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The map label for this gene is uvrC [H]

Identifier: 150003780

GI number: 150003780

Start: 1631215

End: 1633035

Strand: Reverse

Name: uvrC [H]

Synonym: BVU_1212

Alternate gene names: 150003780

Gene position: 1633035-1631215 (Counterclockwise)

Preceding gene: 150003781

Following gene: 150003779

Centisome position: 31.63

GC content: 45.3

Gene sequence:

>1821_bases
ATGGAAAAAGAAGAGATTACAACCAATGATTATCTGAAAGGAATTGTACTAAACCTGCCCGACAGCCCCGGCATTTACCA
ATACTTGAACTCCGAAGGAACCATTATCTACGTTGGAAAGGCAAAAAACCTGAAGCGCAGAGTCTCTTCTTATTTTAATA
GAGAACACCCCAACGGCAAGACACGATTGCTGGTCAGCAAAATTGCAGATATCCGTTATATCGTGGTAAAAACAGAAGAA
GACGCCCTTTTACTCGAAAACAACCTGATAAAGAAATACAAGCCACGTTACAATGTATTGCTGAAAGATGACAAGACTTA
CCCCTCTATTTGTGTAAGCAACGAATATTTCCCACGTATTTTCAAAACCCGGCAAGTCATCCGCAACGGATCCTCTTATT
ATGGTCCGTACAGTCACATGCCCTCCATGCTTGCCGTGATGGACTTGATCAAAAAGCTCTACCCCATCCGTACCTGCAAA
CTCAATCTAAGTCCCGAAAACATTCGCGCCGGCAAGTTCAACGTATGTCTGGAATATCACATAAAGAACTGCAAAGGGCC
CTGCATCGGGCAGCAGTCACACGAAGAATACATGAAGAATATCGGTGAAATCAAAAATATTCTGAAAGGAGATACCCAGA
TTGTAAGTGACCTGCTGATGGAAGAGATGCAAGCGCTTGCTGCCGAAATGAAATTTGAGGAAGCACAGAAAATAAAAGAG
AAATATGACTTGATAGAAAACTATCGTTCCAAGAGCGAAGTCGTTAATTCCATCATTCATAATGTGGATGTGTTCTCCAT
TGAAATGGAAGAAAATTCAGCCTATATCAACTATCTGCATATCACAAACGGATGCATCAACCAAGCCTTCACCTTCGAAT
ACAAGAAACGTCTGAACGAAACGAAAGAAGAACTTCTACAATTGGGCATTATTGAGATGCGTGAACGATATAAGAGCACT
TCCCGCGAAATCATCGTACCTTTTGAACTGGATATGGAGATGAACAATGTATCCTTTACCGTTCCCCAACGAGGAGAAAA
GAAGCATTTGCTGGATCTTTCCGTAATGAACGTGAAACAGTATAAAGTGGACCGCTTGAAACAGGCGGAAAAGTTGAATC
CTGAACAAAGAAGCGTCCGTCTGATGAAAGAAATCCAGGAGCAGCTGCACATGAAAAAACTACCGAACCACATCGAATGT
TTCGATAATTCCAATATTCAAGGCTCGGACGCGGTGGCCGCCTGCGTCGTTTTCAAAAAGGCGAAACCAAGCAAGAAGGA
GTACCGGAAATACATCATCAAGACAGTGACCGGACCCGACGATTACGCCTCGATGAAAGAGGTGGTACGCCGCCGGTATA
GCCGTGCCATAGAGGAAGGTTCCCCCCTGCCCGACCTCATCATTACCGACGGTGGAAAGGGGCAAATGGAAGTGGTGAGA
GAAGTGATAGAGGACGAACTTCATCTGGATATCCCCATAGCCGGACTGGCCAAAGACCGCAAGCACCGCACCTCGGAATT
GTTATACGGATTCCCTCCGCTGACCATCGGTGTGAAGCAAAGCACTCCCTTGTTCCATCTGTTGGAAAACATACAGAACG
AGGTACACCGCTTCGCCATCACCTTCCACCGGGACAAACGAAGCAAGAGTCAGGTGGCGTCCGCCTTGGACAATATCAAG
GGAATAGGCGAAAAAAGAAAGACCGCCCTGCTGAAAACATTCAAAAGCGTCAGCCGCATCAGGCAAGCCTCACTGGAAGA
GATTGCAGCCGTGGTAGGTGAAGCAGCCGCTAAAAATATCAAAGAAAATCTCACAGAATAA

Upstream 100 bases:

>100_bases
TGAAGATATATAATGTTACAACCGAAAGATATAGGATGTTGCGGCTGCAACATCAACTCAAGAAACAGTTCTGCCAACCG
GCAATATTCAATAAGCATGT

Downstream 100 bases:

>100_bases
AAGGGATTTCCTACCTTTGCATACATCTACTACAGGGACATGCTCTGCCTCGTATCAGTCCAGGCAAGAAGCCGGCAACA
TATTGTCCATTGTAGAAGCG

Product: excinuclease ABC subunit C

Products: NA

Alternate protein names: Protein uvrC; Excinuclease ABC subunit C [H]

Number of amino acids: Translated: 606; Mature: 606

Protein sequence:

>606_residues
MEKEEITTNDYLKGIVLNLPDSPGIYQYLNSEGTIIYVGKAKNLKRRVSSYFNREHPNGKTRLLVSKIADIRYIVVKTEE
DALLLENNLIKKYKPRYNVLLKDDKTYPSICVSNEYFPRIFKTRQVIRNGSSYYGPYSHMPSMLAVMDLIKKLYPIRTCK
LNLSPENIRAGKFNVCLEYHIKNCKGPCIGQQSHEEYMKNIGEIKNILKGDTQIVSDLLMEEMQALAAEMKFEEAQKIKE
KYDLIENYRSKSEVVNSIIHNVDVFSIEMEENSAYINYLHITNGCINQAFTFEYKKRLNETKEELLQLGIIEMRERYKST
SREIIVPFELDMEMNNVSFTVPQRGEKKHLLDLSVMNVKQYKVDRLKQAEKLNPEQRSVRLMKEIQEQLHMKKLPNHIEC
FDNSNIQGSDAVAACVVFKKAKPSKKEYRKYIIKTVTGPDDYASMKEVVRRRYSRAIEEGSPLPDLIITDGGKGQMEVVR
EVIEDELHLDIPIAGLAKDRKHRTSELLYGFPPLTIGVKQSTPLFHLLENIQNEVHRFAITFHRDKRSKSQVASALDNIK
GIGEKRKTALLKTFKSVSRIRQASLEEIAAVVGEAAAKNIKENLTE

Sequences:

>Translated_606_residues
MEKEEITTNDYLKGIVLNLPDSPGIYQYLNSEGTIIYVGKAKNLKRRVSSYFNREHPNGKTRLLVSKIADIRYIVVKTEE
DALLLENNLIKKYKPRYNVLLKDDKTYPSICVSNEYFPRIFKTRQVIRNGSSYYGPYSHMPSMLAVMDLIKKLYPIRTCK
LNLSPENIRAGKFNVCLEYHIKNCKGPCIGQQSHEEYMKNIGEIKNILKGDTQIVSDLLMEEMQALAAEMKFEEAQKIKE
KYDLIENYRSKSEVVNSIIHNVDVFSIEMEENSAYINYLHITNGCINQAFTFEYKKRLNETKEELLQLGIIEMRERYKST
SREIIVPFELDMEMNNVSFTVPQRGEKKHLLDLSVMNVKQYKVDRLKQAEKLNPEQRSVRLMKEIQEQLHMKKLPNHIEC
FDNSNIQGSDAVAACVVFKKAKPSKKEYRKYIIKTVTGPDDYASMKEVVRRRYSRAIEEGSPLPDLIITDGGKGQMEVVR
EVIEDELHLDIPIAGLAKDRKHRTSELLYGFPPLTIGVKQSTPLFHLLENIQNEVHRFAITFHRDKRSKSQVASALDNIK
GIGEKRKTALLKTFKSVSRIRQASLEEIAAVVGEAAAKNIKENLTE
>Mature_606_residues
MEKEEITTNDYLKGIVLNLPDSPGIYQYLNSEGTIIYVGKAKNLKRRVSSYFNREHPNGKTRLLVSKIADIRYIVVKTEE
DALLLENNLIKKYKPRYNVLLKDDKTYPSICVSNEYFPRIFKTRQVIRNGSSYYGPYSHMPSMLAVMDLIKKLYPIRTCK
LNLSPENIRAGKFNVCLEYHIKNCKGPCIGQQSHEEYMKNIGEIKNILKGDTQIVSDLLMEEMQALAAEMKFEEAQKIKE
KYDLIENYRSKSEVVNSIIHNVDVFSIEMEENSAYINYLHITNGCINQAFTFEYKKRLNETKEELLQLGIIEMRERYKST
SREIIVPFELDMEMNNVSFTVPQRGEKKHLLDLSVMNVKQYKVDRLKQAEKLNPEQRSVRLMKEIQEQLHMKKLPNHIEC
FDNSNIQGSDAVAACVVFKKAKPSKKEYRKYIIKTVTGPDDYASMKEVVRRRYSRAIEEGSPLPDLIITDGGKGQMEVVR
EVIEDELHLDIPIAGLAKDRKHRTSELLYGFPPLTIGVKQSTPLFHLLENIQNEVHRFAITFHRDKRSKSQVASALDNIK
GIGEKRKTALLKTFKSVSRIRQASLEEIAAVVGEAAAKNIKENLTE

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision [H]

COG id: COG0322

COG function: function code L; Nuclease subunit of the excinuclease complex

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain [H]

Homologues:

Organism=Escherichia coli, GI87081999, Length=616, Percent_Identity=33.1168831168831, Blast_Score=314, Evalue=8e-87,
Organism=Escherichia coli, GI1788037, Length=189, Percent_Identity=24.8677248677249, Blast_Score=69, Evalue=6e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003583
- InterPro:   IPR010994
- InterPro:   IPR009055
- InterPro:   IPR004791
- InterPro:   IPR001162
- InterPro:   IPR000305 [H]

Pfam domain/function: PF01541 GIY-YIG; PF08459 UvrC_HhH_N [H]

EC number: NA

Molecular weight: Translated: 69876; Mature: 69876

Theoretical pI: Translated: 9.34; Mature: 9.34

Prosite motif: PS50164 UVRC_1 ; PS50165 UVRC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEKEEITTNDYLKGIVLNLPDSPGIYQYLNSEGTIIYVGKAKNLKRRVSSYFNREHPNGK
CCCCCCCHHHHHCEEEEECCCCCCHHHHHCCCCCEEEEECCHHHHHHHHHHHCCCCCCCH
TRLLVSKIADIRYIVVKTEEDALLLENNLIKKYKPRYNVLLKDDKTYPSICVSNEYFPRI
HHHHHHHHCCEEEEEEECCCCCCHHHHHHHHHCCCCCCEEEECCCCCCCEEECCCHHHHH
FKTRQVIRNGSSYYGPYSHMPSMLAVMDLIKKLYPIRTCKLNLSPENIRAGKFNVCLEYH
HHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCEEEEEEEE
IKNCKGPCIGQQSHEEYMKNIGEIKNILKGDTQIVSDLLMEEMQALAAEMKFEEAQKIKE
ECCCCCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KYDLIENYRSKSEVVNSIIHNVDVFSIEMEENSAYINYLHITNGCINQAFTFEYKKRLNE
HHHHHHHHHHHHHHHHHHHHCCEEEEEEEECCCEEEEEEEECCCHHHHHHHHHHHHHHHH
TKEELLQLGIIEMRERYKSTSREIIVPFELDMEMNNVSFTVPQRGEKKHLLDLSVMNVKQ
HHHHHHHHHHHHHHHHHCCCCCCEEEEEEECEEECCEEEECCCCCCCCCEEEHHHHHHHH
YKVDRLKQAEKLNPEQRSVRLMKEIQEQLHMKKLPNHIECFDNSNIQGSDAVAACVVFKK
HHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCCCCHHHHHHHHHHC
AKPSKKEYRKYIIKTVTGPDDYASMKEVVRRRYSRAIEEGSPLPDLIITDGGKGQMEVVR
CCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCHHHHHH
EVIEDELHLDIPIAGLAKDRKHRTSELLYGFPPLTIGVKQSTPLFHLLENIQNEVHRFAI
HHHHCCCEECCCCHHHHHHHHHHHHHHHCCCCCCEEECCCCCHHHHHHHHHHHHHHHHHH
TFHRDKRSKSQVASALDNIKGIGEKRKTALLKTFKSVSRIRQASLEEIAAVVGEAAAKNI
EEECCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KENLTE
HHHCCC
>Mature Secondary Structure
MEKEEITTNDYLKGIVLNLPDSPGIYQYLNSEGTIIYVGKAKNLKRRVSSYFNREHPNGK
CCCCCCCHHHHHCEEEEECCCCCCHHHHHCCCCCEEEEECCHHHHHHHHHHHCCCCCCCH
TRLLVSKIADIRYIVVKTEEDALLLENNLIKKYKPRYNVLLKDDKTYPSICVSNEYFPRI
HHHHHHHHCCEEEEEEECCCCCCHHHHHHHHHCCCCCCEEEECCCCCCCEEECCCHHHHH
FKTRQVIRNGSSYYGPYSHMPSMLAVMDLIKKLYPIRTCKLNLSPENIRAGKFNVCLEYH
HHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCEEEEEEEE
IKNCKGPCIGQQSHEEYMKNIGEIKNILKGDTQIVSDLLMEEMQALAAEMKFEEAQKIKE
ECCCCCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KYDLIENYRSKSEVVNSIIHNVDVFSIEMEENSAYINYLHITNGCINQAFTFEYKKRLNE
HHHHHHHHHHHHHHHHHHHHCCEEEEEEEECCCEEEEEEEECCCHHHHHHHHHHHHHHHH
TKEELLQLGIIEMRERYKSTSREIIVPFELDMEMNNVSFTVPQRGEKKHLLDLSVMNVKQ
HHHHHHHHHHHHHHHHHCCCCCCEEEEEEECEEECCEEEECCCCCCCCCEEEHHHHHHHH
YKVDRLKQAEKLNPEQRSVRLMKEIQEQLHMKKLPNHIECFDNSNIQGSDAVAACVVFKK
HHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCCCCHHHHHHHHHHC
AKPSKKEYRKYIIKTVTGPDDYASMKEVVRRRYSRAIEEGSPLPDLIITDGGKGQMEVVR
CCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCHHHHHH
EVIEDELHLDIPIAGLAKDRKHRTSELLYGFPPLTIGVKQSTPLFHLLENIQNEVHRFAI
HHHHCCCEECCCCHHHHHHHHHHHHHHHCCCCCCEEECCCCCHHHHHHHHHHHHHHHHHH
TFHRDKRSKSQVASALDNIKGIGEKRKTALLKTFKSVSRIRQASLEEIAAVVGEAAAKNI
EEECCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KENLTE
HHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12663928 [H]