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The map label for this gene is ndk

Identifier: 150008209

GI number: 150008209

Start: 1846203

End: 1846664

Strand: Direct

Name: ndk

Synonym: BDI_1575

Alternate gene names: 150008209

Gene position: 1846203-1846664 (Clockwise)

Preceding gene: 150008208

Following gene: 150008223

Centisome position: 38.37

GC content: 46.54

Gene sequence:

>462_bases
ATGGAAAAAACATTGGTTATTTTAAAGCCTTGTACCGTTCAGCGAGGGCTGATCGGTGAAATCGTAACCCGTTTCGAAAA
GAAGGGACTCCGTCTGGCCGGCATGAAGATGGTTTGGCTAACTGACGAGATCTTGAGTGAGCACTACGCCCACCTGAAAG
AAAAGCCTTTCTTCCAACGTATCAAGGACGCAATGAGTGTATGCCCGGTAATTGTATGTTGCTGGGAAGGGGTAGATGCC
ATACATGTAGTAAGAACCTTGGCCGGCACTACCAATGGTAGAAACGCCGCTCCCGGTACGATACGGGGAGATTATAGTAT
GAGCGTACAAGAGAATATCGTACACGCATCAGACTCACCGGAGACAGCCGAGATCGAATTGAAACGCTTCTTCAAGGATG
ACGAGATATTCGATTATGAGCTGAAAAACCTATTGAGTCTTTACGCCAATGACGAGTTTTAA

Upstream 100 bases:

>100_bases
AAACATTTCATCCTTTATTCCTCTATCATTCATAAAACGCCGCAAGGTTAACATGTATTCAAGACATCAAACATTTGTTT
AATCTTTTAATATAAATCTT

Downstream 100 bases:

>100_bases
ATAAAAAAGAATAGCCGGAAACGAGAGAAATCATTCTCACCTTTCCGGCTCTCATATTTAGAAACCAACATCCTATTCTC
CCGAACTGAATGAACAACCT

Product: nucleoside diphosphate kinase

Products: NA

Alternate protein names: NDK; NDP kinase; Nucleoside-2-P kinase

Number of amino acids: Translated: 153; Mature: 153

Protein sequence:

>153_residues
MEKTLVILKPCTVQRGLIGEIVTRFEKKGLRLAGMKMVWLTDEILSEHYAHLKEKPFFQRIKDAMSVCPVIVCCWEGVDA
IHVVRTLAGTTNGRNAAPGTIRGDYSMSVQENIVHASDSPETAEIELKRFFKDDEIFDYELKNLLSLYANDEF

Sequences:

>Translated_153_residues
MEKTLVILKPCTVQRGLIGEIVTRFEKKGLRLAGMKMVWLTDEILSEHYAHLKEKPFFQRIKDAMSVCPVIVCCWEGVDA
IHVVRTLAGTTNGRNAAPGTIRGDYSMSVQENIVHASDSPETAEIELKRFFKDDEIFDYELKNLLSLYANDEF
>Mature_153_residues
MEKTLVILKPCTVQRGLIGEIVTRFEKKGLRLAGMKMVWLTDEILSEHYAHLKEKPFFQRIKDAMSVCPVIVCCWEGVDA
IHVVRTLAGTTNGRNAAPGTIRGDYSMSVQENIVHASDSPETAEIELKRFFKDDEIFDYELKNLLSLYANDEF

Specific function: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate

COG id: COG0105

COG function: function code F; Nucleoside diphosphate kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NDK family

Homologues:

Organism=Homo sapiens, GI37693993, Length=139, Percent_Identity=45.3237410071942, Blast_Score=142, Evalue=2e-34,
Organism=Homo sapiens, GI4557797, Length=138, Percent_Identity=44.9275362318841, Blast_Score=140, Evalue=5e-34,
Organism=Homo sapiens, GI38045913, Length=138, Percent_Identity=44.9275362318841, Blast_Score=140, Evalue=5e-34,
Organism=Homo sapiens, GI66392203, Length=140, Percent_Identity=44.2857142857143, Blast_Score=139, Evalue=8e-34,
Organism=Homo sapiens, GI66392227, Length=140, Percent_Identity=44.2857142857143, Blast_Score=139, Evalue=8e-34,
Organism=Homo sapiens, GI66392205, Length=140, Percent_Identity=44.2857142857143, Blast_Score=139, Evalue=8e-34,
Organism=Homo sapiens, GI4505409, Length=140, Percent_Identity=44.2857142857143, Blast_Score=139, Evalue=8e-34,
Organism=Homo sapiens, GI66392192, Length=140, Percent_Identity=44.2857142857143, Blast_Score=139, Evalue=8e-34,
Organism=Homo sapiens, GI4826862, Length=138, Percent_Identity=42.7536231884058, Blast_Score=136, Evalue=8e-33,
Organism=Escherichia coli, GI1788866, Length=136, Percent_Identity=41.1764705882353, Blast_Score=110, Evalue=4e-26,
Organism=Caenorhabditis elegans, GI17506807, Length=138, Percent_Identity=41.304347826087, Blast_Score=127, Evalue=3e-30,
Organism=Saccharomyces cerevisiae, GI6322783, Length=147, Percent_Identity=41.4965986394558, Blast_Score=134, Evalue=5e-33,
Organism=Drosophila melanogaster, GI45549037, Length=138, Percent_Identity=41.304347826087, Blast_Score=135, Evalue=8e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NDK_PARD8 (A6LCB6)

Other databases:

- EMBL:   CP000140
- RefSeq:   YP_001302952.1
- ProteinModelPortal:   A6LCB6
- SMR:   A6LCB6
- STRING:   A6LCB6
- GeneID:   5306728
- GenomeReviews:   CP000140_GR
- KEGG:   pdi:BDI_1575
- eggNOG:   COG0105
- HOGENOM:   HBG445152
- OMA:   ERPFFGA
- ProtClustDB:   PRK00668
- BioCyc:   PDIS435591:BDI_1575-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00451
- InterPro:   IPR001564
- InterPro:   IPR023005
- Gene3D:   G3DSA:3.30.70.141
- PANTHER:   PTHR11349
- PRINTS:   PR01243
- SMART:   SM00562

Pfam domain/function: PF00334 NDK; SSF54919 NDK

EC number: =2.7.4.6

Molecular weight: Translated: 17396; Mature: 17396

Theoretical pI: Translated: 5.67; Mature: 5.67

Prosite motif: PS00469 NDP_KINASES

Important sites: ACT_SITE 115-115 BINDING 9-9 BINDING 57-57 BINDING 85-85 BINDING 91-91 BINDING 102-102 BINDING 112-112

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
5.9 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
5.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEKTLVILKPCTVQRGLIGEIVTRFEKKGLRLAGMKMVWLTDEILSEHYAHLKEKPFFQR
CCCCEEEEECCCCCCCHHHHHHHHHHHCCCEEECEEEEEHHHHHHHHHHHHHCCCHHHHH
IKDAMSVCPVIVCCWEGVDAIHVVRTLAGTTNGRNAAPGTIRGDYSMSVQENIVHASDSP
HHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCCEECCCCCCHHHHEEECCCCC
ETAEIELKRFFKDDEIFDYELKNLLSLYANDEF
CHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MEKTLVILKPCTVQRGLIGEIVTRFEKKGLRLAGMKMVWLTDEILSEHYAHLKEKPFFQR
CCCCEEEEECCCCCCCHHHHHHHHHHHCCCEEECEEEEEHHHHHHHHHHHHHCCCHHHHH
IKDAMSVCPVIVCCWEGVDAIHVVRTLAGTTNGRNAAPGTIRGDYSMSVQENIVHASDSP
HHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCCEECCCCCCHHHHEEECCCCC
ETAEIELKRFFKDDEIFDYELKNLLSLYANDEF
CHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA