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The map label for this gene is gyrA [H]

Identifier: 150005805

GI number: 150005805

Start: 4130187

End: 4132754

Strand: Reverse

Name: gyrA [H]

Synonym: BVU_3298

Alternate gene names: 150005805

Gene position: 4132754-4130187 (Counterclockwise)

Preceding gene: 150005809

Following gene: 150005804

Centisome position: 80.04

GC content: 38.9

Gene sequence:

>2568_bases
ATGCTAGAACAAGACAGAATTATAAAGATTAACATCGAAGAGGAAATGAAGTCGTCGTACATTGATTACTCAATGTCAGT
AATTGTTGCGCGCGCCCTCCCGGATGTTCGCGATGGCTTTAAACCGGTTCATAGACGTATCTTATATGGTATGATTGAAC
TGGGAAATACCTCCGATAAAGCTTATAAGAAATCAGCAAGAATTGTAGGTGAAGTTTTGGGTAAATATCACCCGCATGGT
GACTCTTCCGTGTATGGAGCTTTGGTCAGAATGGCTCAGGATTGGGCTATGAGATATCCGTTGGTAGATGGTCAGGGTAA
CTTCGGCTCTGTTGATGGTGACAGCCCTGCTGCCATGCGTTATACGGAAGCAAGATTAAAGAAAATAGGTGAAGAGATGA
TGCAGGATCTTTATAAGGAAACTGTTGATTTTCAGAATAATTTTGATGACACGTTGCAGGAACCGACTGTCATGCCAACA
CGGATTCCTAACTTGTTGGTAAATGGAGCATCCGGTATTGCTGTAGGTATGGCAACCAATATGCCTACCCATAATCTTTC
TGAAGTAATCGATGCATGTATTGCTTACATTGACAATAATGATATTGATATTGAAGGGCTTATGCAATATGTAAAAGCAC
CGGATTTCCCTACAGGTGGATATATATATGGTATAAGCGGGGTACGCGATGCTTACGAAACCGGACGTGGTAGAGTAGTG
ATGCGTGCTAAGGCTGAGATAGAAACTCATACTACACATGACAAGATCATAGTTAATGAAATTCCTTATAATGTAAATAA
GAAGGAATTGATTGAAAATATCGCATCTTTAGTCAATGACAAGAAGATTGATGGTATTTCGTATGTAAATGATGAATCCG
ACCGTGAAGGTATGCGTATTGTTATTGATGTTAAACGTGATGCAAATGCTAGTGTGGTGCTGAACAAATTGTTCAAAATG
ACAGCTCTGCAAACTTCATTTGGAGTAAATAATATCGCTCTGGTCCATGGTCGCCCCAAAATGTTGAATCTGAAAGATTT
AATCAGATATTTTGTAGAACATCGTCATGATGTGGTAATTCGTCGTACTCAGTATGATTTACGGAAGGCACAGGAGCGTG
CTCATATTCTTGAAGGATTGATTATAGCTTCTGATAATATTGATGAAGTGATCCGTATTATTCGTGCTGCAAAAACCCCT
AATGATGCCATAGCAGGGTTAATAGAGCGTTTTAATCTGAGTGAAATTCAGGCACGTGCTATTGTAGAAATGCGTTTGCG
CCAATTAACAGGTTTGATGCAAGATCAGCTTCACGCAGAATATGAAGAGGTGATGAAACAGATTGCTTATTATGAAGAAA
TTCTTTCAAATGATGAACTTTGTAAAAAAGTAATCAAAGATGAGTTAGTAGAGGTAAAAGAGAAGTATGGGGACGCGCGT
CGGTCTGAAATAGTTTATTCTTCAGAAGAATTTAATCCGGAAGATTTTTATGCTGATGATCAGATGGTTATCACGATATC
TCATATGGGATATATCAAACGTACTCCTTTATCAGAATTCCGTGCCCAAAATAGGGGTGGAGTTGGATCAAAAGGAAGTG
AAACCCGTGATGAAGACTTTGTAGAGCATATTTATCCGGCTACAATGCACAATACTATGATGTTCTTCACTCAGAAAGGT
AAGTGCTATTGGTTGAAAGTTTACGAAATTCCCGAAGGAACTAAAAATGCTAAAGGACGCGCTATTCAGAATTTGCTGAA
TATTGATTCCGATGACGTGGTTACAGCATATCTACGTGTGAAAAACCTTAATGATACCGAGTTCATTAACAGCCATTATG
TGCTGTTCTGTACAAAGAATGGCGTCATTAAAAAGACTTTGTTGGAACAATACTCACGGCCTCGCCAGAATGGTGTTAAT
GCGATAACTATTCGTGAGGATGATAAAGTGATTGAAGTTCGTATGACTAACGGTGATAATGAAATCATTATTGCTAACCG
TAACGGGCGTGCAATTCGCTTTCACGAAAGTGCGGTTCGTGTTATGGGACGTACGGCTACAGGGGTGCGTGGTATGACTT
TGGATGAAGATGGTGGCGATGAAGTTATCGGTATGATTTGTATAAAAGATCCTGAAGCTGAATCAATTATGGTAGTTTCT
GAACAAGGATACGGTAAACGTTCTGATATCGAAGATTATCGTAAGACCAATCGTGGCGGTAAGGGTGTAAAAACGTTGAA
TATTACAGATAAAACGGGTAAATTGGTAGCTATCAAGTCTGTTACAGATGAGAATGACTTGATGATTATTAATAAATCTG
GTATTACAATTCGTTTAAAAGTCGCTGAAGTCCGCATCATGGGACGTGCAACACAAGGTGTGCGATTGATAAATTTGGAG
AAACGTAATGACCAAATAGGCTCTGTATGTAAGGTGACATCTGAAGAAGAGGTTACAGATGAAAATTCAAATACAGATCT
TGAAAATATAACTGAAGGAGAGAGTGGTGGTACTACTAATTCTGATACTAATTCAGATTTAACTGCCGAAGCAAATAGTG
AAGAATAA

Upstream 100 bases:

>100_bases
CTTAACTTTTTTATGGGTTTTGTTTCGTATGTCGTATAAAAGTAGTACTTTAGCGTGGTTTTTGGTAAACCAAAAAGATG
TATAATTAATATTTGTTTAA

Downstream 100 bases:

>100_bases
AATAAATTGTATTATTAAATCCACAAAATCATGAGAAAAGTATTATTTACAGTGGCTTTATTGTTAACAGCTTGCTTTGT
GTCTGCACAAGTAAGTGTTG

Product: DNA gyrase A subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 855; Mature: 855

Protein sequence:

>855_residues
MLEQDRIIKINIEEEMKSSYIDYSMSVIVARALPDVRDGFKPVHRRILYGMIELGNTSDKAYKKSARIVGEVLGKYHPHG
DSSVYGALVRMAQDWAMRYPLVDGQGNFGSVDGDSPAAMRYTEARLKKIGEEMMQDLYKETVDFQNNFDDTLQEPTVMPT
RIPNLLVNGASGIAVGMATNMPTHNLSEVIDACIAYIDNNDIDIEGLMQYVKAPDFPTGGYIYGISGVRDAYETGRGRVV
MRAKAEIETHTTHDKIIVNEIPYNVNKKELIENIASLVNDKKIDGISYVNDESDREGMRIVIDVKRDANASVVLNKLFKM
TALQTSFGVNNIALVHGRPKMLNLKDLIRYFVEHRHDVVIRRTQYDLRKAQERAHILEGLIIASDNIDEVIRIIRAAKTP
NDAIAGLIERFNLSEIQARAIVEMRLRQLTGLMQDQLHAEYEEVMKQIAYYEEILSNDELCKKVIKDELVEVKEKYGDAR
RSEIVYSSEEFNPEDFYADDQMVITISHMGYIKRTPLSEFRAQNRGGVGSKGSETRDEDFVEHIYPATMHNTMMFFTQKG
KCYWLKVYEIPEGTKNAKGRAIQNLLNIDSDDVVTAYLRVKNLNDTEFINSHYVLFCTKNGVIKKTLLEQYSRPRQNGVN
AITIREDDKVIEVRMTNGDNEIIIANRNGRAIRFHESAVRVMGRTATGVRGMTLDEDGGDEVIGMICIKDPEAESIMVVS
EQGYGKRSDIEDYRKTNRGGKGVKTLNITDKTGKLVAIKSVTDENDLMIINKSGITIRLKVAEVRIMGRATQGVRLINLE
KRNDQIGSVCKVTSEEEVTDENSNTDLENITEGESGGTTNSDTNSDLTAEANSEE

Sequences:

>Translated_855_residues
MLEQDRIIKINIEEEMKSSYIDYSMSVIVARALPDVRDGFKPVHRRILYGMIELGNTSDKAYKKSARIVGEVLGKYHPHG
DSSVYGALVRMAQDWAMRYPLVDGQGNFGSVDGDSPAAMRYTEARLKKIGEEMMQDLYKETVDFQNNFDDTLQEPTVMPT
RIPNLLVNGASGIAVGMATNMPTHNLSEVIDACIAYIDNNDIDIEGLMQYVKAPDFPTGGYIYGISGVRDAYETGRGRVV
MRAKAEIETHTTHDKIIVNEIPYNVNKKELIENIASLVNDKKIDGISYVNDESDREGMRIVIDVKRDANASVVLNKLFKM
TALQTSFGVNNIALVHGRPKMLNLKDLIRYFVEHRHDVVIRRTQYDLRKAQERAHILEGLIIASDNIDEVIRIIRAAKTP
NDAIAGLIERFNLSEIQARAIVEMRLRQLTGLMQDQLHAEYEEVMKQIAYYEEILSNDELCKKVIKDELVEVKEKYGDAR
RSEIVYSSEEFNPEDFYADDQMVITISHMGYIKRTPLSEFRAQNRGGVGSKGSETRDEDFVEHIYPATMHNTMMFFTQKG
KCYWLKVYEIPEGTKNAKGRAIQNLLNIDSDDVVTAYLRVKNLNDTEFINSHYVLFCTKNGVIKKTLLEQYSRPRQNGVN
AITIREDDKVIEVRMTNGDNEIIIANRNGRAIRFHESAVRVMGRTATGVRGMTLDEDGGDEVIGMICIKDPEAESIMVVS
EQGYGKRSDIEDYRKTNRGGKGVKTLNITDKTGKLVAIKSVTDENDLMIINKSGITIRLKVAEVRIMGRATQGVRLINLE
KRNDQIGSVCKVTSEEEVTDENSNTDLENITEGESGGTTNSDTNSDLTAEANSEE
>Mature_855_residues
MLEQDRIIKINIEEEMKSSYIDYSMSVIVARALPDVRDGFKPVHRRILYGMIELGNTSDKAYKKSARIVGEVLGKYHPHG
DSSVYGALVRMAQDWAMRYPLVDGQGNFGSVDGDSPAAMRYTEARLKKIGEEMMQDLYKETVDFQNNFDDTLQEPTVMPT
RIPNLLVNGASGIAVGMATNMPTHNLSEVIDACIAYIDNNDIDIEGLMQYVKAPDFPTGGYIYGISGVRDAYETGRGRVV
MRAKAEIETHTTHDKIIVNEIPYNVNKKELIENIASLVNDKKIDGISYVNDESDREGMRIVIDVKRDANASVVLNKLFKM
TALQTSFGVNNIALVHGRPKMLNLKDLIRYFVEHRHDVVIRRTQYDLRKAQERAHILEGLIIASDNIDEVIRIIRAAKTP
NDAIAGLIERFNLSEIQARAIVEMRLRQLTGLMQDQLHAEYEEVMKQIAYYEEILSNDELCKKVIKDELVEVKEKYGDAR
RSEIVYSSEEFNPEDFYADDQMVITISHMGYIKRTPLSEFRAQNRGGVGSKGSETRDEDFVEHIYPATMHNTMMFFTQKG
KCYWLKVYEIPEGTKNAKGRAIQNLLNIDSDDVVTAYLRVKNLNDTEFINSHYVLFCTKNGVIKKTLLEQYSRPRQNGVN
AITIREDDKVIEVRMTNGDNEIIIANRNGRAIRFHESAVRVMGRTATGVRGMTLDEDGGDEVIGMICIKDPEAESIMVVS
EQGYGKRSDIEDYRKTNRGGKGVKTLNITDKTGKLVAIKSVTDENDLMIINKSGITIRLKVAEVRIMGRATQGVRLINLE
KRNDQIGSVCKVTSEEEVTDENSNTDLENITEGESGGTTNSDTNSDLTAEANSEE

Specific function: DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings [H]

COG id: COG0188

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the topoisomerase gyrA/parC subunit family [H]

Homologues:

Organism=Homo sapiens, GI19913408, Length=412, Percent_Identity=23.7864077669903, Blast_Score=68, Evalue=4e-11,
Organism=Escherichia coli, GI1788562, Length=837, Percent_Identity=49.7013142174432, Blast_Score=825, Evalue=0.0,
Organism=Escherichia coli, GI1789396, Length=680, Percent_Identity=35.5882352941176, Blast_Score=395, Evalue=1e-111,
Organism=Caenorhabditis elegans, GI212645845, Length=387, Percent_Identity=24.2894056847545, Blast_Score=75, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17535065, Length=170, Percent_Identity=30, Blast_Score=74, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6324241, Length=168, Percent_Identity=32.1428571428571, Blast_Score=75, Evalue=4e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020899
- InterPro:   IPR005743
- InterPro:   IPR006691
- InterPro:   IPR010235
- InterPro:   IPR002205
- InterPro:   IPR013758
- InterPro:   IPR013757
- InterPro:   IPR013760 [H]

Pfam domain/function: PF03989 DNA_gyraseA_C; PF00521 DNA_topoisoIV; PF08780 NTase_sub_bind [H]

EC number: =5.99.1.3 [H]

Molecular weight: Translated: 96387; Mature: 96387

Theoretical pI: Translated: 5.18; Mature: 5.18

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLEQDRIIKINIEEEMKSSYIDYSMSVIVARALPDVRDGFKPVHRRILYGMIELGNTSDK
CCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCHH
AYKKSARIVGEVLGKYHPHGDSSVYGALVRMAQDWAMRYPLVDGQGNFGSVDGDSPAAMR
HHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCEECCCCCCCCCCCCCCHHHH
YTEARLKKIGEEMMQDLYKETVDFQNNFDDTLQEPTVMPTRIPNLLVNGASGIAVGMATN
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHCCCCCCCCCCCHHEEECCCCEEEEEECC
MPTHNLSEVIDACIAYIDNNDIDIEGLMQYVKAPDFPTGGYIYGISGVRDAYETGRGRVV
CCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCCEEEECCCHHHHHHCCCCEEE
MRAKAEIETHTTHDKIIVNEIPYNVNKKELIENIASLVNDKKIDGISYVNDESDREGMRI
EEEECCEEECCCCCEEEEECCCCCCCHHHHHHHHHHHHCCCCCCCCEECCCCCCCCCCEE
VIDVKRDANASVVLNKLFKMTALQTSFGVNNIALVHGRPKMLNLKDLIRYFVEHRHDVVI
EEEECCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCEECHHHHHHHHHHCCCCEEE
RRTQYDLRKAQERAHILEGLIIASDNIDEVIRIIRAAKTPNDAIAGLIERFNLSEIQARA
EEHHHHHHHHHHHHHHHHCEEEECCCHHHHHHHHHHCCCCCHHHHHHHHHCCHHHHHHHH
IVEMRLRQLTGLMQDQLHAEYEEVMKQIAYYEEILSNDELCKKVIKDELVEVKEKYGDAR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCHH
RSEIVYSSEEFNPEDFYADDQMVITISHMGYIKRTPLSEFRAQNRGGVGSKGSETRDEDF
HHCEEECCCCCCCCCCCCCCEEEEEEECCCCEECCCHHHHHHCCCCCCCCCCCCCCHHHH
VEHIYPATMHNTMMFFTQKGKCYWLKVYEIPEGTKNAKGRAIQNLLNIDSDDVVTAYLRV
HHHHCCHHHCCEEEEEEECCCEEEEEEEECCCCCCCCCHHHHHHHHCCCCCCEEEEEEEE
KNLNDTEFINSHYVLFCTKNGVIKKTLLEQYSRPRQNGVNAITIREDDKVIEVRMTNGDN
ECCCCCCEECCCEEEEECCCCCHHHHHHHHHCCHHHCCCCEEEEECCCCEEEEEEECCCC
EIIIANRNGRAIRFHESAVRVMGRTATGVRGMTLDEDGGDEVIGMICIKDPEAESIMVVS
EEEEECCCCCEEEEEHHHHHHHCCCCCCCCCCEECCCCCCCEEEEEEECCCCCCEEEEEE
EQGYGKRSDIEDYRKTNRGGKGVKTLNITDKTGKLVAIKSVTDENDLMIINKSGITIRLK
CCCCCCCCCHHHHHHHCCCCCCEEEEEEECCCCCEEEEEEECCCCCEEEEECCCCEEEEE
VAEVRIMGRATQGVRLINLEKRNDQIGSVCKVTSEEEVTDENSNTDLENITEGESGGTTN
EEEEEEEECCCCCEEEEEEECCCCCCCHHEEECCCCCCCCCCCCCCHHHCCCCCCCCCCC
SDTNSDLTAEANSEE
CCCCCCEECCCCCCC
>Mature Secondary Structure
MLEQDRIIKINIEEEMKSSYIDYSMSVIVARALPDVRDGFKPVHRRILYGMIELGNTSDK
CCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCHH
AYKKSARIVGEVLGKYHPHGDSSVYGALVRMAQDWAMRYPLVDGQGNFGSVDGDSPAAMR
HHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCEECCCCCCCCCCCCCCHHHH
YTEARLKKIGEEMMQDLYKETVDFQNNFDDTLQEPTVMPTRIPNLLVNGASGIAVGMATN
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHCCCCCCCCCCCHHEEECCCCEEEEEECC
MPTHNLSEVIDACIAYIDNNDIDIEGLMQYVKAPDFPTGGYIYGISGVRDAYETGRGRVV
CCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCCEEEECCCHHHHHHCCCCEEE
MRAKAEIETHTTHDKIIVNEIPYNVNKKELIENIASLVNDKKIDGISYVNDESDREGMRI
EEEECCEEECCCCCEEEEECCCCCCCHHHHHHHHHHHHCCCCCCCCEECCCCCCCCCCEE
VIDVKRDANASVVLNKLFKMTALQTSFGVNNIALVHGRPKMLNLKDLIRYFVEHRHDVVI
EEEECCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCEECHHHHHHHHHHCCCCEEE
RRTQYDLRKAQERAHILEGLIIASDNIDEVIRIIRAAKTPNDAIAGLIERFNLSEIQARA
EEHHHHHHHHHHHHHHHHCEEEECCCHHHHHHHHHHCCCCCHHHHHHHHHCCHHHHHHHH
IVEMRLRQLTGLMQDQLHAEYEEVMKQIAYYEEILSNDELCKKVIKDELVEVKEKYGDAR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCHH
RSEIVYSSEEFNPEDFYADDQMVITISHMGYIKRTPLSEFRAQNRGGVGSKGSETRDEDF
HHCEEECCCCCCCCCCCCCCEEEEEEECCCCEECCCHHHHHHCCCCCCCCCCCCCCHHHH
VEHIYPATMHNTMMFFTQKGKCYWLKVYEIPEGTKNAKGRAIQNLLNIDSDDVVTAYLRV
HHHHCCHHHCCEEEEEEECCCEEEEEEEECCCCCCCCCHHHHHHHHCCCCCCEEEEEEEE
KNLNDTEFINSHYVLFCTKNGVIKKTLLEQYSRPRQNGVNAITIREDDKVIEVRMTNGDN
ECCCCCCEECCCEEEEECCCCCHHHHHHHHHCCHHHCCCCEEEEECCCCEEEEEEECCCC
EIIIANRNGRAIRFHESAVRVMGRTATGVRGMTLDEDGGDEVIGMICIKDPEAESIMVVS
EEEEECCCCCEEEEEHHHHHHHCCCCCCCCCCEECCCCCCCEEEEEEECCCCCCEEEEEE
EQGYGKRSDIEDYRKTNRGGKGVKTLNITDKTGKLVAIKSVTDENDLMIINKSGITIRLK
CCCCCCCCCHHHHHHHCCCCCCEEEEEEECCCCCEEEEEEECCCCCEEEEECCCCEEEEE
VAEVRIMGRATQGVRLINLEKRNDQIGSVCKVTSEEEVTDENSNTDLENITEGESGGTTN
EEEEEEEECCCCCEEEEEEECCCCCCCHHEEECCCCCCCCCCCCCCHHHCCCCCCCCCCC
SDTNSDLTAEANSEE
CCCCCCEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10427704; 11058132 [H]