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The map label for this gene is lysC [C]

Identifier: 150008633

GI number: 150008633

Start: 2386227

End: 2387543

Strand: Direct

Name: lysC [C]

Synonym: BDI_2021

Alternate gene names: 150008633

Gene position: 2386227-2387543 (Clockwise)

Preceding gene: 150008632

Following gene: 150008634

Centisome position: 49.6

GC content: 46.32

Gene sequence:

>1317_bases
ATGAAAGTTTTAAAGTTTGGCGGTACTTCTGTGGGATCTGCACAGAGAATGAAAGATGTAGCGAAACTGATCACGGGAGA
CCGTAAGATCGTTGTATTGTCAGCCATGTCGGGTACAACCAACTCGTTAGTCGAGATTTCCGACTACCTGTACAAAAAGA
ACCCAGACGGAGCGAATGAGATCATCAACAAGCTTGCCATGAAATATATGGGCCATGTTGAGGAACTATACAGCACCGAG
GAATATAAACAGAAGGCCAAAGAACTGATAAAATCTCATTTCGAATATATCCGTACGTTCACGAAGGATCTGTTTACCTT
GTTCGAGGAAAAGGTTGTCTTGGCACAAGGAGAGTTGATCTCTACGGGTATGATGAATCTTTATTTGAACGAATGCGGCG
TGAAATCCGTATTGATCCCGGCTTTGGATTATATGCGTACGGATAAGAACGCGGAACCGGACCCTGTCTATATCAAAGAG
AAATTGGTGAAATTACTCGCTGATAATAAGGATGCTGATCTATACATCACACAAGGTTATATCTGCCGCAACGCTTACGG
CGAGATCGATAACCTACAACGAGGTGGTAGCGACTATAGCGCATCCTTAATCGGCGCGGCTATCGGTGCGGAAGAGATCC
AGATCTGGACAGACATCGACGGTATGCACAATAACGACCCTCGTATCGTACAGGGAACGTCTCCAGTCCGTCAATTGCAT
TTCGAGGAAGCTGCCGAATTAGCTTATTTCGGAGCCAAGATCCTTCACCCGACTTGTATATTGCCGGCTAAATTGAACAA
CATCCCGGTTCGTTTGTTAAATACGATGCAGCCGGACGCTCCGGGTACATTGATCTCAAACGCTATCGAAAAAGGTAAGA
TCAAAGCGGTCGCCGCCAAAGACAATATTACCTCTATCAAGATCAAGAGCGGACGTATGTTGCTAGCTACAGGTTTCTTG
CGTAAGGTATTCGAGACTTTCGAGAACTACCAGACTCCGATCGACATGGTTACGACTTCCGAAGTGGGTGTCTCCGTTAC
GATCGATAACCGCAAGCATCTGGAAGAGATCGTTGACGATTTGAAGAAGTACGGAACCGTGACCGTAGACGAGGATATGG
TTATCGTTTGCGTGGTTGGCGACCTAGAATGGGATAACATCGGCTTCGAGGCTCGTATCGTACAAGCTATGAAGGATGTC
CCGGTCCGTATGATCTCCTACGGAGGAAGCAACTACAACGTCTCCTTGCTGATCAAGGCCTCGGACAAGCAGAGAGCGCT
GCAAGCTCTAAGCGATCATTTATTTAACAACAAATAA

Upstream 100 bases:

>100_bases
CGAGAATGCCTGTCTAAGTGATGTCAGAGAATAATTTTTTTGTAACTTTGCGGTCGCATTCGATTGAAAAAGAAAACAAT
TTAATATAGAACAAAAGAAG

Downstream 100 bases:

>100_bases
AAACAAACGAGGGCGGCCTTTTACAGACTGCCCTTATTTATCTTTATATAATTTCGTATAATATGCTCAAAGGAACATTT
CCTGTAGAAAAGTTCAAGCA

Product: aspartokinase

Products: NA

Alternate protein names: Aspartate kinase [H]

Number of amino acids: Translated: 438; Mature: 438

Protein sequence:

>438_residues
MKVLKFGGTSVGSAQRMKDVAKLITGDRKIVVLSAMSGTTNSLVEISDYLYKKNPDGANEIINKLAMKYMGHVEELYSTE
EYKQKAKELIKSHFEYIRTFTKDLFTLFEEKVVLAQGELISTGMMNLYLNECGVKSVLIPALDYMRTDKNAEPDPVYIKE
KLVKLLADNKDADLYITQGYICRNAYGEIDNLQRGGSDYSASLIGAAIGAEEIQIWTDIDGMHNNDPRIVQGTSPVRQLH
FEEAAELAYFGAKILHPTCILPAKLNNIPVRLLNTMQPDAPGTLISNAIEKGKIKAVAAKDNITSIKIKSGRMLLATGFL
RKVFETFENYQTPIDMVTTSEVGVSVTIDNRKHLEEIVDDLKKYGTVTVDEDMVIVCVVGDLEWDNIGFEARIVQAMKDV
PVRMISYGGSNYNVSLLIKASDKQRALQALSDHLFNNK

Sequences:

>Translated_438_residues
MKVLKFGGTSVGSAQRMKDVAKLITGDRKIVVLSAMSGTTNSLVEISDYLYKKNPDGANEIINKLAMKYMGHVEELYSTE
EYKQKAKELIKSHFEYIRTFTKDLFTLFEEKVVLAQGELISTGMMNLYLNECGVKSVLIPALDYMRTDKNAEPDPVYIKE
KLVKLLADNKDADLYITQGYICRNAYGEIDNLQRGGSDYSASLIGAAIGAEEIQIWTDIDGMHNNDPRIVQGTSPVRQLH
FEEAAELAYFGAKILHPTCILPAKLNNIPVRLLNTMQPDAPGTLISNAIEKGKIKAVAAKDNITSIKIKSGRMLLATGFL
RKVFETFENYQTPIDMVTTSEVGVSVTIDNRKHLEEIVDDLKKYGTVTVDEDMVIVCVVGDLEWDNIGFEARIVQAMKDV
PVRMISYGGSNYNVSLLIKASDKQRALQALSDHLFNNK
>Mature_438_residues
MKVLKFGGTSVGSAQRMKDVAKLITGDRKIVVLSAMSGTTNSLVEISDYLYKKNPDGANEIINKLAMKYMGHVEELYSTE
EYKQKAKELIKSHFEYIRTFTKDLFTLFEEKVVLAQGELISTGMMNLYLNECGVKSVLIPALDYMRTDKNAEPDPVYIKE
KLVKLLADNKDADLYITQGYICRNAYGEIDNLQRGGSDYSASLIGAAIGAEEIQIWTDIDGMHNNDPRIVQGTSPVRQLH
FEEAAELAYFGAKILHPTCILPAKLNNIPVRLLNTMQPDAPGTLISNAIEKGKIKAVAAKDNITSIKIKSGRMLLATGFL
RKVFETFENYQTPIDMVTTSEVGVSVTIDNRKHLEEIVDDLKKYGTVTVDEDMVIVCVVGDLEWDNIGFEARIVQAMKDV
PVRMISYGGSNYNVSLLIKASDKQRALQALSDHLFNNK

Specific function: Lysine biosynthesis; first step. [C]

COG id: COG0527

COG function: function code E; Aspartokinases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 ACT domains [H]

Homologues:

Organism=Escherichia coli, GI1790455, Length=458, Percent_Identity=31.8777292576419, Blast_Score=194, Evalue=8e-51,
Organism=Escherichia coli, GI1786183, Length=466, Percent_Identity=27.2532188841202, Blast_Score=151, Evalue=7e-38,
Organism=Escherichia coli, GI1790376, Length=455, Percent_Identity=25.0549450549451, Blast_Score=118, Evalue=8e-28,
Organism=Saccharomyces cerevisiae, GI6320893, Length=492, Percent_Identity=25.8130081300813, Blast_Score=146, Evalue=7e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR001048
- InterPro:   IPR005260
- InterPro:   IPR001341
- InterPro:   IPR018042 [H]

Pfam domain/function: PF00696 AA_kinase; PF01842 ACT [H]

EC number: =2.7.2.4 [H]

Molecular weight: Translated: 48800; Mature: 48800

Theoretical pI: Translated: 5.98; Mature: 5.98

Prosite motif: PS00324 ASPARTOKINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVLKFGGTSVGSAQRMKDVAKLITGDRKIVVLSAMSGTTNSLVEISDYLYKKNPDGANE
CCEEEECCCCCCHHHHHHHHHHHHCCCCEEEEEEECCCCCCHHHHHHHHHHCCCCCCHHH
IINKLAMKYMGHVEELYSTEEYKQKAKELIKSHFEYIRTFTKDLFTLFEEKVVLAQGELI
HHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCH
STGMMNLYLNECGVKSVLIPALDYMRTDKNAEPDPVYIKEKLVKLLADNKDADLYITQGY
HHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCCCEEEECCE
ICRNAYGEIDNLQRGGSDYSASLIGAAIGAEEIQIWTDIDGMHNNDPRIVQGTSPVRQLH
EEECCCCCCHHHHCCCCCCHHHHHHHHCCCCCEEEEECCCCCCCCCCEEEECCCHHHHHH
FEEAAELAYFGAKILHPTCILPAKLNNIPVRLLNTMQPDAPGTLISNAIEKGKIKAVAAK
HHHHHHHHHHHHHHHCCEEECCCCCCCCCHHHHHCCCCCCCHHHHHHHHHCCCEEEEEEC
DNITSIKIKSGRMLLATGFLRKVFETFENYQTPIDMVTTSEVGVSVTIDNRKHLEEIVDD
CCCEEEEEECCCEEEHHHHHHHHHHHHHHCCCCHHEEEECCCCEEEEECCHHHHHHHHHH
LKKYGTVTVDEDMVIVCVVGDLEWDNIGFEARIVQAMKDVPVRMISYGGSNYNVSLLIKA
HHHCCCEEECCCEEEEEEEECCCCCCCCHHHHHHHHHHHCCEEEEEECCCCEEEEEEEEC
SDKQRALQALSDHLFNNK
CCHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MKVLKFGGTSVGSAQRMKDVAKLITGDRKIVVLSAMSGTTNSLVEISDYLYKKNPDGANE
CCEEEECCCCCCHHHHHHHHHHHHCCCCEEEEEEECCCCCCHHHHHHHHHHCCCCCCHHH
IINKLAMKYMGHVEELYSTEEYKQKAKELIKSHFEYIRTFTKDLFTLFEEKVVLAQGELI
HHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCH
STGMMNLYLNECGVKSVLIPALDYMRTDKNAEPDPVYIKEKLVKLLADNKDADLYITQGY
HHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCCCEEEECCE
ICRNAYGEIDNLQRGGSDYSASLIGAAIGAEEIQIWTDIDGMHNNDPRIVQGTSPVRQLH
EEECCCCCCHHHHCCCCCCHHHHHHHHCCCCCEEEEECCCCCCCCCCEEEECCCHHHHHH
FEEAAELAYFGAKILHPTCILPAKLNNIPVRLLNTMQPDAPGTLISNAIEKGKIKAVAAK
HHHHHHHHHHHHHHHCCEEECCCCCCCCCHHHHHCCCCCCCHHHHHHHHHCCCEEEEEEC
DNITSIKIKSGRMLLATGFLRKVFETFENYQTPIDMVTTSEVGVSVTIDNRKHLEEIVDD
CCCEEEEEECCCEEEHHHHHHHHHHHHHHCCCCHHEEEECCCCEEEEECCHHHHHHHHHH
LKKYGTVTVDEDMVIVCVVGDLEWDNIGFEARIVQAMKDVPVRMISYGGSNYNVSLLIKA
HHHCCCEEECCCEEEEEEEECCCCCCCCHHHHHHHHHHHCCEEEEEECCCCEEEEEEEEC
SDKQRALQALSDHLFNNK
CCHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]