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The map label for this gene is adk

Identifier: 150008512

GI number: 150008512

Start: 2254178

End: 2254750

Strand: Reverse

Name: adk

Synonym: BDI_1898

Alternate gene names: 150008512

Gene position: 2254750-2254178 (Counterclockwise)

Preceding gene: 150008513

Following gene: 150008511

Centisome position: 46.86

GC content: 45.38

Gene sequence:

>573_bases
ATGTTGAACGTGGTTATTTTTGGTGCTCCCGGTTCAGGTAAGGGAACACAAAGTGAGTTGATTATTAAAGAATACGGTTT
GGATCATATCTCTACTGGCGATGTATTGCGTGGCGAGATGAAGGCTGAGACAGAACTGGGCAAGATCGCTAAGGATTATA
TCGAGAAGGGACAATTGGTTCCGGACGAGTTGATCGTTGATATGTTGGCGAATGTATTGGATAGCAAGAAGCCGGCTAAG
GGCGTAATCTTCGATGGTTTCCCTCGTACGATCCCTCAAGCGAAAGCCTTGAAGAAGATGTTGAACGAGCGTGGAACAGA
CGTTTCCGTTATGTTGAACCTTCAAGTAGAGGAAGAGGAGTTGATCAAGCGTTTATTGGAGCGCGGTAAAGTATCCGGAC
GTTCTGACGATAACTTGGAGACGATCAAATCCAGACTGGATGTTTACCATACTCAAACAGCTCCTTTGGCAGACTACTAT
GTAGGTGAAGGCAAGCACGTGGCCATCAAAGGGATGGGAACAATCGAGGAAATCTTCGGTCGTATCAAAGAGGCGGTTAA
TAACGTAAAATAA

Upstream 100 bases:

>100_bases
ACATGGTTTGGATTATGATGAGTTGGGCCGCTCATATAAGGATATCTACAAGGTTGTGGAATAAAATAGTATACATTATA
TATAATAAAGGAACAATAGT

Downstream 100 bases:

>100_bases
TTGAAATAAACCAATATGGCTGAATCGAACTTTGTAGATTATGTCAAGATCTATTGCCGCTCAGGAAAGGGTGGAAGAGG
GTCTTCTCACTTCCGTCGTG

Product: adenylate kinase

Products: NA

Alternate protein names: AK; ATP-AMP transphosphorylase

Number of amino acids: Translated: 190; Mature: 190

Protein sequence:

>190_residues
MLNVVIFGAPGSGKGTQSELIIKEYGLDHISTGDVLRGEMKAETELGKIAKDYIEKGQLVPDELIVDMLANVLDSKKPAK
GVIFDGFPRTIPQAKALKKMLNERGTDVSVMLNLQVEEEELIKRLLERGKVSGRSDDNLETIKSRLDVYHTQTAPLADYY
VGEGKHVAIKGMGTIEEIFGRIKEAVNNVK

Sequences:

>Translated_190_residues
MLNVVIFGAPGSGKGTQSELIIKEYGLDHISTGDVLRGEMKAETELGKIAKDYIEKGQLVPDELIVDMLANVLDSKKPAK
GVIFDGFPRTIPQAKALKKMLNERGTDVSVMLNLQVEEEELIKRLLERGKVSGRSDDNLETIKSRLDVYHTQTAPLADYY
VGEGKHVAIKGMGTIEEIFGRIKEAVNNVK
>Mature_190_residues
MLNVVIFGAPGSGKGTQSELIIKEYGLDHISTGDVLRGEMKAETELGKIAKDYIEKGQLVPDELIVDMLANVLDSKKPAK
GVIFDGFPRTIPQAKALKKMLNERGTDVSVMLNLQVEEEELIKRLLERGKVSGRSDDNLETIKSRLDVYHTQTAPLADYY
VGEGKHVAIKGMGTIEEIFGRIKEAVNNVK

Specific function: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. This small ubiquitous enzyme involved in the energy metabolism and nucleotide synthesis, is essential for maintenance and cell growth

COG id: COG0563

COG function: function code F; Adenylate kinase and related kinases

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenylate kinase family

Homologues:

Organism=Homo sapiens, GI4502011, Length=188, Percent_Identity=36.7021276595745, Blast_Score=138, Evalue=3e-33,
Organism=Homo sapiens, GI7706497, Length=186, Percent_Identity=36.0215053763441, Blast_Score=124, Evalue=4e-29,
Organism=Homo sapiens, GI4502013, Length=213, Percent_Identity=31.924882629108, Blast_Score=122, Evalue=2e-28,
Organism=Homo sapiens, GI7524346, Length=215, Percent_Identity=31.6279069767442, Blast_Score=122, Evalue=2e-28,
Organism=Homo sapiens, GI28144899, Length=187, Percent_Identity=31.5508021390374, Blast_Score=119, Evalue=1e-27,
Organism=Homo sapiens, GI28144897, Length=187, Percent_Identity=32.0855614973262, Blast_Score=119, Evalue=1e-27,
Organism=Homo sapiens, GI19923437, Length=191, Percent_Identity=35.6020942408377, Blast_Score=109, Evalue=1e-24,
Organism=Homo sapiens, GI310110345, Length=191, Percent_Identity=34.5549738219895, Blast_Score=105, Evalue=3e-23,
Organism=Homo sapiens, GI53832003, Length=191, Percent_Identity=34.5549738219895, Blast_Score=105, Evalue=3e-23,
Organism=Homo sapiens, GI8051579, Length=191, Percent_Identity=34.5549738219895, Blast_Score=105, Evalue=3e-23,
Organism=Homo sapiens, GI53832001, Length=191, Percent_Identity=34.5549738219895, Blast_Score=105, Evalue=3e-23,
Organism=Homo sapiens, GI209915597, Length=181, Percent_Identity=29.8342541436464, Blast_Score=76, Evalue=2e-14,
Organism=Homo sapiens, GI237858799, Length=128, Percent_Identity=35.9375, Blast_Score=71, Evalue=7e-13,
Organism=Escherichia coli, GI1786680, Length=209, Percent_Identity=35.8851674641148, Blast_Score=131, Evalue=3e-32,
Organism=Caenorhabditis elegans, GI17567503, Length=179, Percent_Identity=41.340782122905, Blast_Score=144, Evalue=2e-35,
Organism=Caenorhabditis elegans, GI17552384, Length=210, Percent_Identity=31.9047619047619, Blast_Score=119, Evalue=7e-28,
Organism=Caenorhabditis elegans, GI17533833, Length=166, Percent_Identity=36.144578313253, Blast_Score=105, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI17550688, Length=162, Percent_Identity=35.8024691358025, Blast_Score=104, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI17537943, Length=202, Percent_Identity=29.7029702970297, Blast_Score=80, Evalue=5e-16,
Organism=Caenorhabditis elegans, GI25147457, Length=188, Percent_Identity=23.4042553191489, Blast_Score=63, Evalue=1e-10,
Organism=Saccharomyces cerevisiae, GI6322828, Length=188, Percent_Identity=35.1063829787234, Blast_Score=132, Evalue=3e-32,
Organism=Saccharomyces cerevisiae, GI6320432, Length=191, Percent_Identity=36.6492146596859, Blast_Score=124, Evalue=1e-29,
Organism=Saccharomyces cerevisiae, GI6321018, Length=195, Percent_Identity=35.3846153846154, Blast_Score=110, Evalue=2e-25,
Organism=Drosophila melanogaster, GI22026816, Length=218, Percent_Identity=34.8623853211009, Blast_Score=139, Evalue=9e-34,
Organism=Drosophila melanogaster, GI221459597, Length=183, Percent_Identity=33.879781420765, Blast_Score=121, Evalue=3e-28,
Organism=Drosophila melanogaster, GI21356893, Length=183, Percent_Identity=33.879781420765, Blast_Score=121, Evalue=3e-28,
Organism=Drosophila melanogaster, GI17737899, Length=216, Percent_Identity=35.1851851851852, Blast_Score=107, Evalue=5e-24,
Organism=Drosophila melanogaster, GI24645822, Length=216, Percent_Identity=35.1851851851852, Blast_Score=107, Evalue=5e-24,
Organism=Drosophila melanogaster, GI24663208, Length=189, Percent_Identity=29.1005291005291, Blast_Score=97, Evalue=7e-21,
Organism=Drosophila melanogaster, GI17647141, Length=189, Percent_Identity=29.1005291005291, Blast_Score=97, Evalue=8e-21,

Paralogues:

None

Copy number: 1640 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 847 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): KAD_PARD8 (A6LD69)

Other databases:

- EMBL:   CP000140
- RefSeq:   YP_001303255.1
- ProteinModelPortal:   A6LD69
- SMR:   A6LD69
- STRING:   A6LD69
- GeneID:   5307048
- GenomeReviews:   CP000140_GR
- KEGG:   pdi:BDI_1898
- eggNOG:   COG0563
- HOGENOM:   HBG630208
- OMA:   RTYHVKY
- ProtClustDB:   PRK00279
- BioCyc:   PDIS435591:BDI_1898-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00235
- InterPro:   IPR006259
- InterPro:   IPR000850
- PANTHER:   PTHR23359
- PRINTS:   PR00094
- TIGRFAMs:   TIGR01351

Pfam domain/function: PF00406 ADK

EC number: =2.7.4.3

Molecular weight: Translated: 20940; Mature: 20940

Theoretical pI: Translated: 5.80; Mature: 5.80

Prosite motif: PS00113 ADENYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLNVVIFGAPGSGKGTQSELIIKEYGLDHISTGDVLRGEMKAETELGKIAKDYIEKGQLV
CCEEEEEECCCCCCCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCC
PDELIVDMLANVLDSKKPAKGVIFDGFPRTIPQAKALKKMLNERGTDVSVMLNLQVEEEE
HHHHHHHHHHHHHCCCCCCCCCEECCCCCCCCHHHHHHHHHHHCCCCEEEEEEEEECHHH
LIKRLLERGKVSGRSDDNLETIKSRLDVYHTQTAPLADYYVGEGKHVAIKGMGTIEEIFG
HHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHCCCCCEEEEECCCCHHHHHH
RIKEAVNNVK
HHHHHHHCCC
>Mature Secondary Structure
MLNVVIFGAPGSGKGTQSELIIKEYGLDHISTGDVLRGEMKAETELGKIAKDYIEKGQLV
CCEEEEEECCCCCCCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCC
PDELIVDMLANVLDSKKPAKGVIFDGFPRTIPQAKALKKMLNERGTDVSVMLNLQVEEEE
HHHHHHHHHHHHHCCCCCCCCCEECCCCCCCCHHHHHHHHHHHCCCCEEEEEEEEECHHH
LIKRLLERGKVSGRSDDNLETIKSRLDVYHTQTAPLADYYVGEGKHVAIKGMGTIEEIFG
HHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHCCCCCEEEEECCCCHHHHHH
RIKEAVNNVK
HHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA