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The map label for this gene is wecC [H]

Identifier: 150004099

GI number: 150004099

Start: 2021933

End: 2023138

Strand: Direct

Name: wecC [H]

Synonym: BVU_1534

Alternate gene names: 150004099

Gene position: 2021933-2023138 (Clockwise)

Preceding gene: 150004098

Following gene: 150004100

Centisome position: 39.16

GC content: 44.78

Gene sequence:

>1206_bases
ATGAAAGCATGTTTCATGGGCTTGGGTTACATCGGACTACCTACAGCCATTATTGCCGCAAAGCACGGCATTCAAATAAC
AGGAGTTGACATTAATCCTCATGTAGTGAAAATGACCAATGCGGGACATTTGCACATCATTGAACCCGGCATGGAGGAAA
TGTTACAGGAAGTAGTGAAAGCTGGCATGTTGAAGGCTTCGGTTACACCGGAAGTCAGCGATGCATACTTCATGGTGGTC
CCAACCCCGTTCAAGGGAAACCACGAGCCGGATGTGAGTTACGTGGAAGCGGCTACACGTGCCGTATTGCCGTTACTGAA
AGAAGGGGATCTTTATGTAATAGAATCCACTTCACCTGTAGGAACTACAGAGGCTATGGCACGCATCATTTTTGGTGAAC
GTCCGGAATTGGAAAGTAAGATTTTCATAGCCTATTGCCCGGAGCGTGTATTGCCAGGTAATGTGATCTATGAATTGGTA
CACAACGATCGGGTCATCGGTGGTTTGAATCCTGAATCTACCGAAAAGGCAATAGCATTCTATTCGCAATTTGTGCAGGG
CACACTTCACAAGACTAACTGCCGTACAGCGGAAATGTGTAAGCTGACGGAGAACTCCAGTCGCGATGTACAGATAGCTT
TTGCCAATGAACTTTCGCTTATCTGCGACAAGGCTGGTATCAATGTTTGGGAACTTATTAACCTTGCCAACAAGCATCCG
CGTGTAAATATCCTGCAACCCGGTTGCGGTGTAGGAGGTCATTGTATTGCGGTAGATCCATACTTTATCACTGCTGATTT
CCCGGCAGAAAGCAAGTTAATCAGCGATGCACGTGATATTAACAACTACAAGAGTTTCTGGTGTGCTGAAAAGGTGAAGA
ACGCCATGTTGAAGTTTGAGTTGAAGAATCATCGTAAACCAGTTATAGCCATGATGGGATTGGCATTCAAACCAAATATT
GACGATTTGCGTGAAAGTCCGGCGAAGTATATTACCACGAAAGTGATGCAGAGCTGCAACAATGCCGACATTTTGGTCGT
AGAACCGAATGTAAAAGAGCACAACGTGTTTAAGCTGACTAACTACTGCGAAGCCTACGACAAGGCAGACATCGTGGTGT
TCCTTACGGCTCACAACGAGTTTAAAGAGCTATCTTGGAGGAAGGATAAAATGATATTGGACTTTTGTGGAATATTCAAG
AAATAA

Upstream 100 bases:

>100_bases
AAATGTGTGTAAAATATAGCGTATTTACATTCGGGAAGACTTTGCCCTAATATGTGTTTTTTTATGTAAATGAATGATTT
AATATTTAATACAAAGATAA

Downstream 100 bases:

>100_bases
TGGATATTTCTAAATAAGTGCAAATACAATTATCACCGAAACTAATGAAAATTGCACATAAAATAGTTCAAGTACCGGAA
ATGAAATTTTTATTAAGACC

Product: putative UDP-ManNAc dehydrogenase

Products: UDP-N-acetyl-D-mannosaminuronic-acid; NADH; Proton [C]

Alternate protein names: UDP-ManNAc 6-dehydrogenase [H]

Number of amino acids: Translated: 401; Mature: 401

Protein sequence:

>401_residues
MKACFMGLGYIGLPTAIIAAKHGIQITGVDINPHVVKMTNAGHLHIIEPGMEEMLQEVVKAGMLKASVTPEVSDAYFMVV
PTPFKGNHEPDVSYVEAATRAVLPLLKEGDLYVIESTSPVGTTEAMARIIFGERPELESKIFIAYCPERVLPGNVIYELV
HNDRVIGGLNPESTEKAIAFYSQFVQGTLHKTNCRTAEMCKLTENSSRDVQIAFANELSLICDKAGINVWELINLANKHP
RVNILQPGCGVGGHCIAVDPYFITADFPAESKLISDARDINNYKSFWCAEKVKNAMLKFELKNHRKPVIAMMGLAFKPNI
DDLRESPAKYITTKVMQSCNNADILVVEPNVKEHNVFKLTNYCEAYDKADIVVFLTAHNEFKELSWRKDKMILDFCGIFK
K

Sequences:

>Translated_401_residues
MKACFMGLGYIGLPTAIIAAKHGIQITGVDINPHVVKMTNAGHLHIIEPGMEEMLQEVVKAGMLKASVTPEVSDAYFMVV
PTPFKGNHEPDVSYVEAATRAVLPLLKEGDLYVIESTSPVGTTEAMARIIFGERPELESKIFIAYCPERVLPGNVIYELV
HNDRVIGGLNPESTEKAIAFYSQFVQGTLHKTNCRTAEMCKLTENSSRDVQIAFANELSLICDKAGINVWELINLANKHP
RVNILQPGCGVGGHCIAVDPYFITADFPAESKLISDARDINNYKSFWCAEKVKNAMLKFELKNHRKPVIAMMGLAFKPNI
DDLRESPAKYITTKVMQSCNNADILVVEPNVKEHNVFKLTNYCEAYDKADIVVFLTAHNEFKELSWRKDKMILDFCGIFK
K
>Mature_401_residues
MKACFMGLGYIGLPTAIIAAKHGIQITGVDINPHVVKMTNAGHLHIIEPGMEEMLQEVVKAGMLKASVTPEVSDAYFMVV
PTPFKGNHEPDVSYVEAATRAVLPLLKEGDLYVIESTSPVGTTEAMARIIFGERPELESKIFIAYCPERVLPGNVIYELV
HNDRVIGGLNPESTEKAIAFYSQFVQGTLHKTNCRTAEMCKLTENSSRDVQIAFANELSLICDKAGINVWELINLANKHP
RVNILQPGCGVGGHCIAVDPYFITADFPAESKLISDARDINNYKSFWCAEKVKNAMLKFELKNHRKPVIAMMGLAFKPNI
DDLRESPAKYITTKVMQSCNNADILVVEPNVKEHNVFKLTNYCEAYDKADIVVFLTAHNEFKELSWRKDKMILDFCGIFK
K

Specific function: Catalyzes the four-electron oxidation of UDP-N-acetyl-D- mannosamine (UDP-ManNAc), reducing NAD(+) and releasing UDP-N- acetylmannosaminuronic acid (UDP-ManNAcA) [H]

COG id: COG0677

COG function: function code M; UDP-N-acetyl-D-mannosaminuronate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4507813, Length=428, Percent_Identity=27.3364485981308, Blast_Score=117, Evalue=2e-26,
Organism=Homo sapiens, GI296040443, Length=419, Percent_Identity=25.0596658711217, Blast_Score=87, Evalue=4e-17,
Organism=Homo sapiens, GI296040438, Length=329, Percent_Identity=27.355623100304, Blast_Score=86, Evalue=4e-17,
Organism=Escherichia coli, GI48994968, Length=414, Percent_Identity=51.4492753623188, Blast_Score=413, Evalue=1e-116,
Organism=Escherichia coli, GI1788340, Length=406, Percent_Identity=24.384236453202, Blast_Score=104, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI17560350, Length=429, Percent_Identity=27.2727272727273, Blast_Score=115, Evalue=4e-26,
Organism=Drosophila melanogaster, GI17136908, Length=381, Percent_Identity=27.8215223097113, Blast_Score=116, Evalue=3e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR016040
- InterPro:   IPR017476
- InterPro:   IPR014027
- InterPro:   IPR014026
- InterPro:   IPR014028
- InterPro:   IPR001732 [H]

Pfam domain/function: PF00984 UDPG_MGDP_dh; PF03720 UDPG_MGDP_dh_C; PF03721 UDPG_MGDP_dh_N [H]

EC number: 1.1.1.- [C]

Molecular weight: Translated: 44686; Mature: 44686

Theoretical pI: Translated: 6.64; Mature: 6.64

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.7 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
6.2 %Cys+Met (Translated Protein)
2.7 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
6.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKACFMGLGYIGLPTAIIAAKHGIQITGVDINPHVVKMTNAGHLHIIEPGMEEMLQEVVK
CCCEEEECCHHHHHHHHHHHHCCCEEEEEECCCEEEEEECCCEEEEECCCHHHHHHHHHH
AGMLKASVTPEVSDAYFMVVPTPFKGNHEPDVSYVEAATRAVLPLLKEGDLYVIESTSPV
HCCEEECCCCCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEECCCCC
GTTEAMARIIFGERPELESKIFIAYCPERVLPGNVIYELVHNDRVIGGLNPESTEKAIAF
CHHHHHHHHHCCCCCCCCCEEEEEECCCCCCCHHHHHHHHHCCEEEECCCCCHHHHHHHH
YSQFVQGTLHKTNCRTAEMCKLTENSSRDVQIAFANELSLICDKAGINVWELINLANKHP
HHHHHHCCCCCCCCCHHHHHEECCCCCCEEEEEEECCEEEEEECCCCCHHHHHHHHCCCC
RVNILQPGCGVGGHCIAVDPYFITADFPAESKLISDARDINNYKSFWCAEKVKNAMLKFE
EEEEECCCCCCCCEEEEECCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHEEEE
LKNHRKPVIAMMGLAFKPNIDDLRESPAKYITTKVMQSCNNADILVVEPNVKEHNVFKLT
HHCCCCCEEEEECCCCCCCHHHHHHCHHHHHHHHHHHCCCCCCEEEECCCCCCCCEEEEH
NYCEAYDKADIVVFLTAHNEFKELSWRKDKMILDFCGIFKK
HHHHHCCCCCEEEEEECCCCHHHHCCCCCHHHHHHHHHCCC
>Mature Secondary Structure
MKACFMGLGYIGLPTAIIAAKHGIQITGVDINPHVVKMTNAGHLHIIEPGMEEMLQEVVK
CCCEEEECCHHHHHHHHHHHHCCCEEEEEECCCEEEEEECCCEEEEECCCHHHHHHHHHH
AGMLKASVTPEVSDAYFMVVPTPFKGNHEPDVSYVEAATRAVLPLLKEGDLYVIESTSPV
HCCEEECCCCCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEECCCCC
GTTEAMARIIFGERPELESKIFIAYCPERVLPGNVIYELVHNDRVIGGLNPESTEKAIAF
CHHHHHHHHHCCCCCCCCCEEEEEECCCCCCCHHHHHHHHHCCEEEECCCCCHHHHHHHH
YSQFVQGTLHKTNCRTAEMCKLTENSSRDVQIAFANELSLICDKAGINVWELINLANKHP
HHHHHHCCCCCCCCCHHHHHEECCCCCCEEEEEEECCEEEEEECCCCCHHHHHHHHCCCC
RVNILQPGCGVGGHCIAVDPYFITADFPAESKLISDARDINNYKSFWCAEKVKNAMLKFE
EEEEECCCCCCCCEEEEECCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHEEEE
LKNHRKPVIAMMGLAFKPNIDDLRESPAKYITTKVMQSCNNADILVVEPNVKEHNVFKLT
HHCCCCCEEEEECCCCCCCHHHHHHCHHHHHHHHHHHCCCCCCEEEECCCCCCCCEEEEH
NYCEAYDKADIVVFLTAHNEFKELSWRKDKMILDFCGIFKK
HHHHHCCCCCEEEEEECCCCHHHHCCCCCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: UDP-N-acetyl-D-mannosamine; NAD [C]

Specific reaction: UDP-N-acetyl-D-mannosamine + NAD = UDP-N-acetyl-D-mannosaminuronic-acid + NADH + Proton [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]