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The map label for this gene is mutB [H]

Identifier: 150008907

GI number: 150008907

Start: 2696633

End: 2698780

Strand: Reverse

Name: mutB [H]

Synonym: BDI_2302

Alternate gene names: 150008907

Gene position: 2698780-2696633 (Counterclockwise)

Preceding gene: 150008908

Following gene: 150008906

Centisome position: 56.09

GC content: 48.65

Gene sequence:

>2148_bases
ATGAGACCAAATTTTAAAAACATAGATATAAAGAATGCCGGATTCGCAGCTACAAACGCTGCCGAATGGGCAAAAGCCAA
TGGTATCGAGCCCAATTGGAAAACACCCGAGCATATCGAGGTGAAACCTGTATATACAAAAGAAGACTTGGAGGGTATGG
AGCACTTGAACTATGCTTCCGGTCTGCCTCCTTATCTACGTGGCCCGTACAGCGGTATGTACGCTATGCGTCCTTGGACA
ATCCGTCAGTACGCGGGTTTCTCTACCGCTGAGGAGTCTAACGCTTTCTATCGCCGTAACTTGGCTTCCGGTCAGAAAGG
TTTGTCCGTTGCGTTCGACCTTCCGACTCACCGTGGTTACGATGCCGACAACGAACGTGTGGTTGGTGATGTAGGTAAAG
CGGGTGTATCTATCTGTTCCTTGGAGAACATGAAAGTGTTGTTCGATGGTATTCCTTTGAACAAGATGTCTGTTTCCATG
ACCATGAATGGTGGTGTGCTTCCGGTATTGGCATTCTATATCAACGCAGGTTTGGAGCAAGGTGCTAAGTTGGAGGAAAT
GGCCGGTACGATCCAGAACGATATATTGAAAGAGTTCATGGTACGTAATACCTATATTTACCCGCCTGAGTTCTCCATGA
AGATTATCGCTGATATCTTCGAGTATACCTCTCAGAAGATGCCGAAGTTCAACTCTATCTCTATCTCCGGTTATCATATG
CAGGAGGCTGGTGCTACGGCTGATATCGAGATGGCTTATACGTTGTGCGACGGTATGGAATATCTTCGTGCCGGTATCAA
CGCCGGTATCGATGTGGATGCGTTCGCTCCCCGTTTGTCATTCTTCTGGGCTATCGGTGTAAATCACTTCATGGAGATCG
CCAAGATGCGTGCGGCTCGTATGTTGTGGGCGAAGATCGTGAAGAGCTTCGGCGCTAAGAACCCGAAATCATTGGCATTG
CGTACACATAGCCAGACTTCCGGTTGGTCATTGACCGAGCAAGATCCGTTCAATAACGTAGGACGTACTTGTATCGAGGC
TATGGCCGCTACATTAGGACATACACAATCTTTGCATACGAACGCATTGGATGAGGCGATCGCTTTGCCGACCGATTTCT
CCGCTCGTATCGCTCGTAATACACAGATTTACATTCAGGAAGAGACTAAGATCTGTAAGGAAATCGACCCGTGGGCTGGT
TCTTACTATGTAGAGTCTTTGACGAATGAATTGGTACATAAAGGTTGGGCGTTGATCCAAGAGATCGAGAGCATGGGTGG
TATGGCGAAAGCCATCGAGACAGGTCTTCCTAAGATGCGTATCGAGGAAGCGGCCGCTCGTACACAGGCTCGTATCGACT
CAGGTGTTCAGACCATCGTTGGTGTTAACAAATATCGTTTGCCGAAGGAAGATCCGATCGATATCCTTGAGATTGATAAT
ACAGCCGTACGTAACGAGCAGATCGCCGCTTTGAAGGAGTTGCGTGCTAACCGTGACGAAGCCGCTGTTCAAAAAGCTTT
GGCTGATATCACGGAGTGCGTGAAGACGAAGAAGGGCAATTTATTAGAGTTGGCTGTTAAGGCTGCCGGCTTGCGTGCGT
CATTGGGAGAGATCTCCGATGCTTGCGAGGTGGTTGTAGGTCGTTATAAAGCAATCATTAGAACTATTTCAGGCGTGTAT
TCATCAGAAACTAAGAAAGACGCAGACTTCCAGAAAGCTTGCGAGCTTTGCGAGCAATTCGCTAAGAAAGAGGGCCGTCA
GCCTCGTATCATGATCGCTAAGATGGGTCAGGACGGACATGACCGTGGCGCTAAGGTTGTTGCTACCGGTTATGCTGACT
GTGGGTTCGACGTAGATATGGGACCGTTGTTCCAGACTCCGGCCGAGGCTGCCCGTCAAGCTGTAGAGAACGATGTTCAC
GTAATGGGCGTTTCTTCTTTGGCCGCTGGTCATAAGACGTTGGTTCCGCAGGTTATCGAGGAGTTGAAGAAATTAGGTCG
TGAGGATATCATCGTTATCGCTGGTGGTGTAATCCCGGCTCAAGACTATGACTTCTTGTATAAGGCTGGCGTTGCCGCTA
TCTTTGGCCCGGGTACTTCCGTATCGAAGGCAGCTTGCCAGATCCTAGAGATCTTGTTAGGCGAATAA

Upstream 100 bases:

>100_bases
GGCTCAAGGTATCGACCAGTTCGTAAATGTAAAGAGCAATGTGCTTGAGACATTGAAAGCATTCAACGCTAAATTAGGAA
TCGCTTAAGTATAAACAATT

Downstream 100 bases:

>100_bases
ATAGCGTTTAAACCTTGCGGTTTTTTAATAAAGAGAGGCTGGACAATTGATTTTGTCCGGCCTTTTTTAGTATTGTATAC
GGGTTTATGTACTTTTGTAG

Product: methylmalonyl-CoA mutase

Products: NA

Alternate protein names: MCM-alpha [H]

Number of amino acids: Translated: 715; Mature: 715

Protein sequence:

>715_residues
MRPNFKNIDIKNAGFAATNAAEWAKANGIEPNWKTPEHIEVKPVYTKEDLEGMEHLNYASGLPPYLRGPYSGMYAMRPWT
IRQYAGFSTAEESNAFYRRNLASGQKGLSVAFDLPTHRGYDADNERVVGDVGKAGVSICSLENMKVLFDGIPLNKMSVSM
TMNGGVLPVLAFYINAGLEQGAKLEEMAGTIQNDILKEFMVRNTYIYPPEFSMKIIADIFEYTSQKMPKFNSISISGYHM
QEAGATADIEMAYTLCDGMEYLRAGINAGIDVDAFAPRLSFFWAIGVNHFMEIAKMRAARMLWAKIVKSFGAKNPKSLAL
RTHSQTSGWSLTEQDPFNNVGRTCIEAMAATLGHTQSLHTNALDEAIALPTDFSARIARNTQIYIQEETKICKEIDPWAG
SYYVESLTNELVHKGWALIQEIESMGGMAKAIETGLPKMRIEEAAARTQARIDSGVQTIVGVNKYRLPKEDPIDILEIDN
TAVRNEQIAALKELRANRDEAAVQKALADITECVKTKKGNLLELAVKAAGLRASLGEISDACEVVVGRYKAIIRTISGVY
SSETKKDADFQKACELCEQFAKKEGRQPRIMIAKMGQDGHDRGAKVVATGYADCGFDVDMGPLFQTPAEAARQAVENDVH
VMGVSSLAAGHKTLVPQVIEELKKLGREDIIVIAGGVIPAQDYDFLYKAGVAAIFGPGTSVSKAACQILEILLGE

Sequences:

>Translated_715_residues
MRPNFKNIDIKNAGFAATNAAEWAKANGIEPNWKTPEHIEVKPVYTKEDLEGMEHLNYASGLPPYLRGPYSGMYAMRPWT
IRQYAGFSTAEESNAFYRRNLASGQKGLSVAFDLPTHRGYDADNERVVGDVGKAGVSICSLENMKVLFDGIPLNKMSVSM
TMNGGVLPVLAFYINAGLEQGAKLEEMAGTIQNDILKEFMVRNTYIYPPEFSMKIIADIFEYTSQKMPKFNSISISGYHM
QEAGATADIEMAYTLCDGMEYLRAGINAGIDVDAFAPRLSFFWAIGVNHFMEIAKMRAARMLWAKIVKSFGAKNPKSLAL
RTHSQTSGWSLTEQDPFNNVGRTCIEAMAATLGHTQSLHTNALDEAIALPTDFSARIARNTQIYIQEETKICKEIDPWAG
SYYVESLTNELVHKGWALIQEIESMGGMAKAIETGLPKMRIEEAAARTQARIDSGVQTIVGVNKYRLPKEDPIDILEIDN
TAVRNEQIAALKELRANRDEAAVQKALADITECVKTKKGNLLELAVKAAGLRASLGEISDACEVVVGRYKAIIRTISGVY
SSETKKDADFQKACELCEQFAKKEGRQPRIMIAKMGQDGHDRGAKVVATGYADCGFDVDMGPLFQTPAEAARQAVENDVH
VMGVSSLAAGHKTLVPQVIEELKKLGREDIIVIAGGVIPAQDYDFLYKAGVAAIFGPGTSVSKAACQILEILLGE
>Mature_715_residues
MRPNFKNIDIKNAGFAATNAAEWAKANGIEPNWKTPEHIEVKPVYTKEDLEGMEHLNYASGLPPYLRGPYSGMYAMRPWT
IRQYAGFSTAEESNAFYRRNLASGQKGLSVAFDLPTHRGYDADNERVVGDVGKAGVSICSLENMKVLFDGIPLNKMSVSM
TMNGGVLPVLAFYINAGLEQGAKLEEMAGTIQNDILKEFMVRNTYIYPPEFSMKIIADIFEYTSQKMPKFNSISISGYHM
QEAGATADIEMAYTLCDGMEYLRAGINAGIDVDAFAPRLSFFWAIGVNHFMEIAKMRAARMLWAKIVKSFGAKNPKSLAL
RTHSQTSGWSLTEQDPFNNVGRTCIEAMAATLGHTQSLHTNALDEAIALPTDFSARIARNTQIYIQEETKICKEIDPWAG
SYYVESLTNELVHKGWALIQEIESMGGMAKAIETGLPKMRIEEAAARTQARIDSGVQTIVGVNKYRLPKEDPIDILEIDN
TAVRNEQIAALKELRANRDEAAVQKALADITECVKTKKGNLLELAVKAAGLRASLGEISDACEVVVGRYKAIIRTISGVY
SSETKKDADFQKACELCEQFAKKEGRQPRIMIAKMGQDGHDRGAKVVATGYADCGFDVDMGPLFQTPAEAARQAVENDVH
VMGVSSLAAGHKTLVPQVIEELKKLGREDIIVIAGGVIPAQDYDFLYKAGVAAIFGPGTSVSKAACQILEILLGE

Specific function: Catalyzes the isomerization of succinyl-CoA to methylmalonyl-CoA during synthesis of propionate from tricarboxylic acid-cycle intermediates [H]

COG id: COG1884

COG function: function code I; Methylmalonyl-CoA mutase, N-terminal domain/subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 B12-binding domain [H]

Homologues:

Organism=Homo sapiens, GI156105689, Length=698, Percent_Identity=62.4641833810888, Blast_Score=908, Evalue=0.0,
Organism=Escherichia coli, GI1789284, Length=683, Percent_Identity=63.6896046852123, Blast_Score=881, Evalue=0.0,
Organism=Caenorhabditis elegans, GI25144500, Length=683, Percent_Identity=63.8360175695461, Blast_Score=900, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006159
- InterPro:   IPR016176
- InterPro:   IPR014348
- InterPro:   IPR006158
- InterPro:   IPR006099
- InterPro:   IPR006098 [H]

Pfam domain/function: PF02310 B12-binding; PF01642 MM_CoA_mutase [H]

EC number: =5.4.99.2 [H]

Molecular weight: Translated: 78370; Mature: 78370

Theoretical pI: Translated: 5.87; Mature: 5.87

Prosite motif: PS00544 METMALONYL_COA_MUTASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRPNFKNIDIKNAGFAATNAAEWAKANGIEPNWKTPEHIEVKPVYTKEDLEGMEHLNYAS
CCCCCCCCCCCCCCCCCCCHHHHHHCCCCCCCCCCCCCEEEEEECCHHHHHHHHHHHHHC
GLPPYLRGPYSGMYAMRPWTIRQYAGFSTAEESNAFYRRNLASGQKGLSVAFDLPTHRGY
CCCHHHCCCCCCEEEECCEEHHHHCCCCCCHHCCHHHHHHHCCCCCCCEEEEECCCCCCC
DADNERVVGDVGKAGVSICSLENMKVLFDGIPLNKMSVSMTMNGGVLPVLAFYINAGLEQ
CCCCCEEECCCCCCCEEEEECCCCEEEECCCCCCCEEEEEEECCCHHHHHHHHHHHHHHC
GAKLEEMAGTIQNDILKEFMVRNTYIYPPEFSMKIIADIFEYTSQKMPKFNSISISGYHM
CCHHHHHHHHHHHHHHHHHHHHCCEECCCCCHHHHHHHHHHHHHHHCCCCCCEEEECEEE
QEAGATADIEMAYTLCDGMEYLRAGINAGIDVDAFAPRLSFFWAIGVNHFMEIAKMRAAR
CCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MLWAKIVKSFGAKNPKSLALRTHSQTSGWSLTEQDPFNNVGRTCIEAMAATLGHTQSLHT
HHHHHHHHHHCCCCCCCEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHH
NALDEAIALPTDFSARIARNTQIYIQEETKICKEIDPWAGSYYVESLTNELVHKGWALIQ
HHHHHHHCCCCCCHHHHCCCCEEEEEHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHH
EIESMGGMAKAIETGLPKMRIEEAAARTQARIDSGVQTIVGVNKYRLPKEDPIDILEIDN
HHHHHCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEECCC
TAVRNEQIAALKELRANRDEAAVQKALADITECVKTKKGNLLELAVKAAGLRASLGEISD
CHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCEEEHHHHHHCHHHHHHHHHH
ACEVVVGRYKAIIRTISGVYSSETKKDADFQKACELCEQFAKKEGRQPRIMIAKMGQDGH
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEECCCCCC
DRGAKVVATGYADCGFDVDMGPLFQTPAEAARQAVENDVHVMGVSSLAAGHKTLVPQVIE
CCCCEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHCCCEEEEHHHHHCCHHHHHHHHHH
ELKKLGREDIIVIAGGVIPAQDYDFLYKAGVAAIFGPGTSVSKAACQILEILLGE
HHHHCCCCCEEEEECCCCCCCCCHHHHHCCCCEEECCCCCHHHHHHHHHHHHHCC
>Mature Secondary Structure
MRPNFKNIDIKNAGFAATNAAEWAKANGIEPNWKTPEHIEVKPVYTKEDLEGMEHLNYAS
CCCCCCCCCCCCCCCCCCCHHHHHHCCCCCCCCCCCCCEEEEEECCHHHHHHHHHHHHHC
GLPPYLRGPYSGMYAMRPWTIRQYAGFSTAEESNAFYRRNLASGQKGLSVAFDLPTHRGY
CCCHHHCCCCCCEEEECCEEHHHHCCCCCCHHCCHHHHHHHCCCCCCCEEEEECCCCCCC
DADNERVVGDVGKAGVSICSLENMKVLFDGIPLNKMSVSMTMNGGVLPVLAFYINAGLEQ
CCCCCEEECCCCCCCEEEEECCCCEEEECCCCCCCEEEEEEECCCHHHHHHHHHHHHHHC
GAKLEEMAGTIQNDILKEFMVRNTYIYPPEFSMKIIADIFEYTSQKMPKFNSISISGYHM
CCHHHHHHHHHHHHHHHHHHHHCCEECCCCCHHHHHHHHHHHHHHHCCCCCCEEEECEEE
QEAGATADIEMAYTLCDGMEYLRAGINAGIDVDAFAPRLSFFWAIGVNHFMEIAKMRAAR
CCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MLWAKIVKSFGAKNPKSLALRTHSQTSGWSLTEQDPFNNVGRTCIEAMAATLGHTQSLHT
HHHHHHHHHHCCCCCCCEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHH
NALDEAIALPTDFSARIARNTQIYIQEETKICKEIDPWAGSYYVESLTNELVHKGWALIQ
HHHHHHHCCCCCCHHHHCCCCEEEEEHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHH
EIESMGGMAKAIETGLPKMRIEEAAARTQARIDSGVQTIVGVNKYRLPKEDPIDILEIDN
HHHHHCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEECCC
TAVRNEQIAALKELRANRDEAAVQKALADITECVKTKKGNLLELAVKAAGLRASLGEISD
CHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCEEEHHHHHHCHHHHHHHHHH
ACEVVVGRYKAIIRTISGVYSSETKKDADFQKACELCEQFAKKEGRQPRIMIAKMGQDGH
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEECCCCCC
DRGAKVVATGYADCGFDVDMGPLFQTPAEAARQAVENDVHVMGVSSLAAGHKTLVPQVIE
CCCCEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHCCCEEEEHHHHHCCHHHHHHHHHH
ELKKLGREDIIVIAGGVIPAQDYDFLYKAGVAAIFGPGTSVSKAACQILEILLGE
HHHHCCCCCEEEEECCCCCCCCCHHHHHCCCCEEECCCCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8566763; 12949112 [H]