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The map label for this gene is ygcM [C]

Identifier: 150007938

GI number: 150007938

Start: 1509287

End: 1509619

Strand: Direct

Name: ygcM [C]

Synonym: BDI_1299

Alternate gene names: 150007938

Gene position: 1509287-1509619 (Clockwise)

Preceding gene: 150007937

Following gene: 150007939

Centisome position: 31.37

GC content: 45.35

Gene sequence:

>333_bases
ATGTATACCGTAATTAAACGTATGGAGATCTCCGCTTCCCATAGCTTGAGATTGTCCTACCCCAGCAAATGTGAGAATCT
ACATGGTCACAATTGGATGATCACGGTTTATTGCCGCTCCAAGGAATTAAACGCCGATGGCATGGTAGTCGATTTCAGCC
ATATCAAGAGATCGGTGAAATCCCTGTTGGACCACCAGAACTTGAACGATATCTTGCCTTTCAACCCGACGGCGGAGAAC
ATAGCCTTTTGGGTATACGAGCAGATCCCGTCTTGTTTCAAGGTAGAGGTAAAAGAGTCTGAGGGTAATACGGCGATCTA
TGAGGAAGATTAA

Upstream 100 bases:

>100_bases
TATTTCGTATATTTGCATCCCGGATTAATATCCGGGATTTTTTTGTGTGCCGAGGTGACATTAGGTACATTATTATTTAT
CGTATAAACATTATTATCGT

Downstream 100 bases:

>100_bases
CGAGATATTCTACAGCTTGCAAGGCGAAGGGTTCCATACGGGGACTCCCGCCGTATTCGTCCGCTTCTCCGGTTGCAACC
TGAGATGTGGCTTCTGCGAC

Product: 6-pyruvoyl-tetrahydropterin synthase

Products: 2-Amino- 4-Oxo-6-(1',2'-Dioxoprolyl)-7,8-Dihydroxypteridine; Triphosphate. [C]

Alternate protein names: Queuosine Biosynthesis Protein QueD; 6-Pyruvoyl-Tetrahydropterin Synthase; 6-Pyruvoyl Tetrahydrobiopterin Synthase; 6-Pyruvoyl Tetrahydrobiopterin Synthase Family Protein; Preq(0) Biosynthesis Protein Qued; 6-Carboxy-5 6 7 8-Tetrahydropterin Synthase; 6-Pyruvoyltetrahydropterin Synthase; Queuosine Biosynthesis Protein; F0F1-Type ATP Synthase Subunit C; 6-Pyruvoyl Tetrahydrobiopterin Synthase-Like Protein

Number of amino acids: Translated: 110; Mature: 110

Protein sequence:

>110_residues
MYTVIKRMEISASHSLRLSYPSKCENLHGHNWMITVYCRSKELNADGMVVDFSHIKRSVKSLLDHQNLNDILPFNPTAEN
IAFWVYEQIPSCFKVEVKESEGNTAIYEED

Sequences:

>Translated_110_residues
MYTVIKRMEISASHSLRLSYPSKCENLHGHNWMITVYCRSKELNADGMVVDFSHIKRSVKSLLDHQNLNDILPFNPTAEN
IAFWVYEQIPSCFKVEVKESEGNTAIYEED
>Mature_110_residues
MYTVIKRMEISASHSLRLSYPSKCENLHGHNWMITVYCRSKELNADGMVVDFSHIKRSVKSLLDHQNLNDILPFNPTAEN
IAFWVYEQIPSCFKVEVKESEGNTAIYEED

Specific function: Tetrahydrobiopterin biosynthesis; second step. [C]

COG id: COG0720

COG function: function code H; 6-pyruvoyl-tetrahydropterin synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

NA

Pfam domain/function: NA

EC number: 4.2.3.12 [C]

Molecular weight: Translated: 12754; Mature: 12754

Theoretical pI: Translated: 5.98; Mature: 5.98

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.7 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
6.4 %Cys+Met (Translated Protein)
2.7 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
6.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYTVIKRMEISASHSLRLSYPSKCENLHGHNWMITVYCRSKELNADGMVVDFSHIKRSVK
CCCEEEEEEECCCCEEEEECCCHHCCCCCCCEEEEEEECCCCCCCCCEEEEHHHHHHHHH
SLLDHQNLNDILPFNPTAENIAFWVYEQIPSCFKVEVKESEGNTAIYEED
HHHCCCCCCCCCCCCCCCCCEEEEEHHHCCCEEEEEEECCCCCEEEEECC
>Mature Secondary Structure
MYTVIKRMEISASHSLRLSYPSKCENLHGHNWMITVYCRSKELNADGMVVDFSHIKRSVK
CCCEEEEEEECCCCEEEEECCCHHCCCCCCCEEEEEEECCCCCCCCCEEEEHHHHHHHHH
SLLDHQNLNDILPFNPTAENIAFWVYEQIPSCFKVEVKESEGNTAIYEED
HHHCCCCCCCCCCCCCCCCCEEEEEHHHCCCEEEEEEECCCCCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Mg2+; Zn2+ [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): 17.7 {6-(L-erythro-1,2-dihydroxypropyl} 5 {6-(L-erythro-1,2-dihydroxypropyl} 0.0091 {6-(L-erythro-1,2-dihydroxypropyl} 0.008 {6-(L-erythro-1,2-dihydroxypropyl} [C]

Substrates: 2-Amino-4-Oxo-6-(Erythro-1',2',3'- Trihydroxyprolyl)-7,8-Dihydroxypteridine Triphosphate [C]

Specific reaction: 2-Amino-4-Oxo-6-(Erythro-1',2',3'- Trihydroxyprolyl)-7,8-Dihydroxypteridine Triphosphate = 2-Amino- 4-Oxo-6-(1',2'-Dioxoprolyl)-7,8-Dihydroxypteridine + Triphosphate. [C]

General reaction: Intramolecular redox reaction; P-O bond cleavage; Triphosphate elimination [C]

Inhibitor: (NH4)2SO4 [C]

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA