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The map label for this gene is apt

Identifier: 150003781

GI number: 150003781

Start: 1633265

End: 1633789

Strand: Reverse

Name: apt

Synonym: BVU_1213

Alternate gene names: 150003781

Gene position: 1633789-1633265 (Counterclockwise)

Preceding gene: 150003782

Following gene: 150003780

Centisome position: 31.64

GC content: 46.86

Gene sequence:

>525_bases
ATGAGCAAAGAAACGCTTAAAGCAAACTTAAGAGAAATTCCAGATTTCCCCATTCCGGGAATTCTGTTTTACGATGTGAC
AACCCTGTTCAAAAACCCCGAATGCTTGCAGGAAATACTAGATACTCTATACGAGATGTACAAGGACAAAGGCATCACCA
AAGTAGTAGGTATTGAATCGCGTGGCTTCATTATGGGTGGTGCGCTGGCGGCACGGTTAGGTGCCGGATTCGTGATGGCA
CGCAAGCCGGGCAAACTTCCCGCAGAAGTAGTAGAGGAAACATACGCAAAAGAGTATGGAACCGACACCATTCAGATACA
TAAAGACGCCATCGATGAGAACGACGTGGTTCTGCTGCACGATGATTTATTGGCTACCGGCGGAACCATGGCGGCCACTC
ATCGCTTGGTACAAAGATGTGGCGCCAAAAAGATTTTCATCAATTTCATTATCGAACTGGGAGGTCTGAACGGCAGAAAG
GCATTCCCCGAAGATATCACGGTGGATACACTGCTTACTTTATAG

Upstream 100 bases:

>100_bases
CTAGCGACATCAATGTCTTACTAGTCCTGCTGGGACGGTGAAACAAGGTATGTTTCACGTGAAACAAGTAATTTAATAGA
CTAACAATAAAATACTGGTT

Downstream 100 bases:

>100_bases
TGTCACACAACATGTCCATCAAAACGGGCCCCATCATCGTTCACAATAAAAAGAGATCTATGGAATGAGATGGACGATGA
AACCGAAAGATATATATCTT

Product: adenine phosphoribosyltransferase

Products: NA

Alternate protein names: APRT

Number of amino acids: Translated: 174; Mature: 173

Protein sequence:

>174_residues
MSKETLKANLREIPDFPIPGILFYDVTTLFKNPECLQEILDTLYEMYKDKGITKVVGIESRGFIMGGALAARLGAGFVMA
RKPGKLPAEVVEETYAKEYGTDTIQIHKDAIDENDVVLLHDDLLATGGTMAATHRLVQRCGAKKIFINFIIELGGLNGRK
AFPEDITVDTLLTL

Sequences:

>Translated_174_residues
MSKETLKANLREIPDFPIPGILFYDVTTLFKNPECLQEILDTLYEMYKDKGITKVVGIESRGFIMGGALAARLGAGFVMA
RKPGKLPAEVVEETYAKEYGTDTIQIHKDAIDENDVVLLHDDLLATGGTMAATHRLVQRCGAKKIFINFIIELGGLNGRK
AFPEDITVDTLLTL
>Mature_173_residues
SKETLKANLREIPDFPIPGILFYDVTTLFKNPECLQEILDTLYEMYKDKGITKVVGIESRGFIMGGALAARLGAGFVMAR
KPGKLPAEVVEETYAKEYGTDTIQIHKDAIDENDVVLLHDDLLATGGTMAATHRLVQRCGAKKIFINFIIELGGLNGRKA
FPEDITVDTLLTL

Specific function: Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis

COG id: COG0503

COG function: function code F; Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family

Homologues:

Organism=Homo sapiens, GI4502171, Length=160, Percent_Identity=37.5, Blast_Score=114, Evalue=4e-26,
Organism=Homo sapiens, GI71773201, Length=127, Percent_Identity=37.7952755905512, Blast_Score=97, Evalue=8e-21,
Organism=Escherichia coli, GI1786675, Length=157, Percent_Identity=52.8662420382166, Blast_Score=159, Evalue=7e-41,
Organism=Caenorhabditis elegans, GI17509087, Length=173, Percent_Identity=40.4624277456647, Blast_Score=129, Evalue=7e-31,
Organism=Saccharomyces cerevisiae, GI6323619, Length=160, Percent_Identity=44.375, Blast_Score=120, Evalue=1e-28,
Organism=Saccharomyces cerevisiae, GI6320649, Length=159, Percent_Identity=35.2201257861635, Blast_Score=86, Evalue=3e-18,
Organism=Drosophila melanogaster, GI17136334, Length=157, Percent_Identity=37.5796178343949, Blast_Score=101, Evalue=2e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): APT_BACV8 (A6KZN9)

Other databases:

- EMBL:   CP000139
- RefSeq:   YP_001298525.1
- ProteinModelPortal:   A6KZN9
- SMR:   A6KZN9
- STRING:   A6KZN9
- GeneID:   5302179
- GenomeReviews:   CP000139_GR
- KEGG:   bvu:BVU_1213
- NMPDR:   fig|435590.6.peg.1145
- eggNOG:   COG0503
- HOGENOM:   HBG703830
- OMA:   GILFYDI
- ProtClustDB:   PRK02304
- GO:   GO:0005737
- HAMAP:   MF_00004
- InterPro:   IPR005764
- InterPro:   IPR000836
- TIGRFAMs:   TIGR01090

Pfam domain/function: PF00156 Pribosyltran

EC number: =2.4.2.7

Molecular weight: Translated: 19189; Mature: 19057

Theoretical pI: Translated: 5.06; Mature: 5.06

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKETLKANLREIPDFPIPGILFYDVTTLFKNPECLQEILDTLYEMYKDKGITKVVGIES
CCCHHHHHHHHHCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCEEEEECCC
RGFIMGGALAARLGAGFVMARKPGKLPAEVVEETYAKEYGTDTIQIHKDAIDENDVVLLH
CCEEEHHHHHHHHCCCEEEECCCCCCCHHHHHHHHHHHHCCCEEEEECCCCCCCCEEEEE
DDLLATGGTMAATHRLVQRCGAKKIFINFIIELGGLNGRKAFPEDITVDTLLTL
CCHHHCCCHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHCC
>Mature Secondary Structure 
SKETLKANLREIPDFPIPGILFYDVTTLFKNPECLQEILDTLYEMYKDKGITKVVGIES
CCHHHHHHHHHCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCEEEEECCC
RGFIMGGALAARLGAGFVMARKPGKLPAEVVEETYAKEYGTDTIQIHKDAIDENDVVLLH
CCEEEHHHHHHHHCCCEEEECCCCCCCHHHHHHHHHHHHCCCEEEEECCCCCCCCEEEEE
DDLLATGGTMAATHRLVQRCGAKKIFINFIIELGGLNGRKAFPEDITVDTLLTL
CCHHHCCCHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA