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The map label for this gene is tdcB [H]

Identifier: 150008593

GI number: 150008593

Start: 2343404

End: 2344603

Strand: Direct

Name: tdcB [H]

Synonym: BDI_1979

Alternate gene names: 150008593

Gene position: 2343404-2344603 (Clockwise)

Preceding gene: 150008591

Following gene: 150008598

Centisome position: 48.71

GC content: 47.58

Gene sequence:

>1200_bases
ATGCTCACACTCGATAAAATTTATCAGGCATCATATGCCTTGAAGACAGTCATCAGACGCACTGATTTAATCAGCGCTCC
CAATATCAATCCGGAATCCCATATTTTTCTAAAACCAGAGAACTTACAAGTAACCGGATCGTTTAAAGTGCGCGGCGCTT
GTTTCAAGATCGCCCAGCTTACGGAAGAAGAGAAATCGCATGGCGTAGTGGCTTGCTCGGCGGGAAACCATGCCCAAGGT
GTGGCATTAGCGGCTACCGCTCATGGTATCAAGTCCTTAATCTGCTTGCCCGATAACGCTCCTATCTCTAAAGTCGAGGC
TACTAAATCTTATGGGGCAGATGTATGCCTTGTCGAAGGTGTTTACGATGACGCCTATAACAAGGCTTTACAATTGAAGG
ATGAGAAAGGATACACATTTATCCATCCGTTTGATGATGAGGATGTGATCGCCGGACAAGGGACCATCGGTTTGGAGTTA
TTGGAACAACTCCCGGAAGTAGAGGCTGTAATCATTCCGATCGGAGGGGGTGGGCTGATCTCCGGAGTCGCCTATGCCAT
CAAGAACTTGAACCCGGATATCAGAGTTTACGGAGTGCAAGCCAAAGGAGCGCCCAGCATGTTAAACTCTATCGAGCATG
GGAAAATCGAACGCCTCGAAGGTGTCCGTACCATAGCCGACGGTATCGCCGTAAAAGAACCGGGAATACATACTTTCGAT
CTTTGCCAGCAATATGTGGACGAGATCGTATCCGTGACAGACGATGAGATTTCCACCGCTATCCTCGCGTTGATCGAGCA
ACATAAATTAATCGCCGAAGGGGCGGGTGCCGTAGCCGTGGCCGCCGCCATGTTTAATAAAGTACCCATCAAAGGGAAAA
AAGTAATCTGTTTGATTTCCGGCGGAAATATCGACGTGAATATCCTTTCCCGGGTAATCGGACGTGGTTTGCAAAAATCC
GGCCGCTCTTGTTCCATGACGATCGAATTGGTAGACAAACCCGGACAATTACAGCACGTATCTGAAATCATTGCCTCTAC
CGGCGCTAACGTAGTATCCGTATATCACGAGCGTGTCAGCCATACGGCTGATATCAATGGCTGTTATCTGCGGTTGGAGA
TGGAAACAAGAAATCAACAGCAAATTAATGAGATCCGGCAATTACTCACCGTTTCGGGATATAAGATAGTGGAAGGATAA

Upstream 100 bases:

>100_bases
ATACTTCTCTATATTTTGATTTATAATATAACAAAGATAAGTATGAATAGGTTGCGGTATTTTTTATACTTTCGCGACAT
CGTTTTAACATACAGACAGA

Downstream 100 bases:

>100_bases
ACAATTCGCCCCAAAGCATACAACTGATTGACAAACTATTACTGTGCCACTACTTTCCATAGGCGTGGCACAGCCGTGCC
ATCCTAGTGGCACACTTGTG

Product: threonine dehydratase

Products: NA

Alternate protein names: Threonine deaminase [H]

Number of amino acids: Translated: 399; Mature: 399

Protein sequence:

>399_residues
MLTLDKIYQASYALKTVIRRTDLISAPNINPESHIFLKPENLQVTGSFKVRGACFKIAQLTEEEKSHGVVACSAGNHAQG
VALAATAHGIKSLICLPDNAPISKVEATKSYGADVCLVEGVYDDAYNKALQLKDEKGYTFIHPFDDEDVIAGQGTIGLEL
LEQLPEVEAVIIPIGGGGLISGVAYAIKNLNPDIRVYGVQAKGAPSMLNSIEHGKIERLEGVRTIADGIAVKEPGIHTFD
LCQQYVDEIVSVTDDEISTAILALIEQHKLIAEGAGAVAVAAAMFNKVPIKGKKVICLISGGNIDVNILSRVIGRGLQKS
GRSCSMTIELVDKPGQLQHVSEIIASTGANVVSVYHERVSHTADINGCYLRLEMETRNQQQINEIRQLLTVSGYKIVEG

Sequences:

>Translated_399_residues
MLTLDKIYQASYALKTVIRRTDLISAPNINPESHIFLKPENLQVTGSFKVRGACFKIAQLTEEEKSHGVVACSAGNHAQG
VALAATAHGIKSLICLPDNAPISKVEATKSYGADVCLVEGVYDDAYNKALQLKDEKGYTFIHPFDDEDVIAGQGTIGLEL
LEQLPEVEAVIIPIGGGGLISGVAYAIKNLNPDIRVYGVQAKGAPSMLNSIEHGKIERLEGVRTIADGIAVKEPGIHTFD
LCQQYVDEIVSVTDDEISTAILALIEQHKLIAEGAGAVAVAAAMFNKVPIKGKKVICLISGGNIDVNILSRVIGRGLQKS
GRSCSMTIELVDKPGQLQHVSEIIASTGANVVSVYHERVSHTADINGCYLRLEMETRNQQQINEIRQLLTVSGYKIVEG
>Mature_399_residues
MLTLDKIYQASYALKTVIRRTDLISAPNINPESHIFLKPENLQVTGSFKVRGACFKIAQLTEEEKSHGVVACSAGNHAQG
VALAATAHGIKSLICLPDNAPISKVEATKSYGADVCLVEGVYDDAYNKALQLKDEKGYTFIHPFDDEDVIAGQGTIGLEL
LEQLPEVEAVIIPIGGGGLISGVAYAIKNLNPDIRVYGVQAKGAPSMLNSIEHGKIERLEGVRTIADGIAVKEPGIHTFD
LCQQYVDEIVSVTDDEISTAILALIEQHKLIAEGAGAVAVAAAMFNKVPIKGKKVICLISGGNIDVNILSRVIGRGLQKS
GRSCSMTIELVDKPGQLQHVSEIIASTGANVVSVYHERVSHTADINGCYLRLEMETRNQQQINEIRQLLTVSGYKIVEG

Specific function: Acts on both serine and threonine, and properly considered as a hydroxy amino acid deaminase [H]

COG id: COG1171

COG function: function code E; Threonine dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the serine/threonine dehydratase family [H]

Homologues:

Organism=Homo sapiens, GI11345492, Length=281, Percent_Identity=37.3665480427046, Blast_Score=178, Evalue=1e-44,
Organism=Homo sapiens, GI33469958, Length=256, Percent_Identity=30.46875, Blast_Score=76, Evalue=6e-14,
Organism=Homo sapiens, GI19923959, Length=291, Percent_Identity=27.4914089347079, Blast_Score=67, Evalue=3e-11,
Organism=Escherichia coli, GI1789505, Length=317, Percent_Identity=45.4258675078864, Blast_Score=224, Evalue=8e-60,
Organism=Escherichia coli, GI1790207, Length=369, Percent_Identity=36.3143631436314, Blast_Score=207, Evalue=1e-54,
Organism=Caenorhabditis elegans, GI71991565, Length=391, Percent_Identity=36.5728900255754, Blast_Score=247, Evalue=6e-66,
Organism=Caenorhabditis elegans, GI17537387, Length=392, Percent_Identity=35.2040816326531, Blast_Score=185, Evalue=3e-47,
Organism=Caenorhabditis elegans, GI17508781, Length=312, Percent_Identity=33.0128205128205, Blast_Score=168, Evalue=4e-42,
Organism=Saccharomyces cerevisiae, GI6322631, Length=313, Percent_Identity=35.7827476038339, Blast_Score=188, Evalue=2e-48,
Organism=Saccharomyces cerevisiae, GI6320930, Length=378, Percent_Identity=33.0687830687831, Blast_Score=185, Evalue=1e-47,
Organism=Saccharomyces cerevisiae, GI6319788, Length=271, Percent_Identity=23.9852398523985, Blast_Score=74, Evalue=5e-14,
Organism=Saccharomyces cerevisiae, GI6322024, Length=145, Percent_Identity=28.2758620689655, Blast_Score=64, Evalue=5e-11,
Organism=Drosophila melanogaster, GI21355833, Length=361, Percent_Identity=34.9030470914127, Blast_Score=191, Evalue=9e-49,
Organism=Drosophila melanogaster, GI24645328, Length=300, Percent_Identity=33.3333333333333, Blast_Score=142, Evalue=3e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR000634
- InterPro:   IPR005789 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =4.3.1.19 [H]

Molecular weight: Translated: 42850; Mature: 42850

Theoretical pI: Translated: 5.79; Mature: 5.79

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLTLDKIYQASYALKTVIRRTDLISAPNINPESHIFLKPENLQVTGSFKVRGACFKIAQL
CCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEECCCCEEEEEEEEECHHHHHHHHH
TEEEKSHGVVACSAGNHAQGVALAATAHGIKSLICLPDNAPISKVEATKSYGADVCLVEG
HHHHHCCCEEEECCCCCCCCEEEEEEHHCCEEEEECCCCCCCCHHHHHHHCCCCEEEEEC
VYDDAYNKALQLKDEKGYTFIHPFDDEDVIAGQGTIGLELLEQLPEVEAVIIPIGGGGLI
CHHHHHCCEEEEECCCCEEEECCCCCCCEEECCCCHHHHHHHHCCCCEEEEEEECCCHHH
SGVAYAIKNLNPDIRVYGVQAKGAPSMLNSIEHGKIERLEGVRTIADGIAVKEPGIHTFD
HHHHHHHHCCCCCEEEEEEECCCCHHHHHCCCCCCHHHHHHHHHHHCCCEECCCCCCHHH
LCQQYVDEIVSVTDDEISTAILALIEQHKLIAEGAGAVAVAAAMFNKVPIKGKKVICLIS
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCEEEEEEE
GGNIDVNILSRVIGRGLQKSGRSCSMTIELVDKPGQLQHVSEIIASTGANVVSVYHERVS
CCCEEHHHHHHHHHHHHHHCCCCEEEEEEEECCCCHHHHHHHHHHHCCCHHHHHHHHHHH
HTADINGCYLRLEMETRNQQQINEIRQLLTVSGYKIVEG
CCCCCCEEEEEEEECCCCHHHHHHHHHHHHHCCEEEECC
>Mature Secondary Structure
MLTLDKIYQASYALKTVIRRTDLISAPNINPESHIFLKPENLQVTGSFKVRGACFKIAQL
CCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEECCCCEEEEEEEEECHHHHHHHHH
TEEEKSHGVVACSAGNHAQGVALAATAHGIKSLICLPDNAPISKVEATKSYGADVCLVEG
HHHHHCCCEEEECCCCCCCCEEEEEEHHCCEEEEECCCCCCCCHHHHHHHCCCCEEEEEC
VYDDAYNKALQLKDEKGYTFIHPFDDEDVIAGQGTIGLELLEQLPEVEAVIIPIGGGGLI
CHHHHHCCEEEEECCCCEEEECCCCCCCEEECCCCHHHHHHHHCCCCEEEEEEECCCHHH
SGVAYAIKNLNPDIRVYGVQAKGAPSMLNSIEHGKIERLEGVRTIADGIAVKEPGIHTFD
HHHHHHHHCCCCCEEEEEEECCCCHHHHHCCCCCCHHHHHHHHHHHCCCEECCCCCCHHH
LCQQYVDEIVSVTDDEISTAILALIEQHKLIAEGAGAVAVAAAMFNKVPIKGKKVICLIS
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCEEEEEEE
GGNIDVNILSRVIGRGLQKSGRSCSMTIELVDKPGQLQHVSEIIASTGANVVSVYHERVS
CCCEEHHHHHHHHHHHHHHCCCCEEEEEEEECCCCHHHHHHHHHHHCCCHHHHHHHHHHH
HTADINGCYLRLEMETRNQQQINEIRQLLTVSGYKIVEG
CCCCCCEEEEEEEECCCCHHHHHHHHHHHHHCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA