Click here to switch to the map view.

The map label for this gene is bcc [H]

Identifier: 150005024

GI number: 150005024

Start: 3191242

End: 3191676

Strand: Reverse

Name: bcc [H]

Synonym: BVU_2489

Alternate gene names: 150005024

Gene position: 3191676-3191242 (Counterclockwise)

Preceding gene: 150005025

Following gene: 150005023

Centisome position: 61.82

GC content: 41.38

Gene sequence:

>435_bases
ATGATGAAAGAATATAAATATAAGATCAACGGTAACGTATACAAAGTTGCCATTGGAGATATAGAAGACAATATCGCTCA
TGTTGAAGTGAACGGTACTCCTTACAAAGTGGAAATGGAAAAAGCTCCGAAAGCTGTAGTGAAACCGGTAGTTCGTCCTG
TATCAACCAGCCCTGCTCCGGCACCAGCTACAGTAGTAAAGCCTGCTGCAACTTCTACAGGTAAATCGGGCGTTAAATCT
CCGTTGCCGGGGGTAATCCTTGATATCAAGGTAAATGTGGGTGATACCGTAAAAAAGGGGCAAACCATCATTATCCTTGA
AGCTATGAAGATGGAAAATAACATCAATGCAGACAAAGACGGCAAGATCACCGCAATCAATGTAAGTAAAGGAGAATCCG
TTCTCGAAGGTACTGACCTTGTAATTATTGAATAA

Upstream 100 bases:

>100_bases
CCATTACCCGTGTAAAACGTAGTTATTCACCGTGGAGTTCCAAGATTTATACCTTGCGTGAAACTCCCCACAAAAAGTAA
GTCACCAATAAAAAGATAAA

Downstream 100 bases:

>100_bases
TATGGGAGAATTTATCAACTTTTTAGGGAATAACCTAGCTGACTTTTGGACATATACGGGTTTTGCCAATGCTACTGTTG
GTCATATCGTAATGATCCTG

Product: biotin carboxyl carrier protein

Products: propanoyl-CoA; CO2

Alternate protein names: BCCP [H]

Number of amino acids: Translated: 144; Mature: 144

Protein sequence:

>144_residues
MMKEYKYKINGNVYKVAIGDIEDNIAHVEVNGTPYKVEMEKAPKAVVKPVVRPVSTSPAPAPATVVKPAATSTGKSGVKS
PLPGVILDIKVNVGDTVKKGQTIIILEAMKMENNINADKDGKITAINVSKGESVLEGTDLVIIE

Sequences:

>Translated_144_residues
MMKEYKYKINGNVYKVAIGDIEDNIAHVEVNGTPYKVEMEKAPKAVVKPVVRPVSTSPAPAPATVVKPAATSTGKSGVKS
PLPGVILDIKVNVGDTVKKGQTIIILEAMKMENNINADKDGKITAINVSKGESVLEGTDLVIIE
>Mature_144_residues
MMKEYKYKINGNVYKVAIGDIEDNIAHVEVNGTPYKVEMEKAPKAVVKPVVRPVSTSPAPAPATVVKPAATSTGKSGVKS
PLPGVILDIKVNVGDTVKKGQTIIILEAMKMENNINADKDGKITAINVSKGESVLEGTDLVIIE

Specific function: This Protein Is A Component Of The Acetyl Coenzyme A Carboxylase Complex; First, Biotin Carboxylase Catalyzes The Carboxylation Of The Carrier Protein And Then The Transcarboxylase Transfers The Carboxyl Group To Form Malonyl-CoA. [C]

COG id: COG0511

COG function: function code I; Biotin carboxyl carrier protein

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 biotinyl-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1789653, Length=142, Percent_Identity=35.2112676056338, Blast_Score=59, Evalue=1e-10,
Organism=Caenorhabditis elegans, GI17567343, Length=67, Percent_Identity=46.2686567164179, Blast_Score=65, Evalue=1e-11,
Organism=Drosophila melanogaster, GI281363050, Length=78, Percent_Identity=42.3076923076923, Blast_Score=66, Evalue=7e-12,
Organism=Drosophila melanogaster, GI24652224, Length=78, Percent_Identity=42.3076923076923, Blast_Score=66, Evalue=7e-12,
Organism=Drosophila melanogaster, GI24652222, Length=78, Percent_Identity=42.3076923076923, Blast_Score=66, Evalue=7e-12,
Organism=Drosophila melanogaster, GI24652220, Length=78, Percent_Identity=42.3076923076923, Blast_Score=66, Evalue=7e-12,
Organism=Drosophila melanogaster, GI24652218, Length=78, Percent_Identity=42.3076923076923, Blast_Score=66, Evalue=7e-12,
Organism=Drosophila melanogaster, GI24652212, Length=78, Percent_Identity=42.3076923076923, Blast_Score=66, Evalue=8e-12,
Organism=Drosophila melanogaster, GI24652210, Length=78, Percent_Identity=42.3076923076923, Blast_Score=66, Evalue=8e-12,
Organism=Drosophila melanogaster, GI24652214, Length=78, Percent_Identity=42.3076923076923, Blast_Score=66, Evalue=8e-12,
Organism=Drosophila melanogaster, GI19921944, Length=78, Percent_Identity=42.3076923076923, Blast_Score=66, Evalue=8e-12,
Organism=Drosophila melanogaster, GI24652216, Length=78, Percent_Identity=42.3076923076923, Blast_Score=66, Evalue=8e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001882
- InterPro:   IPR000089
- InterPro:   IPR011053 [H]

Pfam domain/function: PF00364 Biotin_lipoyl [H]

EC number: 4.1.1.41

Molecular weight: Translated: 15283; Mature: 15283

Theoretical pI: Translated: 9.33; Mature: 9.33

Prosite motif: PS50968 BIOTINYL_LIPOYL ; PS00188 BIOTIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMKEYKYKINGNVYKVAIGDIEDNIAHVEVNGTPYKVEMEKAPKAVVKPVVRPVSTSPAP
CCCCEEEEECCCEEEEEECCCCCCEEEEEECCCEEEEECCCCCHHHHHHHHCCCCCCCCC
APATVVKPAATSTGKSGVKSPLPGVILDIKVNVGDTVKKGQTIIILEAMKMENNINADKD
CCCEEEECCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCCEEEEEEEEECCCCCCCCCC
GKITAINVSKGESVLEGTDLVIIE
CCEEEEECCCCCCEECCCEEEEEC
>Mature Secondary Structure
MMKEYKYKINGNVYKVAIGDIEDNIAHVEVNGTPYKVEMEKAPKAVVKPVVRPVSTSPAP
CCCCEEEEECCCEEEEEECCCCCCEEEEEECCCEEEEECCCCCHHHHHHHHCCCCCCCCC
APATVVKPAATSTGKSGVKSPLPGVILDIKVNVGDTVKKGQTIIILEAMKMENNINADKD
CCCEEEECCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCCEEEEEEEEECCCCCCCCCC
GKITAINVSKGESVLEGTDLVIIE
CCEEEEECCCCCCEECCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: (S)-methylmalonyl-CoA

Specific reaction: (S)-methylmalonyl-CoA = propanoyl-CoA + CO2

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8431283; 12397186 [H]