| Definition | Parabacteroides distasonis ATCC 8503 chromosome, complete genome. |
|---|---|
| Accession | NC_009615 |
| Length | 4,811,379 |
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The map label for this gene is fabG [C]
Identifier: 150008784
GI number: 150008784
Start: 2560635
End: 2561462
Strand: Direct
Name: fabG [C]
Synonym: BDI_2174
Alternate gene names: 150008784
Gene position: 2560635-2561462 (Clockwise)
Preceding gene: 150008782
Following gene: 150008785
Centisome position: 53.22
GC content: 47.95
Gene sequence:
>828_bases ATGGCAGACAACTATTTGGAAAAAAAATACGAGCAATATCAAGTCCGGAAAACCTCCGGGACAAGAACCAGTCACAATAC GAAGACACTCCATAAAACAAGAAGAGTCTTCATTACCGGTGGGGCCGAGGGGATCGGAAAAGCCATCGTGAGAACGTTCA GGGGAGCCGGCCATCGAGTAGCGTTCTGTGATAAAAACGAAGCATCAGGAAAAGAGACCGCATTACAAACCGGAACTCAA TTCTTTCCCGTGGACGTTAGCGATAAGACCGCATTGGAGGATTGCCTGCAAAAGATCATCGAGGAATGGGGCGATATCGA TATCATCATCAATAACGCGGGTATCAGCCAGTTCTCATCCATCACGGAAACGAGTGTAGAGGATTTTGATAAGATATTAT CCATAAACCTACGTCCCGCGTTCATCACTTCCCGGCGATTAGCGCTCCATCGGCAATCTCTCGAGACCCCCAATCCATAC GGCAGGATTATCAACATCTGCTCTACCCGTTACTTGATGAGTGAACCCGGTAGCGAGGGTTACGCCGCCTCTAAAGGAGG TATCTATTCTTTGACGCATGCGTTGGCCTTATCGCTCTCGGAATGGCATATCACGGTAAACTCTATCGCTCCCGGTTGGA TACAGAATAACAATTACGACCAGCTTCGTCCGGAGGATCATGCTCAACATCCATCCGGACGGGTGGGCAAGCCGGAGGAT ATCGCCCGTATGTGCTTATTTCTCTGTCAAGAGGAAAACGATTTCATTAATGGCGAGAATATTACGATTGACGGTGGGAT GACCAAGAAAATGATCTATCTCGACTAA
Upstream 100 bases:
>100_bases AATCGCTATTTTCATGATTCTAAATGATCTTTACCTTATAAACAAGCGCACAACCTATTTAGTTAAACACTATATTTGTT CTTTCAACTAATAATGGATC
Downstream 100 bases:
>100_bases ATAAACATCCGTATATGACACAAACATCGAATATAGAAACCAACCGTCTTGTGCTCCGTCCTTTCAGCGAAAGCGATGCT CCTGATGTTTTTGAGAGCTG
Product: putative oxidoreductase
Products: (3R)-hydroxyacyl-[acyl-carrier-protein]; NADP; NADPH; Proton; beta-ketoacyl-ACP [C]
Alternate protein names: NA
Number of amino acids: Translated: 275; Mature: 274
Protein sequence:
>275_residues MADNYLEKKYEQYQVRKTSGTRTSHNTKTLHKTRRVFITGGAEGIGKAIVRTFRGAGHRVAFCDKNEASGKETALQTGTQ FFPVDVSDKTALEDCLQKIIEEWGDIDIIINNAGISQFSSITETSVEDFDKILSINLRPAFITSRRLALHRQSLETPNPY GRIINICSTRYLMSEPGSEGYAASKGGIYSLTHALALSLSEWHITVNSIAPGWIQNNNYDQLRPEDHAQHPSGRVGKPED IARMCLFLCQEENDFINGENITIDGGMTKKMIYLD
Sequences:
>Translated_275_residues MADNYLEKKYEQYQVRKTSGTRTSHNTKTLHKTRRVFITGGAEGIGKAIVRTFRGAGHRVAFCDKNEASGKETALQTGTQ FFPVDVSDKTALEDCLQKIIEEWGDIDIIINNAGISQFSSITETSVEDFDKILSINLRPAFITSRRLALHRQSLETPNPY GRIINICSTRYLMSEPGSEGYAASKGGIYSLTHALALSLSEWHITVNSIAPGWIQNNNYDQLRPEDHAQHPSGRVGKPED IARMCLFLCQEENDFINGENITIDGGMTKKMIYLD >Mature_274_residues ADNYLEKKYEQYQVRKTSGTRTSHNTKTLHKTRRVFITGGAEGIGKAIVRTFRGAGHRVAFCDKNEASGKETALQTGTQF FPVDVSDKTALEDCLQKIIEEWGDIDIIINNAGISQFSSITETSVEDFDKILSINLRPAFITSRRLALHRQSLETPNPYG RIINICSTRYLMSEPGSEGYAASKGGIYSLTHALALSLSEWHITVNSIAPGWIQNNNYDQLRPEDHAQHPSGRVGKPEDI ARMCLFLCQEENDFINGENITIDGGMTKKMIYLD
Specific function: Fatty acid biosynthesis pathway; first reduction step. [C]
COG id: NA
COG function: NA
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]
Homologues:
Organism=Homo sapiens, GI15277342, Length=254, Percent_Identity=29.5275590551181, Blast_Score=110, Evalue=2e-24, Organism=Homo sapiens, GI40254992, Length=233, Percent_Identity=28.3261802575107, Blast_Score=103, Evalue=2e-22, Organism=Homo sapiens, GI59889578, Length=230, Percent_Identity=30.4347826086957, Blast_Score=100, Evalue=2e-21, Organism=Homo sapiens, GI4758504, Length=247, Percent_Identity=30.3643724696356, Blast_Score=95, Evalue=5e-20, Organism=Homo sapiens, GI31542939, Length=208, Percent_Identity=30.2884615384615, Blast_Score=89, Evalue=4e-18, Organism=Homo sapiens, GI7705925, Length=243, Percent_Identity=25.9259259259259, Blast_Score=89, Evalue=6e-18, Organism=Homo sapiens, GI32483357, Length=252, Percent_Identity=27.7777777777778, Blast_Score=89, Evalue=6e-18, Organism=Homo sapiens, GI5031737, Length=271, Percent_Identity=28.4132841328413, Blast_Score=85, Evalue=7e-17, Organism=Homo sapiens, GI19923817, Length=271, Percent_Identity=24.3542435424354, Blast_Score=82, Evalue=5e-16, Organism=Homo sapiens, GI83715985, Length=243, Percent_Identity=28.3950617283951, Blast_Score=82, Evalue=7e-16, Organism=Homo sapiens, GI20149619, Length=203, Percent_Identity=28.0788177339901, Blast_Score=81, Evalue=9e-16, Organism=Homo sapiens, GI224922801, Length=182, Percent_Identity=30.7692307692308, Blast_Score=79, Evalue=6e-15, Organism=Homo sapiens, GI4504505, Length=231, Percent_Identity=28.5714285714286, Blast_Score=78, Evalue=1e-14, Organism=Homo sapiens, GI7706318, Length=192, Percent_Identity=26.0416666666667, Blast_Score=69, Evalue=4e-12, Organism=Homo sapiens, GI109715829, Length=233, Percent_Identity=24.8927038626609, Blast_Score=68, Evalue=7e-12, Organism=Homo sapiens, GI66933014, Length=225, Percent_Identity=22.2222222222222, Blast_Score=68, Evalue=1e-11, Organism=Homo sapiens, GI10190704, Length=252, Percent_Identity=25.7936507936508, Blast_Score=67, Evalue=1e-11, Organism=Homo sapiens, GI4503301, Length=217, Percent_Identity=27.1889400921659, Blast_Score=67, Evalue=2e-11, Organism=Escherichia coli, GI1787335, Length=237, Percent_Identity=32.9113924050633, Blast_Score=129, Evalue=3e-31, Organism=Escherichia coli, GI1790717, Length=246, Percent_Identity=29.6747967479675, Blast_Score=112, Evalue=3e-26, Organism=Escherichia coli, GI1789208, Length=240, Percent_Identity=30, Blast_Score=109, Evalue=2e-25, Organism=Escherichia coli, GI87082160, Length=247, Percent_Identity=27.9352226720648, Blast_Score=108, Evalue=3e-25, Organism=Escherichia coli, GI2367365, Length=238, Percent_Identity=33.6134453781513, Blast_Score=102, Evalue=2e-23, Organism=Escherichia coli, GI1788459, Length=240, Percent_Identity=28.75, Blast_Score=98, Evalue=6e-22, Organism=Escherichia coli, GI87082100, Length=252, Percent_Identity=27.7777777777778, Blast_Score=96, Evalue=2e-21, Organism=Escherichia coli, GI1789057, Length=254, Percent_Identity=24.8031496062992, Blast_Score=86, Evalue=2e-18, Organism=Escherichia coli, GI2367175, Length=248, Percent_Identity=27.0161290322581, Blast_Score=84, Evalue=1e-17, Organism=Escherichia coli, GI1786812, Length=259, Percent_Identity=25.0965250965251, Blast_Score=83, Evalue=2e-17, Organism=Escherichia coli, GI1787905, Length=245, Percent_Identity=30.6122448979592, Blast_Score=81, Evalue=8e-17, Organism=Escherichia coli, GI1787820, Length=191, Percent_Identity=27.7486910994764, Blast_Score=74, Evalue=1e-14, Organism=Escherichia coli, GI1789378, Length=250, Percent_Identity=25.6, Blast_Score=73, Evalue=3e-14, Organism=Caenorhabditis elegans, GI17555706, Length=247, Percent_Identity=27.9352226720648, Blast_Score=111, Evalue=5e-25, Organism=Caenorhabditis elegans, GI25147288, Length=243, Percent_Identity=29.6296296296296, Blast_Score=107, Evalue=9e-24, Organism=Caenorhabditis elegans, GI17538182, Length=246, Percent_Identity=30.4878048780488, Blast_Score=96, Evalue=1e-20, Organism=Caenorhabditis elegans, GI17560676, Length=256, Percent_Identity=28.125, Blast_Score=92, Evalue=3e-19, Organism=Caenorhabditis elegans, GI17559104, Length=265, Percent_Identity=27.1698113207547, Blast_Score=91, Evalue=4e-19, Organism=Caenorhabditis elegans, GI71994600, Length=259, Percent_Identity=24.3243243243243, Blast_Score=91, Evalue=5e-19, Organism=Caenorhabditis elegans, GI17562908, Length=259, Percent_Identity=26.2548262548263, Blast_Score=87, Evalue=7e-18, Organism=Caenorhabditis elegans, GI71994604, Length=248, Percent_Identity=23.3870967741935, Blast_Score=87, Evalue=7e-18, Organism=Caenorhabditis elegans, GI17563726, Length=263, Percent_Identity=27.7566539923954, Blast_Score=87, Evalue=7e-18, Organism=Caenorhabditis elegans, GI17560150, Length=266, Percent_Identity=26.3157894736842, Blast_Score=87, Evalue=9e-18, Organism=Caenorhabditis elegans, GI17562990, Length=263, Percent_Identity=25.8555133079848, Blast_Score=87, Evalue=1e-17, Organism=Caenorhabditis elegans, GI17562904, Length=265, Percent_Identity=26.0377358490566, Blast_Score=86, Evalue=2e-17, Organism=Caenorhabditis elegans, GI17561402, Length=254, Percent_Identity=27.1653543307087, Blast_Score=86, Evalue=2e-17, Organism=Caenorhabditis elegans, GI17536651, Length=252, Percent_Identity=26.984126984127, Blast_Score=84, Evalue=6e-17, Organism=Caenorhabditis elegans, GI17562910, Length=266, Percent_Identity=26.3157894736842, Blast_Score=84, Evalue=8e-17, Organism=Caenorhabditis elegans, GI17562906, Length=262, Percent_Identity=25.1908396946565, Blast_Score=83, Evalue=2e-16, Organism=Caenorhabditis elegans, GI115534694, Length=247, Percent_Identity=26.3157894736842, Blast_Score=82, Evalue=3e-16, Organism=Caenorhabditis elegans, GI72000259, Length=263, Percent_Identity=25.4752851711027, Blast_Score=82, Evalue=3e-16, Organism=Caenorhabditis elegans, GI17538480, Length=264, Percent_Identity=24.6212121212121, Blast_Score=82, Evalue=4e-16, Organism=Caenorhabditis elegans, GI17508651, Length=255, Percent_Identity=27.843137254902, Blast_Score=80, Evalue=1e-15, Organism=Caenorhabditis elegans, GI17536025, Length=251, Percent_Identity=26.2948207171315, Blast_Score=79, Evalue=2e-15, Organism=Caenorhabditis elegans, GI17551412, Length=261, Percent_Identity=24.5210727969349, Blast_Score=78, Evalue=5e-15, Organism=Caenorhabditis elegans, GI17560220, Length=262, Percent_Identity=26.3358778625954, Blast_Score=77, Evalue=9e-15, Organism=Caenorhabditis elegans, GI17531453, Length=266, Percent_Identity=24.4360902255639, Blast_Score=77, Evalue=1e-14, Organism=Caenorhabditis elegans, GI193204405, Length=265, Percent_Identity=25.2830188679245, Blast_Score=76, Evalue=1e-14, Organism=Caenorhabditis elegans, GI17560332, Length=264, Percent_Identity=25, Blast_Score=76, Evalue=2e-14, Organism=Caenorhabditis elegans, GI17538486, Length=259, Percent_Identity=25.8687258687259, Blast_Score=74, Evalue=1e-13, Organism=Caenorhabditis elegans, GI17567345, Length=171, Percent_Identity=29.8245614035088, Blast_Score=70, Evalue=1e-12, Organism=Caenorhabditis elegans, GI17565030, Length=263, Percent_Identity=23.574144486692, Blast_Score=68, Evalue=5e-12, Organism=Caenorhabditis elegans, GI193203117, Length=226, Percent_Identity=27.4336283185841, Blast_Score=64, Evalue=6e-11, Organism=Saccharomyces cerevisiae, GI6322861, Length=238, Percent_Identity=27.3109243697479, Blast_Score=78, Evalue=1e-15, Organism=Saccharomyces cerevisiae, GI6324126, Length=257, Percent_Identity=24.5136186770428, Blast_Score=75, Evalue=1e-14, Organism=Drosophila melanogaster, GI24639444, Length=241, Percent_Identity=28.6307053941909, Blast_Score=114, Evalue=8e-26, Organism=Drosophila melanogaster, GI24644339, Length=252, Percent_Identity=29.3650793650794, Blast_Score=106, Evalue=2e-23, Organism=Drosophila melanogaster, GI23397609, Length=245, Percent_Identity=28.9795918367347, Blast_Score=106, Evalue=2e-23, Organism=Drosophila melanogaster, GI21357041, Length=251, Percent_Identity=28.2868525896414, Blast_Score=102, Evalue=4e-22, Organism=Drosophila melanogaster, GI28571526, Length=254, Percent_Identity=27.5590551181102, Blast_Score=97, Evalue=1e-20, Organism=Drosophila melanogaster, GI17737361, Length=249, Percent_Identity=28.9156626506024, Blast_Score=92, Evalue=6e-19, Organism=Drosophila melanogaster, GI24644337, Length=193, Percent_Identity=26.4248704663212, Blast_Score=81, Evalue=8e-16, Organism=Drosophila melanogaster, GI24643142, Length=246, Percent_Identity=26.8292682926829, Blast_Score=80, Evalue=1e-15, Organism=Drosophila melanogaster, GI21355319, Length=247, Percent_Identity=25.1012145748988, Blast_Score=76, Evalue=2e-14,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR002198 - InterPro: IPR002347 - InterPro: IPR016040 - InterPro: IPR020904 [H]
Pfam domain/function: PF00106 adh_short [H]
EC number: 1.1.1.100 [C]
Molecular weight: Translated: 30766; Mature: 30635
Theoretical pI: Translated: 6.72; Mature: 6.72
Prosite motif: PS00061 ADH_SHORT
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
1.8 %Cys (Translated Protein) 1.8 %Met (Translated Protein) 3.6 %Cys+Met (Translated Protein) 1.8 %Cys (Mature Protein) 1.5 %Met (Mature Protein) 3.3 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MADNYLEKKYEQYQVRKTSGTRTSHNTKTLHKTRRVFITGGAEGIGKAIVRTFRGAGHRV CCCHHHHHHHHHHHEECCCCCCCCCCHHHHHHEEEEEEECCCHHHHHHHHHHHCCCCCEE AFCDKNEASGKETALQTGTQFFPVDVSDKTALEDCLQKIIEEWGDIDIIINNAGISQFSS EEECCCCCCCHHHHHHCCCEEEEECCCCHHHHHHHHHHHHHHHCCEEEEEECCCCHHHHH ITETSVEDFDKILSINLRPAFITSRRLALHRQSLETPNPYGRIINICSTRYLMSEPGSEG HHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCC YAASKGGIYSLTHALALSLSEWHITVNSIAPGWIQNNNYDQLRPEDHAQHPSGRVGKPED CCCCCCCHHHHHHHHHHHHHHEEEEEECCCCCCEECCCCCCCCCHHHCCCCCCCCCCHHH IARMCLFLCQEENDFINGENITIDGGMTKKMIYLD HHHHHHHHHCCCCCEECCCEEEECCCCCEEEEEEC >Mature Secondary Structure ADNYLEKKYEQYQVRKTSGTRTSHNTKTLHKTRRVFITGGAEGIGKAIVRTFRGAGHRV CCHHHHHHHHHHHEECCCCCCCCCCHHHHHHEEEEEEECCCHHHHHHHHHHHCCCCCEE AFCDKNEASGKETALQTGTQFFPVDVSDKTALEDCLQKIIEEWGDIDIIINNAGISQFSS EEECCCCCCCHHHHHHCCCEEEEECCCCHHHHHHHHHHHHHHHCCEEEEEECCCCHHHHH ITETSVEDFDKILSINLRPAFITSRRLALHRQSLETPNPYGRIINICSTRYLMSEPGSEG HHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCC YAASKGGIYSLTHALALSLSEWHITVNSIAPGWIQNNNYDQLRPEDHAQHPSGRVGKPED CCCCCCCHHHHHHHHHHHHHHEEEEEECCCCCCEECCCCCCCCCHHHCCCCCCCCCCHHH IARMCLFLCQEENDFINGENITIDGGMTKKMIYLD HHHHHHHHHCCCCCEECCCEEEECCCCCEEEEEEC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NADPH [C]
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: Oxoacyl-[acyl-carrier-protein]; NADPH; D-3-hydroxy-acyl-ACP; NADP [C]
Specific reaction: Oxoacyl-[acyl-carrier-protein] + NADPH = (3R)-hydroxyacyl-[acyl-carrier-protein] + NADP+ D-3-hydroxy-acyl-ACP + NADP = NADPH + Proton + beta-ketoacyl-ACP [C]
General reaction: Redox reaction [C]
Inhibitor: NA
Structure determination priority: 10.0
TargetDB status: NA
Availability: NA
References: 8550425; 10360571 [H]