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The map label for this gene is dapA

Identifier: 150005809

GI number: 150005809

Start: 4140982

End: 4141875

Strand: Reverse

Name: dapA

Synonym: BVU_3305

Alternate gene names: 150005809

Gene position: 4141875-4140982 (Counterclockwise)

Preceding gene: 150005810

Following gene: 150005805

Centisome position: 80.22

GC content: 41.05

Gene sequence:

>894_bases
ATGATACAGACAAGATTAAAAGGCATGGGAGTAGCGTTGATTACTCCTTTCAAGGAAGATGACAGCGTTGATTATGATGC
GTTACTTCGTCTGGTTGATTACCAGCTTCAAAATGGAACAGACTTTTTATGCGTGTTGGGAACCACGGCTGAAACCCCAA
CTTTGACTAAAGAAGAAAAAGACAAGATAAAACGTTTGATAATCGAAAGAGTGAATGGACGTATTCCTATTCTGCTGGGG
GTTAGCAGTAACTGTACCCGTGCTGTTGTGGAAACGCTGAAAAATGATGATATGACAGGAGTTGATGCCGTGCTTGTTGC
TGTACCTTATTATAACAAACCTTCTCAGGAAGGTATTTACCAACACTATAAAGCGATTGCTGAAGCAACGGATCTTCCTG
TGGTTCTTTATAATGTGCCGGGACGTACTGGTGTGAACATGACTGCTGAGACCACCTTGCGTTTGGCACGTGATTTCAAG
AATATTATCGCTATCAAGGAGGCATCGGGTAATATTACTCAGATGGATGATATCATCAAGAATAAACCGGCTAATTTTGA
TGTGATTTCGGGTGATGATGGTATTACATTTCCTTTGATTACTTTGGGTGCTGTAGGGGTTATTTCGGTTATCGGTAATG
CATTTCCGCGTGAATTCAGCCGTATGACCCGTTTGGCATTACAGGGTGATTTTGCAAATGCATTGACTATTCATCATAAG
TTTACGGAATTATTCAGCCTGTTGTTCGTAGATGGTAACCCTGCTGGGGTGAAGGCTATGTTGAATGTAATGGGGCTGAT
TGAAAACAAATTGCGTTTGCCGCTTGTACCGACTCGTATCACAACATTTGAAAAGATGCGTGCTATTTTGAATGAATTGA
AAATAAAATGCTGA

Upstream 100 bases:

>100_bases
TTTTTAGCGAGTATAAAGTAAAAATAGTGTGATTTTTATCGCTAAAATAGAAAATATTCGTACTTTTGTAGGCTATTAAA
TAAGAATTTATAATTCATTT

Downstream 100 bases:

>100_bases
TAAAGGAATCTTTTTAATTAGATAAGACTGGTGCTTCTCATATAAAAAACACCAGTCTTTTTTTATGCCTACCTGTTCAT
TCTTTGATATATATGTTATA

Product: dihydrodipicolinate synthase

Products: NA

Alternate protein names: DHDPS

Number of amino acids: Translated: 297; Mature: 297

Protein sequence:

>297_residues
MIQTRLKGMGVALITPFKEDDSVDYDALLRLVDYQLQNGTDFLCVLGTTAETPTLTKEEKDKIKRLIIERVNGRIPILLG
VSSNCTRAVVETLKNDDMTGVDAVLVAVPYYNKPSQEGIYQHYKAIAEATDLPVVLYNVPGRTGVNMTAETTLRLARDFK
NIIAIKEASGNITQMDDIIKNKPANFDVISGDDGITFPLITLGAVGVISVIGNAFPREFSRMTRLALQGDFANALTIHHK
FTELFSLLFVDGNPAGVKAMLNVMGLIENKLRLPLVPTRITTFEKMRAILNELKIKC

Sequences:

>Translated_297_residues
MIQTRLKGMGVALITPFKEDDSVDYDALLRLVDYQLQNGTDFLCVLGTTAETPTLTKEEKDKIKRLIIERVNGRIPILLG
VSSNCTRAVVETLKNDDMTGVDAVLVAVPYYNKPSQEGIYQHYKAIAEATDLPVVLYNVPGRTGVNMTAETTLRLARDFK
NIIAIKEASGNITQMDDIIKNKPANFDVISGDDGITFPLITLGAVGVISVIGNAFPREFSRMTRLALQGDFANALTIHHK
FTELFSLLFVDGNPAGVKAMLNVMGLIENKLRLPLVPTRITTFEKMRAILNELKIKC
>Mature_297_residues
MIQTRLKGMGVALITPFKEDDSVDYDALLRLVDYQLQNGTDFLCVLGTTAETPTLTKEEKDKIKRLIIERVNGRIPILLG
VSSNCTRAVVETLKNDDMTGVDAVLVAVPYYNKPSQEGIYQHYKAIAEATDLPVVLYNVPGRTGVNMTAETTLRLARDFK
NIIAIKEASGNITQMDDIIKNKPANFDVISGDDGITFPLITLGAVGVISVIGNAFPREFSRMTRLALQGDFANALTIHHK
FTELFSLLFVDGNPAGVKAMLNVMGLIENKLRLPLVPTRITTFEKMRAILNELKIKC

Specific function: Biosynthesis of diaminopimelate and lysine from aspartate semialdehyde; first step. [C]

COG id: COG0329

COG function: function code EM; Dihydrodipicolinate synthase/N-acetylneuraminate lyase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHDPS family

Homologues:

Organism=Homo sapiens, GI31543060, Length=281, Percent_Identity=26.3345195729537, Blast_Score=109, Evalue=3e-24,
Organism=Homo sapiens, GI13540533, Length=284, Percent_Identity=22.5352112676056, Blast_Score=71, Evalue=1e-12,
Organism=Escherichia coli, GI1788823, Length=283, Percent_Identity=40.6360424028269, Blast_Score=221, Evalue=4e-59,
Organism=Escherichia coli, GI87082415, Length=243, Percent_Identity=29.6296296296296, Blast_Score=119, Evalue=2e-28,
Organism=Escherichia coli, GI1786463, Length=240, Percent_Identity=30, Blast_Score=119, Evalue=2e-28,
Organism=Escherichia coli, GI1789620, Length=292, Percent_Identity=28.0821917808219, Blast_Score=118, Evalue=4e-28,

Paralogues:

None

Copy number: 840 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): DAPA_BACV8 (A6L5G7)

Other databases:

- EMBL:   CP000139
- RefSeq:   YP_001300553.1
- ProteinModelPortal:   A6L5G7
- SMR:   A6L5G7
- STRING:   A6L5G7
- GeneID:   5304266
- GenomeReviews:   CP000139_GR
- KEGG:   bvu:BVU_3305
- NMPDR:   fig|435590.6.peg.3081
- eggNOG:   COG0329
- HOGENOM:   HBG358848
- OMA:   QKGLIEH
- ProtClustDB:   PRK03170
- GO:   GO:0005737
- HAMAP:   MF_00418
- InterPro:   IPR013785
- InterPro:   IPR005263
- InterPro:   IPR002220
- InterPro:   IPR020625
- Gene3D:   G3DSA:3.20.20.70
- PANTHER:   PTHR12128
- PRINTS:   PR00146
- TIGRFAMs:   TIGR00674

Pfam domain/function: PF00701 DHDPS

EC number: =4.2.1.52

Molecular weight: Translated: 32788; Mature: 32788

Theoretical pI: Translated: 7.43; Mature: 7.43

Prosite motif: PS00665 DHDPS_1; PS00666 DHDPS_2

Important sites: ACT_SITE 166-166 BINDING 110-110

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIQTRLKGMGVALITPFKEDDSVDYDALLRLVDYQLQNGTDFLCVLGTTAETPTLTKEEK
CCCCHHCCCCEEEEECCCCCCCCCHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCHHHH
DKIKRLIIERVNGRIPILLGVSSNCTRAVVETLKNDDMTGVDAVLVAVPYYNKPSQEGIY
HHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHCCCCCCCCCEEEEEECCCCCCCHHHHH
QHYKAIAEATDLPVVLYNVPGRTGVNMTAETTLRLARDFKNIIAIKEASGNITQMDDIIK
HHHHHHHHHCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHEEEECCCCCCHHHHHHHH
NKPANFDVISGDDGITFPLITLGAVGVISVIGNAFPREFSRMTRLALQGDFANALTIHHK
CCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCHHEEHHHH
FTELFSLLFVDGNPAGVKAMLNVMGLIENKLRLPLVPTRITTFEKMRAILNELKIKC
HHHHHHEEEECCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MIQTRLKGMGVALITPFKEDDSVDYDALLRLVDYQLQNGTDFLCVLGTTAETPTLTKEEK
CCCCHHCCCCEEEEECCCCCCCCCHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCHHHH
DKIKRLIIERVNGRIPILLGVSSNCTRAVVETLKNDDMTGVDAVLVAVPYYNKPSQEGIY
HHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHCCCCCCCCCEEEEEECCCCCCCHHHHH
QHYKAIAEATDLPVVLYNVPGRTGVNMTAETTLRLARDFKNIIAIKEASGNITQMDDIIK
HHHHHHHHHCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHEEEECCCCCCHHHHHHHH
NKPANFDVISGDDGITFPLITLGAVGVISVIGNAFPREFSRMTRLALQGDFANALTIHHK
CCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCHHEEHHHH
FTELFSLLFVDGNPAGVKAMLNVMGLIENKLRLPLVPTRITTFEKMRAILNELKIKC
HHHHHHEEEECCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA