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The map label for this gene is fumC [H]

Identifier: 150008281

GI number: 150008281

Start: 1950094

End: 1951494

Strand: Reverse

Name: fumC [H]

Synonym: BDI_1650

Alternate gene names: 150008281

Gene position: 1951494-1950094 (Counterclockwise)

Preceding gene: 150008282

Following gene: 150008280

Centisome position: 40.56

GC content: 49.82

Gene sequence:

>1401_bases
ATGAAGTATAGAATAGAGAAAGATACCTTAGGTGAGGTGGAAGTGCCGGCGGACGTTTATTATGGGCCGCAAACACAACG
GAGCGTGAATAATTTCAAGATCGCCACCGATATTAGCCGGATGCCCGAAGAGGTGATAGAGGCGTTCGCTTACTTGAAAA
AAGGAGCGGCTTTGGCTAATAAAGACGCCGGTGTCTTGTCTCCGGAGAAATGCGAGTTGATCGGTAAGGTATGCGACGAG
ATCTTGGCGGGTAAATTAAATGACTCCTTCCCCTTGATCGTATGGCAAACGGGGAGCGGGACCCAGACGAATATGAATGT
CAATGAGGTGATCGCCAACCGGGCACATGTGCTGAGCGGAGGAAAGCTAACGGATAAGGAGAAAGTGCTGCTTCCGAACG
ATGACGTGAATAAATCGCAATCCTCCAATGATACGTTTCCTTCCGCTATGCATATTGCCGCCTATAAGGTGATAGCGGAG
GTGACGATCCCGGGATTGGAGAGTCTGTATCGTGCGTTGGCGCTAAAAAGTGAGGAGTTCATGAAGATCGTGAAGATCGG
GAGGACTCATTTTATGGATGCCACTCCATTGACATTGGGGCAAGAGTTCAGTGGCTATGCGGCTCAATTAGAATATGGTA
TACGGAAAGTAAAGGATTCCCTATCGCATATCTCCGAATTGGCTTTAGGAGGTACGGCGGTTGGGACCGGTATTAACGCC
CCGGTCAATTATGACGAGTGTGTCGCTAAGAAGATATCAGAGTTGACTGGGCTTCCTTTTGTAACCGCTCCGAATAAATT
CGAGGCCCTAGCTACCCATGATGCCTTGGTTGAGGCGCATGGAGCCTTGAAATCCGTAGCGGTCAGCTTAATGAAGATCG
CAAACGATATACGAATGTTGGGCTCAGGTCCTCGTGCCGGTATCGGTGAGATCCATTTGCCGGAGAACGAGCCGGGTTCC
TCCATCATGCCGGGAAAGGTGAATCCTACGCAATGCGAGTCATTGACGATGATCGCCGCTCAAGTAATGGGTAACGACGT
GACAATCTCGATAGCCGGCTCCAACGGGCAGTTCGAGTTGAACGTATTTAAGCCGGTGATTATCTCGAACTTCTTGCAAA
GCGCCCGCTTGATCGGTGACGGTTGCCTGAATTTCAGCGAACATTGCGTAAAAGGCATTACCCCGGTGAACGAAAACATC
AAACGCCATCTGGATAGCTCCTTAATGCTGGTTACCGCCTTGAATCCGAAAATAGGATATTACAAGGCCGCCGCTATCGC
CCAGAAAGCCTATCAAGAAAATAAGACTTTGCGGGAGGCGGCTATCGAGTCCGGTTATGTGACCGCCGAGGAGTTTGATC
GTTGGGTAGACCCGTCCAAGATGGTAGGAAAGATTGAGTAG

Upstream 100 bases:

>100_bases
CATGATAAATGTCTTTTCATGATATACTCGTGAATGTAACATAAACAATTCGATATCCAGATAGTTTATACATAGAAGAG
ATTAATAAAACTTATGTGTC

Downstream 100 bases:

>100_bases
TGTCAAAACTGCTACATCTTCTCCCAAAAATGAAACAAAGAGTTAAGATGATAATGGATATTTTTGTACCGTTATCATTT
TAATTCTTTGTATTATGAAG

Product: fumarate hydratase

Products: NA

Alternate protein names: Fumarase C [H]

Number of amino acids: Translated: 466; Mature: 466

Protein sequence:

>466_residues
MKYRIEKDTLGEVEVPADVYYGPQTQRSVNNFKIATDISRMPEEVIEAFAYLKKGAALANKDAGVLSPEKCELIGKVCDE
ILAGKLNDSFPLIVWQTGSGTQTNMNVNEVIANRAHVLSGGKLTDKEKVLLPNDDVNKSQSSNDTFPSAMHIAAYKVIAE
VTIPGLESLYRALALKSEEFMKIVKIGRTHFMDATPLTLGQEFSGYAAQLEYGIRKVKDSLSHISELALGGTAVGTGINA
PVNYDECVAKKISELTGLPFVTAPNKFEALATHDALVEAHGALKSVAVSLMKIANDIRMLGSGPRAGIGEIHLPENEPGS
SIMPGKVNPTQCESLTMIAAQVMGNDVTISIAGSNGQFELNVFKPVIISNFLQSARLIGDGCLNFSEHCVKGITPVNENI
KRHLDSSLMLVTALNPKIGYYKAAAIAQKAYQENKTLREAAIESGYVTAEEFDRWVDPSKMVGKIE

Sequences:

>Translated_466_residues
MKYRIEKDTLGEVEVPADVYYGPQTQRSVNNFKIATDISRMPEEVIEAFAYLKKGAALANKDAGVLSPEKCELIGKVCDE
ILAGKLNDSFPLIVWQTGSGTQTNMNVNEVIANRAHVLSGGKLTDKEKVLLPNDDVNKSQSSNDTFPSAMHIAAYKVIAE
VTIPGLESLYRALALKSEEFMKIVKIGRTHFMDATPLTLGQEFSGYAAQLEYGIRKVKDSLSHISELALGGTAVGTGINA
PVNYDECVAKKISELTGLPFVTAPNKFEALATHDALVEAHGALKSVAVSLMKIANDIRMLGSGPRAGIGEIHLPENEPGS
SIMPGKVNPTQCESLTMIAAQVMGNDVTISIAGSNGQFELNVFKPVIISNFLQSARLIGDGCLNFSEHCVKGITPVNENI
KRHLDSSLMLVTALNPKIGYYKAAAIAQKAYQENKTLREAAIESGYVTAEEFDRWVDPSKMVGKIE
>Mature_466_residues
MKYRIEKDTLGEVEVPADVYYGPQTQRSVNNFKIATDISRMPEEVIEAFAYLKKGAALANKDAGVLSPEKCELIGKVCDE
ILAGKLNDSFPLIVWQTGSGTQTNMNVNEVIANRAHVLSGGKLTDKEKVLLPNDDVNKSQSSNDTFPSAMHIAAYKVIAE
VTIPGLESLYRALALKSEEFMKIVKIGRTHFMDATPLTLGQEFSGYAAQLEYGIRKVKDSLSHISELALGGTAVGTGINA
PVNYDECVAKKISELTGLPFVTAPNKFEALATHDALVEAHGALKSVAVSLMKIANDIRMLGSGPRAGIGEIHLPENEPGS
SIMPGKVNPTQCESLTMIAAQVMGNDVTISIAGSNGQFELNVFKPVIISNFLQSARLIGDGCLNFSEHCVKGITPVNENI
KRHLDSSLMLVTALNPKIGYYKAAAIAQKAYQENKTLREAAIESGYVTAEEFDRWVDPSKMVGKIE

Specific function: Tricarboxylic acid cycle [C]

COG id: COG0114

COG function: function code C; Fumarase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II fumarase/aspartase family. Fumarase subfamily [H]

Homologues:

Organism=Homo sapiens, GI19743875, Length=461, Percent_Identity=62.9067245119306, Blast_Score=580, Evalue=1e-166,
Organism=Homo sapiens, GI266458395, Length=79, Percent_Identity=50.6329113924051, Blast_Score=84, Evalue=2e-16,
Organism=Escherichia coli, GI1787896, Length=463, Percent_Identity=59.1792656587473, Blast_Score=555, Evalue=1e-159,
Organism=Escherichia coli, GI87082375, Length=452, Percent_Identity=41.1504424778761, Blast_Score=339, Evalue=2e-94,
Organism=Caenorhabditis elegans, GI17553882, Length=462, Percent_Identity=59.95670995671, Blast_Score=560, Evalue=1e-160,
Organism=Caenorhabditis elegans, GI32565146, Length=325, Percent_Identity=61.5384615384615, Blast_Score=418, Evalue=1e-117,
Organism=Saccharomyces cerevisiae, GI6324993, Length=461, Percent_Identity=58.1344902386117, Blast_Score=530, Evalue=1e-151,
Organism=Drosophila melanogaster, GI24640177, Length=463, Percent_Identity=60.6911447084233, Blast_Score=565, Evalue=1e-161,
Organism=Drosophila melanogaster, GI24640179, Length=463, Percent_Identity=60.6911447084233, Blast_Score=565, Evalue=1e-161,
Organism=Drosophila melanogaster, GI78710009, Length=463, Percent_Identity=58.963282937365, Blast_Score=549, Evalue=1e-156,
Organism=Drosophila melanogaster, GI24662684, Length=465, Percent_Identity=56.1290322580645, Blast_Score=526, Evalue=1e-149,
Organism=Drosophila melanogaster, GI24583245, Length=462, Percent_Identity=51.0822510822511, Blast_Score=473, Evalue=1e-133,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005677
- InterPro:   IPR018951
- InterPro:   IPR000362
- InterPro:   IPR020557
- InterPro:   IPR008948
- InterPro:   IPR022761 [H]

Pfam domain/function: PF10415 FumaraseC_C; PF00206 Lyase_1 [H]

EC number: =4.2.1.2 [H]

Molecular weight: Translated: 50392; Mature: 50392

Theoretical pI: Translated: 5.88; Mature: 5.88

Prosite motif: PS00163 FUMARATE_LYASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKYRIEKDTLGEVEVPADVYYGPQTQRSVNNFKIATDISRMPEEVIEAFAYLKKGAALAN
CCEECCCCCCCCEECCCCEEECCCCCCCCCCEEEEHHHHHCHHHHHHHHHHHHHCCHHCC
KDAGVLSPEKCELIGKVCDEILAGKLNDSFPLIVWQTGSGTQTNMNVNEVIANRAHVLSG
CCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHEECC
GKLTDKEKVLLPNDDVNKSQSSNDTFPSAMHIAAYKVIAEVTIPGLESLYRALALKSEEF
CCCCCCCEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHCHHHH
MKIVKIGRTHFMDATPLTLGQEFSGYAAQLEYGIRKVKDSLSHISELALGGTAVGTGINA
HHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCCCCC
PVNYDECVAKKISELTGLPFVTAPNKFEALATHDALVEAHGALKSVAVSLMKIANDIRML
CCCHHHHHHHHHHHHCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GSGPRAGIGEIHLPENEPGSSIMPGKVNPTQCESLTMIAAQVMGNDVTISIAGSNGQFEL
CCCCCCCCCCEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEEECCCCEEEE
NVFKPVIISNFLQSARLIGDGCLNFSEHCVKGITPVNENIKRHLDSSLMLVTALNPKIGY
EEHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCHHHHHHHCCCCEEEEEECCCCCCH
YKAAAIAQKAYQENKTLREAAIESGYVTAEEFDRWVDPSKMVGKIE
HHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCHHHHCCCCC
>Mature Secondary Structure
MKYRIEKDTLGEVEVPADVYYGPQTQRSVNNFKIATDISRMPEEVIEAFAYLKKGAALAN
CCEECCCCCCCCEECCCCEEECCCCCCCCCCEEEEHHHHHCHHHHHHHHHHHHHCCHHCC
KDAGVLSPEKCELIGKVCDEILAGKLNDSFPLIVWQTGSGTQTNMNVNEVIANRAHVLSG
CCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHEECC
GKLTDKEKVLLPNDDVNKSQSSNDTFPSAMHIAAYKVIAEVTIPGLESLYRALALKSEEF
CCCCCCCEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHCHHHH
MKIVKIGRTHFMDATPLTLGQEFSGYAAQLEYGIRKVKDSLSHISELALGGTAVGTGINA
HHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCCCCC
PVNYDECVAKKISELTGLPFVTAPNKFEALATHDALVEAHGALKSVAVSLMKIANDIRML
CCCHHHHHHHHHHHHCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GSGPRAGIGEIHLPENEPGSSIMPGKVNPTQCESLTMIAAQVMGNDVTISIAGSNGQFEL
CCCCCCCCCCEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEEECCCCEEEE
NVFKPVIISNFLQSARLIGDGCLNFSEHCVKGITPVNENIKRHLDSSLMLVTALNPKIGY
EEHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCHHHHHHHCCCCEEEEEECCCCCCH
YKAAAIAQKAYQENKTLREAAIESGYVTAEEFDRWVDPSKMVGKIE
HHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA