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The map label for this gene is hisC

Identifier: 150004900

GI number: 150004900

Start: 3042579

End: 3043619

Strand: Direct

Name: hisC

Synonym: BVU_2363

Alternate gene names: 150004900

Gene position: 3042579-3043619 (Clockwise)

Preceding gene: 150004899

Following gene: 150004901

Centisome position: 58.93

GC content: 41.31

Gene sequence:

>1041_bases
ATGAAAGATTTGAAAGAATTGACGCGCCCGAATATTTGGGCTTTGAAACCCTATTCATCGGCACGTGACGAATATAATGG
AGCGGAGGCATCTGTTTTTCTGGATGCCAATGAGAACCCGTACAATACACCTAATAACCGTTATCCTGATCCTATGCAGC
GGGAATTGAAGAATATGATAGCTCCTATTAAAAAGGTAGACCCCGATACGATCTTTCTGGGAAACGGCAGTGATGAGGCT
ATTGACTTGGTGTATCGCGCGTTCTGTATTCCGGGGGTGGATAATGTAGTGGCTATTGACCCTACTTATGGTATGTATCA
GGTGTGTGCCGATGTCAACGATGTAGAATATCGCAAGGTGTTATTGGATGAAAACTATCAGTTCAGTGCCGATAAACTAT
TGGCGGCAACAGACGATCACACCAAACTGGTTTTTCTTTGCTCGCCCAATAATCCTACCGGTAATAACCTGGATCGTAGG
GAAATGGAAAAATTACTGGATACTTTTCAGGGATTGGTGATTATAGACGAGGCCTATTCCGATTTTTCTGATGCGCCGTC
TTTCCTTGCCGATTTAGATAAATATCCTAATTTGATTGTCTTTCAGACTTTTTCTAAGGCATGGGGATGTGCTGCCATTC
GTTTGGGCATGGCCTTTGCGTCTAAAGAAATCATCTCTATTTTCAGTAAGATTAAATATCCGTATAATGTGAATCTGCTG
ACACAGAAAGAGGCTGTTATGATGTTGCACCGGCATTATGAGGTAGAACGTTGGGTAAAGTCGTTATTGGAAGAACGGAC
GCGTTTGGTCAATGAATTTGTAGAACTGCCTTGTTGTGAGAAAATCTATCCTACGGATGCCAATTTCTTTCTAGCTAAAG
TGACAGATGCCAAGAAAATATATAATTATTTGGTAGGTAAAGGTATCATAGTGCGTAACCGTACCAGTATTTCTTTATGT
CGTGATTGTTTGCGTGTGACTATTGGTACACGTCCGGAGAATGATATGTTGTTGGAAGCATTGAAGAATTATGAATGTTG
A

Upstream 100 bases:

>100_bases
GTATTCAGAATATCGGTCCTGCTATTGAGGTGATGGCGGCTAATGAACAACTGGGTGCGCATAAGAATGCAGTAACCGTA
AGATTAAAAACAGTATAAAG

Downstream 100 bases:

>100_bases
AGTATGAAGAAAGCGTTGTTTATAGATCGTGACGGTACGTTGGTTATAGAGCCACCGGTTGACTACCAATTGGATTCTTT
CCATAAATTGGAGTTTTATC

Product: histidinol-phosphate aminotransferase

Products: NA

Alternate protein names: Imidazole acetol-phosphate transaminase

Number of amino acids: Translated: 346; Mature: 346

Protein sequence:

>346_residues
MKDLKELTRPNIWALKPYSSARDEYNGAEASVFLDANENPYNTPNNRYPDPMQRELKNMIAPIKKVDPDTIFLGNGSDEA
IDLVYRAFCIPGVDNVVAIDPTYGMYQVCADVNDVEYRKVLLDENYQFSADKLLAATDDHTKLVFLCSPNNPTGNNLDRR
EMEKLLDTFQGLVIIDEAYSDFSDAPSFLADLDKYPNLIVFQTFSKAWGCAAIRLGMAFASKEIISIFSKIKYPYNVNLL
TQKEAVMMLHRHYEVERWVKSLLEERTRLVNEFVELPCCEKIYPTDANFFLAKVTDAKKIYNYLVGKGIIVRNRTSISLC
RDCLRVTIGTRPENDMLLEALKNYEC

Sequences:

>Translated_346_residues
MKDLKELTRPNIWALKPYSSARDEYNGAEASVFLDANENPYNTPNNRYPDPMQRELKNMIAPIKKVDPDTIFLGNGSDEA
IDLVYRAFCIPGVDNVVAIDPTYGMYQVCADVNDVEYRKVLLDENYQFSADKLLAATDDHTKLVFLCSPNNPTGNNLDRR
EMEKLLDTFQGLVIIDEAYSDFSDAPSFLADLDKYPNLIVFQTFSKAWGCAAIRLGMAFASKEIISIFSKIKYPYNVNLL
TQKEAVMMLHRHYEVERWVKSLLEERTRLVNEFVELPCCEKIYPTDANFFLAKVTDAKKIYNYLVGKGIIVRNRTSISLC
RDCLRVTIGTRPENDMLLEALKNYEC
>Mature_346_residues
MKDLKELTRPNIWALKPYSSARDEYNGAEASVFLDANENPYNTPNNRYPDPMQRELKNMIAPIKKVDPDTIFLGNGSDEA
IDLVYRAFCIPGVDNVVAIDPTYGMYQVCADVNDVEYRKVLLDENYQFSADKLLAATDDHTKLVFLCSPNNPTGNNLDRR
EMEKLLDTFQGLVIIDEAYSDFSDAPSFLADLDKYPNLIVFQTFSKAWGCAAIRLGMAFASKEIISIFSKIKYPYNVNLL
TQKEAVMMLHRHYEVERWVKSLLEERTRLVNEFVELPCCEKIYPTDANFFLAKVTDAKKIYNYLVGKGIIVRNRTSISLC
RDCLRVTIGTRPENDMLLEALKNYEC

Specific function: Histidine biosynthesis; seventh step. [C]

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily

Homologues:

Organism=Escherichia coli, GI1788332, Length=355, Percent_Identity=34.0845070422535, Blast_Score=206, Evalue=3e-54,
Organism=Saccharomyces cerevisiae, GI6322075, Length=377, Percent_Identity=36.8700265251989, Blast_Score=226, Evalue=3e-60,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS8_BACV8 (A6L2V8)

Other databases:

- EMBL:   CP000139
- RefSeq:   YP_001299644.1
- ProteinModelPortal:   A6L2V8
- SMR:   A6L2V8
- STRING:   A6L2V8
- GeneID:   5303327
- GenomeReviews:   CP000139_GR
- KEGG:   bvu:BVU_2363
- NMPDR:   fig|435590.6.peg.2218
- eggNOG:   COG0079
- HOGENOM:   HBG646350
- OMA:   DDCIRIS
- ProtClustDB:   CLSK822088
- HAMAP:   MF_01023
- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR005861
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- TIGRFAMs:   TIGR01141

Pfam domain/function: PF00155 Aminotran_1_2; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =2.6.1.9

Molecular weight: Translated: 39609; Mature: 39609

Theoretical pI: Translated: 4.86; Mature: 4.86

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKDLKELTRPNIWALKPYSSARDEYNGAEASVFLDANENPYNTPNNRYPDPMQRELKNMI
CCCHHHHCCCCEEEECCCCHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCHHHHHHHHHH
APIKKVDPDTIFLGNGSDEAIDLVYRAFCIPGVDNVVAIDPTYGMYQVCADVNDVEYRKV
HHHHHCCCCEEEEECCCCHHHHHHHHHHHCCCCCCEEEECCCCCHHHHHCCCCCHHHHHH
LLDENYQFSADKLLAATDDHTKLVFLCSPNNPTGNNLDRREMEKLLDTFQGLVIIDEAYS
HCCCCCCCCCCCEEEECCCCEEEEEEECCCCCCCCCCCHHHHHHHHHHHCCEEEEECHHC
DFSDAPSFLADLDKYPNLIVFQTFSKAWGCAAIRLGMAFASKEIISIFSKIKYPYNVNLL
CCCCCHHHHHHHHHCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEE
TQKEAVMMLHRHYEVERWVKSLLEERTRLVNEFVELPCCEKIYPTDANFFLAKVTDAKKI
EHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEEHHHHHH
YNYLVGKGIIVRNRTSISLCRDCLRVTIGTRPENDMLLEALKNYEC
HHHHHCCCEEEECCCHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCC
>Mature Secondary Structure
MKDLKELTRPNIWALKPYSSARDEYNGAEASVFLDANENPYNTPNNRYPDPMQRELKNMI
CCCHHHHCCCCEEEECCCCHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCHHHHHHHHHH
APIKKVDPDTIFLGNGSDEAIDLVYRAFCIPGVDNVVAIDPTYGMYQVCADVNDVEYRKV
HHHHHCCCCEEEEECCCCHHHHHHHHHHHCCCCCCEEEECCCCCHHHHHCCCCCHHHHHH
LLDENYQFSADKLLAATDDHTKLVFLCSPNNPTGNNLDRREMEKLLDTFQGLVIIDEAYS
HCCCCCCCCCCCEEEECCCCEEEEEEECCCCCCCCCCCHHHHHHHHHHHCCEEEEECHHC
DFSDAPSFLADLDKYPNLIVFQTFSKAWGCAAIRLGMAFASKEIISIFSKIKYPYNVNLL
CCCCCHHHHHHHHHCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEE
TQKEAVMMLHRHYEVERWVKSLLEERTRLVNEFVELPCCEKIYPTDANFFLAKVTDAKKI
EHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEEHHHHHH
YNYLVGKGIIVRNRTSISLCRDCLRVTIGTRPENDMLLEALKNYEC
HHHHHCCCEEEECCCHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA