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The map label for this gene is hpt [H]

Identifier: 150004240

GI number: 150004240

Start: 2172613

End: 2173149

Strand: Direct

Name: hpt [H]

Synonym: BVU_1681

Alternate gene names: 150004240

Gene position: 2172613-2173149 (Clockwise)

Preceding gene: 150004237

Following gene: 150004241

Centisome position: 42.08

GC content: 41.15

Gene sequence:

>537_bases
ATGGATACCATTCAAATCAAAGATAAACGTTTCACTCCTTTCATTCCTGAAGAACGGATCTTAAAAGAAGTGGCACGGGT
AGCGAGTGAGATTAATCGGGATTTAGAAGGAACTAATCCCTTGTTTTTAAGTGTATTGAACGGCGCATTCATGTTTGCTG
CCGACTTGATGCGTAACCTTACCATTCCCAGTGAAATTTCTTTCGTGAAACTGGCCTCTTATGCAGGAACTTCTTCTACA
GGAAAGGTAAAAGAGTTGGTAGGTTTGAATGATGATATTGAGGGTCGTACAGTGGTGATTGTGGAAGATATTGTGGATAC
CGGGGTGACAATGAAGCACTTGTTGGAAACATTACAAGCTAGAAAACCGAAAGAGATCCGTATCGCTACCTTGCTGCTGA
AACCTGATAAATTGAAGGTGGAATTGGATATACATTATGTGGCCATGCGTATTCCCAATGATTTTATTGTGGGGTATGGT
CTGGATTATGATGGCTTGGGACGTAACTATCGGGATATTTACACCGTAATGGAATGA

Upstream 100 bases:

>100_bases
ACGTACAAAGATAACACTATTTACAAAAAGAGGTTATGTGAATACTTCGATACTTGGAATAAAAATGTTATTTTTGCAGC
AATTTAATAAAATAGCGGTT

Downstream 100 bases:

>100_bases
AATTTGTACAACTAAATATAAAAATAAAAGGTAAAACAAGATGTTGAACATTGTAATTTTTGGAGCTCCGGGTTCTGGTA
AGGGTACTCAGAGTGAACGT

Product: putative hypoxanthine guanine phosphoribosyltransferase

Products: NA

Alternate protein names: HGPRT; HGPRTase [H]

Number of amino acids: Translated: 178; Mature: 178

Protein sequence:

>178_residues
MDTIQIKDKRFTPFIPEERILKEVARVASEINRDLEGTNPLFLSVLNGAFMFAADLMRNLTIPSEISFVKLASYAGTSST
GKVKELVGLNDDIEGRTVVIVEDIVDTGVTMKHLLETLQARKPKEIRIATLLLKPDKLKVELDIHYVAMRIPNDFIVGYG
LDYDGLGRNYRDIYTVME

Sequences:

>Translated_178_residues
MDTIQIKDKRFTPFIPEERILKEVARVASEINRDLEGTNPLFLSVLNGAFMFAADLMRNLTIPSEISFVKLASYAGTSST
GKVKELVGLNDDIEGRTVVIVEDIVDTGVTMKHLLETLQARKPKEIRIATLLLKPDKLKVELDIHYVAMRIPNDFIVGYG
LDYDGLGRNYRDIYTVME
>Mature_178_residues
MDTIQIKDKRFTPFIPEERILKEVARVASEINRDLEGTNPLFLSVLNGAFMFAADLMRNLTIPSEISFVKLASYAGTSST
GKVKELVGLNDDIEGRTVVIVEDIVDTGVTMKHLLETLQARKPKEIRIATLLLKPDKLKVELDIHYVAMRIPNDFIVGYG
LDYDGLGRNYRDIYTVME

Specific function: This Enzyme Acts Exclusively On Hypoxanthine; It Does Not Act On Guanine (By Similarity). [C]

COG id: COG0634

COG function: function code F; Hypoxanthine-guanine phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI4504483, Length=177, Percent_Identity=35.5932203389831, Blast_Score=106, Evalue=1e-23,
Organism=Homo sapiens, GI9910262, Length=176, Percent_Identity=33.5227272727273, Blast_Score=99, Evalue=3e-21,
Organism=Escherichia coli, GI87081689, Length=163, Percent_Identity=38.0368098159509, Blast_Score=118, Evalue=2e-28,
Organism=Caenorhabditis elegans, GI17510817, Length=169, Percent_Identity=36.094674556213, Blast_Score=92, Evalue=2e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005904
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.4.2.8 [H]

Molecular weight: Translated: 20092; Mature: 20092

Theoretical pI: Translated: 5.09; Mature: 5.09

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDTIQIKDKRFTPFIPEERILKEVARVASEINRDLEGTNPLFLSVLNGAFMFAADLMRNL
CCCEEECCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHC
TIPSEISFVKLASYAGTSSTGKVKELVGLNDDIEGRTVVIVEDIVDTGVTMKHLLETLQA
CCCCCCCCEEEECCCCCCCCCCHHHHHCCCCCCCCCEEEEEECHHCCCCHHHHHHHHHHH
RKPKEIRIATLLLKPDKLKVELDIHYVAMRIPNDFIVGYGLDYDGLGRNYRDIYTVME
CCCCCEEEEEEEECCCCEEEEEEEEEEEEECCCCEEEEECCCCCCCCCCHHHHHEECC
>Mature Secondary Structure
MDTIQIKDKRFTPFIPEERILKEVARVASEINRDLEGTNPLFLSVLNGAFMFAADLMRNL
CCCEEECCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHC
TIPSEISFVKLASYAGTSSTGKVKELVGLNDDIEGRTVVIVEDIVDTGVTMKHLLETLQA
CCCCCCCCEEEECCCCCCCCCCHHHHHCCCCCCCCCEEEEEECHHCCCCHHHHHHHHHHH
RKPKEIRIATLLLKPDKLKVELDIHYVAMRIPNDFIVGYGLDYDGLGRNYRDIYTVME
CCCCCEEEEEEEECCCCEEEEEEEEEEEEECCCCEEEEECCCCCCCCCCHHHHHEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12354221 [H]