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The map label for this gene is hisD [H]

Identifier: 150007614

GI number: 150007614

Start: 1122211

End: 1123491

Strand: Direct

Name: hisD [H]

Synonym: BDI_0967

Alternate gene names: 150007614

Gene position: 1122211-1123491 (Clockwise)

Preceding gene: 150007613

Following gene: 150007615

Centisome position: 23.32

GC content: 52.38

Gene sequence:

>1281_bases
ATGGAGATTATAAAATATCCCGGACGTGAGGAATGGAGCTCACTAATCAAACGTCCCGCGTTGGATGTAACCACCTTGTT
CGATACGGTCCGTACGGTATTGGACGAGGTACGTGAGCAGGGTGACATCGCCGTAAAAGCGTATGAGGAAAAGTTTGATA
AGGTGCAGCTTTCTTCCCTTCAAGTCTCGGAAGAGGAGATGCGGGAAGCGGATGCCTTGGTCGCTGAGGACTTGAAACAG
GCGATCCGTACGGCAAAGGCGAATATCGAGAAGTTCCATGCCTCGCAGCGTTTCGAGGGAAAGAAAGTGGAGACTACCCC
GGGAGTCACTTGTTGGCAGAAAGCGGTAGCGATTGAGAAAGTCGGTTTATATATTCCGGGCGGAACGGCGCCTTTGTTTT
CCACGGTATTGATGTTGGCAGTGCCCGCACGTATCGCCGGCTGCAAGGAGATCGTATTATGTACGCCACCGAACCGGGAA
GGGAAAGTACATCCCGCTATCCTGTTCGCCGCAGAGGTCGCAGGTGTAAGTAAGATATTCAAGGCTGGAGGAATCCAAGC
GATAGCGGCGATGGCCTATGGGACGGAATCGGTCCCCAAGGTGTATAAGATCTTTGGCCCCGGTAATCAATACGTGACGG
CGGCAAAGCAATTAGTAAGCCTGAAAGAGGTCGCCATTGATATGCCCGCCGGACCATCCGAGGTAGAGGTGATCGCGGAC
GAGACGGCGAATCCCGATTTTATCGCCGCCGATTTCCTCTCGCAAGCCGAACATGGGGTGGATAGCCAAGCGATCCTCGT
AACCTCTTCGGAAACGATCGTGAAACCCGTGGCCCGTGCCATCCAAGAGCAACTCGATCGTTTGCCCCGAAAGGAGATTA
CCGAGAAATCATTAGCGCACAGCCGTATCATCGTATTGAAAGATTCGCGGGAAGTCGTAGACTTCACGAACCAATACGCT
CCCGAGCACTTGATTATCCAAACATCGGATTACACCGCTATCGCGGAGCGAATCGAGAACGCCGGCAGTGTCTTTATGGG
TCCATATACTCCGGAAAGCGCAGGCGATTATGCTTCCGGCACGAATCATACCTTGCCGACCAACGGCTATGCCAAGGCAT
ATAGCGGCGTGAACTTGGATAGTTTCATCAAGAAGATCACTTTCCAAGAGATCACTTCCGATGGTATCCGTGCCTTGGGT
AGTACGATCCAAACCATGGCGGCCAACGAGCAGCTGGATGCTCACCGCAACGCAGTAACAATTAGATTGAACACGATATG
A

Upstream 100 bases:

>100_bases
GTGATCGCCGAGAAGCATTTCTGGGAAATTATTGGTAAACTAAAATCATTGGGGGCTGAAGGCATCTTAGTGCTTCCGAT
CGAGAAAATGATTGTATAAT

Downstream 100 bases:

>100_bases
AAGACCTAAAAGATTTAGTAAGACCGAATGTCTGGAATTTGAAACCGTATTCATCCGCACGTGATGAGTTTCATGGGGAT
GCCTCCGTTTTTCTGGACGC

Product: histidinol dehydrogenase

Products: NA

Alternate protein names: HDH [H]

Number of amino acids: Translated: 426; Mature: 426

Protein sequence:

>426_residues
MEIIKYPGREEWSSLIKRPALDVTTLFDTVRTVLDEVREQGDIAVKAYEEKFDKVQLSSLQVSEEEMREADALVAEDLKQ
AIRTAKANIEKFHASQRFEGKKVETTPGVTCWQKAVAIEKVGLYIPGGTAPLFSTVLMLAVPARIAGCKEIVLCTPPNRE
GKVHPAILFAAEVAGVSKIFKAGGIQAIAAMAYGTESVPKVYKIFGPGNQYVTAAKQLVSLKEVAIDMPAGPSEVEVIAD
ETANPDFIAADFLSQAEHGVDSQAILVTSSETIVKPVARAIQEQLDRLPRKEITEKSLAHSRIIVLKDSREVVDFTNQYA
PEHLIIQTSDYTAIAERIENAGSVFMGPYTPESAGDYASGTNHTLPTNGYAKAYSGVNLDSFIKKITFQEITSDGIRALG
STIQTMAANEQLDAHRNAVTIRLNTI

Sequences:

>Translated_426_residues
MEIIKYPGREEWSSLIKRPALDVTTLFDTVRTVLDEVREQGDIAVKAYEEKFDKVQLSSLQVSEEEMREADALVAEDLKQ
AIRTAKANIEKFHASQRFEGKKVETTPGVTCWQKAVAIEKVGLYIPGGTAPLFSTVLMLAVPARIAGCKEIVLCTPPNRE
GKVHPAILFAAEVAGVSKIFKAGGIQAIAAMAYGTESVPKVYKIFGPGNQYVTAAKQLVSLKEVAIDMPAGPSEVEVIAD
ETANPDFIAADFLSQAEHGVDSQAILVTSSETIVKPVARAIQEQLDRLPRKEITEKSLAHSRIIVLKDSREVVDFTNQYA
PEHLIIQTSDYTAIAERIENAGSVFMGPYTPESAGDYASGTNHTLPTNGYAKAYSGVNLDSFIKKITFQEITSDGIRALG
STIQTMAANEQLDAHRNAVTIRLNTI
>Mature_426_residues
MEIIKYPGREEWSSLIKRPALDVTTLFDTVRTVLDEVREQGDIAVKAYEEKFDKVQLSSLQVSEEEMREADALVAEDLKQ
AIRTAKANIEKFHASQRFEGKKVETTPGVTCWQKAVAIEKVGLYIPGGTAPLFSTVLMLAVPARIAGCKEIVLCTPPNRE
GKVHPAILFAAEVAGVSKIFKAGGIQAIAAMAYGTESVPKVYKIFGPGNQYVTAAKQLVSLKEVAIDMPAGPSEVEVIAD
ETANPDFIAADFLSQAEHGVDSQAILVTSSETIVKPVARAIQEQLDRLPRKEITEKSLAHSRIIVLKDSREVVDFTNQYA
PEHLIIQTSDYTAIAERIENAGSVFMGPYTPESAGDYASGTNHTLPTNGYAKAYSGVNLDSFIKKITFQEITSDGIRALG
STIQTMAANEQLDAHRNAVTIRLNTI

Specific function: Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine [H]

COG id: COG0141

COG function: function code E; Histidinol dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the histidinol dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI1788331, Length=420, Percent_Identity=53.3333333333333, Blast_Score=446, Evalue=1e-126,
Organism=Saccharomyces cerevisiae, GI6319819, Length=433, Percent_Identity=48.729792147806, Blast_Score=403, Evalue=1e-113,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016161
- InterPro:   IPR022695
- InterPro:   IPR001692
- InterPro:   IPR012131 [H]

Pfam domain/function: PF00815 Histidinol_dh [H]

EC number: =1.1.1.23 [H]

Molecular weight: Translated: 46384; Mature: 46384

Theoretical pI: Translated: 5.12; Mature: 5.12

Prosite motif: PS00611 HISOL_DEHYDROGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEIIKYPGREEWSSLIKRPALDVTTLFDTVRTVLDEVREQGDIAVKAYEEKFDKVQLSSL
CCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCEEEEEHHHHHHHHHHHHH
QVSEEEMREADALVAEDLKQAIRTAKANIEKFHASQRFEGKKVETTPGVTCWQKAVAIEK
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEECCCCCHHHHHHHHHHHH
VGLYIPGGTAPLFSTVLMLAVPARIAGCKEIVLCTPPNREGKVHPAILFAAEVAGVSKIF
CCEEECCCCHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHH
KAGGIQAIAAMAYGTESVPKVYKIFGPGNQYVTAAKQLVSLKEVAIDMPAGPSEVEVIAD
HHCCHHHHHHHHHCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHEECCCCCCCEEEEEC
ETANPDFIAADFLSQAEHGVDSQAILVTSSETIVKPVARAIQEQLDRLPRKEITEKSLAH
CCCCCCCHHHHHHHHHHCCCCCCEEEEECCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHH
SRIIVLKDSREVVDFTNQYAPEHLIIQTSDYTAIAERIENAGSVFMGPYTPESAGDYASG
CEEEEEECCCHHHHHHHCCCCCEEEEECCCHHHHHHHHHCCCCEEECCCCCCCCCCCCCC
TNHTLPTNGYAKAYSGVNLDSFIKKITFQEITSDGIRALGSTIQTMAANEQLDAHRNAVT
CCCCCCCCCCHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCEEE
IRLNTI
EEEECC
>Mature Secondary Structure
MEIIKYPGREEWSSLIKRPALDVTTLFDTVRTVLDEVREQGDIAVKAYEEKFDKVQLSSL
CCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCEEEEEHHHHHHHHHHHHH
QVSEEEMREADALVAEDLKQAIRTAKANIEKFHASQRFEGKKVETTPGVTCWQKAVAIEK
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEECCCCCHHHHHHHHHHHH
VGLYIPGGTAPLFSTVLMLAVPARIAGCKEIVLCTPPNREGKVHPAILFAAEVAGVSKIF
CCEEECCCCHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHH
KAGGIQAIAAMAYGTESVPKVYKIFGPGNQYVTAAKQLVSLKEVAIDMPAGPSEVEVIAD
HHCCHHHHHHHHHCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHEECCCCCCCEEEEEC
ETANPDFIAADFLSQAEHGVDSQAILVTSSETIVKPVARAIQEQLDRLPRKEITEKSLAH
CCCCCCCHHHHHHHHHHCCCCCCEEEEECCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHH
SRIIVLKDSREVVDFTNQYAPEHLIIQTSDYTAIAERIENAGSVFMGPYTPESAGDYASG
CEEEEEECCCHHHHHHHCCCCCEEEEECCCHHHHHHHHHCCCCEEECCCCCCCCCCCCCC
TNHTLPTNGYAKAYSGVNLDSFIKKITFQEITSDGIRALGSTIQTMAANEQLDAHRNAVT
CCCCCCCCCCHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCEEE
IRLNTI
EEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12663928 [H]