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The map label for this gene is lepB [H]

Identifier: 150003826

GI number: 150003826

Start: 1688435

End: 1689859

Strand: Direct

Name: lepB [H]

Synonym: BVU_1258

Alternate gene names: 150003826

Gene position: 1688435-1689859 (Clockwise)

Preceding gene: 150003825

Following gene: 150003827

Centisome position: 32.7

GC content: 44.7

Gene sequence:

>1425_bases
ATGATAAGAGCAACACGTACACAGTGGATTAAGTTTGCCGTTGTTCTGGCGCTTTACCTGATATTTCTTGTCTGGTTGAG
AAGCTGGCTGGGATTGGTGGTTGTACCGTTTATCTTCGATGCGTATATCACAAAGAAGATTCCATGGACTTGGTGGAGAG
AGTCCAAGAACCGTCATGTAGTGACTGTCATGGGATGGGTGGATGCTATTGTATTCGCACTGGTGGCGGTATACTTTGTC
AACCTCTATTTCTTCCAGAACTATGTGATTCCTTCTTCTTCGCTGGAAAAATCATTGCTGACGGGTGATTATCTGTTTGT
GAGTAAAATGAGTTATGGGCCCCGTGTGCCTCAGACTCCGCTGCACATGCCGTTGGCACAACACACACTGCCGTTTTTTA
ATTGTAAATCATACCTTGAGCATCCACAATGGGATTATAAACGGGTGAAAGGTTTGGGGGATGTACAGTTGAATGATATC
GTTGTCTTTAACTTTCCGGCCGGAGATACAGTTGCCACCGGTGTGCCCAATGATGATATTTACCGTCTGAGTTATGGCGC
AGGCAAGGAGCTGGCAAAACCGGTGGATTTGGCTTCCATGACTCCGGAGCAGCAACGGGTGGTCTATGATTATTATTATC
AGTTGGGACGGGAGTACCTGAAAGAGAATCCACAGAATTTCGGTGAGATAATCAGCCGTCCGGTAGACCGCCGTGAGAAC
TACGTGAAGCGGTGTGTGGGTTTGCCCGGACAAACGCTGGAGATAAAGGATCGTATTATTTATTTGGATGGTAAAGCTAA
TAAAGAGCCTGATAATGTGCAGTATCGTTATCTGGTGAAAACCAAGCGTCCTATTCCCGATGACCTGGCTCATGAACTGG
GTATCAGCAAGGAGGATATGATGATGTATTATACGGATGCTTCTGTTTATAATATGCCTCTGACGGAAAAAGCGAAAGCG
GGTTTGTTGGCGCGTAAGGATATTGTAGTCAGTATTGAGAATACACCGGCTGATGATGCGGGGGGCTTGTACCCGCTGAA
TATGTATAAGAACTGGACTACGGATAACTACGGACCTGTATGGATTCCCAAAAAGGGAGAGACGGTGAAACTCACGATAG
AGAATCTTCCTGTTTATGAGCGTCCTATTCATGTTTACGAGGGTAATGAACTGGCGGTGAAAGATGGAAAGATTTATATT
AACGGCAAGGAAACCGATGAGTATACTTTCAAGATGGATTATTATTGGATGATGGGAGATAACCGTCATAATTCGGCTGA
CTCCCGCTTTTGGGGATTTGTTCCTGAAGATCATGTGGTGGGAAAACCTATCTTTATCTGGTTGTCATTGGATAATGACC
GTGGCTGGCTGGATGGAAAAATACGTTGGAACCGATTGTTTACCTTTGTAGATAACATTAAATAA

Upstream 100 bases:

>100_bases
GAATCGGAAGGGGTTTGCCTTGGGAGCTGTTTTGGCGGCGGAATATACATCCAGGCATGAAGGGTTATTAGGAATGAGTG
ATTTATTTCAGTTTTAAGAT

Downstream 100 bases:

>100_bases
ATTGCGCATACCCTGTATTCCTGTATGGATAAAAGCAATGCTTACTGCTGTCATTCTGGTACTGTTGGTAAAGACATTTG
CTTTCACCTCCTGCACCATT

Product: signal peptidase I

Products: NA

Alternate protein names: SPase I; Leader peptidase I [H]

Number of amino acids: Translated: 474; Mature: 474

Protein sequence:

>474_residues
MIRATRTQWIKFAVVLALYLIFLVWLRSWLGLVVVPFIFDAYITKKIPWTWWRESKNRHVVTVMGWVDAIVFALVAVYFV
NLYFFQNYVIPSSSLEKSLLTGDYLFVSKMSYGPRVPQTPLHMPLAQHTLPFFNCKSYLEHPQWDYKRVKGLGDVQLNDI
VVFNFPAGDTVATGVPNDDIYRLSYGAGKELAKPVDLASMTPEQQRVVYDYYYQLGREYLKENPQNFGEIISRPVDRREN
YVKRCVGLPGQTLEIKDRIIYLDGKANKEPDNVQYRYLVKTKRPIPDDLAHELGISKEDMMMYYTDASVYNMPLTEKAKA
GLLARKDIVVSIENTPADDAGGLYPLNMYKNWTTDNYGPVWIPKKGETVKLTIENLPVYERPIHVYEGNELAVKDGKIYI
NGKETDEYTFKMDYYWMMGDNRHNSADSRFWGFVPEDHVVGKPIFIWLSLDNDRGWLDGKIRWNRLFTFVDNIK

Sequences:

>Translated_474_residues
MIRATRTQWIKFAVVLALYLIFLVWLRSWLGLVVVPFIFDAYITKKIPWTWWRESKNRHVVTVMGWVDAIVFALVAVYFV
NLYFFQNYVIPSSSLEKSLLTGDYLFVSKMSYGPRVPQTPLHMPLAQHTLPFFNCKSYLEHPQWDYKRVKGLGDVQLNDI
VVFNFPAGDTVATGVPNDDIYRLSYGAGKELAKPVDLASMTPEQQRVVYDYYYQLGREYLKENPQNFGEIISRPVDRREN
YVKRCVGLPGQTLEIKDRIIYLDGKANKEPDNVQYRYLVKTKRPIPDDLAHELGISKEDMMMYYTDASVYNMPLTEKAKA
GLLARKDIVVSIENTPADDAGGLYPLNMYKNWTTDNYGPVWIPKKGETVKLTIENLPVYERPIHVYEGNELAVKDGKIYI
NGKETDEYTFKMDYYWMMGDNRHNSADSRFWGFVPEDHVVGKPIFIWLSLDNDRGWLDGKIRWNRLFTFVDNIK
>Mature_474_residues
MIRATRTQWIKFAVVLALYLIFLVWLRSWLGLVVVPFIFDAYITKKIPWTWWRESKNRHVVTVMGWVDAIVFALVAVYFV
NLYFFQNYVIPSSSLEKSLLTGDYLFVSKMSYGPRVPQTPLHMPLAQHTLPFFNCKSYLEHPQWDYKRVKGLGDVQLNDI
VVFNFPAGDTVATGVPNDDIYRLSYGAGKELAKPVDLASMTPEQQRVVYDYYYQLGREYLKENPQNFGEIISRPVDRREN
YVKRCVGLPGQTLEIKDRIIYLDGKANKEPDNVQYRYLVKTKRPIPDDLAHELGISKEDMMMYYTDASVYNMPLTEKAKA
GLLARKDIVVSIENTPADDAGGLYPLNMYKNWTTDNYGPVWIPKKGETVKLTIENLPVYERPIHVYEGNELAVKDGKIYI
NGKETDEYTFKMDYYWMMGDNRHNSADSRFWGFVPEDHVVGKPIFIWLSLDNDRGWLDGKIRWNRLFTFVDNIK

Specific function: Unknown

COG id: COG0681

COG function: function code U; Signal peptidase I

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S26 family [H]

Homologues:

Organism=Escherichia coli, GI1788921, Length=236, Percent_Identity=25.8474576271186, Blast_Score=67, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000223
- InterPro:   IPR019758
- InterPro:   IPR019757
- InterPro:   IPR019756
- InterPro:   IPR019759
- InterPro:   IPR015927
- InterPro:   IPR011056
- InterPro:   IPR019533
- InterPro:   IPR019766 [H]

Pfam domain/function: PF00717 Peptidase_S24; PF10502 Peptidase_S26 [H]

EC number: =3.4.21.89 [H]

Molecular weight: Translated: 55207; Mature: 55207

Theoretical pI: Translated: 8.10; Mature: 8.10

Prosite motif: PS00761 SPASE_I_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIRATRTQWIKFAVVLALYLIFLVWLRSWLGLVVVPFIFDAYITKKIPWTWWRESKNRHV
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCCCEE
VTVMGWVDAIVFALVAVYFVNLYFFQNYVIPSSSLEKSLLTGDYLFVSKMSYGPRVPQTP
EEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCEEEEEECCCCCCCCCCC
LHMPLAQHTLPFFNCKSYLEHPQWDYKRVKGLGDVQLNDIVVFNFPAGDTVATGVPNDDI
CCCCHHHHCCCHHHHHHHHCCCCCCHHHHCCCCCEEECCEEEEECCCCCEEECCCCCCCE
YRLSYGAGKELAKPVDLASMTPEQQRVVYDYYYQLGREYLKENPQNFGEIISRPVDRREN
EEEECCCCHHHCCCCCHHHCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCHHHHHH
YVKRCVGLPGQTLEIKDRIIYLDGKANKEPDNVQYRYLVKTKRPIPDDLAHELGISKEDM
HHHHHHCCCCCEEEEEEEEEEEECCCCCCCCCCEEEEEEECCCCCCHHHHHHHCCCCCCE
MMYYTDASVYNMPLTEKAKAGLLARKDIVVSIENTPADDAGGLYPLNMYKNWTTDNYGPV
EEEEECCEEEECCCCHHHHCCCEEECEEEEEECCCCCCCCCCEEEECCCCCCCCCCCCCE
WIPKKGETVKLTIENLPVYERPIHVYEGNELAVKDGKIYINGKETDEYTFKMDYYWMMGD
EECCCCCEEEEEEECCCCCCCCEEEEECCEEEEECCEEEECCCCCCCEEEEEEEEEEECC
NRHNSADSRFWGFVPEDHVVGKPIFIWLSLDNDRGWLDGKIRWNRLFTFVDNIK
CCCCCCCCCEECCCCCCCCCCCEEEEEEEECCCCCEECCEEEHHHHHEEHHCCC
>Mature Secondary Structure
MIRATRTQWIKFAVVLALYLIFLVWLRSWLGLVVVPFIFDAYITKKIPWTWWRESKNRHV
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCCCEE
VTVMGWVDAIVFALVAVYFVNLYFFQNYVIPSSSLEKSLLTGDYLFVSKMSYGPRVPQTP
EEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCEEEEEECCCCCCCCCCC
LHMPLAQHTLPFFNCKSYLEHPQWDYKRVKGLGDVQLNDIVVFNFPAGDTVATGVPNDDI
CCCCHHHHCCCHHHHHHHHCCCCCCHHHHCCCCCEEECCEEEEECCCCCEEECCCCCCCE
YRLSYGAGKELAKPVDLASMTPEQQRVVYDYYYQLGREYLKENPQNFGEIISRPVDRREN
EEEECCCCHHHCCCCCHHHCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCHHHHHH
YVKRCVGLPGQTLEIKDRIIYLDGKANKEPDNVQYRYLVKTKRPIPDDLAHELGISKEDM
HHHHHHCCCCCEEEEEEEEEEEECCCCCCCCCCEEEEEEECCCCCCHHHHHHHCCCCCCE
MMYYTDASVYNMPLTEKAKAGLLARKDIVVSIENTPADDAGGLYPLNMYKNWTTDNYGPV
EEEEECCEEEECCCCHHHHCCCEEECEEEEEECCCCCCCCCCEEEECCCCCCCCCCCCCE
WIPKKGETVKLTIENLPVYERPIHVYEGNELAVKDGKIYINGKETDEYTFKMDYYWMMGD
EECCCCCEEEEEEECCCCCCCCEEEEECCEEEEECCEEEECCCCCCCEEEEEEEEEEECC
NRHNSADSRFWGFVPEDHVVGKPIFIWLSLDNDRGWLDGKIRWNRLFTFVDNIK
CCCCCCCCCEECCCCCCCCCCCEEEEEEEECCCCCEECCEEEHHHHHEEHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10993077 [H]