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The map label for this gene is hisD [H]

Identifier: 150004899

GI number: 150004899

Start: 3041296

End: 3042576

Strand: Direct

Name: hisD [H]

Synonym: BVU_2362

Alternate gene names: 150004899

Gene position: 3041296-3042576 (Clockwise)

Preceding gene: 150004898

Following gene: 150004900

Centisome position: 58.9

GC content: 45.51

Gene sequence:

>1281_bases
ATGAAGAAAATAATATATCCTGAAAAGAAAGACTGGATGGAAATTCTCCGTCGTCCGGCATTGAATACAGACACGCTGCG
CAATACGGTTAAAGAAGTGCTGGATAAAGTGAAGACGGAAGGAGATAAAGCGGTGAGGGAATATGAAGAACGTTTTGATA
AGGTGAAACTGGACTCACTGGGGGTTACTGAAACGGAAATTGCTGAAGCGGAAAAGGAGGTACCCATTGAATTGAAGGCA
GCTATCATGCTGGCACAGAAAAATATTCATACTTTTCATAGTTCTCAGCGGTTTGAAGGGAAAAAGGTGCAGACCGTACC
CGGGGTAACTTGTTGGCAGAAGGCGGTTGCTATTGAAAAGGTGGGCTTGTATATTCCCGGAGGCACGGCGCCTTTATTTT
CTACCGTATTGATGTTGGCTACTCCGGCACAGATTGCAGGTTGCAAGGAAATCGTACTTTGTACTCCTCCTGATAAAGAA
GGAAAGGTTCATCCTGCTATCTTGTATGCGGCAAAATTGGCCGGGGTAAATAAAATATTCAAAGCAGGAGGGGTGCAGGC
CATCGCTGCTATGGCATACGGAACGGAAAGTGTGCCTAAGGTTTATAAAATTTTCGGTCCGGGTAACCAATATGTAACGG
CTGCCAAGCAGCAGGTTTCTTTGCGGGATGTTGCGATAGATATGCCTGCCGGTCCTTCTGAAGTCGAAGTGCTGGCCGAC
GAGACGGCTAATCCTGTATTTGTGGCAGCCGATTTGCTTTCACAGGCGGAACATGGAGTTGATAGTCAGGCCATGCTGAT
AACTACTTCTGAGAAATTAATGAAGGAGGTGGAGTATGAGGTACAACGCCAGTTGGCTTTGCTTCCCAGATGGGAAATAG
CCGAAAAGTCGTTGGCAAGCAGCAAATTGATTTTGGTGAGGGATATGGATGAGGCAATTGCTCTGACGAATGAATATGCT
CCCGAGCATTTGATTATCGAGACCAGGGATTATATGGAACAGGCAGAGCGTATTGTCAATGCCGGATCTGTATTTCTAGG
TTCACTTACTCCGGAGAGTGCCGGTGATTATGCATCCGGAACCAATCATACTTTACCTACCAATGGTTATGCCAAAGCGT
ATAGTGGGGTGAGTCTGGATAGTTTTATCCGTAAAATCACTTTTCAGGAGATTAATGGCGAGGGTATTCAGAATATCGGT
CCTGCTATTGAGGTGATGGCGGCTAATGAACAACTGGGTGCGCATAAGAATGCAGTAACCGTAAGATTAAAAACAGTATA
A

Upstream 100 bases:

>100_bases
TTGGGCGCGGAAGGTATTTTGGTATTGCCCATTGAGAAAATGATATTATAGCCGGTCCATACGTCAGGCGAGATTTGTAA
ACTTATAAAAGAATACATGT

Downstream 100 bases:

>100_bases
AGATGAAAGATTTGAAAGAATTGACGCGCCCGAATATTTGGGCTTTGAAACCCTATTCATCGGCACGTGACGAATATAAT
GGAGCGGAGGCATCTGTTTT

Product: histidinol dehydrogenase

Products: NA

Alternate protein names: HDH [H]

Number of amino acids: Translated: 426; Mature: 426

Protein sequence:

>426_residues
MKKIIYPEKKDWMEILRRPALNTDTLRNTVKEVLDKVKTEGDKAVREYEERFDKVKLDSLGVTETEIAEAEKEVPIELKA
AIMLAQKNIHTFHSSQRFEGKKVQTVPGVTCWQKAVAIEKVGLYIPGGTAPLFSTVLMLATPAQIAGCKEIVLCTPPDKE
GKVHPAILYAAKLAGVNKIFKAGGVQAIAAMAYGTESVPKVYKIFGPGNQYVTAAKQQVSLRDVAIDMPAGPSEVEVLAD
ETANPVFVAADLLSQAEHGVDSQAMLITTSEKLMKEVEYEVQRQLALLPRWEIAEKSLASSKLILVRDMDEAIALTNEYA
PEHLIIETRDYMEQAERIVNAGSVFLGSLTPESAGDYASGTNHTLPTNGYAKAYSGVSLDSFIRKITFQEINGEGIQNIG
PAIEVMAANEQLGAHKNAVTVRLKTV

Sequences:

>Translated_426_residues
MKKIIYPEKKDWMEILRRPALNTDTLRNTVKEVLDKVKTEGDKAVREYEERFDKVKLDSLGVTETEIAEAEKEVPIELKA
AIMLAQKNIHTFHSSQRFEGKKVQTVPGVTCWQKAVAIEKVGLYIPGGTAPLFSTVLMLATPAQIAGCKEIVLCTPPDKE
GKVHPAILYAAKLAGVNKIFKAGGVQAIAAMAYGTESVPKVYKIFGPGNQYVTAAKQQVSLRDVAIDMPAGPSEVEVLAD
ETANPVFVAADLLSQAEHGVDSQAMLITTSEKLMKEVEYEVQRQLALLPRWEIAEKSLASSKLILVRDMDEAIALTNEYA
PEHLIIETRDYMEQAERIVNAGSVFLGSLTPESAGDYASGTNHTLPTNGYAKAYSGVSLDSFIRKITFQEINGEGIQNIG
PAIEVMAANEQLGAHKNAVTVRLKTV
>Mature_426_residues
MKKIIYPEKKDWMEILRRPALNTDTLRNTVKEVLDKVKTEGDKAVREYEERFDKVKLDSLGVTETEIAEAEKEVPIELKA
AIMLAQKNIHTFHSSQRFEGKKVQTVPGVTCWQKAVAIEKVGLYIPGGTAPLFSTVLMLATPAQIAGCKEIVLCTPPDKE
GKVHPAILYAAKLAGVNKIFKAGGVQAIAAMAYGTESVPKVYKIFGPGNQYVTAAKQQVSLRDVAIDMPAGPSEVEVLAD
ETANPVFVAADLLSQAEHGVDSQAMLITTSEKLMKEVEYEVQRQLALLPRWEIAEKSLASSKLILVRDMDEAIALTNEYA
PEHLIIETRDYMEQAERIVNAGSVFLGSLTPESAGDYASGTNHTLPTNGYAKAYSGVSLDSFIRKITFQEINGEGIQNIG
PAIEVMAANEQLGAHKNAVTVRLKTV

Specific function: Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine [H]

COG id: COG0141

COG function: function code E; Histidinol dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the histidinol dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI1788331, Length=416, Percent_Identity=53.8461538461538, Blast_Score=450, Evalue=1e-128,
Organism=Saccharomyces cerevisiae, GI6319819, Length=415, Percent_Identity=49.3975903614458, Blast_Score=384, Evalue=1e-107,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016161
- InterPro:   IPR022695
- InterPro:   IPR001692
- InterPro:   IPR012131 [H]

Pfam domain/function: PF00815 Histidinol_dh [H]

EC number: =1.1.1.23 [H]

Molecular weight: Translated: 46542; Mature: 46542

Theoretical pI: Translated: 5.55; Mature: 5.55

Prosite motif: PS00611 HISOL_DEHYDROGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKIIYPEKKDWMEILRRPALNTDTLRNTVKEVLDKVKTEGDKAVREYEERFDKVKLDSL
CCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHEECCCC
GVTETEIAEAEKEVPIELKAAIMLAQKNIHTFHSSQRFEGKKVQTVPGVTCWQKAVAIEK
CCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCCEEECCCCHHHHHHHHHHHH
VGLYIPGGTAPLFSTVLMLATPAQIAGCKEIVLCTPPDKEGKVHPAILYAAKLAGVNKIF
CCEEECCCCHHHHHHHHHHCCCHHHCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHH
KAGGVQAIAAMAYGTESVPKVYKIFGPGNQYVTAAKQQVSLRDVAIDMPAGPSEVEVLAD
HCCCHHHHHHHHCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHEEEECCCCCCHHHEEEC
ETANPVFVAADLLSQAEHGVDSQAMLITTSEKLMKEVEYEVQRQLALLPRWEIAEKSLAS
CCCCCEEEHHHHHHHHHCCCCCCEEEEECHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCC
SKLILVRDMDEAIALTNEYAPEHLIIETRDYMEQAERIVNAGSVFLGSLTPESAGDYASG
CCEEEEECCHHHHHHHCCCCCCEEEEECHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCC
TNHTLPTNGYAKAYSGVSLDSFIRKITFQEINGEGIQNIGPAIEVMAANEQLGAHKNAVT
CCCCCCCCCCHHHCCCCCHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCHHHCCCCCEEE
VRLKTV
EEEEEC
>Mature Secondary Structure
MKKIIYPEKKDWMEILRRPALNTDTLRNTVKEVLDKVKTEGDKAVREYEERFDKVKLDSL
CCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHEECCCC
GVTETEIAEAEKEVPIELKAAIMLAQKNIHTFHSSQRFEGKKVQTVPGVTCWQKAVAIEK
CCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCCEEECCCCHHHHHHHHHHHH
VGLYIPGGTAPLFSTVLMLATPAQIAGCKEIVLCTPPDKEGKVHPAILYAAKLAGVNKIF
CCEEECCCCHHHHHHHHHHCCCHHHCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHH
KAGGVQAIAAMAYGTESVPKVYKIFGPGNQYVTAAKQQVSLRDVAIDMPAGPSEVEVLAD
HCCCHHHHHHHHCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHEEEECCCCCCHHHEEEC
ETANPVFVAADLLSQAEHGVDSQAMLITTSEKLMKEVEYEVQRQLALLPRWEIAEKSLAS
CCCCCEEEHHHHHHHHHCCCCCCEEEEECHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCC
SKLILVRDMDEAIALTNEYAPEHLIIETRDYMEQAERIVNAGSVFLGSLTPESAGDYASG
CCEEEEECCHHHHHHHCCCCCCEEEEECHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCC
TNHTLPTNGYAKAYSGVSLDSFIRKITFQEINGEGIQNIGPAIEVMAANEQLGAHKNAVT
CCCCCCCCCCHHHCCCCCHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCHHHCCCCCEEE
VRLKTV
EEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA