Click here to switch to the map view.

The map label for this gene is ilvD

Identifier: 150005089

GI number: 150005089

Start: 3259381

End: 3261183

Strand: Direct

Name: ilvD

Synonym: BVU_2554

Alternate gene names: 150005089

Gene position: 3259381-3261183 (Clockwise)

Preceding gene: 150005088

Following gene: 150005090

Centisome position: 63.13

GC content: 44.76

Gene sequence:

>1803_bases
ATGAAGAATCAGTTACGCAGTTCGTTTAGCACACAGGGTCGCCGTATGGCAGGAGCGAGAGCTTTATGGGTAGCTAACGG
CATGAAAAAAGAAATGATGGGCAAGCCCATTATAGCCATAGTAAATTCGTTTACACAGTTTGTTCCGGGACATACCCATC
TGCATGAAATAGGTCAGCAAGTAAAAGCCGAGATCGAAAAACTGGGATGTTTTGCAGCAGAGTTCAATACAATTGCCATT
GATGACGGAATAGCTATGGGACACGATGGTATGCTATATTCACTGCCCAGTCGTGATATCATTGCCGACAGCGTGGAATA
TATGGTGAATGCTCATAAGGCGGATGCAATGGTGTGTATCAGTAATTGTGACAAAATCACTCCGGGTATGCTGATGGCTG
CCATGCGGCTGAACATACCGACTGTTTTTGTATCGGGTGGTCCTATGGAGGCAGGAGAATGGAATAACCAGCATCTTGAT
TTGATAGACGCCATGATTAAATCTGCTGATGCATCGGTCAGCGATGAGGATGTGGCTCAAATAGAAGATAATGCGTGTCC
CGGCTGTGGATGCTGTTCAGGTATGTTTACGGCTAATTCCATGAATTGTCTTAATGAGGCTATTGGTCTGGGACTTCCGG
GTAATGGCACTATTTTGGCAACTCATGCCAATCGTACTCAGTTGTTTAAAGATGCGGCTGCTCTGATAGTGAAGAATGCT
TATAAATACTATGAGGAAGGAGATGACAGCGTGTTGCCACGCAGCATTGCTACTCGTGATGCTTTTCTGAATGCCATGAC
ATTGGATATTGCAATGGGTGGTTCCACCAATACTGTGCTCCATCTTTTAGCTATCGCCCACGAGGCGGAAGTAGATTTCA
AGATGGATGATATTGATATGCTTTCACGCCATGTGCCTTGTTTGTGTAAAGTAGCTCCGAACACACAGAAATATCATATC
CAGGATGTGAACCGTGCCGGCGGTATCCTTAATATATTGGGAGAATTATCCAAGGGTGGTTTGCTGAAAACCGATGTGAA
ACGAGTGGACGGTCTGACATTGGCGGAAGCTGTCGAAAAATATAATATATGTAAGAAGGAAGTGGATACTGAAGCAAAAC
GTATCTATTCAAGTGCTCCGGGAAACAAATTCAATATAAAGCTGGGTTCTCAGAATGCTGTTTATAAAGAACTGGATACA
GATCGTGCCAATGGTTGTATCCGTGATTTGCAACATGCTTATAGTAAGGACGGAGGTTTGGCTGTTTTGAAAGGGAACAT
TGCACAGGATGGTTGCGTAGTGAAAACAGCCGGAGTGGATGAAAGTATTTGGAAATTCTCGGGACCTGCCAAGGTGTTCG
ATTCGCAGGATGCTGCTTGTGAAGGTATTCTAGGAGGAAAGGTAGTCAGCGGAGATGTTGTTGTTATCACTCATGAAGGT
CCGAAAGGTGGTCCCGGTATGCAGGAAATGCTTTATCCTACTTCTTATATCAAATCCAAGCATTTAGGAAAAGAATGTGC
TCTGATTACCGACGGACGTTTTAGTGGAGGAACCTCGGGATTAAGCATCGGGCATATTTCTCCCGAAGCTGCAGCGGGTG
GTAATATCGGAAAAATAGTGGATGGTGATATAATTGAAATCGATATTCCGAACCGCAGTATCAATGTGAAACTGAGCGAC
GAAGAATTGGCCGCCCGACCGATGGCACCGGTGACCCGCGACCGTAAAGTTCCTAAAAGCTTGAAGGCATACGCTAGTAT
GGTAAGTTCTGCAGATAAAGGAGGAGTGAGAATCATTGACTAA

Upstream 100 bases:

>100_bases
GTATGTGTAGTTGTACATATAAAGAAATAATTGAAAGCCTTTCTCACATGGTGAGGAAGGCTTTTTCAATAAGTATAGGA
CGTTATAGATTTAGAATAAG

Downstream 100 bases:

>100_bases
ATTAGAAATTAAAAATTGAGAATAAAAAACAGTTTCGTTGTCATCGGCCAGTTGTCCGGCATCGTATTTTTTTGAATCTC
AATTCTCAACTAAACAATTA

Product: dihydroxy-acid dehydratase

Products: NA

Alternate protein names: DAD

Number of amino acids: Translated: 600; Mature: 600

Protein sequence:

>600_residues
MKNQLRSSFSTQGRRMAGARALWVANGMKKEMMGKPIIAIVNSFTQFVPGHTHLHEIGQQVKAEIEKLGCFAAEFNTIAI
DDGIAMGHDGMLYSLPSRDIIADSVEYMVNAHKADAMVCISNCDKITPGMLMAAMRLNIPTVFVSGGPMEAGEWNNQHLD
LIDAMIKSADASVSDEDVAQIEDNACPGCGCCSGMFTANSMNCLNEAIGLGLPGNGTILATHANRTQLFKDAAALIVKNA
YKYYEEGDDSVLPRSIATRDAFLNAMTLDIAMGGSTNTVLHLLAIAHEAEVDFKMDDIDMLSRHVPCLCKVAPNTQKYHI
QDVNRAGGILNILGELSKGGLLKTDVKRVDGLTLAEAVEKYNICKKEVDTEAKRIYSSAPGNKFNIKLGSQNAVYKELDT
DRANGCIRDLQHAYSKDGGLAVLKGNIAQDGCVVKTAGVDESIWKFSGPAKVFDSQDAACEGILGGKVVSGDVVVITHEG
PKGGPGMQEMLYPTSYIKSKHLGKECALITDGRFSGGTSGLSIGHISPEAAAGGNIGKIVDGDIIEIDIPNRSINVKLSD
EELAARPMAPVTRDRKVPKSLKAYASMVSSADKGGVRIID

Sequences:

>Translated_600_residues
MKNQLRSSFSTQGRRMAGARALWVANGMKKEMMGKPIIAIVNSFTQFVPGHTHLHEIGQQVKAEIEKLGCFAAEFNTIAI
DDGIAMGHDGMLYSLPSRDIIADSVEYMVNAHKADAMVCISNCDKITPGMLMAAMRLNIPTVFVSGGPMEAGEWNNQHLD
LIDAMIKSADASVSDEDVAQIEDNACPGCGCCSGMFTANSMNCLNEAIGLGLPGNGTILATHANRTQLFKDAAALIVKNA
YKYYEEGDDSVLPRSIATRDAFLNAMTLDIAMGGSTNTVLHLLAIAHEAEVDFKMDDIDMLSRHVPCLCKVAPNTQKYHI
QDVNRAGGILNILGELSKGGLLKTDVKRVDGLTLAEAVEKYNICKKEVDTEAKRIYSSAPGNKFNIKLGSQNAVYKELDT
DRANGCIRDLQHAYSKDGGLAVLKGNIAQDGCVVKTAGVDESIWKFSGPAKVFDSQDAACEGILGGKVVSGDVVVITHEG
PKGGPGMQEMLYPTSYIKSKHLGKECALITDGRFSGGTSGLSIGHISPEAAAGGNIGKIVDGDIIEIDIPNRSINVKLSD
EELAARPMAPVTRDRKVPKSLKAYASMVSSADKGGVRIID
>Mature_600_residues
MKNQLRSSFSTQGRRMAGARALWVANGMKKEMMGKPIIAIVNSFTQFVPGHTHLHEIGQQVKAEIEKLGCFAAEFNTIAI
DDGIAMGHDGMLYSLPSRDIIADSVEYMVNAHKADAMVCISNCDKITPGMLMAAMRLNIPTVFVSGGPMEAGEWNNQHLD
LIDAMIKSADASVSDEDVAQIEDNACPGCGCCSGMFTANSMNCLNEAIGLGLPGNGTILATHANRTQLFKDAAALIVKNA
YKYYEEGDDSVLPRSIATRDAFLNAMTLDIAMGGSTNTVLHLLAIAHEAEVDFKMDDIDMLSRHVPCLCKVAPNTQKYHI
QDVNRAGGILNILGELSKGGLLKTDVKRVDGLTLAEAVEKYNICKKEVDTEAKRIYSSAPGNKFNIKLGSQNAVYKELDT
DRANGCIRDLQHAYSKDGGLAVLKGNIAQDGCVVKTAGVDESIWKFSGPAKVFDSQDAACEGILGGKVVSGDVVVITHEG
PKGGPGMQEMLYPTSYIKSKHLGKECALITDGRFSGGTSGLSIGHISPEAAAGGNIGKIVDGDIIEIDIPNRSINVKLSD
EELAARPMAPVTRDRKVPKSLKAYASMVSSADKGGVRIID

Specific function: Valine and isoleucine biosynthesis; fourth step. [C]

COG id: COG0129

COG function: function code EG; Dihydroxyacid dehydratase/phosphogluconate dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ilvD/edd family

Homologues:

Organism=Escherichia coli, GI48994964, Length=608, Percent_Identity=65.9539473684211, Blast_Score=813, Evalue=0.0,
Organism=Escherichia coli, GI2367371, Length=540, Percent_Identity=31.8518518518519, Blast_Score=198, Evalue=7e-52,
Organism=Escherichia coli, GI1788157, Length=572, Percent_Identity=29.020979020979, Blast_Score=193, Evalue=3e-50,
Organism=Escherichia coli, GI1786464, Length=552, Percent_Identity=30.4347826086957, Blast_Score=187, Evalue=1e-48,
Organism=Saccharomyces cerevisiae, GI6322476, Length=598, Percent_Identity=35.2842809364548, Blast_Score=327, Evalue=5e-90,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ILVD_BACV8 (A6L3E7)

Other databases:

- EMBL:   CP000139
- RefSeq:   YP_001299833.1
- STRING:   A6L3E7
- GeneID:   5303518
- GenomeReviews:   CP000139_GR
- KEGG:   bvu:BVU_2554
- NMPDR:   fig|435590.6.peg.2398
- eggNOG:   COG0129
- HOGENOM:   HBG671001
- OMA:   KVPCLSK
- ProtClustDB:   PRK12448
- HAMAP:   MF_00012
- InterPro:   IPR015928
- InterPro:   IPR004404
- InterPro:   IPR000581
- InterPro:   IPR020558
- PANTHER:   PTHR21000
- TIGRFAMs:   TIGR00110

Pfam domain/function: PF00920 ILVD_EDD; SSF52016 Aconitase/3IPM_dehydase_swvl

EC number: =4.2.1.9

Molecular weight: Translated: 64114; Mature: 64114

Theoretical pI: Translated: 6.13; Mature: 6.13

Prosite motif: PS00886 ILVD_EDD_1; PS00887 ILVD_EDD_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
6.5 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
6.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNQLRSSFSTQGRRMAGARALWVANGMKKEMMGKPIIAIVNSFTQFVPGHTHLHEIGQQ
CCCHHHHHHHHCCHHHHCCEEEEECCCCHHHHCCCHHHHHHHHHHHHCCCCHHHHHHHHH
VKAEIEKLGCFAAEFNTIAIDDGIAMGHDGMLYSLPSRDIIADSVEYMVNAHKADAMVCI
HHHHHHHHHHHEECCCEEEEECCEEECCCCEEEECCCCHHHHHHHHHHHHCCCCCEEEEE
SNCDKITPGMLMAAMRLNIPTVFVSGGPMEAGEWNNQHLDLIDAMIKSADASVSDEDVAQ
CCCCCCCHHHHHHHHHCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHCCCCCCCHHHHH
IEDNACPGCGCCSGMFTANSMNCLNEAIGLGLPGNGTILATHANRTQLFKDAAALIVKNA
HCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCEEEEEECCHHHHHHHHHHHHHHHH
YKYYEEGDDSVLPRSIATRDAFLNAMTLDIAMGGSTNTVLHLLAIAHEAEVDFKMDDIDM
HHHHHCCCCCCCCHHHHHHHHHHHEEEEEEEECCCHHHHHHHHHHHHHCCCCEEECHHHH
LSRHVPCLCKVAPNTQKYHIQDVNRAGGILNILGELSKGGLLKTDVKRVDGLTLAEAVEK
HHCCCCEEEEECCCCCEEEEEECHHCCCHHHHHHHHCCCCEEHHHHHHHCCCHHHHHHHH
YNICKKEVDTEAKRIYSSAPGNKFNIKLGSQNAVYKELDTDRANGCIRDLQHAYSKDGGL
HHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHCCCCHHHHHHHHHHHHHCCCCCE
AVLKGNIAQDGCVVKTAGVDESIWKFSGPAKVFDSQDAACEGILGGKVVSGDVVVITHEG
EEEECCCCCCCEEEEECCCCHHHHHCCCCCHHCCCCCHHHCCCCCCEEEECCEEEEECCC
PKGGPGMQEMLYPTSYIKSKHLGKECALITDGRFSGGTSGLSIGHISPEAAAGGNIGKIV
CCCCCCHHHHHCCHHHHHHHHCCCCEEEEECCCCCCCCCCEEECCCCCHHCCCCCCCEEC
DGDIIEIDIPNRSINVKLSDEELAARPMAPVTRDRKVPKSLKAYASMVSSADKGGVRIID
CCCEEEEECCCCEEEEEECCHHHHCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCEEEEC
>Mature Secondary Structure
MKNQLRSSFSTQGRRMAGARALWVANGMKKEMMGKPIIAIVNSFTQFVPGHTHLHEIGQQ
CCCHHHHHHHHCCHHHHCCEEEEECCCCHHHHCCCHHHHHHHHHHHHCCCCHHHHHHHHH
VKAEIEKLGCFAAEFNTIAIDDGIAMGHDGMLYSLPSRDIIADSVEYMVNAHKADAMVCI
HHHHHHHHHHHEECCCEEEEECCEEECCCCEEEECCCCHHHHHHHHHHHHCCCCCEEEEE
SNCDKITPGMLMAAMRLNIPTVFVSGGPMEAGEWNNQHLDLIDAMIKSADASVSDEDVAQ
CCCCCCCHHHHHHHHHCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHCCCCCCCHHHHH
IEDNACPGCGCCSGMFTANSMNCLNEAIGLGLPGNGTILATHANRTQLFKDAAALIVKNA
HCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCEEEEEECCHHHHHHHHHHHHHHHH
YKYYEEGDDSVLPRSIATRDAFLNAMTLDIAMGGSTNTVLHLLAIAHEAEVDFKMDDIDM
HHHHHCCCCCCCCHHHHHHHHHHHEEEEEEEECCCHHHHHHHHHHHHHCCCCEEECHHHH
LSRHVPCLCKVAPNTQKYHIQDVNRAGGILNILGELSKGGLLKTDVKRVDGLTLAEAVEK
HHCCCCEEEEECCCCCEEEEEECHHCCCHHHHHHHHCCCCEEHHHHHHHCCCHHHHHHHH
YNICKKEVDTEAKRIYSSAPGNKFNIKLGSQNAVYKELDTDRANGCIRDLQHAYSKDGGL
HHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHCCCCHHHHHHHHHHHHHCCCCCE
AVLKGNIAQDGCVVKTAGVDESIWKFSGPAKVFDSQDAACEGILGGKVVSGDVVVITHEG
EEEECCCCCCCEEEEECCCCHHHHHCCCCCHHCCCCCHHHCCCCCCEEEECCEEEEECCC
PKGGPGMQEMLYPTSYIKSKHLGKECALITDGRFSGGTSGLSIGHISPEAAAGGNIGKIV
CCCCCCHHHHHCCHHHHHHHHCCCCEEEEECCCCCCCCCCEEECCCCCHHCCCCCCCEEC
DGDIIEIDIPNRSINVKLSDEELAARPMAPVTRDRKVPKSLKAYASMVSSADKGGVRIID
CCCEEEEECCCCEEEEEECCHHHHCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA