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The map label for this gene is ilvG [H]

Identifier: 150005090

GI number: 150005090

Start: 3261283

End: 3262980

Strand: Direct

Name: ilvG [H]

Synonym: BVU_2555

Alternate gene names: 150005090

Gene position: 3261283-3262980 (Clockwise)

Preceding gene: 150005089

Following gene: 150005091

Centisome position: 63.16

GC content: 45.58

Gene sequence:

>1698_bases
ATGGCAAAAGAAAAGATAACAGGAGCAGAGGCGATGATGCGTTCTTTGGAGTATCAAGGAGTAAAAACTCTTTTCGGATA
TCCCGGAGGTTCTATCATGCCTACTTTTGATGCTTTATATCATCATAAAGATACATTGAACCATATATTGGTCCGTCATG
AACAGGGAGCTGCCCATGCAGCACAGGGATTTGCCCGCGTATCCGGGGAGGTTGGTGTCTGTTTGGTGACTAGCGGACCC
GGTGCGACAAATACCATCACCGGCATTGCCGATGCTATGATTGACAGCACGCCTATTGTGGTGATTGCCGGACAGGTAGG
AGCTTCTTTTTTGGGTACGGATGCTTTTCAGGAAGTAGATCTGGTGGGCATCACTCAGCCTATTACCAAATGGAGTTACC
AAATTCGCCGTGCGGAAGATGTAGCTTGGGCTGTAGCCCGTGCTTTCTATATAGCCAAAAGCGGACGTCCCGGTCCTGTT
GTTCTGGACTTTGCCAAGAATGCACAAGTGGAGATGGTGGATTATGAACCGATGAAGCTTGATTTTATCCGTAGTTATGA
TCCGGAACCTAATCCTGATAAGGAATCTCTTCAGGAGGCTGCCGAATTGATAAACAATGCCCAAAGGCCATTAGTGTTGG
TAGGGCAGGGGGTAGAGTTGGGTAACGCGCAAGATGAGTTACGTGCATTCATAGAAAAAGCCGATATGCCTTGTGGCTGT
ACTTTGCTGGGACTTTCGGCTATACCGACTTCGCATCCTTTAAATAAAGGAATGTTAGGTATGCATGGAAATCTGGGGCC
CAATGTCAAGACTAATGAATGTGATGTGTTGATTGCCGTAGGTATGCGCTTTGACGACCGTGTAACCGGAAAATTAGAGA
CATATGCTAAACAGGCAAAGGTGATTCATTTGGATATTGACCATTCTGAAATAGACAAGAATGTAAAAGTGGATGTACCC
GTATTAGGTAATTGTAAACATACGCTAGCTATGCTGACGCAACTTATCCGGGAGAATAAACATTCCGAATGGATTGATAG
CTTTGCTGAATATGAAAAGACGGAATATGAACATGTTATCAGTAAAGAAATTCATCCTGTTGACGGGGCATTGAATATGG
GTGAAGTGGTGCGTGCGGTGAGTGAGGCTTCGAATAATGAGGCCGTACTGGTGACAGATGTGGGACAGAACCAAATGATG
GCTGCTCGTTATTTTAAATACAGTAAGAACCGCAGCATTGTAACTTCGGGTGGATTGGGAACAATGGGATTCGGTCTTCC
CGCTGCTATAGGCGCTACTTTCGGTTGCCCGGATCGTACTGTATGCGTATTTATGGGTGATGGCGGTTTGCAGATGAATA
TTCAAGAATTGGGAACTATCCTGGAGCAAAAAGCGCCGGTAAAGATTATTTTGTTGAACAATAACTATTTGGGTAATGTT
CGTCAGTGGCAAGCTATGTTTTTCGGTCATCGTTATTCATTTACTCCGATGTTGAATCCGGATTACATGAAGATTGCCGA
GGCATACGAGATTCCTGCCCGTCGTGTCATGAAGCGCGAGGAATTGCAGGATGCTATCCATGAGATGCTGGCTAATGACG
GGCCGTTCCTGTTGGAGGCTTGTGTGATAGAAGAGGGAAATGTATTGCCGATGACACCTCCGGGAAGCTCGGTGAATCAG
ATGTTACTGGAATGCTAA

Upstream 100 bases:

>100_bases
AATTAGAAATTAAAAATTGAGAATAAAAAACAGTTTCGTTGTCATCGGCCAGTTGTCCGGCATCGTATTTTTTTGAATCT
CAATTCTCAACTAAACAATT

Downstream 100 bases:

>100_bases
TTTAATAATTATGGATAAGACATTATATACATTAATCGTTCATTCAGAAAATATCGCCGGTTTGCTGAACCAGATTACGG
CTGTGTTTACTCGTCGCCAA

Product: acetolactate synthase large subunit

Products: NA

Alternate protein names: AHAS-II; ALS-II; Acetohydroxy-acid synthase II large subunit [H]

Number of amino acids: Translated: 565; Mature: 564

Protein sequence:

>565_residues
MAKEKITGAEAMMRSLEYQGVKTLFGYPGGSIMPTFDALYHHKDTLNHILVRHEQGAAHAAQGFARVSGEVGVCLVTSGP
GATNTITGIADAMIDSTPIVVIAGQVGASFLGTDAFQEVDLVGITQPITKWSYQIRRAEDVAWAVARAFYIAKSGRPGPV
VLDFAKNAQVEMVDYEPMKLDFIRSYDPEPNPDKESLQEAAELINNAQRPLVLVGQGVELGNAQDELRAFIEKADMPCGC
TLLGLSAIPTSHPLNKGMLGMHGNLGPNVKTNECDVLIAVGMRFDDRVTGKLETYAKQAKVIHLDIDHSEIDKNVKVDVP
VLGNCKHTLAMLTQLIRENKHSEWIDSFAEYEKTEYEHVISKEIHPVDGALNMGEVVRAVSEASNNEAVLVTDVGQNQMM
AARYFKYSKNRSIVTSGGLGTMGFGLPAAIGATFGCPDRTVCVFMGDGGLQMNIQELGTILEQKAPVKIILLNNNYLGNV
RQWQAMFFGHRYSFTPMLNPDYMKIAEAYEIPARRVMKREELQDAIHEMLANDGPFLLEACVIEEGNVLPMTPPGSSVNQ
MLLEC

Sequences:

>Translated_565_residues
MAKEKITGAEAMMRSLEYQGVKTLFGYPGGSIMPTFDALYHHKDTLNHILVRHEQGAAHAAQGFARVSGEVGVCLVTSGP
GATNTITGIADAMIDSTPIVVIAGQVGASFLGTDAFQEVDLVGITQPITKWSYQIRRAEDVAWAVARAFYIAKSGRPGPV
VLDFAKNAQVEMVDYEPMKLDFIRSYDPEPNPDKESLQEAAELINNAQRPLVLVGQGVELGNAQDELRAFIEKADMPCGC
TLLGLSAIPTSHPLNKGMLGMHGNLGPNVKTNECDVLIAVGMRFDDRVTGKLETYAKQAKVIHLDIDHSEIDKNVKVDVP
VLGNCKHTLAMLTQLIRENKHSEWIDSFAEYEKTEYEHVISKEIHPVDGALNMGEVVRAVSEASNNEAVLVTDVGQNQMM
AARYFKYSKNRSIVTSGGLGTMGFGLPAAIGATFGCPDRTVCVFMGDGGLQMNIQELGTILEQKAPVKIILLNNNYLGNV
RQWQAMFFGHRYSFTPMLNPDYMKIAEAYEIPARRVMKREELQDAIHEMLANDGPFLLEACVIEEGNVLPMTPPGSSVNQ
MLLEC
>Mature_564_residues
AKEKITGAEAMMRSLEYQGVKTLFGYPGGSIMPTFDALYHHKDTLNHILVRHEQGAAHAAQGFARVSGEVGVCLVTSGPG
ATNTITGIADAMIDSTPIVVIAGQVGASFLGTDAFQEVDLVGITQPITKWSYQIRRAEDVAWAVARAFYIAKSGRPGPVV
LDFAKNAQVEMVDYEPMKLDFIRSYDPEPNPDKESLQEAAELINNAQRPLVLVGQGVELGNAQDELRAFIEKADMPCGCT
LLGLSAIPTSHPLNKGMLGMHGNLGPNVKTNECDVLIAVGMRFDDRVTGKLETYAKQAKVIHLDIDHSEIDKNVKVDVPV
LGNCKHTLAMLTQLIRENKHSEWIDSFAEYEKTEYEHVISKEIHPVDGALNMGEVVRAVSEASNNEAVLVTDVGQNQMMA
ARYFKYSKNRSIVTSGGLGTMGFGLPAAIGATFGCPDRTVCVFMGDGGLQMNIQELGTILEQKAPVKIILLNNNYLGNVR
QWQAMFFGHRYSFTPMLNPDYMKIAEAYEIPARRVMKREELQDAIHEMLANDGPFLLEACVIEEGNVLPMTPPGSSVNQM
LLEC

Specific function: Catalyzes the first step in the biosynthesis of branched-chain amino acids [H]

COG id: COG0028

COG function: function code EH; Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the TPP enzyme family [H]

Homologues:

Organism=Homo sapiens, GI21361361, Length=560, Percent_Identity=25.3571428571429, Blast_Score=170, Evalue=3e-42,
Organism=Homo sapiens, GI93004078, Length=553, Percent_Identity=26.9439421338156, Blast_Score=162, Evalue=1e-39,
Organism=Escherichia coli, GI87081685, Length=571, Percent_Identity=41.3309982486865, Blast_Score=442, Evalue=1e-125,
Organism=Escherichia coli, GI1790104, Length=563, Percent_Identity=42.0959147424512, Blast_Score=429, Evalue=1e-121,
Organism=Escherichia coli, GI1786717, Length=546, Percent_Identity=30.7692307692308, Blast_Score=276, Evalue=3e-75,
Organism=Escherichia coli, GI1787096, Length=553, Percent_Identity=27.8481012658228, Blast_Score=193, Evalue=2e-50,
Organism=Escherichia coli, GI1788716, Length=569, Percent_Identity=24.780316344464, Blast_Score=171, Evalue=2e-43,
Organism=Caenorhabditis elegans, GI17542570, Length=528, Percent_Identity=26.1363636363636, Blast_Score=157, Evalue=2e-38,
Organism=Caenorhabditis elegans, GI17531299, Length=563, Percent_Identity=26.4653641207815, Blast_Score=142, Evalue=6e-34,
Organism=Caenorhabditis elegans, GI17531301, Length=563, Percent_Identity=26.4653641207815, Blast_Score=141, Evalue=7e-34,
Organism=Saccharomyces cerevisiae, GI6323755, Length=582, Percent_Identity=38.659793814433, Blast_Score=401, Evalue=1e-112,
Organism=Saccharomyces cerevisiae, GI6320816, Length=489, Percent_Identity=22.6993865030675, Blast_Score=93, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6321524, Length=494, Percent_Identity=22.6720647773279, Blast_Score=90, Evalue=8e-19,
Organism=Saccharomyces cerevisiae, GI6320588, Length=587, Percent_Identity=21.8057921635434, Blast_Score=89, Evalue=3e-18,
Organism=Drosophila melanogaster, GI19922626, Length=484, Percent_Identity=27.2727272727273, Blast_Score=169, Evalue=7e-42,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012846
- InterPro:   IPR012000
- InterPro:   IPR012001
- InterPro:   IPR000399
- InterPro:   IPR011766 [H]

Pfam domain/function: PF02775 TPP_enzyme_C; PF00205 TPP_enzyme_M; PF02776 TPP_enzyme_N [H]

EC number: =2.2.1.6 [H]

Molecular weight: Translated: 61835; Mature: 61704

Theoretical pI: Translated: 5.09; Mature: 5.09

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
5.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKEKITGAEAMMRSLEYQGVKTLFGYPGGSIMPTFDALYHHKDTLNHILVRHEQGAAHA
CCCCCCCCHHHHHHHHHHCCCHHHHCCCCCCCCCHHHHHHHHHHHHHHHEEECCCCCHHH
AQGFARVSGEVGVCLVTSGPGATNTITGIADAMIDSTPIVVIAGQVGASFLGTDAFQEVD
HHHHHHCCCCCCEEEEECCCCCCCHHHHHHHHHHCCCCEEEEECCCCCHHHCCHHHHHCC
LVGITQPITKWSYQIRRAEDVAWAVARAFYIAKSGRPGPVVLDFAKNAQVEMVDYEPMKL
EEECCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCEEEEEECCCCEE
DFIRSYDPEPNPDKESLQEAAELINNAQRPLVLVGQGVELGNAQDELRAFIEKADMPCGC
EEEECCCCCCCCCHHHHHHHHHHHHCCCCCEEEEECCCCCCCCHHHHHHHHHHCCCCCCE
TLLGLSAIPTSHPLNKGMLGMHGNLGPNVKTNECDVLIAVGMRFDDRVTGKLETYAKQAK
EEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCCCCHHHHHHHCCE
VIHLDIDHSEIDKNVKVDVPVLGNCKHTLAMLTQLIRENKHSEWIDSFAEYEKTEYEHVI
EEEEECCHHHHCCCCEEECCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
SKEIHPVDGALNMGEVVRAVSEASNNEAVLVTDVGQNQMMAARYFKYSKNRSIVTSGGLG
HHCCCCCCCCCCHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHCCCCEEEEECCCC
TMGFGLPAAIGATFGCPDRTVCVFMGDGGLQMNIQELGTILEQKAPVKIILLNNNYLGNV
CCCCCCHHHHCCCCCCCCCEEEEEECCCCCEEEHHHHHHHHHCCCCEEEEEECCCCCCCH
RQWQAMFFGHRYSFTPMLNPDYMKIAEAYEIPARRVMKREELQDAIHEMLANDGPFLLEA
HHHHHHHHCCCEEECCCCCCHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHCCCCCEEEEE
CVIEEGNVLPMTPPGSSVNQMLLEC
EEECCCCEEECCCCCCHHHHHHHCC
>Mature Secondary Structure 
AKEKITGAEAMMRSLEYQGVKTLFGYPGGSIMPTFDALYHHKDTLNHILVRHEQGAAHA
CCCCCCCHHHHHHHHHHCCCHHHHCCCCCCCCCHHHHHHHHHHHHHHHEEECCCCCHHH
AQGFARVSGEVGVCLVTSGPGATNTITGIADAMIDSTPIVVIAGQVGASFLGTDAFQEVD
HHHHHHCCCCCCEEEEECCCCCCCHHHHHHHHHHCCCCEEEEECCCCCHHHCCHHHHHCC
LVGITQPITKWSYQIRRAEDVAWAVARAFYIAKSGRPGPVVLDFAKNAQVEMVDYEPMKL
EEECCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCEEEEEECCCCEE
DFIRSYDPEPNPDKESLQEAAELINNAQRPLVLVGQGVELGNAQDELRAFIEKADMPCGC
EEEECCCCCCCCCHHHHHHHHHHHHCCCCCEEEEECCCCCCCCHHHHHHHHHHCCCCCCE
TLLGLSAIPTSHPLNKGMLGMHGNLGPNVKTNECDVLIAVGMRFDDRVTGKLETYAKQAK
EEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCCCCHHHHHHHCCE
VIHLDIDHSEIDKNVKVDVPVLGNCKHTLAMLTQLIRENKHSEWIDSFAEYEKTEYEHVI
EEEEECCHHHHCCCCEEECCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
SKEIHPVDGALNMGEVVRAVSEASNNEAVLVTDVGQNQMMAARYFKYSKNRSIVTSGGLG
HHCCCCCCCCCCHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHCCCCEEEEECCCC
TMGFGLPAAIGATFGCPDRTVCVFMGDGGLQMNIQELGTILEQKAPVKIILLNNNYLGNV
CCCCCCHHHHCCCCCCCCCEEEEEECCCCCEEEHHHHHHHHHCCCCEEEEEECCCCCCCH
RQWQAMFFGHRYSFTPMLNPDYMKIAEAYEIPARRVMKREELQDAIHEMLANDGPFLLEA
HHHHHHHHCCCEEECCCCCCHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHCCCCCEEEEE
CVIEEGNVLPMTPPGSSVNQMLLEC
EEECCCCEEECCCCCCHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3550695; 1379743; 9278503; 1995430; 6154938; 7015336; 3897211 [H]