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The map label for this gene is cbh [H]

Identifier: 150007416

GI number: 150007416

Start: 897034

End: 898020

Strand: Reverse

Name: cbh [H]

Synonym: BDI_0767

Alternate gene names: 150007416

Gene position: 898020-897034 (Counterclockwise)

Preceding gene: 150007418

Following gene: 150007415

Centisome position: 18.66

GC content: 46.81

Gene sequence:

>987_bases
ATGTGTACAAGAGTAGTTTATTCGGGAACAAACGGGATGGTAGCGACTGGTCGCACGATGGACTGGAAGACCGATATGCA
TAGTAACCTATGGGTGTTTCCTAGGGGGATGGAGAGAAACGGGGAGACAGGAAAGGATTCTTTAAAGTGGAAATCCAAAT
ACGGCAGCATCATCACCTCCGCTTTCGAGATAGCCAGTACGGACGGAATGAACGAGAAAGGTTTGGTAGCTAATTTGCTC
TGGTTACCCGAAGCCCAATATCCGGCCAGAGATAAGAATAAGCCGGGCCTTGCCATAACGATATGGGTACAATATATGTT
GGATAATTTCGCTACGGTGGAAGAAGCGGTCTCTTTTATCAACGAAGATACGTTTCAAGTAGTATCGGATAAGATGCCGG
ACGGTTCCCGCTTGGCGACCTTACATTTATCGATTTCCGACGCAACCGGTGATTGCGCTATCTTCGAATACATAGGAGGT
AAACTGACCGTTTATCACAGTAAGGAATACAAGGTGATGACTAACTCCCCTACTTATAATAAACAGTTGGCTCTTTGTGA
ATATTGGAAATCGATCGGAGGGCTGAGTTTCCTTCCGGGTACCAACCGTGCATCCGACCGTTTTGCCAGAGCTAGTTTTT
ATATAGATGCCGTACTTAAGACGGACGATGAGAAGATAGCTATCGCCTGTGTATTCAGCGTGATCCGTAACGCCTCTGTC
CCTTATGGCATATCGACTCCCGAGAGTCCGGAGATATCCACCACGCAATGGAGAACGGTATCCGAAAGCAAGAACCTGAT
TTATTTCTTTGAGTCGAGCCTGACCCCGAACACTTTCTGGGTACGACTGAGAGACATGGACTTATCGGAGGGTGCGCCGG
TACTTAAACTATCCATCGCCAACGGTGAGACCTATCATGGCAACACTTCAAAAGACTTTAAGCCGGCGCAACCATTCAAG
TTTATGGGTGTAAAGGATCTTATTTAG

Upstream 100 bases:

>100_bases
CGTACTCTTTGATGCGAAAACGTAAACTGAACATTAAGAGGTTCTAACTGTTGATATATCAATCAAATATTTGAAGATAA
CCTATTAAAAGTTGAAAATC

Downstream 100 bases:

>100_bases
TCTTGGCTAACTATTTTTTGGGATAATATGTTCCATATTTCCTTTTACAACATTTGAGTTTCAATTAATATTTATATTTG
ACGTCAAAAATCTTACAATA

Product: choloylglycine hydrolase

Products: NA

Alternate protein names: Bile salt hydrolase; Conjugated bile acid hydrolase; CBAH [H]

Number of amino acids: Translated: 328; Mature: 328

Protein sequence:

>328_residues
MCTRVVYSGTNGMVATGRTMDWKTDMHSNLWVFPRGMERNGETGKDSLKWKSKYGSIITSAFEIASTDGMNEKGLVANLL
WLPEAQYPARDKNKPGLAITIWVQYMLDNFATVEEAVSFINEDTFQVVSDKMPDGSRLATLHLSISDATGDCAIFEYIGG
KLTVYHSKEYKVMTNSPTYNKQLALCEYWKSIGGLSFLPGTNRASDRFARASFYIDAVLKTDDEKIAIACVFSVIRNASV
PYGISTPESPEISTTQWRTVSESKNLIYFFESSLTPNTFWVRLRDMDLSEGAPVLKLSIANGETYHGNTSKDFKPAQPFK
FMGVKDLI

Sequences:

>Translated_328_residues
MCTRVVYSGTNGMVATGRTMDWKTDMHSNLWVFPRGMERNGETGKDSLKWKSKYGSIITSAFEIASTDGMNEKGLVANLL
WLPEAQYPARDKNKPGLAITIWVQYMLDNFATVEEAVSFINEDTFQVVSDKMPDGSRLATLHLSISDATGDCAIFEYIGG
KLTVYHSKEYKVMTNSPTYNKQLALCEYWKSIGGLSFLPGTNRASDRFARASFYIDAVLKTDDEKIAIACVFSVIRNASV
PYGISTPESPEISTTQWRTVSESKNLIYFFESSLTPNTFWVRLRDMDLSEGAPVLKLSIANGETYHGNTSKDFKPAQPFK
FMGVKDLI
>Mature_328_residues
MCTRVVYSGTNGMVATGRTMDWKTDMHSNLWVFPRGMERNGETGKDSLKWKSKYGSIITSAFEIASTDGMNEKGLVANLL
WLPEAQYPARDKNKPGLAITIWVQYMLDNFATVEEAVSFINEDTFQVVSDKMPDGSRLATLHLSISDATGDCAIFEYIGG
KLTVYHSKEYKVMTNSPTYNKQLALCEYWKSIGGLSFLPGTNRASDRFARASFYIDAVLKTDDEKIAIACVFSVIRNASV
PYGISTPESPEISTTQWRTVSESKNLIYFFESSLTPNTFWVRLRDMDLSEGAPVLKLSIANGETYHGNTSKDFKPAQPFK
FMGVKDLI

Specific function: The enzyme catalyzes the degradation of conjugated bile acids in the mammalian gut [H]

COG id: COG3049

COG function: function code M; Penicillin V acylase and related amidases

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase C59 family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003199 [H]

Pfam domain/function: PF02275 CBAH [H]

EC number: =3.5.1.24 [H]

Molecular weight: Translated: 36683; Mature: 36683

Theoretical pI: Translated: 6.53; Mature: 6.53

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MCTRVVYSGTNGMVATGRTMDWKTDMHSNLWVFPRGMERNGETGKDSLKWKSKYGSIITS
CCCEEEEECCCCEEEECCCCCCCCCCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHH
AFEIASTDGMNEKGLVANLLWLPEAQYPARDKNKPGLAITIWVQYMLDNFATVEEAVSFI
HHHHHCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCEEEEEEHHHHHHHHHHHHHHHHHH
NEDTFQVVSDKMPDGSRLATLHLSISDATGDCAIFEYIGGKLTVYHSKEYKVMTNSPTYN
CCCHHHHHHCCCCCCCEEEEEEEEEECCCCCEEEEEECCCEEEEEECCCEEEEECCCCCC
KQLALCEYWKSIGGLSFLPGTNRASDRFARASFYIDAVLKTDDEKIAIACVFSVIRNASV
CHHHHHHHHHHHCCEEECCCCCCCHHHHHHHEEEEEEEEECCCCCCHHHHHHHHHHCCCC
PYGISTPESPEISTTQWRTVSESKNLIYFFESSLTPNTFWVRLRDMDLSEGAPVLKLSIA
CCCCCCCCCCCCCCCEEEEECCCCCEEEEEECCCCCCEEEEEEEECCCCCCCCEEEEEEC
NGETYHGNTSKDFKPAQPFKFMGVKDLI
CCCEECCCCCCCCCCCCCEEECCHHHCC
>Mature Secondary Structure
MCTRVVYSGTNGMVATGRTMDWKTDMHSNLWVFPRGMERNGETGKDSLKWKSKYGSIITS
CCCEEEEECCCCEEEECCCCCCCCCCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHH
AFEIASTDGMNEKGLVANLLWLPEAQYPARDKNKPGLAITIWVQYMLDNFATVEEAVSFI
HHHHHCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCEEEEEEHHHHHHHHHHHHHHHHHH
NEDTFQVVSDKMPDGSRLATLHLSISDATGDCAIFEYIGGKLTVYHSKEYKVMTNSPTYN
CCCHHHHHHCCCCCCCEEEEEEEEEECCCCCEEEEEECCCEEEEEECCCEEEEECCCCCC
KQLALCEYWKSIGGLSFLPGTNRASDRFARASFYIDAVLKTDDEKIAIACVFSVIRNASV
CHHHHHHHHHHHCCEEECCCCCCCHHHHHHHEEEEEEEEECCCCCCHHHHHHHHHHCCCC
PYGISTPESPEISTTQWRTVSESKNLIYFFESSLTPNTFWVRLRDMDLSEGAPVLKLSIA
CCCCCCCCCCCCCCCEEEEECCCCCEEEEEECCCCCCEEEEEEEECCCCCCCCEEEEEEC
NGETYHGNTSKDFKPAQPFKFMGVKDLI
CCCEECCCCCCCCCCCCCEEECCHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7618863; 11792842 [H]