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The map label for this gene is prs [H]

Identifier: 148828406

GI number: 148828406

Start: 1860327

End: 1861274

Strand: Reverse

Name: prs [H]

Synonym: CGSHiGG_10075

Alternate gene names: 148828406

Gene position: 1861274-1860327 (Counterclockwise)

Preceding gene: 148828407

Following gene: 148828402

Centisome position: 98.63

GC content: 42.3

Gene sequence:

>948_bases
ATGCCTGACATTAAACTCTTCGCAGGTAATGCTACACCTGAACTTGCAAAACGTATTTCTGAACGTTTATATATTTCACT
AGGCGATGCAACAGTCGCTCGTTTCAGCGATGGAGAAATTCAAGTTCAAATTAATGAAAATGTGCGTGGTGCGGATGTAT
TTATCATCCAATCAACTTGTGCGCCAACCAATGATAACTTGATGGAATTGGTTGTGATGGTAGATGCGTTACGTCGTGCA
TCTGCTGGTCGTATTACTGCCGTGATTCCTTATTTCGGCTATGCTCGCCAAGATCGTCGTGTTCGTTCTGCTCGTGTGCC
TATTACCGCTAAAGTTGTGGCAGATTTACTTTCAATTGTTGGTATTGACCGTGTCTTAACCTGTGACCTACACGCAGAAC
AAATCCAAGGTTTCTTTGATGTTCCCGTAGACAACGTATTTGGTTCGCCAGTTTTAATTCACGATATTTTGAAAAAATCT
GATCTTAAAAATCCAATTGTTGTTTCCCCAGATATTGGCGGCGTTGTGCGTGCTCGCGCTGTCGCTAAATTATTAAACGA
TACGGATATGGCTATTATTGACAAACGTCGTCCACGCGCAAACGTAGCACAAGTAATGCATATTATCGGTGATGTTGCAG
ATCGTGATTGTATTTTGGTTGATGATATGATTGATACTGGCGGTACGCTTTGTAAAGCGGCAGAAGCATTAAAAGAACGT
GGTGCAAAACGTGTTTTTGCTTATGCAACTCACGCCGTTTTCTCTGGTGCAGCAGCCAAAAATTTAGCCAGCGATGCCAT
TGATGAAGTTGTAGTTACTGACACGATTCCTCTATCAGAAGAAATGAAAGCGATCGGTAAAGTTCGCGTGCTTACACTTT
CTTCCATGCTGGCAGAAGCCATTCGCCGCATTAGCAACGAAGAATCTATTTCTGCGATGTTTAACTAA

Upstream 100 bases:

>100_bases
TTCATCGCTAAAGGACTCAATGTGTCTCCCTTGCACGCAATGTTGAAGCAGCTATCATCAACTCATACTCATAGACAATC
TAAACCTGAGGTTTTATAAA

Downstream 100 bases:

>100_bases
ATTAAAATTTCAATAAAAAATACCGCACTTTTATTGCCAAAGTGCGGTATTTTTTTATTTACTTTATTTAACTGTATCTA
CTTTATTCAATCGTTACACG

Product: ribose-phosphate pyrophosphokinase

Products: NA

Alternate protein names: RPPK; Phosphoribosyl pyrophosphate synthase; P-Rib-PP synthase; PRPP synthase [H]

Number of amino acids: Translated: 315; Mature: 314

Protein sequence:

>315_residues
MPDIKLFAGNATPELAKRISERLYISLGDATVARFSDGEIQVQINENVRGADVFIIQSTCAPTNDNLMELVVMVDALRRA
SAGRITAVIPYFGYARQDRRVRSARVPITAKVVADLLSIVGIDRVLTCDLHAEQIQGFFDVPVDNVFGSPVLIHDILKKS
DLKNPIVVSPDIGGVVRARAVAKLLNDTDMAIIDKRRPRANVAQVMHIIGDVADRDCILVDDMIDTGGTLCKAAEALKER
GAKRVFAYATHAVFSGAAAKNLASDAIDEVVVTDTIPLSEEMKAIGKVRVLTLSSMLAEAIRRISNEESISAMFN

Sequences:

>Translated_315_residues
MPDIKLFAGNATPELAKRISERLYISLGDATVARFSDGEIQVQINENVRGADVFIIQSTCAPTNDNLMELVVMVDALRRA
SAGRITAVIPYFGYARQDRRVRSARVPITAKVVADLLSIVGIDRVLTCDLHAEQIQGFFDVPVDNVFGSPVLIHDILKKS
DLKNPIVVSPDIGGVVRARAVAKLLNDTDMAIIDKRRPRANVAQVMHIIGDVADRDCILVDDMIDTGGTLCKAAEALKER
GAKRVFAYATHAVFSGAAAKNLASDAIDEVVVTDTIPLSEEMKAIGKVRVLTLSSMLAEAIRRISNEESISAMFN
>Mature_314_residues
PDIKLFAGNATPELAKRISERLYISLGDATVARFSDGEIQVQINENVRGADVFIIQSTCAPTNDNLMELVVMVDALRRAS
AGRITAVIPYFGYARQDRRVRSARVPITAKVVADLLSIVGIDRVLTCDLHAEQIQGFFDVPVDNVFGSPVLIHDILKKSD
LKNPIVVSPDIGGVVRARAVAKLLNDTDMAIIDKRRPRANVAQVMHIIGDVADRDCILVDDMIDTGGTLCKAAEALKERG
AKRVFAYATHAVFSGAAAKNLASDAIDEVVVTDTIPLSEEMKAIGKVRVLTLSSMLAEAIRRISNEESISAMFN

Specific function: Utilized by both the de novo and the salvage pathways by which endogenously formed or exogenously added pyrimidine, purine, or pyridine bases are converted to the corresponding ribonucleoside monophosphates. [C]

COG id: COG0462

COG function: function code FE; Phosphoribosylpyrophosphate synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ribose-phosphate pyrophosphokinase family [H]

Homologues:

Organism=Homo sapiens, GI4506127, Length=316, Percent_Identity=49.0506329113924, Blast_Score=311, Evalue=5e-85,
Organism=Homo sapiens, GI4506129, Length=316, Percent_Identity=49.0506329113924, Blast_Score=311, Evalue=5e-85,
Organism=Homo sapiens, GI84875539, Length=318, Percent_Identity=48.7421383647799, Blast_Score=310, Evalue=8e-85,
Organism=Homo sapiens, GI28557709, Length=316, Percent_Identity=49.3670886075949, Blast_Score=309, Evalue=3e-84,
Organism=Homo sapiens, GI4506133, Length=343, Percent_Identity=36.734693877551, Blast_Score=199, Evalue=2e-51,
Organism=Homo sapiens, GI194018537, Length=343, Percent_Identity=36.4431486880466, Blast_Score=193, Evalue=2e-49,
Organism=Homo sapiens, GI310128524, Length=145, Percent_Identity=29.6551724137931, Blast_Score=79, Evalue=6e-15,
Organism=Homo sapiens, GI310115209, Length=145, Percent_Identity=29.6551724137931, Blast_Score=79, Evalue=6e-15,
Organism=Homo sapiens, GI310118259, Length=145, Percent_Identity=29.6551724137931, Blast_Score=79, Evalue=6e-15,
Organism=Homo sapiens, GI310119946, Length=145, Percent_Identity=29.6551724137931, Blast_Score=79, Evalue=6e-15,
Organism=Escherichia coli, GI1787458, Length=314, Percent_Identity=85.6687898089172, Blast_Score=547, Evalue=1e-157,
Organism=Caenorhabditis elegans, GI25149168, Length=316, Percent_Identity=47.4683544303797, Blast_Score=304, Evalue=4e-83,
Organism=Caenorhabditis elegans, GI17554702, Length=316, Percent_Identity=47.4683544303797, Blast_Score=304, Evalue=5e-83,
Organism=Caenorhabditis elegans, GI71989924, Length=316, Percent_Identity=47.4683544303797, Blast_Score=303, Evalue=7e-83,
Organism=Caenorhabditis elegans, GI17554704, Length=311, Percent_Identity=46.9453376205788, Blast_Score=295, Evalue=3e-80,
Organism=Caenorhabditis elegans, GI17570245, Length=336, Percent_Identity=36.3095238095238, Blast_Score=204, Evalue=5e-53,
Organism=Saccharomyces cerevisiae, GI6320946, Length=313, Percent_Identity=46.6453674121406, Blast_Score=277, Evalue=1e-75,
Organism=Saccharomyces cerevisiae, GI6321776, Length=317, Percent_Identity=47.9495268138801, Blast_Score=275, Evalue=5e-75,
Organism=Saccharomyces cerevisiae, GI6319403, Length=314, Percent_Identity=46.4968152866242, Blast_Score=271, Evalue=1e-73,
Organism=Saccharomyces cerevisiae, GI6322667, Length=206, Percent_Identity=42.2330097087379, Blast_Score=155, Evalue=8e-39,
Organism=Saccharomyces cerevisiae, GI6324511, Length=113, Percent_Identity=41.5929203539823, Blast_Score=101, Evalue=1e-22,
Organism=Drosophila melanogaster, GI21355239, Length=316, Percent_Identity=48.4177215189873, Blast_Score=299, Evalue=2e-81,
Organism=Drosophila melanogaster, GI45551540, Length=338, Percent_Identity=45.2662721893491, Blast_Score=290, Evalue=8e-79,
Organism=Drosophila melanogaster, GI24651458, Length=355, Percent_Identity=34.9295774647887, Blast_Score=203, Evalue=1e-52,
Organism=Drosophila melanogaster, GI24651456, Length=355, Percent_Identity=34.9295774647887, Blast_Score=203, Evalue=1e-52,
Organism=Drosophila melanogaster, GI281362873, Length=355, Percent_Identity=34.9295774647887, Blast_Score=203, Evalue=1e-52,
Organism=Drosophila melanogaster, GI24651454, Length=355, Percent_Identity=34.9295774647887, Blast_Score=203, Evalue=1e-52,
Organism=Drosophila melanogaster, GI45552010, Length=374, Percent_Identity=33.1550802139037, Blast_Score=197, Evalue=5e-51,
Organism=Drosophila melanogaster, GI24651462, Length=374, Percent_Identity=33.1550802139037, Blast_Score=197, Evalue=5e-51,
Organism=Drosophila melanogaster, GI24651464, Length=374, Percent_Identity=33.1550802139037, Blast_Score=197, Evalue=5e-51,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000842
- InterPro:   IPR005946
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.7.6.1 [H]

Molecular weight: Translated: 34170; Mature: 34039

Theoretical pI: Translated: 6.16; Mature: 6.16

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER ; PS00114 PRPP_SYNTHETASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPDIKLFAGNATPELAKRISERLYISLGDATVARFSDGEIQVQINENVRGADVFIIQSTC
CCCCEEEECCCCHHHHHHHHHHEEEEECCCEEEEECCCEEEEEECCCCCCCEEEEEECCC
APTNDNLMELVVMVDALRRASAGRITAVIPYFGYARQDRRVRSARVPITAKVVADLLSIV
CCCCCHHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHCCCCHHHHHHHHHHHH
GIDRVLTCDLHAEQIQGFFDVPVDNVFGSPVLIHDILKKSDLKNPIVVSPDIGGVVRARA
CCCCEEEECCCHHHCCCEECCCHHHHCCCHHHHHHHHHHHCCCCCEEECCCCCHHHHHHH
VAKLLNDTDMAIIDKRRPRANVAQVMHIIGDVADRDCILVDDMIDTGGTLCKAAEALKER
HHHHHCCCCEEEEECCCCCHHHHHHHHHHHCCCCCCEEEEECHHCCCCHHHHHHHHHHHC
GAKRVFAYATHAVFSGAAAKNLASDAIDEVVVTDTIPLSEEMKAIGKVRVLTLSSMLAEA
CCHHHHHHHHHHHHCCHHHHHHHHHHHHHEEEECCCCCHHHHHHHHHHHHHHHHHHHHHH
IRRISNEESISAMFN
HHHHCCCHHHHHHCC
>Mature Secondary Structure 
PDIKLFAGNATPELAKRISERLYISLGDATVARFSDGEIQVQINENVRGADVFIIQSTC
CCCEEEECCCCHHHHHHHHHHEEEEECCCEEEEECCCEEEEEECCCCCCCEEEEEECCC
APTNDNLMELVVMVDALRRASAGRITAVIPYFGYARQDRRVRSARVPITAKVVADLLSIV
CCCCCHHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHCCCCHHHHHHHHHHHH
GIDRVLTCDLHAEQIQGFFDVPVDNVFGSPVLIHDILKKSDLKNPIVVSPDIGGVVRARA
CCCCEEEECCCHHHCCCEECCCHHHHCCCHHHHHHHHHHHCCCCCEEECCCCCHHHHHHH
VAKLLNDTDMAIIDKRRPRANVAQVMHIIGDVADRDCILVDDMIDTGGTLCKAAEALKER
HHHHHCCCCEEEEECCCCCHHHHHHHHHHHCCCCCCEEEEECHHCCCCHHHHHHHHHHHC
GAKRVFAYATHAVFSGAAAKNLASDAIDEVVVTDTIPLSEEMKAIGKVRVLTLSSMLAEA
CCHHHHHHHHHHHHCCHHHHHHHHHHHHHEEEECCCCCHHHHHHHHHHHHHHHHHHHHHH
IRRISNEESISAMFN
HHHHCCCHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA