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The map label for this gene is lpxK

Identifier: 150004167

GI number: 150004167

Start: 2086779

End: 2087879

Strand: Reverse

Name: lpxK

Synonym: BVU_1603

Alternate gene names: 150004167

Gene position: 2087879-2086779 (Counterclockwise)

Preceding gene: 150004168

Following gene: 150004166

Centisome position: 40.44

GC content: 42.6

Gene sequence:

>1101_bases
ATGGAAGGTAATCTTATCAAGATAAACAAGTGGCTATATCCGGTTTCATGGATTTATGGGACCGGTGTATGGCTGCGTAA
TAAATTGTTTGACTGGGGAATATACAAAGAACGTAAGTTTGATATCCCGGTCATCTCGGTAGGCAACATCACCGTAGGCG
GAACCGGAAAGACCCCCCATACAGAATACCTGATAAGATTATTGCAGAAAGATTACAAAGTAGCCGTACTAAGCCGCGGC
TACAAACGCAAATCCAAAGGCTTTGTACTTGCCAGACCGGATACGTCCGTACAGATGATAGGTGACGAACCTTTCCAAAT
GAAACAGAAGTTTCCGGATATCCATATGGCAGTAGACCGGGACCGTTGTCATGGCATAGAGCAGTTATGCAATAGTCACA
TCGCCCCTGGAACAGAAGTGATTATTTTGGATGATGCTTTCCAGCACCGATATGTAAAGCCCGGAATAAACATCTTATTA
GTAGATTACCACCGACTGATTTGCGAAGACACCTTGCTGCCTGCCGGACGAATGCGCGAACCTGAAAACGGAAAAAGCCG
GGCACATATTGTCATTGTCACTAAATGTCCTAAGGACATCACCCCTATGGATTTAAGAGTCTTAAGCAAGCAAATGGAAC
TTTACCCCTATCAGCAGCTCTACTTCACAACATTAACATACGGCAAGCTGCATCCGTTGTTTACAGCAGGGAATGCAGTT
TCATTAAAAGAGATAGAAAAAGACAAGCATATCCTATTGGTGACAGGCATAGCCTCCCCAGCAAAACTCATTCAAGATTT
ATCACCATACAATGAGCACATTGAGTCACTGGCTTTCAGTGACCACCATGACTTTACAGCAAGAGATATGGAACTGATAA
AGAAGCGTTTCATGAAACTTCCGGAAGGTAAACGCATGATTATCACCACTGAAAAAGACTCTGTACGACTAGCAGCCCAT
CCACTGATGGACGAAATGCTGAAACCTTATATATATATGCTGCCCATTGAGGTAGCCTTTTTACAAGACCAACAAGAACT
GTTTAACTCAAATATAACCGACTATGTTAGAAAAAATTCAAGAAACAGCAACTTTTCTTAG

Upstream 100 bases:

>100_bases
GGAAGCTATTATAACAGCTTCAAGGCGCTGGAGAACATAAAAGACGCCAACTGTATACAGGCACGTATGCCGTTTGACCC
TAATATCCAATAAATTGCAC

Downstream 100 bases:

>100_bases
AGAAAAGATGCATACCAGTCCCGAAACTGCTATTATATTAGGTACCGGCTTAGGAAGCCTGGTACACGAAATTACCGATA
AATACGAGATCAGTTACAAA

Product: tetraacyldisaccharide 4'-kinase

Products: NA

Alternate protein names: Lipid A 4'-kinase

Number of amino acids: Translated: 366; Mature: 366

Protein sequence:

>366_residues
MEGNLIKINKWLYPVSWIYGTGVWLRNKLFDWGIYKERKFDIPVISVGNITVGGTGKTPHTEYLIRLLQKDYKVAVLSRG
YKRKSKGFVLARPDTSVQMIGDEPFQMKQKFPDIHMAVDRDRCHGIEQLCNSHIAPGTEVIILDDAFQHRYVKPGINILL
VDYHRLICEDTLLPAGRMREPENGKSRAHIVIVTKCPKDITPMDLRVLSKQMELYPYQQLYFTTLTYGKLHPLFTAGNAV
SLKEIEKDKHILLVTGIASPAKLIQDLSPYNEHIESLAFSDHHDFTARDMELIKKRFMKLPEGKRMIITTEKDSVRLAAH
PLMDEMLKPYIYMLPIEVAFLQDQQELFNSNITDYVRKNSRNSNFS

Sequences:

>Translated_366_residues
MEGNLIKINKWLYPVSWIYGTGVWLRNKLFDWGIYKERKFDIPVISVGNITVGGTGKTPHTEYLIRLLQKDYKVAVLSRG
YKRKSKGFVLARPDTSVQMIGDEPFQMKQKFPDIHMAVDRDRCHGIEQLCNSHIAPGTEVIILDDAFQHRYVKPGINILL
VDYHRLICEDTLLPAGRMREPENGKSRAHIVIVTKCPKDITPMDLRVLSKQMELYPYQQLYFTTLTYGKLHPLFTAGNAV
SLKEIEKDKHILLVTGIASPAKLIQDLSPYNEHIESLAFSDHHDFTARDMELIKKRFMKLPEGKRMIITTEKDSVRLAAH
PLMDEMLKPYIYMLPIEVAFLQDQQELFNSNITDYVRKNSRNSNFS
>Mature_366_residues
MEGNLIKINKWLYPVSWIYGTGVWLRNKLFDWGIYKERKFDIPVISVGNITVGGTGKTPHTEYLIRLLQKDYKVAVLSRG
YKRKSKGFVLARPDTSVQMIGDEPFQMKQKFPDIHMAVDRDRCHGIEQLCNSHIAPGTEVIILDDAFQHRYVKPGINILL
VDYHRLICEDTLLPAGRMREPENGKSRAHIVIVTKCPKDITPMDLRVLSKQMELYPYQQLYFTTLTYGKLHPLFTAGNAV
SLKEIEKDKHILLVTGIASPAKLIQDLSPYNEHIESLAFSDHHDFTARDMELIKKRFMKLPEGKRMIITTEKDSVRLAAH
PLMDEMLKPYIYMLPIEVAFLQDQQELFNSNITDYVRKNSRNSNFS

Specific function: Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA)

COG id: COG1663

COG function: function code M; Tetraacyldisaccharide-1-P 4'-kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxK family

Homologues:

Organism=Escherichia coli, GI1787144, Length=352, Percent_Identity=25.2840909090909, Blast_Score=105, Evalue=5e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LPXK_BACV8 (A6L0S5)

Other databases:

- EMBL:   CP000139
- RefSeq:   YP_001298911.1
- STRING:   A6L0S5
- GeneID:   5302569
- GenomeReviews:   CP000139_GR
- KEGG:   bvu:BVU_1603
- NMPDR:   fig|435590.6.peg.1512
- eggNOG:   COG1663
- HOGENOM:   HBG663914
- OMA:   TPHVEYL
- ProtClustDB:   CLSK822920
- HAMAP:   MF_00409
- InterPro:   IPR003758
- TIGRFAMs:   TIGR00682

Pfam domain/function: PF02606 LpxK

EC number: =2.7.1.130

Molecular weight: Translated: 42283; Mature: 42283

Theoretical pI: Translated: 9.25; Mature: 9.25

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEGNLIKINKWLYPVSWIYGTGVWLRNKLFDWGIYKERKFDIPVISVGNITVGGTGKTPH
CCCCEEEEECCEEEEHHHHHCCHHHHHHHHCCCCCCCCCCCCCEEEECCEEECCCCCCCH
TEYLIRLLQKDYKVAVLSRGYKRKSKGFVLARPDTSVQMIGDEPFQMKQKFPDIHMAVDR
HHHHHHHHHCCCEEEEECCCCCCCCCCEEEECCCCCEEEECCCCHHHHHHCCCEEEEECC
DRCHGIEQLCNSHIAPGTEVIILDDAFQHRYVKPGINILLVDYHRLICEDTLLPAGRMRE
HHHHHHHHHHCCCCCCCCEEEEEECHHHCCEECCCCEEEEEEHHHHHHHHHCCCCCCCCC
PENGKSRAHIVIVTKCPKDITPMDLRVLSKQMELYPYQQLYFTTLTYGKLHPLFTAGNAV
CCCCCCCEEEEEEEECCCCCCCHHHHHHHHHHHCCCHHHEEEEEEECCCCCCEEECCCEE
SLKEIEKDKHILLVTGIASPAKLIQDLSPYNEHIESLAFSDHHDFTARDMELIKKRFMKL
EHHHHCCCCEEEEEECCCCHHHHHHHCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCC
PEGKRMIITTEKDSVRLAAHPLMDEMLKPYIYMLPIEVAFLQDQQELFNSNITDYVRKNS
CCCCEEEEEECCCCEEEEHHHHHHHHHCCEEEEEEEEEEECCCHHHHHCCCHHHHHHCCC
RNSNFS
CCCCCC
>Mature Secondary Structure
MEGNLIKINKWLYPVSWIYGTGVWLRNKLFDWGIYKERKFDIPVISVGNITVGGTGKTPH
CCCCEEEEECCEEEEHHHHHCCHHHHHHHHCCCCCCCCCCCCCEEEECCEEECCCCCCCH
TEYLIRLLQKDYKVAVLSRGYKRKSKGFVLARPDTSVQMIGDEPFQMKQKFPDIHMAVDR
HHHHHHHHHCCCEEEEECCCCCCCCCCEEEECCCCCEEEECCCCHHHHHHCCCEEEEECC
DRCHGIEQLCNSHIAPGTEVIILDDAFQHRYVKPGINILLVDYHRLICEDTLLPAGRMRE
HHHHHHHHHHCCCCCCCCEEEEEECHHHCCEECCCCEEEEEEHHHHHHHHHCCCCCCCCC
PENGKSRAHIVIVTKCPKDITPMDLRVLSKQMELYPYQQLYFTTLTYGKLHPLFTAGNAV
CCCCCCCEEEEEEEECCCCCCCHHHHHHHHHHHCCCHHHEEEEEEECCCCCCEEECCCEE
SLKEIEKDKHILLVTGIASPAKLIQDLSPYNEHIESLAFSDHHDFTARDMELIKKRFMKL
EHHHHCCCCEEEEEECCCCHHHHHHHCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCC
PEGKRMIITTEKDSVRLAAHPLMDEMLKPYIYMLPIEVAFLQDQQELFNSNITDYVRKNS
CCCCEEEEEECCCCEEEEHHHHHHHHHCCEEEEEEEEEEECCCHHHHHCCCHHHHHHCCC
RNSNFS
CCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA