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The map label for this gene is lysA [H]

Identifier: 150006522

GI number: 150006522

Start: 4975141

End: 4976316

Strand: Reverse

Name: lysA [H]

Synonym: BVU_4042

Alternate gene names: 150006522

Gene position: 4976316-4975141 (Counterclockwise)

Preceding gene: 150006523

Following gene: 150006521

Centisome position: 96.38

GC content: 32.91

Gene sequence:

>1176_bases
ATGCAGTTAAGTAATCTAAAAACACCTTGTTTTATTTTGGATTCGGATAAGTTGGTATCTAATGTTTTGGAATTTAAAAG
AGCTTTGAACAGTCGCTTTTCAAACCATTGCATTGGATACTCAATTAAGACGAATTCACTTCCTTATATGTTGCACATGC
TTAATGAGTTGGGATGCTATGCTGAAGTAGTATCTTATACAGAGTATGCATTAGCTTTGCAAGTTGGTTTTGAGAAGAGC
CATATTGTATATAATGGTCCAGCTAAAGATAAGGAGACTTTTTTAGATGCAATAAAGAATGGTGCATATGTAAATATAGA
TACAAAACGTGAAATAGAATGGTTGAATGATTTGAACAAACAGCATTCTTATAAGGTCGGCATTCGTGTCAATTTGAATT
TAGGGAAGATTTCGCCAGAAGATGCTAAAGAGGGTGAATCGGATAGCAGATTTGGTTTTTCGTTTGAGAATGGAGAACTG
GAAGAAGCAATAAATAAGATTCAATTATGCAAAAATGTAAAACTTGGAGGTTTGCATCTGCATCGTACTTCATTGACTCG
TTCTTTAAATGTTTATAGGAATATTTGCAAATATGCTATTCGGATCATTAATTCATTAGGTCTAGAACTTGATTATATTG
ATGTTGGTGGTGGTTATTTTGGTGACAAGCCTAATGCACCTACTTATAAAGAATATGTGGACACTATCTATTCAAGTTTG
TTAGAGGAAGGGATTGATGTTTCTAAAATGAAAGTCATAGTGGAACCAGGAAATGCAATAGTTGCTTCACCTTTTAGTTT
TTTATCGGAGATCATTGATACAAAAAAAATAGGTGACTCTCAAATTATAGTAACTGATGGTTCTCGTAATGATGTGGACC
CTTTTTTCCTGAAAAAAGACTATTTTAAATCTTTCATCAGAAAGCAAGAGGAAAAAGTGTTCATTGATTCACAAATGGTT
GTAGGATGTAGTTGTTTGGAGTATGATAAGCTTTTTACACTTCAAAATCAGCCATTACTAAATGTCGGTGATAGAATACT
TTACCAAAATGTCGGTGCATACACTATGACTTTATCACCATTGTTCATTCGATTTTTTCCTAGAGTTTATTTGAAAACTT
TAAATGGTTATGAGATAATTAGAGAGGAATGGACTGTCAATGATTTAAAGCAATAA

Upstream 100 bases:

>100_bases
GAAACAGACGAATTTCAGCAAATGTTAAAGTATATTGATAATCCTTATGGTGATGGCAATGCTTCCAAACGTATTGTAGA
ACAGATAAAAATGTATTTTA

Downstream 100 bases:

>100_bases
CAATAAACTTTATAGTTATGAATAATATTCTGTGTTGTAATGCGGGCCGTAGAGGGCGTTTAATGATAGATATGCGTAAG
ACTATCGGTGATAGTGGTAA

Product: diaminopimelate decarboxylase

Products: NA

Alternate protein names: DAP decarboxylase [H]

Number of amino acids: Translated: 391; Mature: 391

Protein sequence:

>391_residues
MQLSNLKTPCFILDSDKLVSNVLEFKRALNSRFSNHCIGYSIKTNSLPYMLHMLNELGCYAEVVSYTEYALALQVGFEKS
HIVYNGPAKDKETFLDAIKNGAYVNIDTKREIEWLNDLNKQHSYKVGIRVNLNLGKISPEDAKEGESDSRFGFSFENGEL
EEAINKIQLCKNVKLGGLHLHRTSLTRSLNVYRNICKYAIRIINSLGLELDYIDVGGGYFGDKPNAPTYKEYVDTIYSSL
LEEGIDVSKMKVIVEPGNAIVASPFSFLSEIIDTKKIGDSQIIVTDGSRNDVDPFFLKKDYFKSFIRKQEEKVFIDSQMV
VGCSCLEYDKLFTLQNQPLLNVGDRILYQNVGAYTMTLSPLFIRFFPRVYLKTLNGYEIIREEWTVNDLKQ

Sequences:

>Translated_391_residues
MQLSNLKTPCFILDSDKLVSNVLEFKRALNSRFSNHCIGYSIKTNSLPYMLHMLNELGCYAEVVSYTEYALALQVGFEKS
HIVYNGPAKDKETFLDAIKNGAYVNIDTKREIEWLNDLNKQHSYKVGIRVNLNLGKISPEDAKEGESDSRFGFSFENGEL
EEAINKIQLCKNVKLGGLHLHRTSLTRSLNVYRNICKYAIRIINSLGLELDYIDVGGGYFGDKPNAPTYKEYVDTIYSSL
LEEGIDVSKMKVIVEPGNAIVASPFSFLSEIIDTKKIGDSQIIVTDGSRNDVDPFFLKKDYFKSFIRKQEEKVFIDSQMV
VGCSCLEYDKLFTLQNQPLLNVGDRILYQNVGAYTMTLSPLFIRFFPRVYLKTLNGYEIIREEWTVNDLKQ
>Mature_391_residues
MQLSNLKTPCFILDSDKLVSNVLEFKRALNSRFSNHCIGYSIKTNSLPYMLHMLNELGCYAEVVSYTEYALALQVGFEKS
HIVYNGPAKDKETFLDAIKNGAYVNIDTKREIEWLNDLNKQHSYKVGIRVNLNLGKISPEDAKEGESDSRFGFSFENGEL
EEAINKIQLCKNVKLGGLHLHRTSLTRSLNVYRNICKYAIRIINSLGLELDYIDVGGGYFGDKPNAPTYKEYVDTIYSSL
LEEGIDVSKMKVIVEPGNAIVASPFSFLSEIIDTKKIGDSQIIVTDGSRNDVDPFFLKKDYFKSFIRKQEEKVFIDSQMV
VGCSCLEYDKLFTLQNQPLLNVGDRILYQNVGAYTMTLSPLFIRFFPRVYLKTLNGYEIIREEWTVNDLKQ

Specific function: Lysine biosynthesis; last step. [C]

COG id: COG0019

COG function: function code E; Diaminopimelate decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Orn/Lys/Arg decarboxylase class-II family [H]

Homologues:

Organism=Homo sapiens, GI22538418, Length=357, Percent_Identity=26.3305322128852, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI21361583, Length=357, Percent_Identity=26.3305322128852, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI4505489, Length=356, Percent_Identity=23.0337078651685, Blast_Score=70, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17562780, Length=402, Percent_Identity=23.6318407960199, Blast_Score=87, Evalue=1e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009006
- InterPro:   IPR002986
- InterPro:   IPR022643
- InterPro:   IPR022657
- InterPro:   IPR022644
- InterPro:   IPR022653
- InterPro:   IPR000183 [H]

Pfam domain/function: PF02784 Orn_Arg_deC_N; PF00278 Orn_DAP_Arg_deC [H]

EC number: =4.1.1.20 [H]

Molecular weight: Translated: 44601; Mature: 44601

Theoretical pI: Translated: 6.27; Mature: 6.27

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQLSNLKTPCFILDSDKLVSNVLEFKRALNSRFSNHCIGYSIKTNSLPYMLHMLNELGCY
CCCCCCCCCEEEECCHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCHHHHHHHHHHHHH
AEVVSYTEYALALQVGFEKSHIVYNGPAKDKETFLDAIKNGAYVNIDTKREIEWLNDLNK
HHHHHHHHHEEEEEECCCCCEEEECCCCCCHHHHHHHHHCCCEEEECCHHHHHHHHHCCC
QHSYKVGIRVNLNLGKISPEDAKEGESDSRFGFSFENGELEEAINKIQLCKNVKLGGLHL
CCCEEEEEEEEEEECCCCCCHHCCCCCCCCCCEEECCCCHHHHHHHHHHHHCCCCCCEEE
HRTSLTRSLNVYRNICKYAIRIINSLGLELDYIDVGGGYFGDKPNAPTYKEYVDTIYSSL
EHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHH
LEEGIDVSKMKVIVEPGNAIVASPFSFLSEIIDTKKIGDSQIIVTDGSRNDVDPFFLKKD
HHCCCCEEEEEEEECCCCEEEECHHHHHHHHHHHHCCCCCEEEEECCCCCCCCHHHHHHH
YFKSFIRKQEEKVFIDSQMVVGCSCLEYDKLFTLQNQPLLNVGDRILYQNVGAYTMTLSP
HHHHHHHHHHCEEEECCCCEECCCHHHHHHEEEECCCCCHHHCCHHHHHCCCCEEEEHHH
LFIRFFPRVYLKTLNGYEIIREEWTVNDLKQ
HHHHHHHHHHHHHCCCHHHHHHCCCHHHCCC
>Mature Secondary Structure
MQLSNLKTPCFILDSDKLVSNVLEFKRALNSRFSNHCIGYSIKTNSLPYMLHMLNELGCY
CCCCCCCCCEEEECCHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCHHHHHHHHHHHHH
AEVVSYTEYALALQVGFEKSHIVYNGPAKDKETFLDAIKNGAYVNIDTKREIEWLNDLNK
HHHHHHHHHEEEEEECCCCCEEEECCCCCCHHHHHHHHHCCCEEEECCHHHHHHHHHCCC
QHSYKVGIRVNLNLGKISPEDAKEGESDSRFGFSFENGELEEAINKIQLCKNVKLGGLHL
CCCEEEEEEEEEEECCCCCCHHCCCCCCCCCCEEECCCCHHHHHHHHHHHHCCCCCCEEE
HRTSLTRSLNVYRNICKYAIRIINSLGLELDYIDVGGGYFGDKPNAPTYKEYVDTIYSSL
EHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHH
LEEGIDVSKMKVIVEPGNAIVASPFSFLSEIIDTKKIGDSQIIVTDGSRNDVDPFFLKKD
HHCCCCEEEEEEEECCCCEEEECHHHHHHHHHHHHCCCCCEEEEECCCCCCCCHHHHHHH
YFKSFIRKQEEKVFIDSQMVVGCSCLEYDKLFTLQNQPLLNVGDRILYQNVGAYTMTLSP
HHHHHHHHHHCEEEECCCCEECCCHHHHHHEEEECCCCCHHHCCHHHHHCCCCEEEEHHH
LFIRFFPRVYLKTLNGYEIIREEWTVNDLKQ
HHHHHHHHHHHHHCCCHHHHHHCCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]