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The map label for this gene is galK [H]

Identifier: 150004862

GI number: 150004862

Start: 3001166

End: 3002320

Strand: Reverse

Name: galK [H]

Synonym: BVU_2325

Alternate gene names: 150004862

Gene position: 3002320-3001166 (Counterclockwise)

Preceding gene: 150004863

Following gene: 150004861

Centisome position: 58.15

GC content: 41.04

Gene sequence:

>1155_bases
ATGGATATAGAATACGTAAGAAGTCGCTTCATCAAACATTTTGATGGCACAACAGGTTCAGTATATGCATCACCCGGACG
TATTAACCTTATTGGAGAACATACCGATTATAACGGTGGTTTTGTCTTTCCCGGAGCAGTAGATAAAGGTATGATTGCTG
AAATCAAACCTAATGGTACTGATAAGGTACGTGCTTATTCTATTGATCTAAAAGACTATGTAGAATTCGGCTTGAACGAA
GAAGATGCCCCTAAAGCCAGTTGGGCAAGATATATTTTCGGCGTTTGCCGTGAAATGATCAAACGTGGTGTAGATGTGAA
AGGTTTTGACACTGCTTTTGCGGGTGACGTACCTTTGGGTGCAGGTATGTCTTCATCTGCTGCATTGGAAAGTACGTATG
CTTTCGCTATCAACGAACTTTTCGGTGACAACAAAATAGATAAATTTGAATTAGCCAAGGTAGGTCAGGCAACAGAACAT
AATTATTGTGGTGTAAATTGCGGTATTATGGATCAATTTGCATCTGTATTCGGAAAAGAAGGTAGTTTGATCCGTTTGGA
CTGTCGTTCATTGGAATATCAATACTTCCCGTTCAAACCGGAAGGTTACCGATTGGTATTGGTTGACTCGGTAGTCAAAC
ACGAATTGGCTTCTTCTGCTTATAATAAACGTCGCCAAAGCTGCGAAGCTGCTGTAGCCGCCATCCAGAAAAAACATCCT
CATGTAGAATTTTTACGTGATTGTACAATGGAAATGTTGCAGGAAGCAAAAGCCGAGATCAGTGAAGAAGACTATATGCG
TGCAGAATACGTCATTGAAGAAATCCAACGTGTACTTGATGTTTGCGATGCTTTGGAAAGAGGTGATTACGAAACCGTAG
GACAGAAGATGTATGAAACTCACTATGGCATGAGTAAATTGTATGAAGTAAGCTGTGAAGAACTTGACTTCTTGAATGAT
GTTGCTTTCGACTGCGGTGTCACCGGTTCACGTGTCATGGGTGGAGGTTTCGGTGGATGTACAATCAACCTGGTTAAAAA
TGAACTATACGAAACATTCATCACCACTGCCAAAGAAAGATTCAAAGAGAAGTTCGGAAGAAGTCCCAAAGTTTACGATG
TAGTCATCAGTGACGGTTCTCGCAAGCTGGTATAA

Upstream 100 bases:

>100_bases
CTGTTGTTCTATGGTTTGGTAGGATGCAAGAACGTAAACAAAGACATTCCTGTAGAATAATTATAAAAACATATAGTATT
AACTTTAAACTATTAATATC

Downstream 100 bases:

>100_bases
AAAAGATCTCAAATTCGCTAACATATGAAAAAACCGCTTTGGATTCAAAGCGGTTTTTTCTTCTTTATGCTATAAAAGTG
TAGGAAATACACTTTTATGT

Product: galactokinase

Products: NA

Alternate protein names: Galactose kinase [H]

Number of amino acids: Translated: 384; Mature: 384

Protein sequence:

>384_residues
MDIEYVRSRFIKHFDGTTGSVYASPGRINLIGEHTDYNGGFVFPGAVDKGMIAEIKPNGTDKVRAYSIDLKDYVEFGLNE
EDAPKASWARYIFGVCREMIKRGVDVKGFDTAFAGDVPLGAGMSSSAALESTYAFAINELFGDNKIDKFELAKVGQATEH
NYCGVNCGIMDQFASVFGKEGSLIRLDCRSLEYQYFPFKPEGYRLVLVDSVVKHELASSAYNKRRQSCEAAVAAIQKKHP
HVEFLRDCTMEMLQEAKAEISEEDYMRAEYVIEEIQRVLDVCDALERGDYETVGQKMYETHYGMSKLYEVSCEELDFLND
VAFDCGVTGSRVMGGGFGGCTINLVKNELYETFITTAKERFKEKFGRSPKVYDVVISDGSRKLV

Sequences:

>Translated_384_residues
MDIEYVRSRFIKHFDGTTGSVYASPGRINLIGEHTDYNGGFVFPGAVDKGMIAEIKPNGTDKVRAYSIDLKDYVEFGLNE
EDAPKASWARYIFGVCREMIKRGVDVKGFDTAFAGDVPLGAGMSSSAALESTYAFAINELFGDNKIDKFELAKVGQATEH
NYCGVNCGIMDQFASVFGKEGSLIRLDCRSLEYQYFPFKPEGYRLVLVDSVVKHELASSAYNKRRQSCEAAVAAIQKKHP
HVEFLRDCTMEMLQEAKAEISEEDYMRAEYVIEEIQRVLDVCDALERGDYETVGQKMYETHYGMSKLYEVSCEELDFLND
VAFDCGVTGSRVMGGGFGGCTINLVKNELYETFITTAKERFKEKFGRSPKVYDVVISDGSRKLV
>Mature_384_residues
MDIEYVRSRFIKHFDGTTGSVYASPGRINLIGEHTDYNGGFVFPGAVDKGMIAEIKPNGTDKVRAYSIDLKDYVEFGLNE
EDAPKASWARYIFGVCREMIKRGVDVKGFDTAFAGDVPLGAGMSSSAALESTYAFAINELFGDNKIDKFELAKVGQATEH
NYCGVNCGIMDQFASVFGKEGSLIRLDCRSLEYQYFPFKPEGYRLVLVDSVVKHELASSAYNKRRQSCEAAVAAIQKKHP
HVEFLRDCTMEMLQEAKAEISEEDYMRAEYVIEEIQRVLDVCDALERGDYETVGQKMYETHYGMSKLYEVSCEELDFLND
VAFDCGVTGSRVMGGGFGGCTINLVKNELYETFITTAKERFKEKFGRSPKVYDVVISDGSRKLV

Specific function: Galactose metabolism; first step. [C]

COG id: COG0153

COG function: function code G; Galactokinase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GHMP kinase family. GalK subfamily [H]

Homologues:

Organism=Homo sapiens, GI4503895, Length=389, Percent_Identity=36.7609254498715, Blast_Score=228, Evalue=5e-60,
Organism=Homo sapiens, GI48527957, Length=428, Percent_Identity=25.9345794392523, Blast_Score=116, Evalue=3e-26,
Organism=Homo sapiens, GI4503897, Length=414, Percent_Identity=25.8454106280193, Blast_Score=116, Evalue=5e-26,
Organism=Escherichia coli, GI1786972, Length=385, Percent_Identity=34.025974025974, Blast_Score=217, Evalue=1e-57,
Organism=Caenorhabditis elegans, GI71989053, Length=392, Percent_Identity=24.7448979591837, Blast_Score=89, Evalue=4e-18,
Organism=Saccharomyces cerevisiae, GI6319494, Length=249, Percent_Identity=29.718875502008, Blast_Score=82, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6320212, Length=245, Percent_Identity=27.7551020408163, Blast_Score=75, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24661292, Length=411, Percent_Identity=25.5474452554745, Blast_Score=93, Evalue=4e-19,
Organism=Drosophila melanogaster, GI21355577, Length=411, Percent_Identity=25.5474452554745, Blast_Score=93, Evalue=4e-19,
Organism=Drosophila melanogaster, GI24661285, Length=411, Percent_Identity=25.5474452554745, Blast_Score=93, Evalue=4e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000705
- InterPro:   IPR022963
- InterPro:   IPR019741
- InterPro:   IPR019539
- InterPro:   IPR006204
- InterPro:   IPR013750
- InterPro:   IPR006203
- InterPro:   IPR006206
- InterPro:   IPR020568
- InterPro:   IPR014721 [H]

Pfam domain/function: PF10509 GalKase_gal_bdg; PF08544 GHMP_kinases_C; PF00288 GHMP_kinases_N [H]

EC number: =2.7.1.6 [H]

Molecular weight: Translated: 42992; Mature: 42992

Theoretical pI: Translated: 4.84; Mature: 4.84

Prosite motif: PS00106 GALACTOKINASE ; PS00627 GHMP_KINASES_ATP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDIEYVRSRFIKHFDGTTGSVYASPGRINLIGEHTDYNGGFVFPGAVDKGMIAEIKPNGT
CCHHHHHHHHHHHHCCCCCEEEECCCEEEEEECCCCCCCCEEECCCCCCCCEEEECCCCC
DKVRAYSIDLKDYVEFGLNEEDAPKASWARYIFGVCREMIKRGVDVKGFDTAFAGDVPLG
CCEEEEEECHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC
AGMSSSAALESTYAFAINELFGDNKIDKFELAKVGQATEHNYCGVNCGIMDQFASVFGKE
CCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHCCC
GSLIRLDCRSLEYQYFPFKPEGYRLVLVDSVVKHELASSAYNKRRQSCEAAVAAIQKKHP
CCEEEEECCCCCEEECCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
HVEFLRDCTMEMLQEAKAEISEEDYMRAEYVIEEIQRVLDVCDALERGDYETVGQKMYET
HHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
HYGMSKLYEVSCEELDFLNDVAFDCGVTGSRVMGGGFGGCTINLVKNELYETFITTAKER
HHCHHHHHHHCHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHH
FKEKFGRSPKVYDVVISDGSRKLV
HHHHHCCCCCEEEEEEECCCCCCC
>Mature Secondary Structure
MDIEYVRSRFIKHFDGTTGSVYASPGRINLIGEHTDYNGGFVFPGAVDKGMIAEIKPNGT
CCHHHHHHHHHHHHCCCCCEEEECCCEEEEEECCCCCCCCEEECCCCCCCCEEEECCCCC
DKVRAYSIDLKDYVEFGLNEEDAPKASWARYIFGVCREMIKRGVDVKGFDTAFAGDVPLG
CCEEEEEECHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC
AGMSSSAALESTYAFAINELFGDNKIDKFELAKVGQATEHNYCGVNCGIMDQFASVFGKE
CCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHCCC
GSLIRLDCRSLEYQYFPFKPEGYRLVLVDSVVKHELASSAYNKRRQSCEAAVAAIQKKHP
CCEEEEECCCCCEEECCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
HVEFLRDCTMEMLQEAKAEISEEDYMRAEYVIEEIQRVLDVCDALERGDYETVGQKMYET
HHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
HYGMSKLYEVSCEELDFLNDVAFDCGVTGSRVMGGGFGGCTINLVKNELYETFITTAKER
HHCHHHHHHHCHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHH
FKEKFGRSPKVYDVVISDGSRKLV
HHHHHCCCCCEEEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA