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The map label for this gene is lysA [H]

Identifier: 150008634

GI number: 150008634

Start: 2387606

End: 2388763

Strand: Direct

Name: lysA [H]

Synonym: BDI_2022

Alternate gene names: 150008634

Gene position: 2387606-2388763 (Clockwise)

Preceding gene: 150008633

Following gene: 150008635

Centisome position: 49.62

GC content: 46.63

Gene sequence:

>1158_bases
ATGCTCAAAGGAACATTTCCTGTAGAAAAGTTCAAGCAGCTTTCTACGCCTTTTTATTATTATGATGTCAAGCTATTGCA
AGACACATTAGACGTAGTAAAAACCGAATCCGGGAAATATGGTTACCACGTGCATTATGCCGTGAAAGCGAATGCCAATC
CCCGTATCCTTTCCATCATAGCGGCAAACGGCCTTGGCGCAGACTGCGTAAGTGGCGGCGAGGTACAGGCAGCTTTAGAT
GCCGGTTTTCCTGCCGATAAGATTGTCTTTGCCGGTGTTGGCAAAGCGGATTGGGAGATCAACCTAGGACTGGACAATGA
TATTTTCTGCTTTAACGTGGAATCTGCCGTTGAGCTGGGAATCATCAATGAGCTGGCGGCCGCTAAAAATAAAGTAGCCT
CTATCGCCCTTCGTATCAACCCGGAAGTGGATGCCCATACGCATGCCAAGATCACGACGGGTATGAAAGAGAATAAATTC
GGTATCAACCTTAGCCAATTAGGAGGTGTACTGGATAAATTAAAGGAGATGAAGAATGTGAAGTTGATCGGTATCCATAG
CCATATCGGTTCACAGATCACGGATATGTCTAGCTTCCGCAATTTGGTAATTCGTTTCAACGAGATACAGGAAGAACTGG
AAGCTCATGGGGTTACAGTGGAGAACCTAAACTTCGGAGGTGGATTAGGTATCGATTACTATCACCCGAATCATTTATCG
ATCCCGGCTTTCGATAACTATTTCGCGGCCATTCATAAACTGCTTCAAGTACGTCCGGGTCAACAGGTACATTTTGAGCC
GGGACGTTCGATCGTCGCTCAATGCGGAACATTAATCTCTAAGGTATTATATGTCAAGGAAGGAGAGACGAAGAAATTCG
CTATCCTTGATGCAGGTTTCACGGAATTGATCCGCCCGGCGATGTACGACGCTTATCACCGTATCGAGAACATCAGCAGC
GATGAGGCAGTAGAGACTTACGATGTAGTGGGCCCTATCTGTGAGTCATCGGATGTATTCGGTAAGGATGTAGAGTTGAA
TAAGGCTCATCGTGGCGACTTGATCGCCCTTCGTTCCGCCGGCGCTTATGGCGAGGTCATGGCCTCCCAATACAACTGCC
GCCATTTACCGAAAGCCTATTATTCCGATACGATATAA

Upstream 100 bases:

>100_bases
TGCAAGCTCTAAGCGATCATTTATTTAACAACAAATAAAAACAAACGAGGGCGGCCTTTTACAGACTGCCCTTATTTATC
TTTATATAATTTCGTATAAT

Downstream 100 bases:

>100_bases
TAAAGAGGTAATAGCGCTTCGCTACTATACCAATATACCCATGCGAATACGTTTTAGGTATCGCATTGGTATATTGTCGT
TTTAGCACATTGACATTTAA

Product: diaminopimelate decarboxylase

Products: NA

Alternate protein names: DAP decarboxylase [H]

Number of amino acids: Translated: 385; Mature: 385

Protein sequence:

>385_residues
MLKGTFPVEKFKQLSTPFYYYDVKLLQDTLDVVKTESGKYGYHVHYAVKANANPRILSIIAANGLGADCVSGGEVQAALD
AGFPADKIVFAGVGKADWEINLGLDNDIFCFNVESAVELGIINELAAAKNKVASIALRINPEVDAHTHAKITTGMKENKF
GINLSQLGGVLDKLKEMKNVKLIGIHSHIGSQITDMSSFRNLVIRFNEIQEELEAHGVTVENLNFGGGLGIDYYHPNHLS
IPAFDNYFAAIHKLLQVRPGQQVHFEPGRSIVAQCGTLISKVLYVKEGETKKFAILDAGFTELIRPAMYDAYHRIENISS
DEAVETYDVVGPICESSDVFGKDVELNKAHRGDLIALRSAGAYGEVMASQYNCRHLPKAYYSDTI

Sequences:

>Translated_385_residues
MLKGTFPVEKFKQLSTPFYYYDVKLLQDTLDVVKTESGKYGYHVHYAVKANANPRILSIIAANGLGADCVSGGEVQAALD
AGFPADKIVFAGVGKADWEINLGLDNDIFCFNVESAVELGIINELAAAKNKVASIALRINPEVDAHTHAKITTGMKENKF
GINLSQLGGVLDKLKEMKNVKLIGIHSHIGSQITDMSSFRNLVIRFNEIQEELEAHGVTVENLNFGGGLGIDYYHPNHLS
IPAFDNYFAAIHKLLQVRPGQQVHFEPGRSIVAQCGTLISKVLYVKEGETKKFAILDAGFTELIRPAMYDAYHRIENISS
DEAVETYDVVGPICESSDVFGKDVELNKAHRGDLIALRSAGAYGEVMASQYNCRHLPKAYYSDTI
>Mature_385_residues
MLKGTFPVEKFKQLSTPFYYYDVKLLQDTLDVVKTESGKYGYHVHYAVKANANPRILSIIAANGLGADCVSGGEVQAALD
AGFPADKIVFAGVGKADWEINLGLDNDIFCFNVESAVELGIINELAAAKNKVASIALRINPEVDAHTHAKITTGMKENKF
GINLSQLGGVLDKLKEMKNVKLIGIHSHIGSQITDMSSFRNLVIRFNEIQEELEAHGVTVENLNFGGGLGIDYYHPNHLS
IPAFDNYFAAIHKLLQVRPGQQVHFEPGRSIVAQCGTLISKVLYVKEGETKKFAILDAGFTELIRPAMYDAYHRIENISS
DEAVETYDVVGPICESSDVFGKDVELNKAHRGDLIALRSAGAYGEVMASQYNCRHLPKAYYSDTI

Specific function: Lysine biosynthesis; last step. [C]

COG id: COG0019

COG function: function code E; Diaminopimelate decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Orn/Lys/Arg decarboxylase class-II family [H]

Homologues:

Organism=Homo sapiens, GI4505489, Length=360, Percent_Identity=26.3888888888889, Blast_Score=102, Evalue=6e-22,
Organism=Homo sapiens, GI16506287, Length=345, Percent_Identity=23.1884057971014, Blast_Score=73, Evalue=4e-13,
Organism=Homo sapiens, GI22538418, Length=360, Percent_Identity=23.6111111111111, Blast_Score=69, Evalue=8e-12,
Organism=Homo sapiens, GI21361583, Length=360, Percent_Identity=23.6111111111111, Blast_Score=69, Evalue=8e-12,
Organism=Escherichia coli, GI1789203, Length=388, Percent_Identity=31.1855670103093, Blast_Score=147, Evalue=1e-36,
Organism=Caenorhabditis elegans, GI17562780, Length=359, Percent_Identity=23.1197771587744, Blast_Score=82, Evalue=6e-16,
Organism=Saccharomyces cerevisiae, GI6322664, Length=357, Percent_Identity=22.6890756302521, Blast_Score=73, Evalue=6e-14,
Organism=Drosophila melanogaster, GI24586472, Length=354, Percent_Identity=24.5762711864407, Blast_Score=88, Evalue=1e-17,
Organism=Drosophila melanogaster, GI24586474, Length=357, Percent_Identity=23.5294117647059, Blast_Score=76, Evalue=5e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009006
- InterPro:   IPR002986
- InterPro:   IPR022643
- InterPro:   IPR022644
- InterPro:   IPR000183 [H]

Pfam domain/function: PF02784 Orn_Arg_deC_N; PF00278 Orn_DAP_Arg_deC [H]

EC number: =4.1.1.20 [H]

Molecular weight: Translated: 42274; Mature: 42274

Theoretical pI: Translated: 6.15; Mature: 6.15

Prosite motif: PS00878 ODR_DC_2_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLKGTFPVEKFKQLSTPFYYYDVKLLQDTLDVVKTESGKYGYHVHYAVKANANPRILSII
CCCCCCCHHHHHHHCCCEEEEHHHHHHHHHHHHCCCCCCCEEEEEEEEECCCCCEEEEEE
AANGLGADCVSGGEVQAALDAGFPADKIVFAGVGKADWEINLGLDNDIFCFNVESAVELG
EECCCCCCCCCCCCEEEEECCCCCCCCEEEEECCCCCEEEEECCCCCEEEEECHHHHHHH
IINELAAAKNKVASIALRINPEVDAHTHAKITTGMKENKFGINLSQLGGVLDKLKEMKNV
HHHHHHHHHCCEEEEEEEECCCCCCCCCEEEECCCCCCCCCCCHHHHHHHHHHHHHHCCE
KLIGIHSHIGSQITDMSSFRNLVIRFNEIQEELEAHGVTVENLNFGGGLGIDYYHPNHLS
EEEEEHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCCCEECCCCCC
IPAFDNYFAAIHKLLQVRPGQQVHFEPGRSIVAQCGTLISKVLYVKEGETKKFAILDAGF
CCCCHHHHHHHHHHHHCCCCCEEEECCCHHHHHHHHHHHHHHHEEECCCCCEEEEEECCH
TELIRPAMYDAYHRIENISSDEAVETYDVVGPICESSDVFGKDVELNKAHRGDLIALRSA
HHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCEEEEECC
GAYGEVMASQYNCRHLPKAYYSDTI
CCHHHHHHCCCCCCCCCHHHHCCCC
>Mature Secondary Structure
MLKGTFPVEKFKQLSTPFYYYDVKLLQDTLDVVKTESGKYGYHVHYAVKANANPRILSII
CCCCCCCHHHHHHHCCCEEEEHHHHHHHHHHHHCCCCCCCEEEEEEEEECCCCCEEEEEE
AANGLGADCVSGGEVQAALDAGFPADKIVFAGVGKADWEINLGLDNDIFCFNVESAVELG
EECCCCCCCCCCCCEEEEECCCCCCCCEEEEECCCCCEEEEECCCCCEEEEECHHHHHHH
IINELAAAKNKVASIALRINPEVDAHTHAKITTGMKENKFGINLSQLGGVLDKLKEMKNV
HHHHHHHHHCCEEEEEEEECCCCCCCCCEEEECCCCCCCCCCCHHHHHHHHHHHHHHCCE
KLIGIHSHIGSQITDMSSFRNLVIRFNEIQEELEAHGVTVENLNFGGGLGIDYYHPNHLS
EEEEEHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCCCEECCCCCC
IPAFDNYFAAIHKLLQVRPGQQVHFEPGRSIVAQCGTLISKVLYVKEGETKKFAILDAGF
CCCCHHHHHHHHHHHHCCCCCEEEECCCHHHHHHHHHHHHHHHEEECCCCCEEEEEECCH
TELIRPAMYDAYHRIENISSDEAVETYDVVGPICESSDVFGKDVELNKAHRGDLIALRSA
HHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCEEEEECC
GAYGEVMASQYNCRHLPKAYYSDTI
CCHHHHHHCCCCCCCCCHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA