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The map label for this gene is lctP [H]

Identifier: 150005240

GI number: 150005240

Start: 3452175

End: 3453680

Strand: Direct

Name: lctP [H]

Synonym: BVU_2711

Alternate gene names: 150005240

Gene position: 3452175-3453680 (Clockwise)

Preceding gene: 150005239

Following gene: 150005241

Centisome position: 66.86

GC content: 42.36

Gene sequence:

>1506_bases
ATGGTTATGAATCTAGTCCTTGCTATTATTCCGGTATTGCTATTAATTATCCTGATGGCGTTTTTTAAAATGTCCGGTGA
CAAAAGTAGTGTGATTTCCCTTGTCGTTACTATGCTGATTGCTTTTTTCGGCTTTCATTTTCCGGTAAACGATTTGCTGT
CTTCTTTTCTGTATGGTGCATTGAAAGCTGTTTCTCCTATTCTGATTATTATTTTGATGGCGATATTCAGCTATAATGTT
TTATTGAAGACTGAAAAAATGGAGATTATCAAGCAACAGTTTTCTTCTATTTCTACCGATAAAAGTATTCAGGTATTGCT
GTTGACATGGGGATTTGGCGGCTTGCTTGAAGCTATGGCAGGATTTGGTACGGCAGTGGCTATACCGGCGGCGATTCTTG
TCAGTCTCGGATTCAAACCGGTCTTTTCGGCAACAGTCAGTTTGATTGCCAATAGTGTGGCTACTGCTTTTGGGGCTATT
GGTACACCGGTCTTGGTATTGGCGAAAGAAACGAATCTGGATGTATTGGTGCTAAGCGCCAATGTCGTGTTGCAGCTTTC
GGTACTGATGTTTCTCATTCCTTTCGTATTGCTGTTCCTGACCGATTCGAAATTAAAATCCTTACCTAAAAATATTTTCC
TGTCTTTGTTGGTCGGTGGTGTCTCATTAGGCAGCCAGTATATTGCCGCCCGCTATATGGGGGCGGAGTCTCCGGCTATT
ATTGGAAGTATTTTATCTATCATTGTTATTGTAGCCTATGGCAAACTGACTGCTTCTAAAGAGGAAAAAGCAAGGAAAAG
CACATTGAAAGGGCTAGAGGTACTGAACGCGTGGAGTATCTATCTTCTTATCTTGTTCTTGATTGTTCTGACTAGTCCGT
TGTTTCCCGGTTTACGTACAACACTTGAAAATAATTGGGTGACCCGTATCAGTCTTCCGATTAATGATTCAACTATGAAT
TATACGGTTTCTTGGCTGACCCATGCGGGAGTTTTACTTTTTGTAGGCACGTTTGTCGGCGGGCTGATACAGGGAGCCAA
GATATGGGAGCTGTTTGCTGTACTCTGGAATACGGTAAAGCAGTTAAAGAAAACTTTTATCACGGTAATTTGTCTGGTGA
GTTTGTCCACTATCATGGATACGGCAGGTATGATTTCAGTTATAGCCACTGCTTTGGCAGTTGCTACAGGAAGTCTTTAT
CCGTTGTTTGCCCCTGTTATAGGTTGCCTGGGTACCTTTATTACGGGCAGTGACACTTCTTCAAATATTTTGTTCGGCAA
ATTACAGGCTAATGTGGCCGGGCATATTCAAGTAAGTCCCGACTGGTTGTCGGCAGCCAATACGGTGGGGGCGACAGGTG
GAAAAATAATTTCTCCGCAAAGTATCGCTATTGCCACTTCTGCCGGAAACCAACAGGGAAAAGAAGGAGAAATCCTAAAA
TCCGCCATTCCATATGCATTGGCGTATGTGTTGATAACCGGAGTGATTGTTTATATTTTCAGCTGA

Upstream 100 bases:

>100_bases
AGGATTCTTTTTTGTTATTAAAAAAAGAATTTTTGCGGAAGTGGGGTTTCAAAGGCTTAATTTAAGAGTTTATGGATACC
GTTTCTTTAACTTAAATACA

Downstream 100 bases:

>100_bases
TAATCGTTTGTAAATTCAAGAGGGCGTTTTAATATTGCCTGTTATGGATTGAAATACCCTGTAAACGAGGATCAACTGTT
GAAAAATCGTAAAAAAAGAG

Product: L-lactate permease

Products: lactate [Cytoplasm]; Proton [Cytoplasm]; glycolate [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 501; Mature: 501

Protein sequence:

>501_residues
MVMNLVLAIIPVLLLIILMAFFKMSGDKSSVISLVVTMLIAFFGFHFPVNDLLSSFLYGALKAVSPILIIILMAIFSYNV
LLKTEKMEIIKQQFSSISTDKSIQVLLLTWGFGGLLEAMAGFGTAVAIPAAILVSLGFKPVFSATVSLIANSVATAFGAI
GTPVLVLAKETNLDVLVLSANVVLQLSVLMFLIPFVLLFLTDSKLKSLPKNIFLSLLVGGVSLGSQYIAARYMGAESPAI
IGSILSIIVIVAYGKLTASKEEKARKSTLKGLEVLNAWSIYLLILFLIVLTSPLFPGLRTTLENNWVTRISLPINDSTMN
YTVSWLTHAGVLLFVGTFVGGLIQGAKIWELFAVLWNTVKQLKKTFITVICLVSLSTIMDTAGMISVIATALAVATGSLY
PLFAPVIGCLGTFITGSDTSSNILFGKLQANVAGHIQVSPDWLSAANTVGATGGKIISPQSIAIATSAGNQQGKEGEILK
SAIPYALAYVLITGVIVYIFS

Sequences:

>Translated_501_residues
MVMNLVLAIIPVLLLIILMAFFKMSGDKSSVISLVVTMLIAFFGFHFPVNDLLSSFLYGALKAVSPILIIILMAIFSYNV
LLKTEKMEIIKQQFSSISTDKSIQVLLLTWGFGGLLEAMAGFGTAVAIPAAILVSLGFKPVFSATVSLIANSVATAFGAI
GTPVLVLAKETNLDVLVLSANVVLQLSVLMFLIPFVLLFLTDSKLKSLPKNIFLSLLVGGVSLGSQYIAARYMGAESPAI
IGSILSIIVIVAYGKLTASKEEKARKSTLKGLEVLNAWSIYLLILFLIVLTSPLFPGLRTTLENNWVTRISLPINDSTMN
YTVSWLTHAGVLLFVGTFVGGLIQGAKIWELFAVLWNTVKQLKKTFITVICLVSLSTIMDTAGMISVIATALAVATGSLY
PLFAPVIGCLGTFITGSDTSSNILFGKLQANVAGHIQVSPDWLSAANTVGATGGKIISPQSIAIATSAGNQQGKEGEILK
SAIPYALAYVLITGVIVYIFS
>Mature_501_residues
MVMNLVLAIIPVLLLIILMAFFKMSGDKSSVISLVVTMLIAFFGFHFPVNDLLSSFLYGALKAVSPILIIILMAIFSYNV
LLKTEKMEIIKQQFSSISTDKSIQVLLLTWGFGGLLEAMAGFGTAVAIPAAILVSLGFKPVFSATVSLIANSVATAFGAI
GTPVLVLAKETNLDVLVLSANVVLQLSVLMFLIPFVLLFLTDSKLKSLPKNIFLSLLVGGVSLGSQYIAARYMGAESPAI
IGSILSIIVIVAYGKLTASKEEKARKSTLKGLEVLNAWSIYLLILFLIVLTSPLFPGLRTTLENNWVTRISLPINDSTMN
YTVSWLTHAGVLLFVGTFVGGLIQGAKIWELFAVLWNTVKQLKKTFITVICLVSLSTIMDTAGMISVIATALAVATGSLY
PLFAPVIGCLGTFITGSDTSSNILFGKLQANVAGHIQVSPDWLSAANTVGATGGKIISPQSIAIATSAGNQQGKEGEILK
SAIPYALAYVLITGVIVYIFS

Specific function: Plays a role in L-lactate utilization [H]

COG id: COG1620

COG function: function code C; L-lactate permease

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lactate permease family [H]

Homologues:

Organism=Escherichia coli, GI1789347, Length=542, Percent_Identity=31.3653136531365, Blast_Score=236, Evalue=2e-63,
Organism=Escherichia coli, GI1790031, Length=523, Percent_Identity=31.3575525812619, Blast_Score=213, Evalue=3e-56,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003804 [H]

Pfam domain/function: PF02652 Lactate_perm [H]

EC number: NA

Molecular weight: Translated: 53286; Mature: 53286

Theoretical pI: Translated: 9.72; Mature: 9.72

Prosite motif: PS50999 COX2_TM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVMNLVLAIIPVLLLIILMAFFKMSGDKSSVISLVVTMLIAFFGFHFPVNDLLSSFLYGA
CHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
LKAVSPILIIILMAIFSYNVLLKTEKMEIIKQQFSSISTDKSIQVLLLTWGFGGLLEAMA
HHHHHHHHHHHHHHHHHHHHHEEHHHHHHHHHHHHCCCCCCCEEEEEEECCHHHHHHHHH
GFGTAVAIPAAILVSLGFKPVFSATVSLIANSVATAFGAIGTPVLVLAKETNLDVLVLSA
CCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCEEEECH
NVVLQLSVLMFLIPFVLLFLTDSKLKSLPKNIFLSLLVGGVSLGSQYIAARYMGAESPAI
HHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHH
IGSILSIIVIVAYGKLTASKEEKARKSTLKGLEVLNAWSIYLLILFLIVLTSPLFPGLRT
HHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHH
TLENNWVTRISLPINDSTMNYTVSWLTHAGVLLFVGTFVGGLIQGAKIWELFAVLWNTVK
HHCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHH
QLKKTFITVICLVSLSTIMDTAGMISVIATALAVATGSLYPLFAPVIGCLGTFITGSDTS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCC
SNILFGKLQANVAGHIQVSPDWLSAANTVGATGGKIISPQSIAIATSAGNQQGKEGEILK
CCEEEEEEECCCEEEEEECCHHHHHHCCCCCCCCCEECCCCEEEEECCCCCCCCCHHHHH
SAIPYALAYVLITGVIVYIFS
HHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MVMNLVLAIIPVLLLIILMAFFKMSGDKSSVISLVVTMLIAFFGFHFPVNDLLSSFLYGA
CHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
LKAVSPILIIILMAIFSYNVLLKTEKMEIIKQQFSSISTDKSIQVLLLTWGFGGLLEAMA
HHHHHHHHHHHHHHHHHHHHHEEHHHHHHHHHHHHCCCCCCCEEEEEEECCHHHHHHHHH
GFGTAVAIPAAILVSLGFKPVFSATVSLIANSVATAFGAIGTPVLVLAKETNLDVLVLSA
CCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCEEEECH
NVVLQLSVLMFLIPFVLLFLTDSKLKSLPKNIFLSLLVGGVSLGSQYIAARYMGAESPAI
HHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHH
IGSILSIIVIVAYGKLTASKEEKARKSTLKGLEVLNAWSIYLLILFLIVLTSPLFPGLRT
HHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHH
TLENNWVTRISLPINDSTMNYTVSWLTHAGVLLFVGTFVGGLIQGAKIWELFAVLWNTVK
HHCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHH
QLKKTFITVICLVSLSTIMDTAGMISVIATALAVATGSLYPLFAPVIGCLGTFITGSDTS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCC
SNILFGKLQANVAGHIQVSPDWLSAANTVGATGGKIISPQSIAIATSAGNQQGKEGEILK
CCEEEEEEECCCEEEEEECCHHHHHHCCCCCCCCCEECCCCEEEEECCCCCCCCCHHHHH
SAIPYALAYVLITGVIVYIFS
HHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: lactate [Periplasm]; Proton [Periplasm]; glycolate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + lactate [Periplasm] = Proton [Cytoplasm] + lactate [Cytoplasm] Proton [Periplasm] + glycolate [Periplasm] = Proton [Cytoplasm] + glycolate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10508058 [H]