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The map label for this gene is adk

Identifier: 150004241

GI number: 150004241

Start: 2173190

End: 2173759

Strand: Direct

Name: adk

Synonym: BVU_1682

Alternate gene names: 150004241

Gene position: 2173190-2173759 (Clockwise)

Preceding gene: 150004240

Following gene: 150004242

Centisome position: 42.09

GC content: 43.68

Gene sequence:

>570_bases
ATGTTGAACATTGTAATTTTTGGAGCTCCGGGTTCTGGTAAGGGTACTCAGAGTGAACGTATTGTAGAGAAATTCGGTAT
TAATCACATTTCAACAGGGGATGTGCTTCGTGCTGAGATTAAGAAGGGTACAGAATTGGGAAAGACAGCCAAAGGATATA
TCGATCAGGGCCAGTTGCTGCCTGATGAATTGATTATTGATATTCTGGCAAGTACGCTGGATAGCTTTAAGGAAAGCAAA
GGGGTTATTTTTGATGGATTTCCCAGAACCATCGCCCAGGCAGAAGCGTTGAAGAAAATGCTGGCCGAACGTGGACAGGA
AGTATCTGTTATGTTGGACTTGGATGTACCCGAAGAAGAATTGATGACTCGCCTGATTAAGCGTGGACAGGAATCGGGAC
GTGCGGATGATAACGAGGAAACAATAAAGAAACGTTTGGTTGTTTATCACTCGCAGACGGCTCCGCTGATTGACTGGTAC
AAGAACGAAGGTAAATATCAGCACATTCACGGTTTGGGTACGATGGATGCTATTTTTGCCGACATTGTTGCTGCTGTTGA
AAAATTATAG

Upstream 100 bases:

>100_bases
GGTCTGGATTATGATGGCTTGGGACGTAACTATCGGGATATTTACACCGTAATGGAATGAAATTTGTACAACTAAATATA
AAAATAAAAGGTAAAACAAG

Downstream 100 bases:

>100_bases
TAATATGCTAATGTGCTGATGCAGCAGTCCGCCAATGTGTCAGTCTGCATAATGATACATGGAGTACAGTTTCGTTGGCA
CATTAGTAAATTGATAAATT

Product: adenylate kinase

Products: NA

Alternate protein names: AK; ATP-AMP transphosphorylase

Number of amino acids: Translated: 189; Mature: 189

Protein sequence:

>189_residues
MLNIVIFGAPGSGKGTQSERIVEKFGINHISTGDVLRAEIKKGTELGKTAKGYIDQGQLLPDELIIDILASTLDSFKESK
GVIFDGFPRTIAQAEALKKMLAERGQEVSVMLDLDVPEEELMTRLIKRGQESGRADDNEETIKKRLVVYHSQTAPLIDWY
KNEGKYQHIHGLGTMDAIFADIVAAVEKL

Sequences:

>Translated_189_residues
MLNIVIFGAPGSGKGTQSERIVEKFGINHISTGDVLRAEIKKGTELGKTAKGYIDQGQLLPDELIIDILASTLDSFKESK
GVIFDGFPRTIAQAEALKKMLAERGQEVSVMLDLDVPEEELMTRLIKRGQESGRADDNEETIKKRLVVYHSQTAPLIDWY
KNEGKYQHIHGLGTMDAIFADIVAAVEKL
>Mature_189_residues
MLNIVIFGAPGSGKGTQSERIVEKFGINHISTGDVLRAEIKKGTELGKTAKGYIDQGQLLPDELIIDILASTLDSFKESK
GVIFDGFPRTIAQAEALKKMLAERGQEVSVMLDLDVPEEELMTRLIKRGQESGRADDNEETIKKRLVVYHSQTAPLIDWY
KNEGKYQHIHGLGTMDAIFADIVAAVEKL

Specific function: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. This small ubiquitous enzyme involved in the energy metabolism and nucleotide synthesis, is essential for maintenance and cell growth

COG id: COG0563

COG function: function code F; Adenylate kinase and related kinases

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenylate kinase family

Homologues:

Organism=Homo sapiens, GI4502011, Length=187, Percent_Identity=39.572192513369, Blast_Score=157, Evalue=8e-39,
Organism=Homo sapiens, GI4502013, Length=214, Percent_Identity=35.0467289719626, Blast_Score=151, Evalue=4e-37,
Organism=Homo sapiens, GI7524346, Length=214, Percent_Identity=35.0467289719626, Blast_Score=151, Evalue=4e-37,
Organism=Homo sapiens, GI7706497, Length=192, Percent_Identity=34.8958333333333, Blast_Score=127, Evalue=6e-30,
Organism=Homo sapiens, GI19923437, Length=214, Percent_Identity=35.0467289719626, Blast_Score=125, Evalue=3e-29,
Organism=Homo sapiens, GI28144897, Length=187, Percent_Identity=31.0160427807487, Blast_Score=123, Evalue=1e-28,
Organism=Homo sapiens, GI28144899, Length=187, Percent_Identity=31.0160427807487, Blast_Score=122, Evalue=1e-28,
Organism=Homo sapiens, GI310110345, Length=201, Percent_Identity=35.8208955223881, Blast_Score=118, Evalue=2e-27,
Organism=Homo sapiens, GI53832003, Length=201, Percent_Identity=35.8208955223881, Blast_Score=118, Evalue=2e-27,
Organism=Homo sapiens, GI8051579, Length=201, Percent_Identity=35.8208955223881, Blast_Score=118, Evalue=2e-27,
Organism=Homo sapiens, GI53832001, Length=201, Percent_Identity=35.8208955223881, Blast_Score=118, Evalue=2e-27,
Organism=Homo sapiens, GI209915597, Length=187, Percent_Identity=27.807486631016, Blast_Score=82, Evalue=4e-16,
Organism=Homo sapiens, GI237858799, Length=136, Percent_Identity=32.3529411764706, Blast_Score=70, Evalue=1e-12,
Organism=Escherichia coli, GI1786680, Length=213, Percent_Identity=40.3755868544601, Blast_Score=150, Evalue=5e-38,
Organism=Caenorhabditis elegans, GI17567503, Length=185, Percent_Identity=43.2432432432432, Blast_Score=160, Evalue=3e-40,
Organism=Caenorhabditis elegans, GI17552384, Length=222, Percent_Identity=32.8828828828829, Blast_Score=130, Evalue=4e-31,
Organism=Caenorhabditis elegans, GI17533833, Length=184, Percent_Identity=34.7826086956522, Blast_Score=120, Evalue=5e-28,
Organism=Caenorhabditis elegans, GI17550688, Length=185, Percent_Identity=34.0540540540541, Blast_Score=114, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI17537943, Length=219, Percent_Identity=28.310502283105, Blast_Score=85, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI25147457, Length=189, Percent_Identity=26.4550264550265, Blast_Score=82, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6320432, Length=215, Percent_Identity=36.2790697674419, Blast_Score=140, Evalue=1e-34,
Organism=Saccharomyces cerevisiae, GI6322828, Length=186, Percent_Identity=33.8709677419355, Blast_Score=125, Evalue=4e-30,
Organism=Saccharomyces cerevisiae, GI6321018, Length=205, Percent_Identity=37.5609756097561, Blast_Score=122, Evalue=3e-29,
Organism=Drosophila melanogaster, GI22026816, Length=212, Percent_Identity=36.3207547169811, Blast_Score=141, Evalue=2e-34,
Organism=Drosophila melanogaster, GI17737899, Length=187, Percent_Identity=39.0374331550802, Blast_Score=118, Evalue=2e-27,
Organism=Drosophila melanogaster, GI24645822, Length=187, Percent_Identity=39.0374331550802, Blast_Score=118, Evalue=2e-27,
Organism=Drosophila melanogaster, GI221459597, Length=181, Percent_Identity=32.0441988950276, Blast_Score=116, Evalue=9e-27,
Organism=Drosophila melanogaster, GI21356893, Length=181, Percent_Identity=32.0441988950276, Blast_Score=116, Evalue=9e-27,
Organism=Drosophila melanogaster, GI24663208, Length=187, Percent_Identity=32.620320855615, Blast_Score=107, Evalue=3e-24,
Organism=Drosophila melanogaster, GI17647141, Length=187, Percent_Identity=32.620320855615, Blast_Score=107, Evalue=4e-24,

Paralogues:

None

Copy number: 1640 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 847 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): KAD_BACV8 (A6L0Z9)

Other databases:

- EMBL:   CP000139
- RefSeq:   YP_001298985.1
- ProteinModelPortal:   A6L0Z9
- SMR:   A6L0Z9
- STRING:   A6L0Z9
- GeneID:   5302648
- GenomeReviews:   CP000139_GR
- KEGG:   bvu:BVU_1682
- NMPDR:   fig|435590.6.peg.1588
- eggNOG:   COG0563
- HOGENOM:   HBG630208
- OMA:   RTYHVKY
- ProtClustDB:   PRK00279
- GO:   GO:0005737
- HAMAP:   MF_00235
- InterPro:   IPR006259
- InterPro:   IPR000850
- PANTHER:   PTHR23359
- PRINTS:   PR00094
- TIGRFAMs:   TIGR01351

Pfam domain/function: PF00406 ADK

EC number: =2.7.4.3

Molecular weight: Translated: 20884; Mature: 20884

Theoretical pI: Translated: 5.14; Mature: 5.14

Prosite motif: PS00113 ADENYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLNIVIFGAPGSGKGTQSERIVEKFGINHISTGDVLRAEIKKGTELGKTAKGYIDQGQLL
CEEEEEEECCCCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHCHHCCCHHHCCCCCCCCC
PDELIIDILASTLDSFKESKGVIFDGFPRTIAQAEALKKMLAERGQEVSVMLDLDVPEEE
HHHHHHHHHHHHHHHHHHCCCCEECCCHHHHHHHHHHHHHHHHCCCEEEEEEECCCCHHH
LMTRLIKRGQESGRADDNEETIKKRLVVYHSQTAPLIDWYKNEGKYQHIHGLGTMDAIFA
HHHHHHHCCHHCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHCCCCEEEECCCCHHHHHHH
DIVAAVEKL
HHHHHHHCC
>Mature Secondary Structure
MLNIVIFGAPGSGKGTQSERIVEKFGINHISTGDVLRAEIKKGTELGKTAKGYIDQGQLL
CEEEEEEECCCCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHCHHCCCHHHCCCCCCCCC
PDELIIDILASTLDSFKESKGVIFDGFPRTIAQAEALKKMLAERGQEVSVMLDLDVPEEE
HHHHHHHHHHHHHHHHHHCCCCEECCCHHHHHHHHHHHHHHHHCCCEEEEEEECCCCHHH
LMTRLIKRGQESGRADDNEETIKKRLVVYHSQTAPLIDWYKNEGKYQHIHGLGTMDAIFA
HHHHHHHCCHHCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHCCCCEEEECCCCHHHHHHH
DIVAAVEKL
HHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA