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The map label for this gene is rnz

Identifier: 150005115

GI number: 150005115

Start: 3294841

End: 3295770

Strand: Reverse

Name: rnz

Synonym: BVU_2582

Alternate gene names: 150005115

Gene position: 3295770-3294841 (Counterclockwise)

Preceding gene: 150005116

Following gene: 150005114

Centisome position: 63.83

GC content: 40.97

Gene sequence:

>930_bases
ATGGAGAAATTTGAAGTACATATATTAGGATGCGGGTCAGCATTGCCGACCACACGGCATTTTGCAACATCACAAGTCGT
AAATATCCGTGAAAAACTATTTATGATAGACTGTGGTGAAGGAGCACAGATGCAATTACGCAAATCAAAACTGAAATTCA
CCCGGCTAAACCATATATTCATTTCACATTTGCACGGTGATCATTGTTTCGGACTAATGGGACTGATATCAACTTTCGGT
ATGCTGGGAAGGACAGCCACACTCTATATTCACTGTCACGCAGAATTAGAACGTCTTCTTACTCCACAACTCGACTTTTT
TTGCAAAGGTATGAGTTACAAAGTCGTTTTCCAAACTTTTGATCCGGGCAAAGCTGAAATAATTTATGATGACCGTTCGC
TAACCATAGAAACAATTCCCTTACGTCATCGGATACCAACATGCGGATTCCTCTTTTCAGAGAAACAGATCCCCGCCCAT
ATTCGTCGCGACATGATTGACTTTTATGAAATCCCCGTATACGAACTCAACCGGATAAAGAATGGCGCCGATTACACATT
ACCGGACGGAAAAATAGTACCAAACAACAAATTGACTATCCCTTCTGCCCTTCCCCGCCGATATGCCTATTGTTCAGATA
CTATTTATTTGCCACATATCATAGAACAAATATACGGAGTGGACCTGTTATTTCATGAAGCCACCTTTGCACAAAGCGAA
CAAGCCCGTGCGAAAGAAACCTTTCACACAACTGCTTCGCAAGCTGGAGAAATCGCCCGTACCGCAAAAGTAAAACAACT
TCTTATAGGACATTTTTCAGCCCGCTACGAAGATGAAAGCATATTGTTACAGGAAGCATCGGATATTTTTCCTAACACTC
TACTTGCACGGGAAACATTAAAAATTTCAATAGAATCCATTAAACCATAA

Upstream 100 bases:

>100_bases
AATGCTGTGAAAATAAAACTTAAGAAATAGTTCAATCCTATAATGCCGTTTTTACGGCATTTTTTATTTTCCATTCAAAA
AAGATAGTATCTTTGTAACG

Downstream 100 bases:

>100_bases
CATAAACCGGATATCTAATTTAAAAATAGGAACATGAACACTTATAATGAGAAAGAAATAATAGCGTTATTACAGGACCC
GGCACGACAAAAAGAAGCCT

Product: ribonuclease Z

Products: NA

Alternate protein names: RNase Z; tRNA 3 endonuclease; tRNase Z

Number of amino acids: Translated: 309; Mature: 309

Protein sequence:

>309_residues
MEKFEVHILGCGSALPTTRHFATSQVVNIREKLFMIDCGEGAQMQLRKSKLKFTRLNHIFISHLHGDHCFGLMGLISTFG
MLGRTATLYIHCHAELERLLTPQLDFFCKGMSYKVVFQTFDPGKAEIIYDDRSLTIETIPLRHRIPTCGFLFSEKQIPAH
IRRDMIDFYEIPVYELNRIKNGADYTLPDGKIVPNNKLTIPSALPRRYAYCSDTIYLPHIIEQIYGVDLLFHEATFAQSE
QARAKETFHTTASQAGEIARTAKVKQLLIGHFSARYEDESILLQEASDIFPNTLLARETLKISIESIKP

Sequences:

>Translated_309_residues
MEKFEVHILGCGSALPTTRHFATSQVVNIREKLFMIDCGEGAQMQLRKSKLKFTRLNHIFISHLHGDHCFGLMGLISTFG
MLGRTATLYIHCHAELERLLTPQLDFFCKGMSYKVVFQTFDPGKAEIIYDDRSLTIETIPLRHRIPTCGFLFSEKQIPAH
IRRDMIDFYEIPVYELNRIKNGADYTLPDGKIVPNNKLTIPSALPRRYAYCSDTIYLPHIIEQIYGVDLLFHEATFAQSE
QARAKETFHTTASQAGEIARTAKVKQLLIGHFSARYEDESILLQEASDIFPNTLLARETLKISIESIKP
>Mature_309_residues
MEKFEVHILGCGSALPTTRHFATSQVVNIREKLFMIDCGEGAQMQLRKSKLKFTRLNHIFISHLHGDHCFGLMGLISTFG
MLGRTATLYIHCHAELERLLTPQLDFFCKGMSYKVVFQTFDPGKAEIIYDDRSLTIETIPLRHRIPTCGFLFSEKQIPAH
IRRDMIDFYEIPVYELNRIKNGADYTLPDGKIVPNNKLTIPSALPRRYAYCSDTIYLPHIIEQIYGVDLLFHEATFAQSE
QARAKETFHTTASQAGEIARTAKVKQLLIGHFSARYEDESILLQEASDIFPNTLLARETLKISIESIKP

Specific function: Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA

COG id: COG1234

COG function: function code R; Metal-dependent hydrolases of the beta-lactamase superfamily III

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the RNase Z family

Homologues:

Organism=Homo sapiens, GI8922122, Length=333, Percent_Identity=30.03003003003, Blast_Score=122, Evalue=3e-28,
Organism=Escherichia coli, GI87082078, Length=303, Percent_Identity=31.023102310231, Blast_Score=134, Evalue=1e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): RNZ_BACV8 (A6L3H3)

Other databases:

- EMBL:   CP000139
- RefSeq:   YP_001299859.1
- ProteinModelPortal:   A6L3H3
- SMR:   A6L3H3
- STRING:   A6L3H3
- GeneID:   5303545
- GenomeReviews:   CP000139_GR
- KEGG:   bvu:BVU_2582
- NMPDR:   fig|435590.6.peg.2424
- eggNOG:   COG1234
- HOGENOM:   HBG648406
- OMA:   HSTSTMA
- ProtClustDB:   PRK00055
- HAMAP:   MF_01818
- InterPro:   IPR001279
- InterPro:   IPR013471
- TIGRFAMs:   TIGR02651

Pfam domain/function: PF00753 Lactamase_B

EC number: =3.1.26.11

Molecular weight: Translated: 35254; Mature: 35254

Theoretical pI: Translated: 7.63; Mature: 7.63

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEKFEVHILGCGSALPTTRHFATSQVVNIREKLFMIDCGEGAQMQLRKSKLKFTRLNHIF
CCCEEEEEEECCCCCCCHHHHHHHHHHHHHHEEEEEECCCCCHHHHHHHHHHHHHHHEEE
ISHLHGDHCFGLMGLISTFGMLGRTATLYIHCHAELERLLTPQLDFFCKGMSYKVVFQTF
EECCCCCHHHHHHHHHHHHHHHCCEEEEEEEEHHHHHHHHCCCHHHHHCCCCEEEEEEEC
DPGKAEIIYDDRSLTIETIPLRHRIPTCGFLFSEKQIPAHIRRDMIDFYEIPVYELNRIK
CCCCEEEEECCCCEEEEEECHHHCCCCCCEEECCCCCCHHHHHHHHHHHCCCHHHHHHCC
NGADYTLPDGKIVPNNKLTIPSALPRRYAYCSDTIYLPHIIEQIYGVDLLFHEATFAQSE
CCCCEECCCCEECCCCCEECCCCCCHHHHHCCCCEEHHHHHHHHHCCCEEEEHHHHHCCH
QARAKETFHTTASQAGEIARTAKVKQLLIGHFSARYEDESILLQEASDIFPNTLLARETL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCHHHHHHEE
KISIESIKP
EEEEECCCC
>Mature Secondary Structure
MEKFEVHILGCGSALPTTRHFATSQVVNIREKLFMIDCGEGAQMQLRKSKLKFTRLNHIF
CCCEEEEEEECCCCCCCHHHHHHHHHHHHHHEEEEEECCCCCHHHHHHHHHHHHHHHEEE
ISHLHGDHCFGLMGLISTFGMLGRTATLYIHCHAELERLLTPQLDFFCKGMSYKVVFQTF
EECCCCCHHHHHHHHHHHHHHHCCEEEEEEEEHHHHHHHHCCCHHHHHCCCCEEEEEEEC
DPGKAEIIYDDRSLTIETIPLRHRIPTCGFLFSEKQIPAHIRRDMIDFYEIPVYELNRIK
CCCCEEEEECCCCEEEEEECHHHCCCCCCEEECCCCCCHHHHHHHHHHHCCCHHHHHHCC
NGADYTLPDGKIVPNNKLTIPSALPRRYAYCSDTIYLPHIIEQIYGVDLLFHEATFAQSE
CCCCEECCCCEECCCCCEECCCCCCHHHHHCCCCEEHHHHHHHHHCCCEEEEHHHHHCCH
QARAKETFHTTASQAGEIARTAKVKQLLIGHFSARYEDESILLQEASDIFPNTLLARETL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCHHHHHHEE
KISIESIKP
EEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA