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The map label for this gene is hisG

Identifier: 150007613

GI number: 150007613

Start: 1121358

End: 1122209

Strand: Direct

Name: hisG

Synonym: BDI_0966

Alternate gene names: 150007613

Gene position: 1121358-1122209 (Clockwise)

Preceding gene: 150007612

Following gene: 150007614

Centisome position: 23.31

GC content: 46.6

Gene sequence:

>852_bases
ATGTTGAGAATTGCGGTACAATCGAAAGGCCGTCTGTACGACGAGACCATGATGTTGCTTGAAGAAGCAGGTATTAAACT
AAACAGGGGCAAACGCATCCTGTTATTATCGGCAAAAGGTTTTCCGGTAGAGGTATTATTCCTTCGTGATGATGATATTC
CTCAGTCTGTAGCTAACGGTGTGGCGGATATTGGTATTGTCGGAGAGAACGAGTACGTAGAGAAAGGGCAAGAGGCGAAA
TTGATCAAGCGTCTGGGCTTTAGTAAGTGCCGTCTATCCTTAGCGATCCCCAAAGATGAGGAATATAAGGGGGCTGAGTG
GTTTGAGGGAAAAACGATCGCTACTTCCTATCCTGCGATCCTACGGTCTTTCTTGGAGGAGAGAGGCGTGAAGGCGGATA
TTCATGTAATCAGCGGCTCTGTGGAAATCGCCCCGGGCATTGGTTTGGCGGACGCTATCTTTGATATCGTAAGCTCCGGT
AGTACTTTGGTAAGCAATCAATTGAGAGAAGTGGAGGTAGTCCTTCCTTGTGAGGCTTTATTGATCGCCAACAATAATCT
ATCCAAAGAGAAACTGGAGATATTGGATGAGCTTCTATTCCGCTTTGAAGCGATTCAAGTCGCCGAGGGCAAGAAGTACG
TGTTGCTGAACGCTCCGAAAGAAAAGCTGGATGAGATTATCGAGGTGCTTCCCGGTATGAAGAGCCCGACCATCACGCCT
TTGGCGAACGATGAATGGGTCTCTGTTCAATCCGTGATCGCCGAGAAGCATTTCTGGGAAATTATTGGTAAACTAAAATC
ATTGGGGGCTGAAGGCATCTTAGTGCTTCCGATCGAGAAAATGATTGTATAA

Upstream 100 bases:

>100_bases
TGAATGGTATGTATGTACTCATGATAAAAAGATAAAGGCTTGCCGTTTTGCGGTAAGCCTTTTTTTGTTGATATTTATAA
TATAAAAATAAGATATAGTT

Downstream 100 bases:

>100_bases
TATGGAGATTATAAAATATCCCGGACGTGAGGAATGGAGCTCACTAATCAAACGTCCCGCGTTGGATGTAACCACCTTGT
TCGATACGGTCCGTACGGTA

Product: ATP phosphoribosyltransferase

Products: NA

Alternate protein names: ATP-PRT; ATP-PRTase

Number of amino acids: Translated: 283; Mature: 283

Protein sequence:

>283_residues
MLRIAVQSKGRLYDETMMLLEEAGIKLNRGKRILLLSAKGFPVEVLFLRDDDIPQSVANGVADIGIVGENEYVEKGQEAK
LIKRLGFSKCRLSLAIPKDEEYKGAEWFEGKTIATSYPAILRSFLEERGVKADIHVISGSVEIAPGIGLADAIFDIVSSG
STLVSNQLREVEVVLPCEALLIANNNLSKEKLEILDELLFRFEAIQVAEGKKYVLLNAPKEKLDEIIEVLPGMKSPTITP
LANDEWVSVQSVIAEKHFWEIIGKLKSLGAEGILVLPIEKMIV

Sequences:

>Translated_283_residues
MLRIAVQSKGRLYDETMMLLEEAGIKLNRGKRILLLSAKGFPVEVLFLRDDDIPQSVANGVADIGIVGENEYVEKGQEAK
LIKRLGFSKCRLSLAIPKDEEYKGAEWFEGKTIATSYPAILRSFLEERGVKADIHVISGSVEIAPGIGLADAIFDIVSSG
STLVSNQLREVEVVLPCEALLIANNNLSKEKLEILDELLFRFEAIQVAEGKKYVLLNAPKEKLDEIIEVLPGMKSPTITP
LANDEWVSVQSVIAEKHFWEIIGKLKSLGAEGILVLPIEKMIV
>Mature_283_residues
MLRIAVQSKGRLYDETMMLLEEAGIKLNRGKRILLLSAKGFPVEVLFLRDDDIPQSVANGVADIGIVGENEYVEKGQEAK
LIKRLGFSKCRLSLAIPKDEEYKGAEWFEGKTIATSYPAILRSFLEERGVKADIHVISGSVEIAPGIGLADAIFDIVSSG
STLVSNQLREVEVVLPCEALLIANNNLSKEKLEILDELLFRFEAIQVAEGKKYVLLNAPKEKLDEIIEVLPGMKSPTITP
LANDEWVSVQSVIAEKHFWEIIGKLKSLGAEGILVLPIEKMIV

Specific function: Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic

COG id: COG0040

COG function: function code E; ATP phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP phosphoribosyltransferase family. Long subfamily

Homologues:

Organism=Escherichia coli, GI1788330, Length=292, Percent_Identity=45.8904109589041, Blast_Score=251, Evalue=3e-68,
Organism=Saccharomyces cerevisiae, GI6320896, Length=288, Percent_Identity=32.9861111111111, Blast_Score=159, Evalue=4e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS1_PARD8 (A6LAM0)

Other databases:

- EMBL:   CP000140
- RefSeq:   YP_001302356.1
- ProteinModelPortal:   A6LAM0
- SMR:   A6LAM0
- STRING:   A6LAM0
- GeneID:   5306120
- GenomeReviews:   CP000140_GR
- KEGG:   pdi:BDI_0966
- eggNOG:   COG0040
- HOGENOM:   HBG391868
- OMA:   YLRPRDI
- ProtClustDB:   PRK00489
- BioCyc:   PDIS435591:BDI_0966-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00079
- InterPro:   IPR001348
- InterPro:   IPR013820
- InterPro:   IPR018198
- InterPro:   IPR020621
- InterPro:   IPR013115
- InterPro:   IPR011322
- InterPro:   IPR015867
- Gene3D:   G3DSA:3.30.70.120
- PANTHER:   PTHR21403
- TIGRFAMs:   TIGR00070
- TIGRFAMs:   TIGR03455

Pfam domain/function: PF01634 HisG; PF08029 HisG_C; SSF54913 N-reg_PII-like_a/b

EC number: =2.4.2.17

Molecular weight: Translated: 31226; Mature: 31226

Theoretical pI: Translated: 4.76; Mature: 4.76

Prosite motif: PS01316 ATP_P_PHORIBOSYLTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLRIAVQSKGRLYDETMMLLEEAGIKLNRGKRILLLSAKGFPVEVLFLRDDDIPQSVANG
CEEEEECCCCCHHHHHHHHHHHCCCEECCCCEEEEEECCCCCEEEEEEECCCCHHHHHCC
VADIGIVGENEYVEKGQEAKLIKRLGFSKCRLSLAIPKDEEYKGAEWFEGKTIATSYPAI
CCEEEEECCCHHHHCCHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCCEEECHHHHH
LRSFLEERGVKADIHVISGSVEIAPGIGLADAIFDIVSSGSTLVSNQLREVEVVLPCEAL
HHHHHHHCCCEEEEEEEECCEEECCCCCHHHHHHHHHHCCCHHHHHHHHEEEEEECCEEE
LIANNNLSKEKLEILDELLFRFEAIQVAEGKKYVLLNAPKEKLDEIIEVLPGMKSPTITP
EEECCCCCHHHHHHHHHHHHHHHHHEECCCCEEEEEECCHHHHHHHHHHHCCCCCCCCCC
LANDEWVSVQSVIAEKHFWEIIGKLKSLGAEGILVLPIEKMIV
CCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEHHHHCC
>Mature Secondary Structure
MLRIAVQSKGRLYDETMMLLEEAGIKLNRGKRILLLSAKGFPVEVLFLRDDDIPQSVANG
CEEEEECCCCCHHHHHHHHHHHCCCEECCCCEEEEEECCCCCEEEEEEECCCCHHHHHCC
VADIGIVGENEYVEKGQEAKLIKRLGFSKCRLSLAIPKDEEYKGAEWFEGKTIATSYPAI
CCEEEEECCCHHHHCCHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCCEEECHHHHH
LRSFLEERGVKADIHVISGSVEIAPGIGLADAIFDIVSSGSTLVSNQLREVEVVLPCEAL
HHHHHHHCCCEEEEEEEECCEEECCCCCHHHHHHHHHHCCCHHHHHHHHEEEEEECCEEE
LIANNNLSKEKLEILDELLFRFEAIQVAEGKKYVLLNAPKEKLDEIIEVLPGMKSPTITP
EEECCCCCHHHHHHHHHHHHHHHHHEECCCCEEEEEECCHHHHHHHHHHHCCCCCCCCCC
LANDEWVSVQSVIAEKHFWEIIGKLKSLGAEGILVLPIEKMIV
CCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA