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The map label for this gene is neuC [H]

Identifier: 150006523

GI number: 150006523

Start: 4976303

End: 4977436

Strand: Reverse

Name: neuC [H]

Synonym: BVU_4043

Alternate gene names: 150006523

Gene position: 4977436-4976303 (Counterclockwise)

Preceding gene: 150006524

Following gene: 150006522

Centisome position: 96.4

GC content: 37.48

Gene sequence:

>1134_bases
ATGAAAAAAATCGCAGTTGTCACTGGTGCACGTTCAGAGTATGGACTGCTACGTTGGGTGATAGATGAGATACATCATGC
TACTGAGTTACAGTTGCAGCTTATCGTTACAGGCGGACACCTGTCTCCCGAACAGGGGTTGACTTATCGTTGTATTGAGG
AGGACGGATATGATATTGATGCTAAAGTCGATATGTTGTTGTCCTCGGATTGTGCTTCTGGTATAGCGAAATCTATGGGG
ATGTGCAGTATTGGGATGAGCGATGCTTTTCTGCATCTTCAGCCTGATATGATTGTTGTCTTAGGTGATAGATATGAGTT
GCTTCCCATAGTTGGTACTGCTTTGGTGATGCGTATTCCGATAGCTCATATTTCAGGAGGTGACATCACTGAAGGAGCTA
TTGACAATGAAGTGCGCAATGCTGTTACAATGATGTCTACACTCCACTTTCCGGGTACTCAAACTTCTGCAGCCCGTATT
GGTAGGATGATTGGAACTATGAAGAATGTTTTTGTTGTAGGTGAGACCAATTTAGATAATTTTTTACGTTTGTCGCTTTT
GTCAAGGAATGAATTAGCAGAGTCTTTAAATATTGATTTAGGTAAAAAATGGATATTGATGACTTACCATCCGGTAACTA
AAGAAAGCCGTGAGAAGAATCTTTTCGATGTAAATAGTTTACTCCATGTGCTCCAGTCGTTAGGTGATGACTATGAAATA
CTAGTTTCTAAGTCTAATACAGATTTATATGGTTCGGATATTAATCAACTTTTAAATGATTATGTATGCAATAAGCCTTG
TTTTCATTTGTTTACCTCGTTAGGACAGAAGTGTTATGTCAGCCTTCTTCCTCAGTTATATTGTATGATAGGTAATTCGT
CCAGTGGAGTATATGAAACGGGTTATTGGAAGTTGCCTACGATTAATATAGGACATCGTCAAGAAGGCAGATATATGACA
TCTAACATTATTTGTTGCGATAATTGTTCTGAGTCTATTATTCAGTCTTTAAAGAAAATTGAAACAGACGAATTTCAGCA
AATGTTAAAGTATATTGATAATCCTTATGGTGATGGCAATGCTTCCAAACGTATTGTAGAACAGATAAAAATGTATTTTA
ATGCAGTTAAGTAA

Upstream 100 bases:

>100_bases
GACTGCCCATGTTCGAGCATTGCGAAACGGACGGGCTGGAGAATACCGAGTGGCTGGCTGACCGGGTGGTGAATATTCCT
AGTAGTGTAAGATTAGATAA

Downstream 100 bases:

>100_bases
TCTAAAAACACCTTGTTTTATTTTGGATTCGGATAAGTTGGTATCTAATGTTTTGGAATTTAAAAGAGCTTTGAACAGTC
GCTTTTCAAACCATTGCATT

Product: UDP-N-acetylglucosamine 2-epimerase

Products: UDP-N-acetyl-D-mannosamine [C]

Alternate protein names: NA

Number of amino acids: Translated: 377; Mature: 377

Protein sequence:

>377_residues
MKKIAVVTGARSEYGLLRWVIDEIHHATELQLQLIVTGGHLSPEQGLTYRCIEEDGYDIDAKVDMLLSSDCASGIAKSMG
MCSIGMSDAFLHLQPDMIVVLGDRYELLPIVGTALVMRIPIAHISGGDITEGAIDNEVRNAVTMMSTLHFPGTQTSAARI
GRMIGTMKNVFVVGETNLDNFLRLSLLSRNELAESLNIDLGKKWILMTYHPVTKESREKNLFDVNSLLHVLQSLGDDYEI
LVSKSNTDLYGSDINQLLNDYVCNKPCFHLFTSLGQKCYVSLLPQLYCMIGNSSSGVYETGYWKLPTINIGHRQEGRYMT
SNIICCDNCSESIIQSLKKIETDEFQQMLKYIDNPYGDGNASKRIVEQIKMYFNAVK

Sequences:

>Translated_377_residues
MKKIAVVTGARSEYGLLRWVIDEIHHATELQLQLIVTGGHLSPEQGLTYRCIEEDGYDIDAKVDMLLSSDCASGIAKSMG
MCSIGMSDAFLHLQPDMIVVLGDRYELLPIVGTALVMRIPIAHISGGDITEGAIDNEVRNAVTMMSTLHFPGTQTSAARI
GRMIGTMKNVFVVGETNLDNFLRLSLLSRNELAESLNIDLGKKWILMTYHPVTKESREKNLFDVNSLLHVLQSLGDDYEI
LVSKSNTDLYGSDINQLLNDYVCNKPCFHLFTSLGQKCYVSLLPQLYCMIGNSSSGVYETGYWKLPTINIGHRQEGRYMT
SNIICCDNCSESIIQSLKKIETDEFQQMLKYIDNPYGDGNASKRIVEQIKMYFNAVK
>Mature_377_residues
MKKIAVVTGARSEYGLLRWVIDEIHHATELQLQLIVTGGHLSPEQGLTYRCIEEDGYDIDAKVDMLLSSDCASGIAKSMG
MCSIGMSDAFLHLQPDMIVVLGDRYELLPIVGTALVMRIPIAHISGGDITEGAIDNEVRNAVTMMSTLHFPGTQTSAARI
GRMIGTMKNVFVVGETNLDNFLRLSLLSRNELAESLNIDLGKKWILMTYHPVTKESREKNLFDVNSLLHVLQSLGDDYEI
LVSKSNTDLYGSDINQLLNDYVCNKPCFHLFTSLGQKCYVSLLPQLYCMIGNSSSGVYETGYWKLPTINIGHRQEGRYMT
SNIICCDNCSESIIQSLKKIETDEFQQMLKYIDNPYGDGNASKRIVEQIKMYFNAVK

Specific function: May be involved in the synthesis of polysialic acid (PSA) [H]

COG id: COG0381

COG function: function code M; UDP-N-acetylglucosamine 2-epimerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI298566312, Length=380, Percent_Identity=27.8947368421053, Blast_Score=135, Evalue=5e-32,
Organism=Homo sapiens, GI4885285, Length=380, Percent_Identity=27.8947368421053, Blast_Score=135, Evalue=7e-32,
Organism=Homo sapiens, GI190014632, Length=380, Percent_Identity=27.8947368421053, Blast_Score=135, Evalue=7e-32,
Organism=Homo sapiens, GI298566325, Length=355, Percent_Identity=27.3239436619718, Blast_Score=121, Evalue=9e-28,
Organism=Homo sapiens, GI298566315, Length=131, Percent_Identity=27.4809160305344, Blast_Score=69, Evalue=6e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020004
- InterPro:   IPR003331 [H]

Pfam domain/function: PF02350 Epimerase_2 [H]

EC number: 5.1.3.14 [C]

Molecular weight: Translated: 42122; Mature: 42122

Theoretical pI: Translated: 5.40; Mature: 5.40

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.7 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
6.9 %Cys+Met (Translated Protein)
2.7 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
6.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKIAVVTGARSEYGLLRWVIDEIHHATELQLQLIVTGGHLSPEQGLTYRCIEEDGYDID
CCEEEEEECCCCHHHHHHHHHHHHCCCCEEEEEEEEECCCCCCCCCCEEEEECCCCCCCC
AKVDMLLSSDCASGIAKSMGMCSIGMSDAFLHLQPDMIVVLGDRYELLPIVGTALVMRIP
HHHHHHHHHHHHHHHHHHCCCEECCCCCCEEEECCCEEEEECCCEEHHHHHHHHHHHHHH
IAHISGGDITEGAIDNEVRNAVTMMSTLHFPGTQTSAARIGRMIGTMKNVFVVGETNLDN
HHCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCEEEEECCCHHH
FLRLSLLSRNELAESLNIDLGKKWILMTYHPVTKESREKNLFDVNSLLHVLQSLGDDYEI
HHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCHHHCCHHHHHHHHHHHHHCCCCEEE
LVSKSNTDLYGSDINQLLNDYVCNKPCFHLFTSLGQKCYVSLLPQLYCMIGNSSSGVYET
EEECCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEC
GYWKLPTINIGHRQEGRYMTSNIICCDNCSESIIQSLKKIETDEFQQMLKYIDNPYGDGN
CCEECCEEECCCCCCCCEEECCEEEECCCHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCC
ASKRIVEQIKMYFNAVK
HHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKKIAVVTGARSEYGLLRWVIDEIHHATELQLQLIVTGGHLSPEQGLTYRCIEEDGYDID
CCEEEEEECCCCHHHHHHHHHHHHCCCCEEEEEEEEECCCCCCCCCCEEEEECCCCCCCC
AKVDMLLSSDCASGIAKSMGMCSIGMSDAFLHLQPDMIVVLGDRYELLPIVGTALVMRIP
HHHHHHHHHHHHHHHHHHCCCEECCCCCCEEEECCCEEEEECCCEEHHHHHHHHHHHHHH
IAHISGGDITEGAIDNEVRNAVTMMSTLHFPGTQTSAARIGRMIGTMKNVFVVGETNLDN
HHCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCEEEEECCCHHH
FLRLSLLSRNELAESLNIDLGKKWILMTYHPVTKESREKNLFDVNSLLHVLQSLGDDYEI
HHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCHHHCCHHHHHHHHHHHHHCCCCEEE
LVSKSNTDLYGSDINQLLNDYVCNKPCFHLFTSLGQKCYVSLLPQLYCMIGNSSSGVYET
EEECCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEC
GYWKLPTINIGHRQEGRYMTSNIICCDNCSESIIQSLKKIETDEFQQMLKYIDNPYGDGN
CCEECCEEECCCCCCCCEEECCEEEECCCHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCC
ASKRIVEQIKMYFNAVK
HHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: UDP-N-acetylglucosamine [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): 0.63 {UDP-N-acetylglucosamine}} 1 {UDP-N-acetylmannosamine}} 0.5 {UDP-N-acetylmannosamine}} [C]

Substrates: UDP-N-acetyl-D-glucosamine [C]

Specific reaction: UDP-N-acetyl-D-glucosamine --> UDP-N-acetyl-D-mannosamine [C]

General reaction: Epimerization [C]

Inhibitor: PCMB [C]

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1729218 [H]