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The map label for this gene is pyrD

Identifier: 150005813

GI number: 150005813

Start: 4145113

End: 4146024

Strand: Reverse

Name: pyrD

Synonym: BVU_3309

Alternate gene names: 150005813

Gene position: 4146024-4145113 (Counterclockwise)

Preceding gene: 150005814

Following gene: 150005810

Centisome position: 80.3

GC content: 43.86

Gene sequence:

>912_bases
ATGGCAGATTTAAGCGTAAATATCGGCGATTTAAAGCTTTGTAACCCGGTTATGACAGCATCGGGTACCTTTGGATACGG
AAAAGAGTTTGAGGATTTTGTAGACCTCGAAAAGATTGGTGGTATCATTGTAAAAGGGACTACCCTTCATCATCGTGAGG
GTAATCCTTACCCACGCATGGCAGAAACCCCTATGGGGATGCTTAATGCGGTAGGGTTACAGAATAAAGGGGTGGATTAT
TTTGTTGAACATATCTATCCGCAGATAAGGGATATTCATACTAATATGATCGTTAATGTATCCGGATCTGCTGTAGAGGA
TTATGTGAAGACTGCCGAGATCATCAATGATCTGGATCATATTCCCGCTATAGAATTGAATATTTCATGCCCTAATGTAA
AGCAGGGTGGTATGGCCTTCGGGGTCTCCGCATGCGGATGTTCCGAGGTTGTAAAAGCTGTACGTAATGTATATAAAAAG
ACGCTGATCGTAAAATTATCTCCCAATGTGACAGACATCACAGAAATAGCACGTGCGGCCGAGGCTTCCGGTGCGGACAG
TGTATCTCTGATCAATACCCTGCTGGGGATGGCTGTCGATGCTGAAAAGCGTAGGCCTGTACTTTCCACTATTACCGGCG
GCATGAGTGGTGCAGCGGTAAAACCAATTGCATTGCGTATGGTATGGCAAGTCGCTAAAGCAGTAAATATTCCTGTCATT
GGACTAGGGGGTATCATGGGATGGAAGGATGCTGTGGAGTTTATGCTAGCAGGTGCCACCGCAATACAGATAGGTACTGC
CAACTTCATAGATCCAGCTATTACTGTCAAAGTTTCAGAAGGAATAAATGACTATTTGGAACGTCATGGATATACATCTG
TAAAAGATATAATAGGTGCTTTGGAAGTCTGA

Upstream 100 bases:

>100_bases
CTTGTGGTGTCGGTGCATGCTTATGCTGTGTGGAGAACACGGACGAAGGGCATTTGTGTGTTTGTAAAGAGGGTCCTGTA
TTTAATATAAAGAAACTATT

Downstream 100 bases:

>100_bases
AAATTTTATCTTTTAAATTATAGCCCTGCGAGAGTGTAGATGAATAAATTGAAGCATCTCTTGCAGGGCTTTTTTTATAA
CCTTCTCTAGATGGAATGAG

Product: dihydroorotate dehydrogenase 1B

Products: NA

Alternate protein names: DHOdehase; DHOD; DHODase; Dihydroorotate oxidase

Number of amino acids: Translated: 303; Mature: 302

Protein sequence:

>303_residues
MADLSVNIGDLKLCNPVMTASGTFGYGKEFEDFVDLEKIGGIIVKGTTLHHREGNPYPRMAETPMGMLNAVGLQNKGVDY
FVEHIYPQIRDIHTNMIVNVSGSAVEDYVKTAEIINDLDHIPAIELNISCPNVKQGGMAFGVSACGCSEVVKAVRNVYKK
TLIVKLSPNVTDITEIARAAEASGADSVSLINTLLGMAVDAEKRRPVLSTITGGMSGAAVKPIALRMVWQVAKAVNIPVI
GLGGIMGWKDAVEFMLAGATAIQIGTANFIDPAITVKVSEGINDYLERHGYTSVKDIIGALEV

Sequences:

>Translated_303_residues
MADLSVNIGDLKLCNPVMTASGTFGYGKEFEDFVDLEKIGGIIVKGTTLHHREGNPYPRMAETPMGMLNAVGLQNKGVDY
FVEHIYPQIRDIHTNMIVNVSGSAVEDYVKTAEIINDLDHIPAIELNISCPNVKQGGMAFGVSACGCSEVVKAVRNVYKK
TLIVKLSPNVTDITEIARAAEASGADSVSLINTLLGMAVDAEKRRPVLSTITGGMSGAAVKPIALRMVWQVAKAVNIPVI
GLGGIMGWKDAVEFMLAGATAIQIGTANFIDPAITVKVSEGINDYLERHGYTSVKDIIGALEV
>Mature_302_residues
ADLSVNIGDLKLCNPVMTASGTFGYGKEFEDFVDLEKIGGIIVKGTTLHHREGNPYPRMAETPMGMLNAVGLQNKGVDYF
VEHIYPQIRDIHTNMIVNVSGSAVEDYVKTAEIINDLDHIPAIELNISCPNVKQGGMAFGVSACGCSEVVKAVRNVYKKT
LIVKLSPNVTDITEIARAAEASGADSVSLINTLLGMAVDAEKRRPVLSTITGGMSGAAVKPIALRMVWQVAKAVNIPVIG
LGGIMGWKDAVEFMLAGATAIQIGTANFIDPAITVKVSEGINDYLERHGYTSVKDIIGALEV

Specific function: Unknown

COG id: COG0167

COG function: function code F; Dihydroorotate dehydrogenase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily

Homologues:

Organism=Homo sapiens, GI119943098, Length=300, Percent_Identity=29, Blast_Score=99, Evalue=4e-21,
Organism=Homo sapiens, GI45006951, Length=321, Percent_Identity=25.5451713395639, Blast_Score=89, Evalue=5e-18,
Organism=Escherichia coli, GI87082059, Length=318, Percent_Identity=26.4150943396226, Blast_Score=100, Evalue=9e-23,
Organism=Caenorhabditis elegans, GI71984108, Length=213, Percent_Identity=32.8638497652582, Blast_Score=96, Evalue=2e-20,
Organism=Saccharomyces cerevisiae, GI6322633, Length=305, Percent_Identity=32.1311475409836, Blast_Score=124, Evalue=2e-29,
Organism=Drosophila melanogaster, GI24640763, Length=265, Percent_Identity=31.3207547169811, Blast_Score=99, Evalue=3e-21,
Organism=Drosophila melanogaster, GI18858217, Length=265, Percent_Identity=31.3207547169811, Blast_Score=99, Evalue=3e-21,
Organism=Drosophila melanogaster, GI281361352, Length=313, Percent_Identity=28.1150159744409, Blast_Score=76, Evalue=4e-14,
Organism=Drosophila melanogaster, GI17137316, Length=313, Percent_Identity=28.1150159744409, Blast_Score=76, Evalue=4e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PYRD_BACV8 (A6L5H1)

Other databases:

- EMBL:   CP000139
- RefSeq:   YP_001300557.1
- ProteinModelPortal:   A6L5H1
- SMR:   A6L5H1
- STRING:   A6L5H1
- GeneID:   5304270
- GenomeReviews:   CP000139_GR
- KEGG:   bvu:BVU_3309
- NMPDR:   fig|435590.6.peg.3084
- eggNOG:   COG0167
- HOGENOM:   HBG472415
- OMA:   NSIGLQN
- ProtClustDB:   PRK07259
- GO:   GO:0005737
- HAMAP:   MF_00224_B
- InterPro:   IPR013785
- InterPro:   IPR005720
- InterPro:   IPR012135
- InterPro:   IPR001295
- Gene3D:   G3DSA:3.20.20.70
- PIRSF:   PIRSF000164
- TIGRFAMs:   TIGR01037

Pfam domain/function: PF01180 DHO_dh

EC number: =1.3.3.1

Molecular weight: Translated: 32304; Mature: 32173

Theoretical pI: Translated: 5.37; Mature: 5.37

Prosite motif: PS00911 DHODEHASE_1; PS00912 DHODEHASE_2

Important sites: ACT_SITE 130-130

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADLSVNIGDLKLCNPVMTASGTFGYGKEFEDFVDLEKIGGIIVKGTTLHHREGNPYPRM
CCCCCCCCCCEECCCHHHHCCCCCCCCCCHHHHHHHHHHCCEEEECCEEECCCCCCCCCC
AETPMGMLNAVGLQNKGVDYFVEHIYPQIRDIHTNMIVNVSGSAVEDYVKTAEIINDLDH
CCCCHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHHHHC
IPAIELNISCPNVKQGGMAFGVSACGCSEVVKAVRNVYKKTLIVKLSPNVTDITEIARAA
CCEEEEEECCCCCCCCCEEECCHHCCHHHHHHHHHHHHHHEEEEEECCCCHHHHHHHHHH
EASGADSVSLINTLLGMAVDAEKRRPVLSTITGGMSGAAVKPIALRMVWQVAKAVNIPVI
HCCCCCHHHHHHHHHHHHCCHHHCCCHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCEE
GLGGIMGWKDAVEFMLAGATAIQIGTANFIDPAITVKVSEGINDYLERHGYTSVKDIIGA
ECCCCCCHHHHHHHHHHCCEEEEECCCCCCCCEEEEEECCCHHHHHHHCCCCHHHHHHHH
LEV
HCC
>Mature Secondary Structure 
ADLSVNIGDLKLCNPVMTASGTFGYGKEFEDFVDLEKIGGIIVKGTTLHHREGNPYPRM
CCCCCCCCCEECCCHHHHCCCCCCCCCCHHHHHHHHHHCCEEEECCEEECCCCCCCCCC
AETPMGMLNAVGLQNKGVDYFVEHIYPQIRDIHTNMIVNVSGSAVEDYVKTAEIINDLDH
CCCCHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHHHHC
IPAIELNISCPNVKQGGMAFGVSACGCSEVVKAVRNVYKKTLIVKLSPNVTDITEIARAA
CCEEEEEECCCCCCCCCEEECCHHCCHHHHHHHHHHHHHHEEEEEECCCCHHHHHHHHHH
EASGADSVSLINTLLGMAVDAEKRRPVLSTITGGMSGAAVKPIALRMVWQVAKAVNIPVI
HCCCCCHHHHHHHHHHHHCCHHHCCCHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCEE
GLGGIMGWKDAVEFMLAGATAIQIGTANFIDPAITVKVSEGINDYLERHGYTSVKDIIGA
ECCCCCCHHHHHHHHHHCCEEEEECCCCCCCCEEEEEECCCHHHHHHHCCCCHHHHHHHH
LEV
HCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA