Click here to switch to the map view.

The map label for this gene is pccB [H]

Identifier: 150006832

GI number: 150006832

Start: 173823

End: 175376

Strand: Reverse

Name: pccB [H]

Synonym: BDI_0163

Alternate gene names: 150006832

Gene position: 175376-173823 (Counterclockwise)

Preceding gene: 150006833

Following gene: 150006831

Centisome position: 3.65

GC content: 46.53

Gene sequence:

>1554_bases
ATGAGTAACCAGCTTGAAAAAGTAAAAGAGCTCATCGCACTTCGTGAGCAAGCTCGTTTGGGTGGAGGAGAGAAAAGAAT
CGAATCACAGCACAAAAAAGGCAAATATACCGCTCGTGAGCGTATCGCCATGTTGCTTGACGAAGGTAGTTTCGAGGAAT
TCGACATGTTTGTTCAACACCGTTGTACAAACTTCGGTATCGAGAAAACTAAATATTTAGGCGATGGTATCGTAACAGGT
TATGGTACGATCGACGGACGTTTGGTATATATCTTCGCTCAAGATTTCACCGTATTCGGTGGAGCCTTGTCTGAGGCTTT
GGCTATGAAGATCTGTAAAGTAATGGATCAAGCCATGAAGATGGGCGCTCCCGTTATCGGTTTGAACGACTCCGGTGGAG
CTCGTATCCAAGAAGGTGTAAACGCCTTGGCAGGATACGCAGAGATTTTCCAACGTAACATCTTGGCATCTGGTGTTGTT
CCCCAGATTTCCGGTATCTTCGGCCCTTGCGCCGGTGGAGCCGTTTATTCTCCGGCTTTGACAGACTTCAACATCATGAC
ACGTGGTACCAGCTACATGTTCTTGACAGGTCCGAAAGTAGTAAAAACCGTAACAGGTGAGGATGTAACCCAAGAGCAGT
TGGGTGGAGCCAGCGTACACACCACGAAATCGGGTGTAGCCCATTTCGCTGTCGATACAGAAGAGGATGGTTTGCAATTG
ATCCGTAAATTGCTCAGTTTCTTACCACAGAACAACTTGGAAGAAACTCCGTTAGTTGAGTGCAAAGACCCGATCGATCG
TCTGGATGATGTATTGAATGATATCATTCCCGATAACGCTAACCAATCTTACGATATGTACGAGGTTATCGGTACGATCG
TCGATAACAACGAGTTCCTAGAGGTCCATGCGGACTACGCTAAGAATATCATCGTAGGTTTCGCTCGTTTCAACGGACAA
TCTGTCGGTATCGTAGCCAACCAGCCGAAGGTTATGGCAGGATGCTTGGATAGCAACGCATCTCGTAAAGCAGGTCGCTT
CGTTCGTTTCTGCGACGCTTTCAATATTCCTTTGGTAACATTGGTTGACGTTCCGGGATTCCTTCCGGGTACAGGTCAGG
AATACAACGGTGTAATCCTTCATGGCGCTAAATTGCTTTACGCTTATGGTGAGGCTACCGTTCCTAAGATTACCGTTACA
TTGCGTAAGTCTTACGGTGGAGCTTATTGCGTGATGAGTTCTAAACATTTACGTGGTGATATGAATTACGCATGGCCGAC
AGCCGAGATCGCCGTTATGGGCCCGAGCGGTGCCGTAGAGGTTATCTTCGCCAAGGAAGTAGCAGCCGCTGAAGATCCGA
AAGCATGCGCAGCAGAGAAAGAAGCTGAATATAAGAAAGCATTCGCTAATCCTTATAACGCAGCTCAATACGGTTATATC
GACGATGTTATCGAACCGCGTAACACTCGTTTCCGTATAATTCGTGCTTTGCAGCAATTGCAGACTAAGAAGCTAAGCAA
TCCTGCTAAGAAACATGATAACCTGCCTCTATAA

Upstream 100 bases:

>100_bases
TTTCCTTCACCCGAAATCAACTTGCAGCGTATTGACAGAACTTTGCATGCCGGGCAACAAATAATTAATCCGTTCATTTC
TAACAACAAATCAAAATACA

Downstream 100 bases:

>100_bases
TCCGTAAAACAGGAGATGAATATGATAAATAAGAAAATAGGGGTATTGCTACTGTTCGCTTTGCTCATTTCATTCGGGGC
AAAGGCACAGCGCGCAACCT

Product: methylmalonyl-CoA decarboxylase subunit alpha

Products: NA

Alternate protein names: PCCase; Propanoyl-CoA:carbon dioxide ligase [H]

Number of amino acids: Translated: 517; Mature: 516

Protein sequence:

>517_residues
MSNQLEKVKELIALREQARLGGGEKRIESQHKKGKYTARERIAMLLDEGSFEEFDMFVQHRCTNFGIEKTKYLGDGIVTG
YGTIDGRLVYIFAQDFTVFGGALSEALAMKICKVMDQAMKMGAPVIGLNDSGGARIQEGVNALAGYAEIFQRNILASGVV
PQISGIFGPCAGGAVYSPALTDFNIMTRGTSYMFLTGPKVVKTVTGEDVTQEQLGGASVHTTKSGVAHFAVDTEEDGLQL
IRKLLSFLPQNNLEETPLVECKDPIDRLDDVLNDIIPDNANQSYDMYEVIGTIVDNNEFLEVHADYAKNIIVGFARFNGQ
SVGIVANQPKVMAGCLDSNASRKAGRFVRFCDAFNIPLVTLVDVPGFLPGTGQEYNGVILHGAKLLYAYGEATVPKITVT
LRKSYGGAYCVMSSKHLRGDMNYAWPTAEIAVMGPSGAVEVIFAKEVAAAEDPKACAAEKEAEYKKAFANPYNAAQYGYI
DDVIEPRNTRFRIIRALQQLQTKKLSNPAKKHDNLPL

Sequences:

>Translated_517_residues
MSNQLEKVKELIALREQARLGGGEKRIESQHKKGKYTARERIAMLLDEGSFEEFDMFVQHRCTNFGIEKTKYLGDGIVTG
YGTIDGRLVYIFAQDFTVFGGALSEALAMKICKVMDQAMKMGAPVIGLNDSGGARIQEGVNALAGYAEIFQRNILASGVV
PQISGIFGPCAGGAVYSPALTDFNIMTRGTSYMFLTGPKVVKTVTGEDVTQEQLGGASVHTTKSGVAHFAVDTEEDGLQL
IRKLLSFLPQNNLEETPLVECKDPIDRLDDVLNDIIPDNANQSYDMYEVIGTIVDNNEFLEVHADYAKNIIVGFARFNGQ
SVGIVANQPKVMAGCLDSNASRKAGRFVRFCDAFNIPLVTLVDVPGFLPGTGQEYNGVILHGAKLLYAYGEATVPKITVT
LRKSYGGAYCVMSSKHLRGDMNYAWPTAEIAVMGPSGAVEVIFAKEVAAAEDPKACAAEKEAEYKKAFANPYNAAQYGYI
DDVIEPRNTRFRIIRALQQLQTKKLSNPAKKHDNLPL
>Mature_516_residues
SNQLEKVKELIALREQARLGGGEKRIESQHKKGKYTARERIAMLLDEGSFEEFDMFVQHRCTNFGIEKTKYLGDGIVTGY
GTIDGRLVYIFAQDFTVFGGALSEALAMKICKVMDQAMKMGAPVIGLNDSGGARIQEGVNALAGYAEIFQRNILASGVVP
QISGIFGPCAGGAVYSPALTDFNIMTRGTSYMFLTGPKVVKTVTGEDVTQEQLGGASVHTTKSGVAHFAVDTEEDGLQLI
RKLLSFLPQNNLEETPLVECKDPIDRLDDVLNDIIPDNANQSYDMYEVIGTIVDNNEFLEVHADYAKNIIVGFARFNGQS
VGIVANQPKVMAGCLDSNASRKAGRFVRFCDAFNIPLVTLVDVPGFLPGTGQEYNGVILHGAKLLYAYGEATVPKITVTL
RKSYGGAYCVMSSKHLRGDMNYAWPTAEIAVMGPSGAVEVIFAKEVAAAEDPKACAAEKEAEYKKAFANPYNAAQYGYID
DVIEPRNTRFRIIRALQQLQTKKLSNPAKKHDNLPL

Specific function: This Protein Is A Component Of The Acetyl Coenzyme A Carboxylase Complex; First, Biotin Carboxylase Catalyzes The Carboxylation Of The Carrier Protein And Then The Transcarboxylase Transfers The Carboxyl Group To Form Malonyl-CoA. [C]

COG id: COG4799

COG function: function code I; Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 carboxyltransferase domain [H]

Homologues:

Organism=Homo sapiens, GI119943100, Length=522, Percent_Identity=61.8773946360153, Blast_Score=663, Evalue=0.0,
Organism=Homo sapiens, GI295821216, Length=542, Percent_Identity=59.5940959409594, Blast_Score=651, Evalue=0.0,
Organism=Homo sapiens, GI11545863, Length=498, Percent_Identity=34.7389558232932, Blast_Score=230, Evalue=2e-60,
Organism=Homo sapiens, GI134142062, Length=407, Percent_Identity=25.3071253071253, Blast_Score=79, Evalue=1e-14,
Organism=Homo sapiens, GI38679974, Length=290, Percent_Identity=26.551724137931, Blast_Score=79, Evalue=1e-14,
Organism=Homo sapiens, GI38679971, Length=290, Percent_Identity=26.551724137931, Blast_Score=79, Evalue=1e-14,
Organism=Homo sapiens, GI38679960, Length=290, Percent_Identity=26.551724137931, Blast_Score=79, Evalue=1e-14,
Organism=Homo sapiens, GI38679977, Length=290, Percent_Identity=26.551724137931, Blast_Score=79, Evalue=1e-14,
Organism=Homo sapiens, GI38679967, Length=290, Percent_Identity=26.551724137931, Blast_Score=79, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI25147362, Length=503, Percent_Identity=60.0397614314115, Blast_Score=650, Evalue=0.0,
Organism=Caenorhabditis elegans, GI25147359, Length=503, Percent_Identity=60.0397614314115, Blast_Score=649, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17552936, Length=518, Percent_Identity=33.011583011583, Blast_Score=243, Evalue=2e-64,
Organism=Caenorhabditis elegans, GI71997163, Length=396, Percent_Identity=25.2525252525253, Blast_Score=85, Evalue=9e-17,
Organism=Saccharomyces cerevisiae, GI6323863, Length=358, Percent_Identity=24.3016759776536, Blast_Score=69, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6324343, Length=294, Percent_Identity=23.469387755102, Blast_Score=65, Evalue=3e-11,
Organism=Drosophila melanogaster, GI24586065, Length=519, Percent_Identity=34.6820809248555, Blast_Score=240, Evalue=1e-63,
Organism=Drosophila melanogaster, GI161076409, Length=343, Percent_Identity=25.3644314868805, Blast_Score=72, Evalue=1e-12,
Organism=Drosophila melanogaster, GI161076407, Length=343, Percent_Identity=25.3644314868805, Blast_Score=72, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24586460, Length=343, Percent_Identity=25.3644314868805, Blast_Score=72, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24586458, Length=343, Percent_Identity=25.3644314868805, Blast_Score=72, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000438
- InterPro:   IPR000022
- InterPro:   IPR011763
- InterPro:   IPR011762 [H]

Pfam domain/function: PF01039 Carboxyl_trans [H]

EC number: =6.4.1.3 [H]

Molecular weight: Translated: 56391; Mature: 56260

Theoretical pI: Translated: 5.93; Mature: 5.93

Prosite motif: PS50980 COA_CT_NTER ; PS50989 COA_CT_CTER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNQLEKVKELIALREQARLGGGEKRIESQHKKGKYTARERIAMLLDEGSFEEFDMFVQH
CCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCHHHHHHHHHHHCCCCHHHHHHHHHH
RCTNFGIEKTKYLGDGIVTGYGTIDGRLVYIFAQDFTVFGGALSEALAMKICKVMDQAMK
HHHCCCCHHHHHCCCCEEEEECCCCCEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHH
MGAPVIGLNDSGGARIQEGVNALAGYAEIFQRNILASGVVPQISGIFGPCAGGAVYSPAL
CCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCCCCCCCCCC
TDFNIMTRGTSYMFLTGPKVVKTVTGEDVTQEQLGGASVHTTKSGVAHFAVDTEEDGLQL
CCCEEEECCCEEEEEECCHHEEECCCCCCCHHHCCCCEEEECCCCCEEEEECCCHHHHHH
IRKLLSFLPQNNLEETPLVECKDPIDRLDDVLNDIIPDNANQSYDMYEVIGTIVDNNEFL
HHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCEE
EVHADYAKNIIVGFARFNGQSVGIVANQPKVMAGCLDSNASRKAGRFVRFCDAFNIPLVT
EEEHHHHCCEEEEEEEECCCEEEEEECCCCEEEEHHCCCCCHHHHHHHHHHHCCCCCEEE
LVDVPGFLPGTGQEYNGVILHGAKLLYAYGEATVPKITVTLRKSYGGAYCVMSSKHLRGD
EECCCCCCCCCCCCCCCEEEECCEEEEEECCCCCCEEEEEEEECCCCEEEEECCHHHCCC
MNYAWPTAEIAVMGPSGAVEVIFAKEVAAAEDPKACAAEKEAEYKKAFANPYNAAQYGYI
CCCCCCCEEEEEECCCCCEEEEEEHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCH
DDVIEPRNTRFRIIRALQQLQTKKLSNPAKKHDNLPL
HHHCCCCCHHHHHHHHHHHHHHHHCCCCHHHCCCCCC
>Mature Secondary Structure 
SNQLEKVKELIALREQARLGGGEKRIESQHKKGKYTARERIAMLLDEGSFEEFDMFVQH
CCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCHHHHHHHHHHHCCCCHHHHHHHHHH
RCTNFGIEKTKYLGDGIVTGYGTIDGRLVYIFAQDFTVFGGALSEALAMKICKVMDQAMK
HHHCCCCHHHHHCCCCEEEEECCCCCEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHH
MGAPVIGLNDSGGARIQEGVNALAGYAEIFQRNILASGVVPQISGIFGPCAGGAVYSPAL
CCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCCCCCCCCCC
TDFNIMTRGTSYMFLTGPKVVKTVTGEDVTQEQLGGASVHTTKSGVAHFAVDTEEDGLQL
CCCEEEECCCEEEEEECCHHEEECCCCCCCHHHCCCCEEEECCCCCEEEEECCCHHHHHH
IRKLLSFLPQNNLEETPLVECKDPIDRLDDVLNDIIPDNANQSYDMYEVIGTIVDNNEFL
HHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCEE
EVHADYAKNIIVGFARFNGQSVGIVANQPKVMAGCLDSNASRKAGRFVRFCDAFNIPLVT
EEEHHHHCCEEEEEEEECCCEEEEEECCCCEEEEHHCCCCCHHHHHHHHHHHCCCCCEEE
LVDVPGFLPGTGQEYNGVILHGAKLLYAYGEATVPKITVTLRKSYGGAYCVMSSKHLRGD
EECCCCCCCCCCCCCCCEEEECCEEEEEECCCCCCEEEEEEEECCCCEEEEECCHHHCCC
MNYAWPTAEIAVMGPSGAVEVIFAKEVAAAEDPKACAAEKEAEYKKAFANPYNAAQYGYI
CCCCCCCEEEEEECCCCCEEEEEEHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCH
DDVIEPRNTRFRIIRALQQLQTKKLSNPAKKHDNLPL
HHHCCCCCHHHHHHHHHHHHHHHHCCCCHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8830278 [H]