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The map label for this gene is ccmA

Identifier: 148828251

GI number: 148828251

Start: 1683001

End: 1683639

Strand: Direct

Name: ccmA

Synonym: CGSHiGG_09085

Alternate gene names: 148828251

Gene position: 1683001-1683639 (Clockwise)

Preceding gene: 148828238

Following gene: 148828252

Centisome position: 89.18

GC content: 41.94

Gene sequence:

>639_bases
ATGTTTGAGCAACACAAGTTATCTCTGCAAAATTTATCCTGCCAACGTGGTGAGCGCGTACTTTTTCGTGCTTTGACTTG
CGATTTTAATAGCGGTGATTTTGTACAAATTGAAGGGCATAACGGCATAGGTAAAACGAGCTTGTTACGTATTCTTGCTG
GTTTAGCCCAACCTTTAGAAGGCGAAGTGCGGTGGGATGCTGAAGCAATTTCTAAACAACGTGAACAGTATCATCAGAAT
TTGCTTTATTTAGGACATCTTTTAGGCGTTAAACCAGAGCTAACGGCGTGGGAAAATTTGCAGTTTTATCAACGAATTAG
TCAAGCTGAACAAAACACCGATATGTTGTGGGATTTGCTTGAGAAAGTGGGATTGCTAGGTCGTGAAGATTTGCCTGCCG
CACAACTTTCTGCAGGACAACAAAAACGTATCGCATTAGGTCGCTTATGGCTGTCTCAAGCGCCCTTATGGATTTTAGAT
GAGCCCTTTACTGCGATTGATAAAAAAGGCGTGGAAATTCTAACCGCACTTTTTGATGAGCATGCTCAACGTGGAGGTAT
TGTGTTATTGACCAGCCACCAAGAAGTGCCAAGTTCTCATCTGCAAAAATTGAATTTAGCGGCTTATAAAGCGGAATAA

Upstream 100 bases:

>100_bases
AATAAACCTATCGATCTACTTCTAAAGAGTTATGCGTTTGAGTTGCGAAAATTTCATCAAATATTAGAATACCACCACTT
TCTATTTTCCCTCTGTAATT

Downstream 100 bases:

>100_bases
CTTAATGATTTTTTTAGAGATAATTAAACGAGAACTTCAAATTGCAATGCGCAAAAATGCGGAGATTTTAAATCCGCTAT
GGTTCTTTTTGCTTGTGATT

Product: cytochrome c biogenesis protein CcmA

Products: NA

Alternate protein names: Heme exporter protein A

Number of amino acids: Translated: 212; Mature: 212

Protein sequence:

>212_residues
MFEQHKLSLQNLSCQRGERVLFRALTCDFNSGDFVQIEGHNGIGKTSLLRILAGLAQPLEGEVRWDAEAISKQREQYHQN
LLYLGHLLGVKPELTAWENLQFYQRISQAEQNTDMLWDLLEKVGLLGREDLPAAQLSAGQQKRIALGRLWLSQAPLWILD
EPFTAIDKKGVEILTALFDEHAQRGGIVLLTSHQEVPSSHLQKLNLAAYKAE

Sequences:

>Translated_212_residues
MFEQHKLSLQNLSCQRGERVLFRALTCDFNSGDFVQIEGHNGIGKTSLLRILAGLAQPLEGEVRWDAEAISKQREQYHQN
LLYLGHLLGVKPELTAWENLQFYQRISQAEQNTDMLWDLLEKVGLLGREDLPAAQLSAGQQKRIALGRLWLSQAPLWILD
EPFTAIDKKGVEILTALFDEHAQRGGIVLLTSHQEVPSSHLQKLNLAAYKAE
>Mature_212_residues
MFEQHKLSLQNLSCQRGERVLFRALTCDFNSGDFVQIEGHNGIGKTSLLRILAGLAQPLEGEVRWDAEAISKQREQYHQN
LLYLGHLLGVKPELTAWENLQFYQRISQAEQNTDMLWDLLEKVGLLGREDLPAAQLSAGQQKRIALGRLWLSQAPLWILD
EPFTAIDKKGVEILTALFDEHAQRGGIVLLTSHQEVPSSHLQKLNLAAYKAE

Specific function: Part of the ABC transporter complex CcmAB involved in the biogenesis of c-type cytochromes; once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system

COG id: COG4133

COG function: function code O; ABC-type transport system involved in cytochrome c biogenesis, ATPase component

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transporter domain

Homologues:

Organism=Homo sapiens, GI46592971, Length=194, Percent_Identity=27.319587628866, Blast_Score=76, Evalue=3e-14,
Organism=Homo sapiens, GI46592956, Length=194, Percent_Identity=27.319587628866, Blast_Score=76, Evalue=3e-14,
Organism=Homo sapiens, GI46592915, Length=194, Percent_Identity=27.319587628866, Blast_Score=76, Evalue=3e-14,
Organism=Homo sapiens, GI46592898, Length=194, Percent_Identity=27.319587628866, Blast_Score=76, Evalue=3e-14,
Organism=Homo sapiens, GI46592978, Length=194, Percent_Identity=27.319587628866, Blast_Score=76, Evalue=3e-14,
Organism=Homo sapiens, GI46592964, Length=194, Percent_Identity=27.319587628866, Blast_Score=75, Evalue=3e-14,
Organism=Homo sapiens, GI47078218, Length=200, Percent_Identity=29.5, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI45446740, Length=200, Percent_Identity=29.5, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI215820660, Length=191, Percent_Identity=24.6073298429319, Blast_Score=68, Evalue=5e-12,
Organism=Homo sapiens, GI20143975, Length=191, Percent_Identity=24.6073298429319, Blast_Score=68, Evalue=5e-12,
Organism=Homo sapiens, GI21536376, Length=202, Percent_Identity=28.7128712871287, Blast_Score=65, Evalue=5e-11,
Organism=Homo sapiens, GI27436953, Length=194, Percent_Identity=29.3814432989691, Blast_Score=64, Evalue=1e-10,
Organism=Escherichia coli, GI87082064, Length=207, Percent_Identity=49.7584541062802, Blast_Score=185, Evalue=2e-48,
Organism=Escherichia coli, GI1787105, Length=183, Percent_Identity=28.4153005464481, Blast_Score=75, Evalue=2e-15,
Organism=Escherichia coli, GI1790467, Length=196, Percent_Identity=27.0408163265306, Blast_Score=75, Evalue=3e-15,
Organism=Escherichia coli, GI87081709, Length=170, Percent_Identity=27.0588235294118, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1787370, Length=159, Percent_Identity=32.0754716981132, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI1788761, Length=169, Percent_Identity=28.4023668639053, Blast_Score=71, Evalue=5e-14,
Organism=Escherichia coli, GI87081834, Length=171, Percent_Identity=29.2397660818713, Blast_Score=70, Evalue=8e-14,
Organism=Escherichia coli, GI1789586, Length=203, Percent_Identity=28.5714285714286, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI1786703, Length=173, Percent_Identity=31.7919075144509, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI1786698, Length=207, Percent_Identity=27.0531400966184, Blast_Score=69, Evalue=2e-13,
Organism=Escherichia coli, GI1788165, Length=174, Percent_Identity=28.1609195402299, Blast_Score=69, Evalue=2e-13,
Organism=Escherichia coli, GI1788225, Length=200, Percent_Identity=27.5, Blast_Score=69, Evalue=3e-13,
Organism=Escherichia coli, GI87082267, Length=158, Percent_Identity=27.8481012658228, Blast_Score=69, Evalue=3e-13,
Organism=Escherichia coli, GI1787029, Length=194, Percent_Identity=25.2577319587629, Blast_Score=68, Evalue=6e-13,
Organism=Escherichia coli, GI1789873, Length=185, Percent_Identity=26.4864864864865, Blast_Score=67, Evalue=9e-13,
Organism=Escherichia coli, GI1787041, Length=206, Percent_Identity=26.6990291262136, Blast_Score=65, Evalue=4e-12,
Organism=Escherichia coli, GI1789991, Length=200, Percent_Identity=26.5, Blast_Score=64, Evalue=6e-12,
Organism=Escherichia coli, GI87081791, Length=172, Percent_Identity=29.6511627906977, Blast_Score=64, Evalue=6e-12,
Organism=Escherichia coli, GI87081782, Length=167, Percent_Identity=28.7425149700599, Blast_Score=63, Evalue=1e-11,
Organism=Escherichia coli, GI1787164, Length=191, Percent_Identity=29.3193717277487, Blast_Score=63, Evalue=2e-11,
Organism=Escherichia coli, GI1786563, Length=193, Percent_Identity=27.979274611399, Blast_Score=62, Evalue=4e-11,
Organism=Escherichia coli, GI1786872, Length=163, Percent_Identity=26.9938650306748, Blast_Score=61, Evalue=7e-11,
Organism=Drosophila melanogaster, GI19920532, Length=186, Percent_Identity=28.494623655914, Blast_Score=87, Evalue=9e-18,
Organism=Drosophila melanogaster, GI24580930, Length=186, Percent_Identity=28.494623655914, Blast_Score=87, Evalue=9e-18,
Organism=Drosophila melanogaster, GI24666092, Length=198, Percent_Identity=26.7676767676768, Blast_Score=72, Evalue=4e-13,
Organism=Drosophila melanogaster, GI28574744, Length=192, Percent_Identity=28.6458333333333, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24662800, Length=187, Percent_Identity=24.5989304812834, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI17647959, Length=208, Percent_Identity=30.7692307692308, Blast_Score=67, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): CCMA_HAEI8 (Q4QLJ9)

Other databases:

- EMBL:   CP000057
- RefSeq:   YP_248758.1
- ProteinModelPortal:   Q4QLJ9
- SMR:   Q4QLJ9
- STRING:   Q4QLJ9
- GeneID:   3430524
- GenomeReviews:   CP000057_GR
- KEGG:   hit:NTHI1253
- eggNOG:   COG4133
- HOGENOM:   HBG758042
- OMA:   ARLWHND
- PhylomeDB:   Q4QLJ9
- ProtClustDB:   PRK13538
- BioCyc:   HINF281310:NTHI1253-MONOMER
- HAMAP:   MF_01707
- InterPro:   IPR003439
- InterPro:   IPR017871
- InterPro:   IPR005895
- InterPro:   IPR003593
- PANTHER:   PTHR19222:SF5
- SMART:   SM00382
- TIGRFAMs:   TIGR01189

Pfam domain/function: PF00005 ABC_tran

EC number: =3.6.3.41

Molecular weight: Translated: 23964; Mature: 23964

Theoretical pI: Translated: 6.16; Mature: 6.16

Prosite motif: PS00211 ABC_TRANSPORTER_1; PS50893 ABC_TRANSPORTER_2; PS51243 CCMA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFEQHKLSLQNLSCQRGERVLFRALTCDFNSGDFVQIEGHNGIGKTSLLRILAGLAQPLE
CCCCHHHHHHHCCHHHHHHHHHHHHEEECCCCCEEEEECCCCCCHHHHHHHHHHHCCCCC
GEVRWDAEAISKQREQYHQNLLYLGHLLGVKPELTAWENLQFYQRISQAEQNTDMLWDLL
CCCEECHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHH
EKVGLLGREDLPAAQLSAGQQKRIALGRLWLSQAPLWILDEPFTAIDKKGVEILTALFDE
HHHCCCCCCCCCHHHHCCCCHHHHHHHHHHHHCCCEEEECCCHHHHHHHHHHHHHHHHHH
HAQRGGIVLLTSHQEVPSSHLQKLNLAAYKAE
HHCCCCEEEEECCCCCCHHHHHHHHHHHCCCC
>Mature Secondary Structure
MFEQHKLSLQNLSCQRGERVLFRALTCDFNSGDFVQIEGHNGIGKTSLLRILAGLAQPLE
CCCCHHHHHHHCCHHHHHHHHHHHHEEECCCCCEEEEECCCCCCHHHHHHHHHHHCCCCC
GEVRWDAEAISKQREQYHQNLLYLGHLLGVKPELTAWENLQFYQRISQAEQNTDMLWDLL
CCCEECHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHH
EKVGLLGREDLPAAQLSAGQQKRIALGRLWLSQAPLWILDEPFTAIDKKGVEILTALFDE
HHHCCCCCCCCCHHHHCCCCHHHHHHHHHHHHCCCEEEECCCHHHHHHHHHHHHHHHHHH
HAQRGGIVLLTSHQEVPSSHLQKLNLAAYKAE
HHCCCCEEEEECCCCCCHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA