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The map label for this gene is pccB [H]

Identifier: 150005026

GI number: 150005026

Start: 3192654

End: 3194207

Strand: Reverse

Name: pccB [H]

Synonym: BVU_2491

Alternate gene names: 150005026

Gene position: 3194207-3192654 (Counterclockwise)

Preceding gene: 150005027

Following gene: 150005025

Centisome position: 61.87

GC content: 45.24

Gene sequence:

>1554_bases
ATGAGCAATCAACTTGAAAAAATAAAAGAGCTTATCGAACGCCGGGCTACAGCACGCATGGGTGGAGGTGATAAAGCAAT
TGCAAAACAGCATGATAAAGGAAAATATACAGCCCGCGAACGCATAGCCATGCTGCTGGATGAGGGCAGTTTCGAAGAAA
TGGATATGTTTGTGGAACACAGATGCACCAATTTCGGCATGGAGAAAAAACATTATCCGGGCGACGGTGTAGTAACAGGT
TGTGGTACCATAGAAGGACGTTTAGTTTACATCTTTGCACAGGATTTCACTGTTTCTGCCGGTTCTCTTTCAGAAACAAT
GTCTCTGAAAATATGCAAAGTAATGGATCAAGCTATGAAAATGGGTGCTCCCTGTATCGGTATCAACGACTCGGGTGGCG
CACGTATTCAAGAAGGTATCAATGCATTGGCCGGTTATGCTGAAATTTTCCAACGCAATATTCTTGCTTCAGGTGTTATT
CCGCAGATCTCAGGTATTTTCGGTCCTTGTGCAGGCGGAGCTGTTTACTCTCCTGCTCTGACAGACTTCACCTTGATGAT
GGAAGGCACATCATATATGTTCCTTACCGGACCGAAAGTGGTAAAGACTGTTACAGGTGAAGATGTAAGCCAGGAAAACT
TAGGTGGTGCAAGCGTTCATTCAACCAAATCCGGTGTTACTCATTTTACAGCCAAGACGGAAGAAGAAGGGTTAGCCATG
ATCCGCAAATTGTTAAGCTATATTCCTCAGAACAATCTGGAAGAAGCTCCCTATGTAGACTGTACCGATCCTATCGACCG
TCTGGAAGACTCTTTGAACGAAATTATCCCCGACAGCCCCAACAAACCATACGATATGTATGAGGTGATCAGCGCCATCG
TAGATAATGGTGAGTTTTTGGAAGTCCAACCTCACTACGCTAAAAATATCATCATTGGTTTCGCACGTTTCAACGGCCAG
TCTGTAGGTATTGTTGCCAACCAGCCCAAATACCTGGCGGGTGTGCTTGACAGCAATGCGTCACGCAAAGGTGCTCGTTT
TGTACGTTTCTGCGACGCTTTCAATATACCTCTTGTTTCATTGGTAGATGTTCCGGGATTCCTTCCGGGTACAGGACAAG
AATACAACGGTGTAATCCTCCACGGTGCCAAGTTGCTGTATGCTTACGGCGAAGCGACTGTACCCAAAGTGACAATTACC
CTGCGTAAATCATACGGCGGATCTCACATTGTAATGAGCTGTAAACAACTTCGCGGTGATATGAATTATGCATGGCCTAC
TGCCGAAATCGCCGTTATGGGTGGTGCAGGTGCAGTAGAAGTATTATACGCACGCGAAGCCAAAGAACAGGAAAATCCTG
CCGCATTCCTAGCCGAAAAAGAAGCTGAATACACCAAGCTGTTCGCCAATCCTTACAATGCTGCCAAATATGGTTACATT
GATGATGTGATTGAACCGCGTAATACCCGTTTCCGCATCATCCGTGCATTGCAACAGTTGCAGACTAAGAAATTAACCAA
TCCGGCTAAGAAGCATGGTAATATTCCTCTTTAA

Upstream 100 bases:

>100_bases
CACGAGATCTGACTATTCACGATTGAAGTCAGTATATTTAGTCTGGTTCAAGCGTAAATAGAATTATTTTTTAATCGTAA
ATTGTAAAATCATAAGTAAA

Downstream 100 bases:

>100_bases
TTAAAAATTAAAAACTGAGAATTGAACATGAAGAAATTAAATATAGGAATATTCCTTTCTTTGCTGCTGATGGTGGGGTT
ATGTTCTTGTGGAGAACAGA

Product: propionyl-CoA carboxylase beta chain

Products: NA

Alternate protein names: PCCase; Propanoyl-CoA:carbon dioxide ligase [H]

Number of amino acids: Translated: 517; Mature: 516

Protein sequence:

>517_residues
MSNQLEKIKELIERRATARMGGGDKAIAKQHDKGKYTARERIAMLLDEGSFEEMDMFVEHRCTNFGMEKKHYPGDGVVTG
CGTIEGRLVYIFAQDFTVSAGSLSETMSLKICKVMDQAMKMGAPCIGINDSGGARIQEGINALAGYAEIFQRNILASGVI
PQISGIFGPCAGGAVYSPALTDFTLMMEGTSYMFLTGPKVVKTVTGEDVSQENLGGASVHSTKSGVTHFTAKTEEEGLAM
IRKLLSYIPQNNLEEAPYVDCTDPIDRLEDSLNEIIPDSPNKPYDMYEVISAIVDNGEFLEVQPHYAKNIIIGFARFNGQ
SVGIVANQPKYLAGVLDSNASRKGARFVRFCDAFNIPLVSLVDVPGFLPGTGQEYNGVILHGAKLLYAYGEATVPKVTIT
LRKSYGGSHIVMSCKQLRGDMNYAWPTAEIAVMGGAGAVEVLYAREAKEQENPAAFLAEKEAEYTKLFANPYNAAKYGYI
DDVIEPRNTRFRIIRALQQLQTKKLTNPAKKHGNIPL

Sequences:

>Translated_517_residues
MSNQLEKIKELIERRATARMGGGDKAIAKQHDKGKYTARERIAMLLDEGSFEEMDMFVEHRCTNFGMEKKHYPGDGVVTG
CGTIEGRLVYIFAQDFTVSAGSLSETMSLKICKVMDQAMKMGAPCIGINDSGGARIQEGINALAGYAEIFQRNILASGVI
PQISGIFGPCAGGAVYSPALTDFTLMMEGTSYMFLTGPKVVKTVTGEDVSQENLGGASVHSTKSGVTHFTAKTEEEGLAM
IRKLLSYIPQNNLEEAPYVDCTDPIDRLEDSLNEIIPDSPNKPYDMYEVISAIVDNGEFLEVQPHYAKNIIIGFARFNGQ
SVGIVANQPKYLAGVLDSNASRKGARFVRFCDAFNIPLVSLVDVPGFLPGTGQEYNGVILHGAKLLYAYGEATVPKVTIT
LRKSYGGSHIVMSCKQLRGDMNYAWPTAEIAVMGGAGAVEVLYAREAKEQENPAAFLAEKEAEYTKLFANPYNAAKYGYI
DDVIEPRNTRFRIIRALQQLQTKKLTNPAKKHGNIPL
>Mature_516_residues
SNQLEKIKELIERRATARMGGGDKAIAKQHDKGKYTARERIAMLLDEGSFEEMDMFVEHRCTNFGMEKKHYPGDGVVTGC
GTIEGRLVYIFAQDFTVSAGSLSETMSLKICKVMDQAMKMGAPCIGINDSGGARIQEGINALAGYAEIFQRNILASGVIP
QISGIFGPCAGGAVYSPALTDFTLMMEGTSYMFLTGPKVVKTVTGEDVSQENLGGASVHSTKSGVTHFTAKTEEEGLAMI
RKLLSYIPQNNLEEAPYVDCTDPIDRLEDSLNEIIPDSPNKPYDMYEVISAIVDNGEFLEVQPHYAKNIIIGFARFNGQS
VGIVANQPKYLAGVLDSNASRKGARFVRFCDAFNIPLVSLVDVPGFLPGTGQEYNGVILHGAKLLYAYGEATVPKVTITL
RKSYGGSHIVMSCKQLRGDMNYAWPTAEIAVMGGAGAVEVLYAREAKEQENPAAFLAEKEAEYTKLFANPYNAAKYGYID
DVIEPRNTRFRIIRALQQLQTKKLTNPAKKHGNIPL

Specific function: This Protein Is A Component Of The Acetyl Coenzyme A Carboxylase Complex; First, Biotin Carboxylase Catalyzes The Carboxylation Of The Carrier Protein And Then The Transcarboxylase Transfers The Carboxyl Group To Form Malonyl-CoA. [C]

COG id: COG4799

COG function: function code I; Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 carboxyltransferase domain [H]

Homologues:

Organism=Homo sapiens, GI119943100, Length=520, Percent_Identity=59.8076923076923, Blast_Score=642, Evalue=0.0,
Organism=Homo sapiens, GI295821216, Length=540, Percent_Identity=57.5925925925926, Blast_Score=630, Evalue=0.0,
Organism=Homo sapiens, GI11545863, Length=502, Percent_Identity=34.4621513944223, Blast_Score=236, Evalue=6e-62,
Organism=Homo sapiens, GI38679977, Length=365, Percent_Identity=27.1232876712329, Blast_Score=83, Evalue=5e-16,
Organism=Homo sapiens, GI38679967, Length=365, Percent_Identity=27.1232876712329, Blast_Score=83, Evalue=5e-16,
Organism=Homo sapiens, GI38679960, Length=365, Percent_Identity=27.1232876712329, Blast_Score=83, Evalue=5e-16,
Organism=Homo sapiens, GI38679974, Length=365, Percent_Identity=27.1232876712329, Blast_Score=83, Evalue=5e-16,
Organism=Homo sapiens, GI38679971, Length=365, Percent_Identity=27.1232876712329, Blast_Score=83, Evalue=5e-16,
Organism=Homo sapiens, GI134142062, Length=330, Percent_Identity=26.6666666666667, Blast_Score=80, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI25147362, Length=517, Percent_Identity=57.4468085106383, Blast_Score=631, Evalue=0.0,
Organism=Caenorhabditis elegans, GI25147359, Length=517, Percent_Identity=57.4468085106383, Blast_Score=631, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17552936, Length=521, Percent_Identity=32.2456813819578, Blast_Score=253, Evalue=2e-67,
Organism=Caenorhabditis elegans, GI71997163, Length=296, Percent_Identity=24.6621621621622, Blast_Score=72, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6323863, Length=305, Percent_Identity=24.5901639344262, Blast_Score=69, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24586065, Length=499, Percent_Identity=33.8677354709419, Blast_Score=251, Evalue=1e-66,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000438
- InterPro:   IPR000022
- InterPro:   IPR011763
- InterPro:   IPR011762 [H]

Pfam domain/function: PF01039 Carboxyl_trans [H]

EC number: =6.4.1.3 [H]

Molecular weight: Translated: 56471; Mature: 56340

Theoretical pI: Translated: 6.26; Mature: 6.26

Prosite motif: PS50980 COA_CT_NTER ; PS50989 COA_CT_CTER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNQLEKIKELIERRATARMGGGDKAIAKQHDKGKYTARERIAMLLDEGSFEEMDMFVEH
CCHHHHHHHHHHHHHHHHHCCCCCHHHHHCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHH
RCTNFGMEKKHYPGDGVVTGCGTIEGRLVYIFAQDFTVSAGSLSETMSLKICKVMDQAMK
HHHCCCCCCCCCCCCCEEEECCCCCCEEEEEEEECEEECCCCHHHHHHHHHHHHHHHHHH
MGAPCIGINDSGGARIQEGINALAGYAEIFQRNILASGVIPQISGIFGPCAGGAVYSPAL
CCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCCCCCCCCCH
TDFTLMMEGTSYMFLTGPKVVKTVTGEDVSQENLGGASVHSTKSGVTHFTAKTEEEGLAM
HCEEEEEECCEEEEEECCHHEEEECCCCCCCCCCCCCCCCCCCCCCEEEECCCCHHHHHH
IRKLLSYIPQNNLEEAPYVDCTDPIDRLEDSLNEIIPDSPNKPYDMYEVISAIVDNGEFL
HHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCEE
EVQPHYAKNIIIGFARFNGQSVGIVANQPKYLAGVLDSNASRKGARFVRFCDAFNIPLVS
EECCCCCCEEEEEEEEECCCEEEEEECCCHHHHHHHCCCCCCCHHHHHHHHHHCCCCCEE
LVDVPGFLPGTGQEYNGVILHGAKLLYAYGEATVPKVTITLRKSYGGSHIVMSCKQLRGD
EECCCCCCCCCCCCCCCEEEECCEEEEEECCCCCCEEEEEEEECCCCCHHHHHHHHHCCC
MNYAWPTAEIAVMGGAGAVEVLYAREAKEQENPAAFLAEKEAEYTKLFANPYNAAKYGYI
CCCCCCCEEEEEECCCCCEEEEEHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCH
DDVIEPRNTRFRIIRALQQLQTKKLTNPAKKHGNIPL
HHHCCCCCHHHHHHHHHHHHHHHHCCCHHHHCCCCCC
>Mature Secondary Structure 
SNQLEKIKELIERRATARMGGGDKAIAKQHDKGKYTARERIAMLLDEGSFEEMDMFVEH
CHHHHHHHHHHHHHHHHHCCCCCHHHHHCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHH
RCTNFGMEKKHYPGDGVVTGCGTIEGRLVYIFAQDFTVSAGSLSETMSLKICKVMDQAMK
HHHCCCCCCCCCCCCCEEEECCCCCCEEEEEEEECEEECCCCHHHHHHHHHHHHHHHHHH
MGAPCIGINDSGGARIQEGINALAGYAEIFQRNILASGVIPQISGIFGPCAGGAVYSPAL
CCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCCCCCCCCCH
TDFTLMMEGTSYMFLTGPKVVKTVTGEDVSQENLGGASVHSTKSGVTHFTAKTEEEGLAM
HCEEEEEECCEEEEEECCHHEEEECCCCCCCCCCCCCCCCCCCCCCEEEECCCCHHHHHH
IRKLLSYIPQNNLEEAPYVDCTDPIDRLEDSLNEIIPDSPNKPYDMYEVISAIVDNGEFL
HHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCEE
EVQPHYAKNIIIGFARFNGQSVGIVANQPKYLAGVLDSNASRKGARFVRFCDAFNIPLVS
EECCCCCCEEEEEEEEECCCEEEEEECCCHHHHHHHCCCCCCCHHHHHHHHHHCCCCCEE
LVDVPGFLPGTGQEYNGVILHGAKLLYAYGEATVPKVTITLRKSYGGSHIVMSCKQLRGD
EECCCCCCCCCCCCCCCEEEECCEEEEEECCCCCCEEEEEEEECCCCCHHHHHHHHHCCC
MNYAWPTAEIAVMGGAGAVEVLYAREAKEQENPAAFLAEKEAEYTKLFANPYNAAKYGYI
CCCCCCCEEEEEECCCCCEEEEEHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCH
DDVIEPRNTRFRIIRALQQLQTKKLTNPAKKHGNIPL
HHHCCCCCHHHHHHHHHHHHHHHHCCCHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8830278 [H]