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The map label for this gene is sppA [H]

Identifier: 150004168

GI number: 150004168

Start: 2087887

End: 2089668

Strand: Reverse

Name: sppA [H]

Synonym: BVU_1604

Alternate gene names: 150004168

Gene position: 2089668-2087887 (Counterclockwise)

Preceding gene: 150004171

Following gene: 150004167

Centisome position: 40.47

GC content: 42.65

Gene sequence:

>1782_bases
ATGAAAGATTTTCTAAAATTTACGTTTGCCAGCGTCATCGGCGTCATTCTGGCAGGCGTAGTGTTCACTATACTAGGGAT
TATCACTCTGGTTGGCATAGTCGCCTCATCGGATACTGAAACGGTGGTGAAAGACAACTCTATCTTCGTACTCGACTTTA
AAGGCAGTTTGTCCGAACGTGTACAGGAAAACCCACTCCAACAACTTTTGGGAGAAGAATTTGAAGCATACGGTTTGGAT
GACATTCTAGCTTCTATCAAGAAGGCAAAAGACAATGACAAAATCAAGGGTATTTATATCCAACCTTCTTATCTGGAAGC
ATCATACGCTTCCTTAGAGGAAATACGCAATGCATTACTGGATTTCAAAGAAAGCGGCAAATTCATCGTTGCTTATGCAG
ACCAATATGCACAGGGGATGTATTATCTTTCCAGCGTGGCCGATAAAATAATTATCAATCCGCAAGGAAGTATTGGATGG
CACGGAGCAGGCATGCAACCTGTTTTCTTCAAAAATCTGGTTTCCAAACTAGGACTGGAAGTACAGGTATTCAGAGTGGG
CACTTACAAATCAGCCGTGGAACCGTTTATTGCTACAGAAATGAGTCCGGCCAACCGCGAACAGATGACCGAATGTCTGG
AATCTGTCTGGCATCGTATTCTTGCAGATGTATCCGACTCACGACGCATCCCGACAGATACTCTGAATGCTTATGCTGAC
CGATATATGGATTTTTGTCAGGCAGAAGAATATATTCAATGCAAACTGGCAGATACCCTGATGTATAAAGATGAGGTTAT
TTCCTATCTGAAACAATTAAGCGGTCGTGACGAAAACGACAAACTAAACAGTCTTTTCATAGAAGACATGATAAACGTCA
AGAAAAATGTGCCCAAAGACAAAAGTGGAAATATAATAGCCGTATATTATGCATACGGCGAGATCCTGGATGCTCCCGGC
AGTTCCACAGAAGATTGTATTGATGTACAAAAGATGTGTAAAGACCTGCGCAAATTACGTGATAACGATGACGTAAAAGC
TGTTGTATTACGCGTCAACTCACCGGGTGGCAGCGCATACGGTTCAGATCAAATATGGCGTGAAGTAGTAAGACTGAAAG
AGAAAAAACCGGTAATCGTTTCTATGGGAGATTATGCTGCATCAGGAGGCTATTACATTTCCTGCGCTGCAAACCGCATT
TTCGCTGACCCGACTACGCTGACTGGTTCTATCGGCATATTCGGCATGATGTATTCAGGTGAGAAACTGTTTACTGAAAC
TTTAGGACTAAATTTTGATGTAGTGAAAACTAATAAAATGGCTGATTTGGGTGCCAGCCTAGGTCCGGTTCTCACCCGCC
CGCTAAATGCATCAGAACAAGAATTAATGCAGAACTATGTCAACCGAGGATACAAGCTGTTCGTAAACCGTTGCGCTGAA
GGTAGAAAAATGTCTACAGAGGCTATTGAAAAAGTTGCTGAAGGCCGTGTATGGACCGGTGCCATGGCAAAAGACCTTGG
TCTGGTAGACGAGCTGGGAGGTATAGACAAAGCATTGAATGCCGCCGCCACCCAAGCCGGTATCGAAAATTACAGTATTA
TCGGCTATCCTGAAAAAGAAAATATTTTCGCAAGCCTGCTGGGAAATCAGAAAAAACATTATATAAACAGCGAAATTAAA
GAATATTTGGGAAGCTATTATAACAGCTTCAAGGCGCTGGAGAACATAAAAGACGCCAACTGTATACAGGCACGTATGCC
GTTTGACCCTAATATCCAATAA

Upstream 100 bases:

>100_bases
AGAACAAACAGGTAACAAAAGAAGTTCACTTTTTTTGCTTTTTTCAATGCAATAACCTATTTTTGTTAGCTAATTATTAA
CATTAAAAACAACACATTCA

Downstream 100 bases:

>100_bases
ATTGCACATGGAAGGTAATCTTATCAAGATAAACAAGTGGCTATATCCGGTTTCATGGATTTATGGGACCGGTGTATGGC
TGCGTAATAAATTGTTTGAC

Product: protease IV

Products: NA

Alternate protein names: Endopeptidase IV; Protease IV homolog; Signal peptide peptidase [H]

Number of amino acids: Translated: 593; Mature: 593

Protein sequence:

>593_residues
MKDFLKFTFASVIGVILAGVVFTILGIITLVGIVASSDTETVVKDNSIFVLDFKGSLSERVQENPLQQLLGEEFEAYGLD
DILASIKKAKDNDKIKGIYIQPSYLEASYASLEEIRNALLDFKESGKFIVAYADQYAQGMYYLSSVADKIIINPQGSIGW
HGAGMQPVFFKNLVSKLGLEVQVFRVGTYKSAVEPFIATEMSPANREQMTECLESVWHRILADVSDSRRIPTDTLNAYAD
RYMDFCQAEEYIQCKLADTLMYKDEVISYLKQLSGRDENDKLNSLFIEDMINVKKNVPKDKSGNIIAVYYAYGEILDAPG
SSTEDCIDVQKMCKDLRKLRDNDDVKAVVLRVNSPGGSAYGSDQIWREVVRLKEKKPVIVSMGDYAASGGYYISCAANRI
FADPTTLTGSIGIFGMMYSGEKLFTETLGLNFDVVKTNKMADLGASLGPVLTRPLNASEQELMQNYVNRGYKLFVNRCAE
GRKMSTEAIEKVAEGRVWTGAMAKDLGLVDELGGIDKALNAAATQAGIENYSIIGYPEKENIFASLLGNQKKHYINSEIK
EYLGSYYNSFKALENIKDANCIQARMPFDPNIQ

Sequences:

>Translated_593_residues
MKDFLKFTFASVIGVILAGVVFTILGIITLVGIVASSDTETVVKDNSIFVLDFKGSLSERVQENPLQQLLGEEFEAYGLD
DILASIKKAKDNDKIKGIYIQPSYLEASYASLEEIRNALLDFKESGKFIVAYADQYAQGMYYLSSVADKIIINPQGSIGW
HGAGMQPVFFKNLVSKLGLEVQVFRVGTYKSAVEPFIATEMSPANREQMTECLESVWHRILADVSDSRRIPTDTLNAYAD
RYMDFCQAEEYIQCKLADTLMYKDEVISYLKQLSGRDENDKLNSLFIEDMINVKKNVPKDKSGNIIAVYYAYGEILDAPG
SSTEDCIDVQKMCKDLRKLRDNDDVKAVVLRVNSPGGSAYGSDQIWREVVRLKEKKPVIVSMGDYAASGGYYISCAANRI
FADPTTLTGSIGIFGMMYSGEKLFTETLGLNFDVVKTNKMADLGASLGPVLTRPLNASEQELMQNYVNRGYKLFVNRCAE
GRKMSTEAIEKVAEGRVWTGAMAKDLGLVDELGGIDKALNAAATQAGIENYSIIGYPEKENIFASLLGNQKKHYINSEIK
EYLGSYYNSFKALENIKDANCIQARMPFDPNIQ
>Mature_593_residues
MKDFLKFTFASVIGVILAGVVFTILGIITLVGIVASSDTETVVKDNSIFVLDFKGSLSERVQENPLQQLLGEEFEAYGLD
DILASIKKAKDNDKIKGIYIQPSYLEASYASLEEIRNALLDFKESGKFIVAYADQYAQGMYYLSSVADKIIINPQGSIGW
HGAGMQPVFFKNLVSKLGLEVQVFRVGTYKSAVEPFIATEMSPANREQMTECLESVWHRILADVSDSRRIPTDTLNAYAD
RYMDFCQAEEYIQCKLADTLMYKDEVISYLKQLSGRDENDKLNSLFIEDMINVKKNVPKDKSGNIIAVYYAYGEILDAPG
SSTEDCIDVQKMCKDLRKLRDNDDVKAVVLRVNSPGGSAYGSDQIWREVVRLKEKKPVIVSMGDYAASGGYYISCAANRI
FADPTTLTGSIGIFGMMYSGEKLFTETLGLNFDVVKTNKMADLGASLGPVLTRPLNASEQELMQNYVNRGYKLFVNRCAE
GRKMSTEAIEKVAEGRVWTGAMAKDLGLVDELGGIDKALNAAATQAGIENYSIIGYPEKENIFASLLGNQKKHYINSEIK
EYLGSYYNSFKALENIKDANCIQARMPFDPNIQ

Specific function: Digestion of the cleaved signal peptides. This activity is necessary to maintain proper secretion of mature proteins across the membrane [H]

COG id: COG0616

COG function: function code OU; Periplasmic serine proteases (ClpP class)

Gene ontology:

Cell location: Cell inner membrane; Single-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S49 family [H]

Homologues:

Organism=Escherichia coli, GI1788064, Length=548, Percent_Identity=35.5839416058394, Blast_Score=287, Evalue=1e-78,
Organism=Escherichia coli, GI1787527, Length=173, Percent_Identity=30.635838150289, Blast_Score=75, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004634
- InterPro:   IPR004635
- InterPro:   IPR002142 [H]

Pfam domain/function: PF01343 Peptidase_S49 [H]

EC number: 3.4.21.-

Molecular weight: Translated: 65878; Mature: 65878

Theoretical pI: Translated: 4.80; Mature: 4.80

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKDFLKFTFASVIGVILAGVVFTILGIITLVGIVASSDTETVVKDNSIFVLDFKGSLSER
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCEEEEECCCCHHHH
VQENPLQQLLGEEFEAYGLDDILASIKKAKDNDKIKGIYIQPSYLEASYASLEEIRNALL
HHHCHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHH
DFKESGKFIVAYADQYAQGMYYLSSVADKIIINPQGSIGWHGAGMQPVFFKNLVSKLGLE
HHHHCCCEEEEECHHHHHHHHHHHHHCCEEEECCCCCCCCCCCCCCHHHHHHHHHHCCCE
VQVFRVGTYKSAVEPFIATEMSPANREQMTECLESVWHRILADVSDSRRIPTDTLNAYAD
EEEEEECCHHHHHCHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHH
RYMDFCQAEEYIQCKLADTLMYKDEVISYLKQLSGRDENDKLNSLFIEDMINVKKNVPKD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCC
KSGNIIAVYYAYGEILDAPGSSTEDCIDVQKMCKDLRKLRDNDDVKAVVLRVNSPGGSAY
CCCCEEEEEEEECHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEEEEEECCCCCCC
GSDQIWREVVRLKEKKPVIVSMGDYAASGGYYISCAANRIFADPTTLTGSIGIFGMMYSG
CCHHHHHHHHHHHCCCCEEEEECCCCCCCCEEEEEECCCEECCCCCCCCCHHHEEEEECC
EKLFTETLGLNFDVVKTNKMADLGASLGPVLTRPLNASEQELMQNYVNRGYKLFVNRCAE
CHHHHHHHCCCEEEEECCCHHHHCCCHHHHHCCCCCCCHHHHHHHHHHCCHHHHHHHHCC
GRKMSTEAIEKVAEGRVWTGAMAKDLGLVDELGGIDKALNAAATQAGIENYSIIGYPEKE
CCCCCHHHHHHHHCCCEEECHHHHHHCHHHHHCCHHHHHHHHHHHHCCCCCEEECCCCHH
NIFASLLGNQKKHYINSEIKEYLGSYYNSFKALENIKDANCIQARMPFDPNIQ
HHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCC
>Mature Secondary Structure
MKDFLKFTFASVIGVILAGVVFTILGIITLVGIVASSDTETVVKDNSIFVLDFKGSLSER
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCEEEEECCCCHHHH
VQENPLQQLLGEEFEAYGLDDILASIKKAKDNDKIKGIYIQPSYLEASYASLEEIRNALL
HHHCHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHH
DFKESGKFIVAYADQYAQGMYYLSSVADKIIINPQGSIGWHGAGMQPVFFKNLVSKLGLE
HHHHCCCEEEEECHHHHHHHHHHHHHCCEEEECCCCCCCCCCCCCCHHHHHHHHHHCCCE
VQVFRVGTYKSAVEPFIATEMSPANREQMTECLESVWHRILADVSDSRRIPTDTLNAYAD
EEEEEECCHHHHHCHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHH
RYMDFCQAEEYIQCKLADTLMYKDEVISYLKQLSGRDENDKLNSLFIEDMINVKKNVPKD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCC
KSGNIIAVYYAYGEILDAPGSSTEDCIDVQKMCKDLRKLRDNDDVKAVVLRVNSPGGSAY
CCCCEEEEEEEECHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEEEEEECCCCCCC
GSDQIWREVVRLKEKKPVIVSMGDYAASGGYYISCAANRIFADPTTLTGSIGIFGMMYSG
CCHHHHHHHHHHHCCCCEEEEECCCCCCCCEEEEEECCCEECCCCCCCCCHHHEEEEECC
EKLFTETLGLNFDVVKTNKMADLGASLGPVLTRPLNASEQELMQNYVNRGYKLFVNRCAE
CHHHHHHHCCCEEEEECCCHHHHCCCHHHHHCCCCCCCHHHHHHHHHHCCHHHHHHHHCC
GRKMSTEAIEKVAEGRVWTGAMAKDLGLVDELGGIDKALNAAATQAGIENYSIIGYPEKE
CCCCCHHHHHHHHCCCEEECHHHHHHCHHHHHCCHHHHHHHHHHHHCCCCCEEECCCCHH
NIFASLLGNQKKHYINSEIKEYLGSYYNSFKALENIKDANCIQARMPFDPNIQ
HHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]