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The map label for this gene is relA [H]

Identifier: 150008662

GI number: 150008662

Start: 2419210

End: 2421423

Strand: Direct

Name: relA [H]

Synonym: BDI_2052

Alternate gene names: 150008662

Gene position: 2419210-2421423 (Clockwise)

Preceding gene: 150008660

Following gene: 150008664

Centisome position: 50.28

GC content: 51.9

Gene sequence:

>2214_bases
ATGGATACAATTGGATTCTTTACGTCTGAGGAAAAGAAGCTGTTCTTCTCCAAATACAGGCTCCTGTTACGAAACCTTTA
CTCTTTCCTCGAGAGGGAAGATATCCGAAAGATGAAGGAGCTGATGAAGCGGGTTGTCGCCCTCGATTGCTACGGCAGGG
ATAAGAATGGTATCAACGGTTTATTGCGAAATATTGACACGGCCTTGATCGCCACCTTGGAGATTGGCTTGAAACGCACC
TCGGTCATCGCCCTCCTATTATACCGCCCGGTATTGAAGAAAGCGATCACGATAGAGGAAGTGGAGCAGAAATTCGGAGC
GGACGTGACCTTGATCATCCGTCGCCTCTTGAAGACCTCCGACCTGTATGCCCGGAACACCGCCGTCAACTCGGAGAATT
TCCATCATTTGCTTTTCTCGTTTGCCGAGGACGTACGTGTGATCTTGCTTATGATCGCCGACCGCCTCTGCCTCATGCGT
ATGGGAAAACAGATGCAAGAGGATGATCGTATCCGGCTGGCTACCGAGGCCTCTTATTTGTACGCTCCCCTCGCCCACCG
GTTGGGCTTATATACGATCAAGAGCGAGCTGGAAGACCTTTCCCTGAAATACACGGACAGGAAACAGTATGACTTCATCA
AACGGAAACTGAATGAGACGAAACGTTCCCGTGACGCTTATATCGCCGAGTTCATCGCCCCGATCAAGCGGAAGCTGGCA
GCGGCAGGATTCAAGTTCGATATCAAGGGGCGTACCAAATCCATACATTCCATTAATAACAAGCTGAAAAAGCAGCAGGT
GGAATTCGAGGGTATCTACGATCTTTTCGCTATCCGGATCGTATTGGATACGCCGCTGGAGAAGGAACGCTCGGAATGCT
GGCAAGTCTACTCCATCGTCACCGATATGTACCAGCCCAACCCGAAGCGTATGAAGGACTGGATCTCCATCCCGAAGACC
AACGGTTACGAGAGCTTGCACATCACGGTGATGGGCCCGCAAAATAAATGGGTGGAGGTGCAGATCCGTACGAAGCGGAT
GGATGAGATCGCCGAGCGAGGCCTAGCGGCGCATTGGAAATACAAGGGCGTGAAAGCGGAGAGCGGGCTAGACGAGTTCT
TGAATACCGTACGTGCCGCCTTGGAGGCCAAGGAGAATAATCCGCTCGACTTGATGCAGGATTTCAAGATGGATCTATAT
AAGGATGAGATCTACGTCTTCACGCCTACCGGCGAGCTTATCAAGCTGGCCAAGGGAGCGACGGTCCTCGATTTCGCCTT
TGCCATCCACACGAAGCTGGGAAGCAAATGCGTATCGGCTAAAGTGAACGGGAAGAACGTACCGATCAAATACACCTTGA
ACAACGGCGATAGCGTATCCGTGATCACGTCGCCGGCGCAAAGCCCGAAGCGGGATTGGCTGAACTTCGTCGTCACCTCC
AAGGCCCGCGTGAAGATCAAGCAGGCCTTGAAGGAGGAGACCGTGAAGGCCGTGGAGTTCGCCAAGGAGATGTTGCAGCG
CCGCTTCAAGAACCGGAAGATCGACATGGACGAGCCAACCATGATGCGCTATATCAAGAAGAAAGGATTCAAGACCGTCA
CGGACTTCTACATCGAGATCGCCGAGGAACGCCTCGATCCCAACCAAGTAATCGACGAATATCTGGAGGCTTTCCGCAAG
GAGACGGAGACGAACGAGCGCACCGAGGTGCGTAGCGCGGAGGAATTCGTGACCACGACTCCGGTGGAGGAGATATCGAC
GAACAAGGATGTCTTGGTGATCGACAAGAACCTGACGGGTATCGAATATAAACTCGCCAAATGCTGCAACCCGATTTATG
GCGACGAGGTTTTCGGTTTCGTCTCCACGCAAGGTATCAAGATACACCGCATGGATTGCCCGAACGCCCAAGAGATGTTC
AGCCGCTTCGGTTACCGGATCATCCGTGCGAAATGGAGCGGCAAGGGAGACAATGGCTATACGGTTACGTTGCGGGTGAT
CGGACGGGACGATATAGCGATCGTCACCAACATCACCTCCGTGATCGGAAAGGAATCGAACGTCACGCTTCGCTCCTTAA
ACATCAACTCGGTAGACGGATTATTCCAAGGTAACTTTACCGTATTGGTAAGAGATACGACCGCATTAAACTTGCTGACG
AAAAAGATCAAGGCGGTAAACGGAGTGAAAGCGGTAGAGCGATTAAATTCTTAG

Upstream 100 bases:

>100_bases
AAAATAACCGCAAGATACATGTTGAAATTCCATAGAAAAAAGTATTTTTACAGCATGTTTTGCGGTTTGTCCTCAACCGG
GCAATAAAAATGATATAACT

Downstream 100 bases:

>100_bases
ACAGTGTACTGTGCACGAAGTACCGTAGTACTCTGTACGAAGTACTACAGTACCCTCTAGGAAGTACCGCAGTACTTCGT
ACAGGGGACTGTGCCAACTG

Product: GTP pyrophosphokinase

Products: NA

Alternate protein names: (p)ppGpp synthase; ATP:GTP 3'-pyrophosphotransferase; ppGpp synthase I [H]

Number of amino acids: Translated: 737; Mature: 737

Protein sequence:

>737_residues
MDTIGFFTSEEKKLFFSKYRLLLRNLYSFLEREDIRKMKELMKRVVALDCYGRDKNGINGLLRNIDTALIATLEIGLKRT
SVIALLLYRPVLKKAITIEEVEQKFGADVTLIIRRLLKTSDLYARNTAVNSENFHHLLFSFAEDVRVILLMIADRLCLMR
MGKQMQEDDRIRLATEASYLYAPLAHRLGLYTIKSELEDLSLKYTDRKQYDFIKRKLNETKRSRDAYIAEFIAPIKRKLA
AAGFKFDIKGRTKSIHSINNKLKKQQVEFEGIYDLFAIRIVLDTPLEKERSECWQVYSIVTDMYQPNPKRMKDWISIPKT
NGYESLHITVMGPQNKWVEVQIRTKRMDEIAERGLAAHWKYKGVKAESGLDEFLNTVRAALEAKENNPLDLMQDFKMDLY
KDEIYVFTPTGELIKLAKGATVLDFAFAIHTKLGSKCVSAKVNGKNVPIKYTLNNGDSVSVITSPAQSPKRDWLNFVVTS
KARVKIKQALKEETVKAVEFAKEMLQRRFKNRKIDMDEPTMMRYIKKKGFKTVTDFYIEIAEERLDPNQVIDEYLEAFRK
ETETNERTEVRSAEEFVTTTPVEEISTNKDVLVIDKNLTGIEYKLAKCCNPIYGDEVFGFVSTQGIKIHRMDCPNAQEMF
SRFGYRIIRAKWSGKGDNGYTVTLRVIGRDDIAIVTNITSVIGKESNVTLRSLNINSVDGLFQGNFTVLVRDTTALNLLT
KKIKAVNGVKAVERLNS

Sequences:

>Translated_737_residues
MDTIGFFTSEEKKLFFSKYRLLLRNLYSFLEREDIRKMKELMKRVVALDCYGRDKNGINGLLRNIDTALIATLEIGLKRT
SVIALLLYRPVLKKAITIEEVEQKFGADVTLIIRRLLKTSDLYARNTAVNSENFHHLLFSFAEDVRVILLMIADRLCLMR
MGKQMQEDDRIRLATEASYLYAPLAHRLGLYTIKSELEDLSLKYTDRKQYDFIKRKLNETKRSRDAYIAEFIAPIKRKLA
AAGFKFDIKGRTKSIHSINNKLKKQQVEFEGIYDLFAIRIVLDTPLEKERSECWQVYSIVTDMYQPNPKRMKDWISIPKT
NGYESLHITVMGPQNKWVEVQIRTKRMDEIAERGLAAHWKYKGVKAESGLDEFLNTVRAALEAKENNPLDLMQDFKMDLY
KDEIYVFTPTGELIKLAKGATVLDFAFAIHTKLGSKCVSAKVNGKNVPIKYTLNNGDSVSVITSPAQSPKRDWLNFVVTS
KARVKIKQALKEETVKAVEFAKEMLQRRFKNRKIDMDEPTMMRYIKKKGFKTVTDFYIEIAEERLDPNQVIDEYLEAFRK
ETETNERTEVRSAEEFVTTTPVEEISTNKDVLVIDKNLTGIEYKLAKCCNPIYGDEVFGFVSTQGIKIHRMDCPNAQEMF
SRFGYRIIRAKWSGKGDNGYTVTLRVIGRDDIAIVTNITSVIGKESNVTLRSLNINSVDGLFQGNFTVLVRDTTALNLLT
KKIKAVNGVKAVERLNS
>Mature_737_residues
MDTIGFFTSEEKKLFFSKYRLLLRNLYSFLEREDIRKMKELMKRVVALDCYGRDKNGINGLLRNIDTALIATLEIGLKRT
SVIALLLYRPVLKKAITIEEVEQKFGADVTLIIRRLLKTSDLYARNTAVNSENFHHLLFSFAEDVRVILLMIADRLCLMR
MGKQMQEDDRIRLATEASYLYAPLAHRLGLYTIKSELEDLSLKYTDRKQYDFIKRKLNETKRSRDAYIAEFIAPIKRKLA
AAGFKFDIKGRTKSIHSINNKLKKQQVEFEGIYDLFAIRIVLDTPLEKERSECWQVYSIVTDMYQPNPKRMKDWISIPKT
NGYESLHITVMGPQNKWVEVQIRTKRMDEIAERGLAAHWKYKGVKAESGLDEFLNTVRAALEAKENNPLDLMQDFKMDLY
KDEIYVFTPTGELIKLAKGATVLDFAFAIHTKLGSKCVSAKVNGKNVPIKYTLNNGDSVSVITSPAQSPKRDWLNFVVTS
KARVKIKQALKEETVKAVEFAKEMLQRRFKNRKIDMDEPTMMRYIKKKGFKTVTDFYIEIAEERLDPNQVIDEYLEAFRK
ETETNERTEVRSAEEFVTTTPVEEISTNKDVLVIDKNLTGIEYKLAKCCNPIYGDEVFGFVSTQGIKIHRMDCPNAQEMF
SRFGYRIIRAKWSGKGDNGYTVTLRVIGRDDIAIVTNITSVIGKESNVTLRSLNINSVDGLFQGNFTVLVRDTTALNLLT
KKIKAVNGVKAVERLNS

Specific function: In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. This enzyme catalyzes the formation of pppGpp which i

COG id: COG0317

COG function: function code TK; Guanosine polyphosphate pyrophosphohydrolases/synthetases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HD domain [H]

Homologues:

Organism=Escherichia coli, GI1789147, Length=676, Percent_Identity=31.0650887573964, Blast_Score=339, Evalue=3e-94,
Organism=Escherichia coli, GI1790082, Length=724, Percent_Identity=29.4198895027624, Blast_Score=336, Evalue=3e-93,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR012675
- InterPro:   IPR003607
- InterPro:   IPR007685
- InterPro:   IPR004811
- InterPro:   IPR004095
- InterPro:   IPR012676 [H]

Pfam domain/function: PF01842 ACT; PF04607 RelA_SpoT; PF02824 TGS [H]

EC number: =2.7.6.5 [H]

Molecular weight: Translated: 84763; Mature: 84763

Theoretical pI: Translated: 9.84; Mature: 9.84

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDTIGFFTSEEKKLFFSKYRLLLRNLYSFLEREDIRKMKELMKRVVALDCYGRDKNGING
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHH
LLRNIDTALIATLEIGLKRTSVIALLLYRPVLKKAITIEEVEQKFGADVTLIIRRLLKTS
HHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHC
DLYARNTAVNSENFHHLLFSFAEDVRVILLMIADRLCLMRMGKQMQEDDRIRLATEASYL
CHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHCCCCCCEEEEECCHHH
YAPLAHRLGLYTIKSELEDLSLKYTDRKQYDFIKRKLNETKRSRDAYIAEFIAPIKRKLA
HHHHHHHHHHHHHHHHHHHCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AAGFKFDIKGRTKSIHSINNKLKKQQVEFEGIYDLFAIRIVLDTPLEKERSECWQVYSIV
HCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHH
TDMYQPNPKRMKDWISIPKTNGYESLHITVMGPQNKWVEVQIRTKRMDEIAERGLAAHWK
HHHHCCCHHHHHHHHCCCCCCCCCEEEEEEECCCCCEEEEEEHHHHHHHHHHCCCEEEEE
YKGVKAESGLDEFLNTVRAALEAKENNPLDLMQDFKMDLYKDEIYVFTPTGELIKLAKGA
ECCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHEECEEEEECCCHHHHHHHCCC
TVLDFAFAIHTKLGSKCVSAKVNGKNVPIKYTLNNGDSVSVITSPAQSPKRDWLNFVVTS
HHHHHHHHHHHHHCCHHHEEEECCCCCCEEEEECCCCEEEEEECCCCCCHHHHHHHHCCC
KARVKIKQALKEETVKAVEFAKEMLQRRFKNRKIDMDEPTMMRYIKKKGFKTVTDFYIEI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCHHHHHHHHHH
AEERLDPNQVIDEYLEAFRKETETNERTEVRSAEEFVTTTPVEEISTNKDVLVIDKNLTG
HHHCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCHHHHCCCCCEEEEECCCCC
IEYKLAKCCNPIYGDEVFGFVSTQGIKIHRMDCPNAQEMFSRFGYRIIRAKWSGKGDNGY
HHHHHHHHCCCCCCCHHHEEEECCCEEEEECCCCCHHHHHHHCCEEEEEEEECCCCCCCE
TVTLRVIGRDDIAIVTNITSVIGKESNVTLRSLNINSVDGLFQGNFTVLVRDTTALNLLT
EEEEEEECCCCEEEEEHHHHHHCCCCCCEEEEECCCCCCCEECCCEEEEEECCHHHHHHH
KKIKAVNGVKAVERLNS
HHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MDTIGFFTSEEKKLFFSKYRLLLRNLYSFLEREDIRKMKELMKRVVALDCYGRDKNGING
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHH
LLRNIDTALIATLEIGLKRTSVIALLLYRPVLKKAITIEEVEQKFGADVTLIIRRLLKTS
HHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHC
DLYARNTAVNSENFHHLLFSFAEDVRVILLMIADRLCLMRMGKQMQEDDRIRLATEASYL
CHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHCCCCCCEEEEECCHHH
YAPLAHRLGLYTIKSELEDLSLKYTDRKQYDFIKRKLNETKRSRDAYIAEFIAPIKRKLA
HHHHHHHHHHHHHHHHHHHCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AAGFKFDIKGRTKSIHSINNKLKKQQVEFEGIYDLFAIRIVLDTPLEKERSECWQVYSIV
HCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHH
TDMYQPNPKRMKDWISIPKTNGYESLHITVMGPQNKWVEVQIRTKRMDEIAERGLAAHWK
HHHHCCCHHHHHHHHCCCCCCCCCEEEEEEECCCCCEEEEEEHHHHHHHHHHCCCEEEEE
YKGVKAESGLDEFLNTVRAALEAKENNPLDLMQDFKMDLYKDEIYVFTPTGELIKLAKGA
ECCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHEECEEEEECCCHHHHHHHCCC
TVLDFAFAIHTKLGSKCVSAKVNGKNVPIKYTLNNGDSVSVITSPAQSPKRDWLNFVVTS
HHHHHHHHHHHHHCCHHHEEEECCCCCCEEEEECCCCEEEEEECCCCCCHHHHHHHHCCC
KARVKIKQALKEETVKAVEFAKEMLQRRFKNRKIDMDEPTMMRYIKKKGFKTVTDFYIEI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCHHHHHHHHHH
AEERLDPNQVIDEYLEAFRKETETNERTEVRSAEEFVTTTPVEEISTNKDVLVIDKNLTG
HHHCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCHHHHCCCCCEEEEECCCCC
IEYKLAKCCNPIYGDEVFGFVSTQGIKIHRMDCPNAQEMFSRFGYRIIRAKWSGKGDNGY
HHHHHHHHCCCCCCCHHHEEEECCCEEEEECCCCCHHHHHHHCCEEEEEEEECCCCCCCE
TVTLRVIGRDDIAIVTNITSVIGKESNVTLRSLNINSVDGLFQGNFTVLVRDTTALNLLT
EEEEEEECCCCEEEEEHHHHHHCCCCCCEEEEECCCCCCCEECCCEEEEEECCHHHHHHH
KKIKAVNGVKAVERLNS
HHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA