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The map label for this gene is rmlA [H]

Identifier: 150006430

GI number: 150006430

Start: 4864105

End: 4864992

Strand: Direct

Name: rmlA [H]

Synonym: BVU_3949

Alternate gene names: 150006430

Gene position: 4864105-4864992 (Clockwise)

Preceding gene: 150006429

Following gene: 150006431

Centisome position: 94.21

GC content: 48.54

Gene sequence:

>888_bases
ATGAAAGGTATTGTACTAGCCGGAGGTTCGGGCACGCGCCTCTATCCTATTACCAAAGGAGTATCCAAACAGCTGCTGCC
TGTCTTCGACAAACCCATGATTTATTATCCTATATCGGTACTTATGCTGGCCGGCATACGGGAAATACTCATTATCTCCA
CCCCATACGACTTACCGAGCTTCAAAAGACTGTTAGGAGACGGAAGCGATTTCGGAGTACGCTTTGAATATGCGGAACAG
CCTTCGCCCGACGGACTGGCTCAGGCTTTCATCATCGGCGAGAAATTCATCGGAAATGATTCCGTCTGCCTTGTACTGGG
TGATAACATATTCCACGGCAACGGCCTGTCCGCCATGTTGAGAGAATCCGTACGTGCTGCCGAAGAGGACAAGAAAGCAA
CGGTATTCGGCTATTGGGTCAGTGACCCCGAAAGATATGGCGTAGCGGAATTTGACAAGGATGGCAATTGTCTCTCTATT
GAAGAAAAACCTGCCCAACCTAAGTCCAACTATGCCGTGGTGGGACTCTATTTCTATCCCAACAAGGTGGTGGAAGTAGC
CAAGAATATCAAGCCTTCGGCACGGGGAGAACTGGAAATCACCACCGTAAACCAGCAATTTCTTCAGGACAAGGAATTGA
AAGTACAGACATTGGGCAGAGGTTTCGCATGGCTGGATACCGGTACTCACGACTCGCTGGCCGAGGCAAGTACCTACATC
GAAGTCATTGAAAAGCGCCAGGGGCTGAAAGTGGCGTGCCTTGAGGGCATAGCTTTGAGAAAAGGCTGGATTACCCCGGA
AAAGATGCAGGAACTGGCCCAGCCGATGCTTAAAAACCAATACGGACAATATTTACTGAAAGTTATAAAAGAACTGGGAT
TAGAATAA

Upstream 100 bases:

>100_bases
TCGACATCCGCATCATGATAAAAACAGTAACCAACATGTTCCGGGGCGAGAAAAACGCCTATTAATCCAAATCGTAGGGA
CATATAAAAAATAAAAAGAT

Downstream 100 bases:

>100_bases
TGGAAGTTATAAAAACAGCAATAGACGGGGTTTTCATTTTGGAACCCCGTATTTTTAATGATGCAAGAGGGTATTTCTTT
GAAAGCTTCTCGGGACGTGA

Product: glucose-1-phosphate thymidyltransferase

Products: NA

Alternate protein names: dTDP-glucose pyrophosphorylase; dTDP-glucose synthase [H]

Number of amino acids: Translated: 295; Mature: 295

Protein sequence:

>295_residues
MKGIVLAGGSGTRLYPITKGVSKQLLPVFDKPMIYYPISVLMLAGIREILIISTPYDLPSFKRLLGDGSDFGVRFEYAEQ
PSPDGLAQAFIIGEKFIGNDSVCLVLGDNIFHGNGLSAMLRESVRAAEEDKKATVFGYWVSDPERYGVAEFDKDGNCLSI
EEKPAQPKSNYAVVGLYFYPNKVVEVAKNIKPSARGELEITTVNQQFLQDKELKVQTLGRGFAWLDTGTHDSLAEASTYI
EVIEKRQGLKVACLEGIALRKGWITPEKMQELAQPMLKNQYGQYLLKVIKELGLE

Sequences:

>Translated_295_residues
MKGIVLAGGSGTRLYPITKGVSKQLLPVFDKPMIYYPISVLMLAGIREILIISTPYDLPSFKRLLGDGSDFGVRFEYAEQ
PSPDGLAQAFIIGEKFIGNDSVCLVLGDNIFHGNGLSAMLRESVRAAEEDKKATVFGYWVSDPERYGVAEFDKDGNCLSI
EEKPAQPKSNYAVVGLYFYPNKVVEVAKNIKPSARGELEITTVNQQFLQDKELKVQTLGRGFAWLDTGTHDSLAEASTYI
EVIEKRQGLKVACLEGIALRKGWITPEKMQELAQPMLKNQYGQYLLKVIKELGLE
>Mature_295_residues
MKGIVLAGGSGTRLYPITKGVSKQLLPVFDKPMIYYPISVLMLAGIREILIISTPYDLPSFKRLLGDGSDFGVRFEYAEQ
PSPDGLAQAFIIGEKFIGNDSVCLVLGDNIFHGNGLSAMLRESVRAAEEDKKATVFGYWVSDPERYGVAEFDKDGNCLSI
EEKPAQPKSNYAVVGLYFYPNKVVEVAKNIKPSARGELEITTVNQQFLQDKELKVQTLGRGFAWLDTGTHDSLAEASTYI
EVIEKRQGLKVACLEGIALRKGWITPEKMQELAQPMLKNQYGQYLLKVIKELGLE

Specific function: Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis [H]

COG id: COG1209

COG function: function code M; dTDP-glucose pyrophosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucose-1-phosphate thymidylyltransferase family [H]

Homologues:

Organism=Escherichia coli, GI1790224, Length=290, Percent_Identity=66.2068965517241, Blast_Score=400, Evalue=1e-113,
Organism=Escherichia coli, GI1788351, Length=290, Percent_Identity=64.8275862068965, Blast_Score=395, Evalue=1e-111,
Organism=Escherichia coli, GI1788355, Length=239, Percent_Identity=25.9414225941423, Blast_Score=71, Evalue=7e-14,
Organism=Escherichia coli, GI1787488, Length=239, Percent_Identity=24.6861924686192, Blast_Score=68, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI133931050, Length=187, Percent_Identity=26.2032085561497, Blast_Score=68, Evalue=4e-12,
Organism=Saccharomyces cerevisiae, GI6320148, Length=257, Percent_Identity=27.6264591439689, Blast_Score=66, Evalue=5e-12,
Organism=Drosophila melanogaster, GI21355443, Length=256, Percent_Identity=23.828125, Blast_Score=72, Evalue=6e-13,
Organism=Drosophila melanogaster, GI24644084, Length=256, Percent_Identity=23.828125, Blast_Score=72, Evalue=6e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005907
- InterPro:   IPR005835 [H]

Pfam domain/function: PF00483 NTP_transferase [H]

EC number: =2.7.7.24 [H]

Molecular weight: Translated: 32722; Mature: 32722

Theoretical pI: Translated: 5.52; Mature: 5.52

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKGIVLAGGSGTRLYPITKGVSKQLLPVFDKPMIYYPISVLMLAGIREILIISTPYDLPS
CCCEEEECCCCCEEEEECCCCHHHHHHHHCCCEEEHHHHHHHHHCCCEEEEEECCCCCHH
FKRLLGDGSDFGVRFEYAEQPSPDGLAQAFIIGEKFIGNDSVCLVLGDNIFHGNGLSAML
HHHHHCCCCCCCEEEEECCCCCCCHHHHHEEECHHEECCCCEEEEECCCEEECCCHHHHH
RESVRAAEEDKKATVFGYWVSDPERYGVAEFDKDGNCLSIEEKPAQPKSNYAVVGLYFYP
HHHHHHHHCCCCEEEEEEECCCCCCCCCCEECCCCCEEEECCCCCCCCCCEEEEEEEECC
NKVVEVAKNIKPSARGELEITTVNQQFLQDKELKVQTLGRGFAWLDTGTHDSLAEASTYI
HHHHHHHHCCCCCCCCCEEEEECCHHHHCCCCCEEEHHCCCEEEEECCCCHHHHHHHHHH
EVIEKRQGLKVACLEGIALRKGWITPEKMQELAQPMLKNQYGQYLLKVIKELGLE
HHHHHCCCCEEEECCCHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKGIVLAGGSGTRLYPITKGVSKQLLPVFDKPMIYYPISVLMLAGIREILIISTPYDLPS
CCCEEEECCCCCEEEEECCCCHHHHHHHHCCCEEEHHHHHHHHHCCCEEEEEECCCCCHH
FKRLLGDGSDFGVRFEYAEQPSPDGLAQAFIIGEKFIGNDSVCLVLGDNIFHGNGLSAML
HHHHHCCCCCCCEEEEECCCCCCCHHHHHEEECHHEECCCCEEEEECCCEEECCCHHHHH
RESVRAAEEDKKATVFGYWVSDPERYGVAEFDKDGNCLSIEEKPAQPKSNYAVVGLYFYP
HHHHHHHHCCCCEEEEEEECCCCCCCCCCEECCCCCEEEECCCCCCCCCCEEEEEEEECC
NKVVEVAKNIKPSARGELEITTVNQQFLQDKELKVQTLGRGFAWLDTGTHDSLAEASTYI
HHHHHHHHCCCCCCCCCEEEEECCHHHHCCCCCEEEHHCCCEEEEECCCCHHHHHHHHHH
EVIEKRQGLKVACLEGIALRKGWITPEKMQELAQPMLKNQYGQYLLKVIKELGLE
HHHHHCCCCEEEECCCHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12397186 [H]