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The map label for this gene is hisA

Identifier: 150006333

GI number: 150006333

Start: 4752966

End: 4753685

Strand: Direct

Name: hisA

Synonym: BVU_3852

Alternate gene names: 150006333

Gene position: 4752966-4753685 (Clockwise)

Preceding gene: 150006332

Following gene: 150006334

Centisome position: 92.05

GC content: 43.89

Gene sequence:

>720_bases
ATGATAGAGTTAATTCCTGCCATCGACATTATTGATGGCAAATGCGTCCGTCTTTCTCAAGGAGATTATAACACACAGAA
AGTATATAACGAAAACCCGGTTGAGGTTGCCAAAGAATTTGAAGCCCATGGGATTCATCGTCTGCACATTGTCGATCTGG
ATGGAGCAGTTTCACGCCATGTTGTGAATTACCGTGTACTAGACCAAATCGCCAGCCGCACTTCTCTGGTCATTGATTTT
GGAGGAGGGATAAAAACAGACGAGGACCTAGTCATCGCTTTCGACAATGGCGCACAAATGGTAACCCTGGGCAGCGTAGC
CGTGAAAAATCCCGGGCTTTTCAAAAAATGGCTGGAACAATACGGAAACGAGAAAATCATTCTGGGAGCTGATGTAAAGG
AGAATAAAATTTCTGTCAATGGCTGGAAAGAGGAAAGTCAGCAGCAGTTGATCCCTTTTTTGAAAGATTATACTAAAGAA
GGGGTTTTCAAGGTGTTATGTACCGACATCAGCCGTGACGGAATGTTGCAAGGACCTTCCGTGGAACTATACCAGCAAAT
CCTGAAGGAGTTCCCGAATATGCATCTGATAGCCAGCGGAGGAGTAAGCTGTATACAGGACATTATCGACCTGGAAATAG
CCAAAGTTCCGGCTGTTGTTTTCGGCAAGGCATTATACGAGGGAAAAATTACATTGAAAGACTTAAACCGTTTCATGTAA

Upstream 100 bases:

>100_bases
ATCCCGAAAAGAGCGGAGCCGTGGGCGAACGAATCCTGAGGAACTTTTTAGAATTGTGAACCATTACATTATATATAACA
ATGTATAAGAAGAAATAGAT

Downstream 100 bases:

>100_bases
AAGCAAATCATGTTAGCAAAAAGAATCATACCTTGCCTGGACATCAAAGACGGGCAGACCGTAAAAGGAACCAATTTCGT
AAACTTACGTCAAGCAGGTG

Product: imidazole-4-carboxamide isomerase

Products: NA

Alternate protein names: Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase

Number of amino acids: Translated: 239; Mature: 239

Protein sequence:

>239_residues
MIELIPAIDIIDGKCVRLSQGDYNTQKVYNENPVEVAKEFEAHGIHRLHIVDLDGAVSRHVVNYRVLDQIASRTSLVIDF
GGGIKTDEDLVIAFDNGAQMVTLGSVAVKNPGLFKKWLEQYGNEKIILGADVKENKISVNGWKEESQQQLIPFLKDYTKE
GVFKVLCTDISRDGMLQGPSVELYQQILKEFPNMHLIASGGVSCIQDIIDLEIAKVPAVVFGKALYEGKITLKDLNRFM

Sequences:

>Translated_239_residues
MIELIPAIDIIDGKCVRLSQGDYNTQKVYNENPVEVAKEFEAHGIHRLHIVDLDGAVSRHVVNYRVLDQIASRTSLVIDF
GGGIKTDEDLVIAFDNGAQMVTLGSVAVKNPGLFKKWLEQYGNEKIILGADVKENKISVNGWKEESQQQLIPFLKDYTKE
GVFKVLCTDISRDGMLQGPSVELYQQILKEFPNMHLIASGGVSCIQDIIDLEIAKVPAVVFGKALYEGKITLKDLNRFM
>Mature_239_residues
MIELIPAIDIIDGKCVRLSQGDYNTQKVYNENPVEVAKEFEAHGIHRLHIVDLDGAVSRHVVNYRVLDQIASRTSLVIDF
GGGIKTDEDLVIAFDNGAQMVTLGSVAVKNPGLFKKWLEQYGNEKIILGADVKENKISVNGWKEESQQQLIPFLKDYTKE
GVFKVLCTDISRDGMLQGPSVELYQQILKEFPNMHLIASGGVSCIQDIIDLEIAKVPAVVFGKALYEGKITLKDLNRFM

Specific function: Histidine biosynthesis; fourth step. [C]

COG id: COG0106

COG function: function code E; Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hisA/hisF family

Homologues:

Organism=Escherichia coli, GI87082028, Length=236, Percent_Identity=36.0169491525424, Blast_Score=171, Evalue=5e-44,
Organism=Escherichia coli, GI1788336, Length=248, Percent_Identity=21.3709677419355, Blast_Score=65, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS4_BACV8 (A6L6Z1)

Other databases:

- EMBL:   CP000139
- RefSeq:   YP_001301077.1
- STRING:   A6L6Z1
- GeneID:   5304811
- GenomeReviews:   CP000139_GR
- KEGG:   bvu:BVU_3852
- NMPDR:   fig|435590.6.peg.3569
- eggNOG:   COG0106
- HOGENOM:   HBG541613
- OMA:   SIIYTDI
- ProtClustDB:   CLSK822682
- GO:   GO:0005737
- HAMAP:   MF_01014
- InterPro:   IPR013785
- InterPro:   IPR006062
- InterPro:   IPR006063
- InterPro:   IPR023016
- InterPro:   IPR011060
- Gene3D:   G3DSA:3.20.20.70
- TIGRFAMs:   TIGR00007

Pfam domain/function: PF00977 His_biosynth; SSF51366 RibP_bind_barrel

EC number: =5.3.1.16

Molecular weight: Translated: 26635; Mature: 26635

Theoretical pI: Translated: 5.16; Mature: 5.16

Prosite motif: NA

Important sites: ACT_SITE 9-9 ACT_SITE 131-131

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIELIPAIDIIDGKCVRLSQGDYNTQKVYNENPVEVAKEFEAHGIHRLHIVDLDGAVSRH
CEEEECCEEECCCCEEEECCCCCCHHHCCCCCHHHHHHHHHHCCEEEEEEEECCCHHHHH
VVNYRVLDQIASRTSLVIDFGGGIKTDEDLVIAFDNGAQMVTLGSVAVKNPGLFKKWLEQ
HHHHHHHHHHHCCCEEEEECCCCCCCCCCEEEEECCCCEEEEECCEEECCCCHHHHHHHH
YGNEKIILGADVKENKISVNGWKEESQQQLIPFLKDYTKEGVFKVLCTDISRDGMLQGPS
HCCCEEEEECCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHEEEEEHHCCCCCCCCCCC
VELYQQILKEFPNMHLIASGGVSCIQDIIDLEIAKVPAVVFGKALYEGKITLKDLNRFM
HHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHCCHHHHHHHHHCCCEEHHHHHHCC
>Mature Secondary Structure
MIELIPAIDIIDGKCVRLSQGDYNTQKVYNENPVEVAKEFEAHGIHRLHIVDLDGAVSRH
CEEEECCEEECCCCEEEECCCCCCHHHCCCCCHHHHHHHHHHCCEEEEEEEECCCHHHHH
VVNYRVLDQIASRTSLVIDFGGGIKTDEDLVIAFDNGAQMVTLGSVAVKNPGLFKKWLEQ
HHHHHHHHHHHCCCEEEEECCCCCCCCCCEEEEECCCCEEEEECCEEECCCCHHHHHHHH
YGNEKIILGADVKENKISVNGWKEESQQQLIPFLKDYTKEGVFKVLCTDISRDGMLQGPS
HCCCEEEEECCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHEEEEEHHCCCCCCCCCCC
VELYQQILKEFPNMHLIASGGVSCIQDIIDLEIAKVPAVVFGKALYEGKITLKDLNRFM
HHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHCCHHHHHHHHHCCCEEHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA