAFLFNNAGAYISQELGYALAWGNELMA
KLTEAGFTADEVAKKIKFNFGISSNYFMEIAKFRAARWLWAEIVAAYKPACECACKMVAHAQTSEWNMTVYDAHVNLLRS
QTEAMSAALAGVDSITVRPFDKIYQTPDDFSERIARNQQLLLKEECHLDKVVDPSAGSYYVEVLTNSLADVAWKLFLEVE
EKGGFSVAVNAGEIQNAVNASNVVRKKAVATRREILLGSNQYPNFTEVAADKIQEKGSCCCGGGHCGEATIPALDFSRGA
SEFEALRMATEKSGKTPKVFMLTIGNLAMRLARSQFSANFFACAGYKIIDNLGFDTVEAGVEAAVKAGAEIVVLCSSDDE
YAEFAPAAYKALAGRAEFVVAGAPACADDLKAQGIDQFVNVKSNVLETLKAFNAKLGIA

Sequences:

>Translated_619_residues
MAELKEKLFSEFAPVSTEEWMAKITADLKGVPFEKKLVWKTGEGFNVNPFYRAEDIEGLKTTESLPGEFPYVRGTKKDND
WKVRQNIEVCCFKGANEKALDLLTKGVTSLGFIIKGDEVNEENIATLLEGICPASVELNFNTCNCKAEKLIGILADYFKG
KGVDAEKCYGSVNYDAFKKPLVKGKENSEWVEGAAAVLKAGQALPNYRVLAVNAFLFNNAGAYISQELGYALAWGNELMA
KLTEAGFTADEVAKKIKFNFGISSNYFMEIAKFRAARWLWAEIVAAYKPACECACKMVAHAQTSEWNMTVYDAHVNLLRS
QTEAMSAALAGVDSITVRPFDKIYQTPDDFSERIARNQQLLLKEECHLDKVVDPSAGSYYVEVLTNSLADVAWKLFLEVE
EKGGFSVAVNAGEIQNAVNASNVVRKKAVATRREILLGSNQYPNFTEVAADKIQEKGSCCCGGGHCGEATIPALDFSRGA
SEFEALRMATEKSGKTPKVFMLTIGNLAMRLARSQFSANFFACAGYKIIDNLGFDTVEAGVEAAVKAGAEIVVLCSSDDE
YAEFAPAAYKALAGRAEFVVAGAPACADDLKAQGIDQFVNVKSNVLETLKAFNAKLGIA
>Mature_618_residues
AELKEKLFSEFAPVSTEEWMAKITADLKGVPFEKKLVWKTGEGFNVNPFYRAEDIEGLKTTESLPGEFPYVRGTKKDNDW
KVRQNIEVCCFKGANEKALDLLTKGVTSLGFIIKGDEVNEENIATLLEGICPASVELNFNTCNCKAEKLIGILADYFKGK
GVDAEKCYGSVNYDAFKKPLVKGKENSEWVEGAAAVLKAGQALPNYRVLAVNAFLFNNAGAYISQELGYALAWGNELMAK
LTEAGFTADEVAKKIKFNFGISSNYFMEIAKFRAARWLWAEIVAAYKPACECACKMVAHAQTSEWNMTVYDAHVNLLRSQ
TEAMSAALAGVDSITVRPFDKIYQTPDDFSERIARNQQLLLKEECHLDKVVDPSAGSYYVEVLTNSLADVAWKLFLEVEE
KGGFSVAVNAGEIQNAVNASNVVRKKAVATRREILLGSNQYPNFTEVAADKIQEKGSCCCGGGHCGEATIPALDFSRGAS
EFEALRMATEKSGKTPKVFMLTIGNLAMRLARSQFSANFFACAGYKIIDNLGFDTVEAGVEAAVKAGAEIVVLCSSDDEY
AEFAPAAYKALAGRAEFVVAGAPACADDLKAQGIDQFVNVKSNVLETLKAFNAKLGIA

Specific function: Catalyzes the isomerization of succinyl-CoA to methylmalonyl-CoA during synthesis of propionate from tricarboxylic acid-cycle intermediates [H]

COG id: COG1884

COG function: function code I; Methylmalonyl-CoA mutase, N-terminal domain/subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methylmalonyl-CoA mutase family [H]

Homologues:

Organism=Homo sapiens, GI156105689, Length=479, Percent_Identity=30.2713987473904, Blast_Score=201, Evalue=2e-51,
Organism=Escherichia coli, GI1789284, Length=443, Percent_Identity=28.8939051918736, Blast_Score=195, Evalue=7e-51,
Organism=Caenorhabditis elegans, GI25144500, Length=464, Percent_Identity=28.0172413793103, Blast_Score=177, Evalue=2e-44,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016176
- InterPro:   IPR014348
- InterPro:   IPR006158
- InterPro:   IPR006099
- InterPro:   IPR004608 [H]

Pfam domain/function: PF01642 MM_CoA_mutase [H]

EC number: =5.4.99.2 [H]

Molecular weight: Translated: 67437; Mature: 67306

Theoretical pI: Translated: 5.00; Mature: 5.00

Prosite motif: PS00544 METMALONYL_COA_MUTASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.7 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
2.8 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAELKEKLFSEFAPVSTEEWMAKITADLKGVPFEKKLVWKTGEGFNVNPFYRAEDIEGLK
CCHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCH
TTESLPGEFPYVRGTKKDNDWKVRQNIEVCCFKGANEKALDLLTKGVTSLGFIIKGDEVN
HHCCCCCCCCCCCCCCCCCCCEEECCCEEEEECCCCHHHHHHHHHHHHHHCEEEECCCCC
EENIATLLEGICPASVELNFNTCNCKAEKLIGILADYFKGKGVDAEKCYGSVNYDAFKKP
HHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHHHHHCCCCCCHHHHCCCCCHHHHHHH
LVKGKENSEWVEGAAAVLKAGQALPNYRVLAVNAFLFNNAGAYISQELGYALAWGNELMA
HHCCCCCCHHHHHHHHHHHHHCCCCCEEEEEEEEEEECCCCCHHHHHCCEEEEHHHHHHH
KLTEAGFTADEVAKKIKFNFGISSNYFMEIAKFRAARWLWAEIVAAYKPACECACKMVAH
HHHHCCCCHHHHHHHHEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHH
AQTSEWNMTVYDAHVNLLRSQTEAMSAALAGVDSITVRPFDKIYQTPDDFSERIARNQQL
CCCCCCCEEEEHHHHHHHHHHHHHHHHHHHCCCCEEECCHHHHHCCCCHHHHHHHCCHHH
LLKEECHLDKVVDPSAGSYYVEVLTNSLADVAWKLFLEVEEKGGFSVAVNAGEIQNAVNA
HHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHEEEECCCCEEEEEEHHHHHHHHHH
SNVVRKKAVATRREILLGSNQYPNFTEVAADKIQEKGSCCCGGGHCGEATIPALDFSRGA
HHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCEEECCCCCCCCCCCCCCCCCCH
SEFEALRMATEKSGKTPKVFMLTIGNLAMRLARSQFSANFFACAGYKIIDNLGFDTVEAG
HHHHHHHHHHHCCCCCCEEEEEEHHHHHHHHHHHHHCCCEEEECCHHHHHHCCCHHHHHH
VEAAVKAGAEIVVLCSSDDEYAEFAPAAYKALAGRAEFVVAGAPACADDLKAQGIDQFVN
HHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHCCHHHHHH
VKSNVLETLKAFNAKLGIA
HHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
AELKEKLFSEFAPVSTEEWMAKITADLKGVPFEKKLVWKTGEGFNVNPFYRAEDIEGLK
CHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCH
TTESLPGEFPYVRGTKKDNDWKVRQNIEVCCFKGANEKALDLLTKGVTSLGFIIKGDEVN
HHCCCCCCCCCCCCCCCCCCCEEECCCEEEEECCCCHHHHHHHHHHHHHHCEEEECCCCC
EENIATLLEGICPASVELNFNTCNCKAEKLIGILADYFKGKGVDAEKCYGSVNYDAFKKP
HHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHHHHHCCCCCCHHHHCCCCCHHHHHHH
LVKGKENSEWVEGAAAVLKAGQALPNYRVLAVNAFLFNNAGAYISQELGYALAWGNELMA
HHCCCCCCHHHHHHHHHHHHHCCCCCEEEEEEEEEEECCCCCHHHHHCCEEEEHHHHHHH
KLTEAGFTADEVAKKIKFNFGISSNYFMEIAKFRAARWLWAEIVAAYKPACECACKMVAH
HHHHCCCCHHHHHHHHEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHH
AQTSEWNMTVYDAHVNLLRSQTEAMSAALAGVDSITVRPFDKIYQTPDDFSERIARNQQL
CCCCCCCEEEEHHHHHHHHHHHHHHHHHHHCCCCEEECCHHHHHCCCCHHHHHHHCCHHH
LLKEECHLDKVVDPSAGSYYVEVLTNSLADVAWKLFLEVEEKGGFSVAVNAGEIQNAVNA
HHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHEEEECCCCEEEEEEHHHHHHHHHH
SNVVRKKAVATRREILLGSNQYPNFTEVAADKIQEKGSCCCGGGHCGEATIPALDFSRGA
HHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCEEECCCCCCCCCCCCCCCCCCH
SEFEALRMATEKSGKTPKVFMLTIGNLAMRLARSQFSANFFACAGYKIIDNLGFDTVEAG
HHHHHHHHHHHCCCCCCEEEEEEHHHHHHHHHHHHHCCCEEEECCHHHHHHCCCHHHHHH
VEAAVKAGAEIVVLCSSDDEYAEFAPAAYKALAGRAEFVVAGAPACADDLKAQGIDQFVN
HHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHCCHHHHHH
VKSNVLETLKAFNAKLGIA
HHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8566763; 12949112 [H]