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The map label for this gene is phoR [H]

Identifier: 150006576

GI number: 150006576

Start: 5038256

End: 5040037

Strand: Direct

Name: phoR [H]

Synonym: BVU_4096

Alternate gene names: 150006576

Gene position: 5038256-5040037 (Clockwise)

Preceding gene: 150006575

Following gene: 150006582

Centisome position: 97.58

GC content: 43.15

Gene sequence:

>1782_bases
ATGACTATTAAATTATCCAGCCACGTCCTGTCATTCAACAAGAAACTATTCTTGTCGGTAATTTCCTTATTCATAGCATT
CGCCATCTGTTTCATGGCATTCCAATATCGCAGGGAGAAGGAATACAAAATAGAATTGCTGAACACACAACTCCAGAATT
ACAACGACCGCCTGAATGATTTTCTCCGTGGCAGGGATACACTGAATATTCAACAATTGAACGACTATGTTTGCGAACAC
ACCTTTGAAGATCTACGCGTGACACTGATCAACAAGAATGGTACTGTAATTTATGACAATCTGGAAAAAGATCCCAGCCA
CTTCGAGAACCACCATAACCGTCAGGAAATAAAAGAAGCCATCATTTATGGCAGCGGCTACTCCATTAACAGACAATCGG
AAAGCCTGGGCGGTGAATTTTTCTATTCGGCAAAGTATTATCCTAATCTGGACTATATCATTCGTTCAGCCCTTCCCTAT
AATGTCAGTCTGATGAGACACCTGAAAGCAGACTCTCATTATGTATGGTTCACACTGATAATCAGCCTGATATTAATAAT
TGTGTTCTACCGATTCACACATAAATTGGGAATGTCTATCACCAAATTGCAACAATTCGCCATGAAAGCCGACCGCAATG
AACCGATAGACACTGATATGCAGGATACCTTTCCCAAAAACGAACTGGGCGAAATATCCCAACATATCATCCAGATTTAC
AAACGTCTGCATCAGGCAAAAGAAGATTTATATATCGAACGCGAGAAACTGATCACCCATCTCCAGATCTCGCACGAAGG
CTTAGGCGTATTCAACCACCGCAAAGAAGAGATTCTGGTAAATAATCTGTTCACACAATACGCCAACCTTATCTCGGACA
AAAATCTGAGTTCTACGGAAGAGATCTTCTCCATCCCCGAATTGCAGCCCATCACCCGTTTCATTACAAAAAACAAGGAA
CGCAGTATCGGCAAAGAAGAGAAACGGATGTCATTGAACATAGACAAAAACGGACGTATCTTTGCCGTGGAATGCATTAT
CTTTCAAGATGACAGCTTTGAAATCTCCATCAATGACATCACTCAGGAAAAGGAACAGGCACTTCTGAAAAAACAGCTGA
CACAGAATATCGCCCACGAATTGAAAACCCCTGTAAGCAGCATACAGGGATATCTGGAAACCATAGTAAACAATCCTACC
CTGCCCCGTGAGAAAATCAATGCTTTCCTGGAGAGAAGCTATGCACAAAGTAACCGGCTGGCACATCTGTTACGGGATAT
CTCCGTACTTACCCGCATGGAAGAAGCTCCGAACATGATCGAAACAGAACCGGTAAACCTCACCACCATGATGCGGAATA
TCCTGAACGAAGTAACTTTGGAACTGGAAGAAAAGCAGATCACAGCCCACAATATGCTGCCTGAAGGACTGACCATACAA
GGCAATTCTTCCCTGCTATACTCCATCTTCCGGAATCTGACAGACAACGCCATTGCATACGCAGGAACTCATATTTCCAT
AACCATCCGCTGTTTCCGTGAAGACGAACGTTTTTATTATTTCAGTTTCTCGGACACAGGCGTAGGAGTAGGACCCGAAC
ATCTAAGCCGTTTGTTCGAGCGTTTCTATCGGGTGGACAAAGGACGTTCACGCAAATTGGGCGGTACCGGACTGGGACTA
GCTATTGTAAAAAACGCAGTCATTCTGCATGGCGGAACAATCTTCGCTAAAAATACCCCCGGTGGAGGTCTGGAATTCAT
ATTTACATTGAGTAAAGAATAA

Upstream 100 bases:

>100_bases
CCGCTTGCGTAAAAAAATAGGCGAATATGGAAAATGCATCGTCACCCGCCTGGGATACGGATACTGTTTTGAATGCGAAT
AACCTAACCTGTACCTTTCC

Downstream 100 bases:

>100_bases
GAGGATACAAGAGCCTGTTTCTAAATTTTCTTCAAAATTTAAACAGGCTCCAAAAAATAAAGAAAGATAATTGTTTTCTT
AAATATAAACTGTATCTTTG

Product: two-component system sensor histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 593; Mature: 592

Protein sequence:

>593_residues
MTIKLSSHVLSFNKKLFLSVISLFIAFAICFMAFQYRREKEYKIELLNTQLQNYNDRLNDFLRGRDTLNIQQLNDYVCEH
TFEDLRVTLINKNGTVIYDNLEKDPSHFENHHNRQEIKEAIIYGSGYSINRQSESLGGEFFYSAKYYPNLDYIIRSALPY
NVSLMRHLKADSHYVWFTLIISLILIIVFYRFTHKLGMSITKLQQFAMKADRNEPIDTDMQDTFPKNELGEISQHIIQIY
KRLHQAKEDLYIEREKLITHLQISHEGLGVFNHRKEEILVNNLFTQYANLISDKNLSSTEEIFSIPELQPITRFITKNKE
RSIGKEEKRMSLNIDKNGRIFAVECIIFQDDSFEISINDITQEKEQALLKKQLTQNIAHELKTPVSSIQGYLETIVNNPT
LPREKINAFLERSYAQSNRLAHLLRDISVLTRMEEAPNMIETEPVNLTTMMRNILNEVTLELEEKQITAHNMLPEGLTIQ
GNSSLLYSIFRNLTDNAIAYAGTHISITIRCFREDERFYYFSFSDTGVGVGPEHLSRLFERFYRVDKGRSRKLGGTGLGL
AIVKNAVILHGGTIFAKNTPGGGLEFIFTLSKE

Sequences:

>Translated_593_residues
MTIKLSSHVLSFNKKLFLSVISLFIAFAICFMAFQYRREKEYKIELLNTQLQNYNDRLNDFLRGRDTLNIQQLNDYVCEH
TFEDLRVTLINKNGTVIYDNLEKDPSHFENHHNRQEIKEAIIYGSGYSINRQSESLGGEFFYSAKYYPNLDYIIRSALPY
NVSLMRHLKADSHYVWFTLIISLILIIVFYRFTHKLGMSITKLQQFAMKADRNEPIDTDMQDTFPKNELGEISQHIIQIY
KRLHQAKEDLYIEREKLITHLQISHEGLGVFNHRKEEILVNNLFTQYANLISDKNLSSTEEIFSIPELQPITRFITKNKE
RSIGKEEKRMSLNIDKNGRIFAVECIIFQDDSFEISINDITQEKEQALLKKQLTQNIAHELKTPVSSIQGYLETIVNNPT
LPREKINAFLERSYAQSNRLAHLLRDISVLTRMEEAPNMIETEPVNLTTMMRNILNEVTLELEEKQITAHNMLPEGLTIQ
GNSSLLYSIFRNLTDNAIAYAGTHISITIRCFREDERFYYFSFSDTGVGVGPEHLSRLFERFYRVDKGRSRKLGGTGLGL
AIVKNAVILHGGTIFAKNTPGGGLEFIFTLSKE
>Mature_592_residues
TIKLSSHVLSFNKKLFLSVISLFIAFAICFMAFQYRREKEYKIELLNTQLQNYNDRLNDFLRGRDTLNIQQLNDYVCEHT
FEDLRVTLINKNGTVIYDNLEKDPSHFENHHNRQEIKEAIIYGSGYSINRQSESLGGEFFYSAKYYPNLDYIIRSALPYN
VSLMRHLKADSHYVWFTLIISLILIIVFYRFTHKLGMSITKLQQFAMKADRNEPIDTDMQDTFPKNELGEISQHIIQIYK
RLHQAKEDLYIEREKLITHLQISHEGLGVFNHRKEEILVNNLFTQYANLISDKNLSSTEEIFSIPELQPITRFITKNKER
SIGKEEKRMSLNIDKNGRIFAVECIIFQDDSFEISINDITQEKEQALLKKQLTQNIAHELKTPVSSIQGYLETIVNNPTL
PREKINAFLERSYAQSNRLAHLLRDISVLTRMEEAPNMIETEPVNLTTMMRNILNEVTLELEEKQITAHNMLPEGLTIQG
NSSLLYSIFRNLTDNAIAYAGTHISITIRCFREDERFYYFSFSDTGVGVGPEHLSRLFERFYRVDKGRSRKLGGTGLGLA
IVKNAVILHGGTIFAKNTPGGGLEFIFTLSKE

Specific function: Member of the two-component regulatory system phoP/phoR involved in the alkaline phosphatase genes regulation. PhoR may function as a membrane-associated protein kinase that phosphorylates phoP in response to environmental signals [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PAS (PER-ARNT-SIM) domain [H]

Homologues:

Organism=Escherichia coli, GI1786600, Length=257, Percent_Identity=34.6303501945525, Blast_Score=140, Evalue=2e-34,
Organism=Escherichia coli, GI1790346, Length=238, Percent_Identity=31.9327731092437, Blast_Score=111, Evalue=1e-25,
Organism=Escherichia coli, GI1788393, Length=233, Percent_Identity=30.4721030042918, Blast_Score=110, Evalue=3e-25,
Organism=Escherichia coli, GI1786783, Length=237, Percent_Identity=27.4261603375527, Blast_Score=99, Evalue=1e-21,
Organism=Escherichia coli, GI1790861, Length=214, Percent_Identity=29.9065420560748, Blast_Score=91, Evalue=2e-19,
Organism=Escherichia coli, GI145693157, Length=252, Percent_Identity=26.984126984127, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI1790436, Length=238, Percent_Identity=27.7310924369748, Blast_Score=83, Evalue=5e-17,
Organism=Escherichia coli, GI1787894, Length=220, Percent_Identity=27.7272727272727, Blast_Score=83, Evalue=6e-17,
Organism=Escherichia coli, GI1788713, Length=246, Percent_Identity=24.390243902439, Blast_Score=82, Evalue=8e-17,
Organism=Escherichia coli, GI1789149, Length=242, Percent_Identity=28.5123966942149, Blast_Score=82, Evalue=1e-16,
Organism=Escherichia coli, GI48994928, Length=224, Percent_Identity=25.4464285714286, Blast_Score=81, Evalue=2e-16,
Organism=Escherichia coli, GI1790551, Length=266, Percent_Identity=24.0601503759398, Blast_Score=79, Evalue=1e-15,
Organism=Escherichia coli, GI1786912, Length=239, Percent_Identity=28.8702928870293, Blast_Score=78, Evalue=2e-15,
Organism=Escherichia coli, GI1789403, Length=219, Percent_Identity=26.9406392694064, Blast_Score=69, Evalue=1e-12,
Organism=Escherichia coli, GI87081816, Length=220, Percent_Identity=25, Blast_Score=65, Evalue=1e-11,
Organism=Escherichia coli, GI1788279, Length=207, Percent_Identity=27.536231884058, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI87082128, Length=221, Percent_Identity=23.9819004524887, Blast_Score=64, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR000014
- InterPro:   IPR013767
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF00989 PAS [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 68723; Mature: 68591

Theoretical pI: Translated: 7.06; Mature: 7.06

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTIKLSSHVLSFNKKLFLSVISLFIAFAICFMAFQYRREKEYKIELLNTQLQNYNDRLND
CEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
FLRGRDTLNIQQLNDYVCEHTFEDLRVTLINKNGTVIYDNLEKDPSHFENHHNRQEIKEA
HHCCCCCCCHHHHHHHHHHCCCCCEEEEEECCCCCEEECCCCCCHHHHHHCCCHHHHHHH
IIYGSGYSINRQSESLGGEFFYSAKYYPNLDYIIRSALPYNVSLMRHLKADSHYVWFTLI
HHCCCCCCCCCCCHHCCCCEEEECCCCCCHHHHHHHCCCCCHHHHHHHCCCCCEEHHHHH
ISLILIIVFYRFTHKLGMSITKLQQFAMKADRNEPIDTDMQDTFPKNELGEISQHIIQIY
HHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCCHHHCCCCCHHHHHHHHHHHHH
KRLHQAKEDLYIEREKLITHLQISHEGLGVFNHRKEEILVNNLFTQYANLISDKNLSSTE
HHHHHHHHHHHHHHHHHHHHHEECCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCHH
EIFSIPELQPITRFITKNKERSIGKEEKRMSLNIDKNGRIFAVECIIFQDDSFEISINDI
HHHCCCCHHHHHHHHHCCCHHCCCCHHHCEEEEECCCCCEEEEEEEEEECCCEEEEEHHH
TQEKEQALLKKQLTQNIAHELKTPVSSIQGYLETIVNNPTLPREKINAFLERSYAQSNRL
HHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHH
AHLLRDISVLTRMEEAPNMIETEPVNLTTMMRNILNEVTLELEEKQITAHNMLPEGLTIQ
HHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEE
GNSSLLYSIFRNLTDNAIAYAGTHISITIRCFREDERFYYFSFSDTGVGVGPEHLSRLFE
CCCHHHHHHHHCCCCCCEEEECCEEEEEEEEEECCCEEEEEEECCCCCCCCHHHHHHHHH
RFYRVDKGRSRKLGGTGLGLAIVKNAVILHGGTIFAKNTPGGGLEFIFTLSKE
HHHHHCCCCCCCCCCCCHHHHHHHCEEEEECCEEEEECCCCCCEEEEEEECCC
>Mature Secondary Structure 
TIKLSSHVLSFNKKLFLSVISLFIAFAICFMAFQYRREKEYKIELLNTQLQNYNDRLND
EEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
FLRGRDTLNIQQLNDYVCEHTFEDLRVTLINKNGTVIYDNLEKDPSHFENHHNRQEIKEA
HHCCCCCCCHHHHHHHHHHCCCCCEEEEEECCCCCEEECCCCCCHHHHHHCCCHHHHHHH
IIYGSGYSINRQSESLGGEFFYSAKYYPNLDYIIRSALPYNVSLMRHLKADSHYVWFTLI
HHCCCCCCCCCCCHHCCCCEEEECCCCCCHHHHHHHCCCCCHHHHHHHCCCCCEEHHHHH
ISLILIIVFYRFTHKLGMSITKLQQFAMKADRNEPIDTDMQDTFPKNELGEISQHIIQIY
HHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCCHHHCCCCCHHHHHHHHHHHHH
KRLHQAKEDLYIEREKLITHLQISHEGLGVFNHRKEEILVNNLFTQYANLISDKNLSSTE
HHHHHHHHHHHHHHHHHHHHHEECCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCHH
EIFSIPELQPITRFITKNKERSIGKEEKRMSLNIDKNGRIFAVECIIFQDDSFEISINDI
HHHCCCCHHHHHHHHHCCCHHCCCCHHHCEEEEECCCCCEEEEEEEEEECCCEEEEEHHH
TQEKEQALLKKQLTQNIAHELKTPVSSIQGYLETIVNNPTLPREKINAFLERSYAQSNRL
HHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHH
AHLLRDISVLTRMEEAPNMIETEPVNLTTMMRNILNEVTLELEEKQITAHNMLPEGLTIQ
HHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEE
GNSSLLYSIFRNLTDNAIAYAGTHISITIRCFREDERFYYFSFSDTGVGVGPEHLSRLFE
CCCHHHHHHHHCCCCCCEEEECCEEEEEEEEEECCCEEEEEEECCCCCCCCHHHHHHHHH
RFYRVDKGRSRKLGGTGLGLAIVKNAVILHGGTIFAKNTPGGGLEFIFTLSKE
HHHHHCCCCCCCCCCCCHHHHHHHCEEEEECCEEEEECCCCCCEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3142862; 9387221; 9384377 [H]