Click here to switch to the map view.

The map label for this gene is mro [H]

Identifier: 150004861

GI number: 150004861

Start: 2999815

End: 3000969

Strand: Reverse

Name: mro [H]

Synonym: BVU_2324

Alternate gene names: 150004861

Gene position: 3000969-2999815 (Counterclockwise)

Preceding gene: 150004862

Following gene: 150004860

Centisome position: 58.12

GC content: 42.08

Gene sequence:

>1155_bases
ATGAAAAGCATGAAAAAAACCTTTCTGGGAACTGGTATCGCACTGACCTTGTTAAGTGCTTGCGCTCCCAAACAATCTCA
AGAAACACTTACAAAGTCCGGATTAAACCCCACTAATTATGAAACAATAGTGGATGGCGTAAAACCTGTTAAACTGTATA
CGCTAAAGAATGCAGCCGGAATGGAAGTATGCGTAACTAATTTTGGCGGACGTATTGTATCTATCATGGTCCCCGACAAA
AATGGAAATCTAAAAGACGTAGTGCTGGGTTTTGACAGCATTGCTGACTACCAAAATATACCAAGCGACTTCGGTGCTTC
TATCGGACGCTATGCCAACCGCATTAATAAAGGAGTCATCGTAATGGATGGAGAAACCATTCAATTACCCCAAAATAATT
TTGGTCACTGCCTGCATGGAGGTCCTAAAGGATGGCAATACCAAGTTTATGAAGCAAACCAATTAAACGACAGTACTATG
ACACTGACTATGAAGTCACCGGATGGAGATGCCAATTTTCCGGGAAATGTAACCGCTACTGTTACTTATGCACTGACAAG
AGACAATGCCATCGACATAAATTACGAAGCGACAACTGACAAAAAGACTGTTATCAATATGACCAACCACTCTTATTTCA
ACTTGAGTGGAAACCCTGCCAATCCGGCCACCGACCATATTCTTTATGTAAATGCAGACAGCATCACTCCCGTTGACAGC
ACATTCATGACCACTGGAGAAATGATGGCAGTAACAGAAACTCCGTTTGATTTCAATACTCCTAAAACCATTGCCCCCGA
TGTGACTAACTTTGAAAACGAACAAATAAAATTCGGTAACGGCTTCGACCATAATTGGGTACTTAACACGAAAGGCGATA
TCAACCAGCTGGCTGCCAAACTGACCAGCCCCACTAGTGGTATCACTTTGGAAGTATATACTAATGAACCGGGAATACAA
GTTTATACAGGCAACTTTTTGGATGGAACCGTAAAAGGGAAAAAGGGAATTACTTATCCGCAACGCGCGTCTGTTTGTCT
GGAAACACAGCACTATCCCGACAGCCCCAACAAATCACAATGGCTTTCTGTAATTCTGGAACCGGGACAGACCTATCACA
GCCAATGTATCTTTAAATTCGGTGTTGAAAAATAA

Upstream 100 bases:

>100_bases
ATGTTGCACAACATACTCTTTTCATATCCAATGTATTAGTAATAGTGTTACTTTTACACCAAAAATCATATACTCTATTA
CTAATTAGTACTTTTATATC

Downstream 100 bases:

>100_bases
TTGTTAAACTTTAAATATTTAATATCATGAATTGGAATTCACATGAATTCATCTGGCTGGACTGGACAATACTGGCAGTC
GGCATTGTAGCTGTGATATG

Product: aldose 1-epimerase precursor

Products: NA

Alternate protein names: Galactose mutarotase; Type-1 mutarotase [H]

Number of amino acids: Translated: 384; Mature: 384

Protein sequence:

>384_residues
MKSMKKTFLGTGIALTLLSACAPKQSQETLTKSGLNPTNYETIVDGVKPVKLYTLKNAAGMEVCVTNFGGRIVSIMVPDK
NGNLKDVVLGFDSIADYQNIPSDFGASIGRYANRINKGVIVMDGETIQLPQNNFGHCLHGGPKGWQYQVYEANQLNDSTM
TLTMKSPDGDANFPGNVTATVTYALTRDNAIDINYEATTDKKTVINMTNHSYFNLSGNPANPATDHILYVNADSITPVDS
TFMTTGEMMAVTETPFDFNTPKTIAPDVTNFENEQIKFGNGFDHNWVLNTKGDINQLAAKLTSPTSGITLEVYTNEPGIQ
VYTGNFLDGTVKGKKGITYPQRASVCLETQHYPDSPNKSQWLSVILEPGQTYHSQCIFKFGVEK

Sequences:

>Translated_384_residues
MKSMKKTFLGTGIALTLLSACAPKQSQETLTKSGLNPTNYETIVDGVKPVKLYTLKNAAGMEVCVTNFGGRIVSIMVPDK
NGNLKDVVLGFDSIADYQNIPSDFGASIGRYANRINKGVIVMDGETIQLPQNNFGHCLHGGPKGWQYQVYEANQLNDSTM
TLTMKSPDGDANFPGNVTATVTYALTRDNAIDINYEATTDKKTVINMTNHSYFNLSGNPANPATDHILYVNADSITPVDS
TFMTTGEMMAVTETPFDFNTPKTIAPDVTNFENEQIKFGNGFDHNWVLNTKGDINQLAAKLTSPTSGITLEVYTNEPGIQ
VYTGNFLDGTVKGKKGITYPQRASVCLETQHYPDSPNKSQWLSVILEPGQTYHSQCIFKFGVEK
>Mature_384_residues
MKSMKKTFLGTGIALTLLSACAPKQSQETLTKSGLNPTNYETIVDGVKPVKLYTLKNAAGMEVCVTNFGGRIVSIMVPDK
NGNLKDVVLGFDSIADYQNIPSDFGASIGRYANRINKGVIVMDGETIQLPQNNFGHCLHGGPKGWQYQVYEANQLNDSTM
TLTMKSPDGDANFPGNVTATVTYALTRDNAIDINYEATTDKKTVINMTNHSYFNLSGNPANPATDHILYVNADSITPVDS
TFMTTGEMMAVTETPFDFNTPKTIAPDVTNFENEQIKFGNGFDHNWVLNTKGDINQLAAKLTSPTSGITLEVYTNEPGIQ
VYTGNFLDGTVKGKKGITYPQRASVCLETQHYPDSPNKSQWLSVILEPGQTYHSQCIFKFGVEK

Specific function: Mutarotase converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose [H]

COG id: COG2017

COG function: function code G; Galactose mutarotase and related enzymes

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aldose epimerase family [H]

Homologues:

Organism=Homo sapiens, GI20270355, Length=322, Percent_Identity=39.4409937888199, Blast_Score=237, Evalue=1e-62,
Organism=Escherichia coli, GI1786971, Length=338, Percent_Identity=38.7573964497041, Blast_Score=232, Evalue=2e-62,
Organism=Caenorhabditis elegans, GI17557428, Length=328, Percent_Identity=32.0121951219512, Blast_Score=179, Evalue=2e-45,
Organism=Caenorhabditis elegans, GI115533334, Length=328, Percent_Identity=32.0121951219512, Blast_Score=179, Evalue=2e-45,
Organism=Saccharomyces cerevisiae, GI6322004, Length=357, Percent_Identity=28.2913165266106, Blast_Score=113, Evalue=5e-26,
Organism=Saccharomyces cerevisiae, GI6319493, Length=343, Percent_Identity=27.6967930029155, Blast_Score=110, Evalue=3e-25,
Organism=Saccharomyces cerevisiae, GI6324399, Length=347, Percent_Identity=27.3775216138329, Blast_Score=109, Evalue=7e-25,
Organism=Drosophila melanogaster, GI24659048, Length=345, Percent_Identity=38.5507246376812, Blast_Score=229, Evalue=2e-60,
Organism=Drosophila melanogaster, GI24583720, Length=348, Percent_Identity=35.9195402298851, Blast_Score=221, Evalue=7e-58,
Organism=Drosophila melanogaster, GI24668282, Length=342, Percent_Identity=35.0877192982456, Blast_Score=213, Evalue=2e-55,
Organism=Drosophila melanogaster, GI24668278, Length=343, Percent_Identity=35.5685131195335, Blast_Score=210, Evalue=2e-54,
Organism=Drosophila melanogaster, GI24641876, Length=348, Percent_Identity=28.1609195402299, Blast_Score=159, Evalue=4e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018052
- InterPro:   IPR008183
- InterPro:   IPR015443
- InterPro:   IPR011013
- InterPro:   IPR014718 [H]

Pfam domain/function: PF01263 Aldose_epim [H]

EC number: =5.1.3.3 [H]

Molecular weight: Translated: 41980; Mature: 41980

Theoretical pI: Translated: 5.63; Mature: 5.63

Prosite motif: PS00013 PROKAR_LIPOPROTEIN ; PS00545 ALDOSE_1_EPIMERASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKSMKKTFLGTGIALTLLSACAPKQSQETLTKSGLNPTNYETIVDGVKPVKLYTLKNAAG
CCCHHHHHHCCCHHHHHHHHCCCCCHHHHHHHCCCCCCCHHHHHCCCCEEEEEEECCCCC
MEVCVTNFGGRIVSIMVPDKNGNLKDVVLGFDSIADYQNIPSDFGASIGRYANRINKGVI
CEEEEECCCCEEEEEEEECCCCCEEEEEEECHHHHHHHCCCHHHHHHHHHHHHHHCCCEE
VMDGETIQLPQNNFGHCLHGGPKGWQYQVYEANQLNDSTMTLTMKSPDGDANFPGNVTAT
EECCCEEECCCCCCCCEECCCCCCCEEEEEECCCCCCCEEEEEEECCCCCCCCCCCEEEE
VTYALTRDNAIDINYEATTDKKTVINMTNHSYFNLSGNPANPATDHILYVNADSITPVDS
EEEEEECCCEEEEEEECCCCCEEEEEECCCEEEEECCCCCCCCCCEEEEEECCCCCCCCH
TFMTTGEMMAVTETPFDFNTPKTIAPDVTNFENEQIKFGNGFDHNWVLNTKGDINQLAAK
HEEECCCEEEEEECCCCCCCCCCCCCCCCCCCCCEEEECCCCCCCEEEECCCCHHHHHHH
LTSPTSGITLEVYTNEPGIQVYTGNFLDGTVKGKKGITYPQRASVCLETQHYPDSPNKSQ
HCCCCCCEEEEEEECCCCEEEEECCEECCEEECCCCCCCCCCCCEEEEECCCCCCCCHHH
WLSVILEPGQTYHSQCIFKFGVEK
EEEEEECCCCCHHHEEEEEECCCC
>Mature Secondary Structure
MKSMKKTFLGTGIALTLLSACAPKQSQETLTKSGLNPTNYETIVDGVKPVKLYTLKNAAG
CCCHHHHHHCCCHHHHHHHHCCCCCHHHHHHHCCCCCCCHHHHHCCCCEEEEEEECCCCC
MEVCVTNFGGRIVSIMVPDKNGNLKDVVLGFDSIADYQNIPSDFGASIGRYANRINKGVI
CEEEEECCCCEEEEEEEECCCCCEEEEEEECHHHHHHHCCCHHHHHHHHHHHHHHCCCEE
VMDGETIQLPQNNFGHCLHGGPKGWQYQVYEANQLNDSTMTLTMKSPDGDANFPGNVTAT
EECCCEEECCCCCCCCEECCCCCCCEEEEEECCCCCCCEEEEEEECCCCCCCCCCCEEEE
VTYALTRDNAIDINYEATTDKKTVINMTNHSYFNLSGNPANPATDHILYVNADSITPVDS
EEEEEECCCEEEEEEECCCCCEEEEEECCCEEEEECCCCCCCCCCEEEEEECCCCCCCCH
TFMTTGEMMAVTETPFDFNTPKTIAPDVTNFENEQIKFGNGFDHNWVLNTKGDINQLAAK
HEEECCCEEEEEECCCCCCCCCCCCCCCCCCCCCEEEECCCCCCCEEEECCCCHHHHHHH
LTSPTSGITLEVYTNEPGIQVYTGNFLDGTVKGKKGITYPQRASVCLETQHYPDSPNKSQ
HCCCCCCEEEEEEECCCCEEEEECCEECCEEECCCCCCCCCCCCEEEEECCCCCCCCHHH
WLSVILEPGQTYHSQCIFKFGVEK
EEEEEECCCCCHHHEEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3012466; 3531172 [H]