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The map label for this gene is panF

Identifier: 148828152

GI number: 148828152

Start: 1561638

End: 1563092

Strand: Direct

Name: panF

Synonym: CGSHiGG_08450

Alternate gene names: 148828152

Gene position: 1561638-1563092 (Clockwise)

Preceding gene: 148828151

Following gene: 148828153

Centisome position: 82.75

GC content: 38.42

Gene sequence:

>1455_bases
ATGAATCTAGGTATTATTCTTCCTTTAATTATTTATCTCACTTTTGTTTTTGGTGCGGCAATTTTTGCCTATGTAAAACG
TACAAAAGGCGATTTTTTAACAGAATATTATGTGGGAAATCGTTCGATGACTGGTTTTGTGCTCGCAATGACAACTGCAT
CAACTTATGCCAGTGCAAGTTCTTTTGTCGGAGGGCCAGGCGCAGCTTATAAATACGGATTAGGTTGGGTATTACTTGCG
ATGATTCAAGTGCCAGTCGTATGGCTTGCATTAGGTGCATTAGGTAAAAAATTCGCGCTATTATCAAGAGAAACCAATGC
TTTAACTATTAATGATCTTTTCTTTTATCGCTATAAAAACAAATATTTAGTTTGGCTATCAAGCCTTGCTCTTCTTCTCG
CATTTTTTGCGGCTATGACCGTGCAATTTATTGGTGGTGCGCGTTTATTAGAAACAACCATCGGCATTTCTTATACTCAA
GCATTACTCTTATTTGCTTTAACGGTAGGTATCTATACTTTTATCGGGGGCTTCCGTGCCGTCGTACTGACGGATACCAT
TCAAGGTACCGTAATGATTTTTGGGACTATAATCCTCCTTATTGGCACGATTTATGCCCTCGGTGGTGTAGAAAGTGCGG
TTAATAAATTAACTGAAATTGATCCTGACTTAGTCACGCCTTACGGGCCAAATGGAATGTTAGATTTCCAATTTATGGCT
TCTTTCTGGATACTTGTCTGTTTCGGGGTGGTTGGTCTTCCACATACCGCAGTTCGATGTATGGCATTTAAAGACAGTAA
AGCCTTACATCGCGGTATGCTGATTGGAACCATTGTACTTTCAATTATTATGTTGGGTATGCACTTAGCTGGTGCGCTTG
GCAGAGCGGTTATTCCAAATTTAACGGTATCAGATCAAGTAATTCCAACATTAATGATAAAAGTATTGCCGCCTATTGTT
GCGGGGATTTTCTTAGCTGCACCAATGTCTGCGATTATGTCCACAATTGATGCACAACTTATTCAATCTTCTTCTATTTT
TGTCAAAGATTTATACCTTTCTGCGAAACCAGAAGCCGCAAAAAATGAGAAAAAAGTAAGTTATTTTTCATCAATTATTA
CGCTGATTTTGACCGCACTTTTAATCTTTGCCGCACTCAATCCACCAGATATGATTATTTGGTTAAACCTATTTGCCTTT
GGCGGACTGGAAGCCGCATTTTTATGGGTGATTGTGCTGGGTATTTACTGGGATAAAGCAAATGCTTATGGTGCGTTAAG
CTCAATGATTATCGGCTTGGGGAGTTATATCTTGCTCACTCAACTTGGTATAAAATTATTTAACTTCCATCAAATCGTGC
CGTCATTAGTATTTGGATTAATTGCCTTTTTAGTGGGTAATAAATTGGGCGAACGTCGTATTGAAAAAACTCAATTAAAA
GTTACCGCACTTTAA

Upstream 100 bases:

>100_bases
GTATTTATTTGCCTATTCTGTTTATTGTAATTGGTTATTGGATTATCAAAATTATTTTTCAGGATATTTCTCTTGAAATT
AACGATCAGGAGAGTCAGAA

Downstream 100 bases:

>100_bases
GTATTAATCAATATGCTGTCACCTTCTTCTAAATGAGAGGAAGGTGATATTTAATTTTCTCACTTTCAGCAATTTCTACG
CTAAAACATAGAATTGGAAC

Product: sodium/panthothenate symporter

Products: Na (I) [Cytoplasm]; pantothenate [Cytoplasm] [C]

Alternate protein names: Pantothenate permease

Number of amino acids: Translated: 484; Mature: 484

Protein sequence:

>484_residues
MNLGIILPLIIYLTFVFGAAIFAYVKRTKGDFLTEYYVGNRSMTGFVLAMTTASTYASASSFVGGPGAAYKYGLGWVLLA
MIQVPVVWLALGALGKKFALLSRETNALTINDLFFYRYKNKYLVWLSSLALLLAFFAAMTVQFIGGARLLETTIGISYTQ
ALLLFALTVGIYTFIGGFRAVVLTDTIQGTVMIFGTIILLIGTIYALGGVESAVNKLTEIDPDLVTPYGPNGMLDFQFMA
SFWILVCFGVVGLPHTAVRCMAFKDSKALHRGMLIGTIVLSIIMLGMHLAGALGRAVIPNLTVSDQVIPTLMIKVLPPIV
AGIFLAAPMSAIMSTIDAQLIQSSSIFVKDLYLSAKPEAAKNEKKVSYFSSIITLILTALLIFAALNPPDMIIWLNLFAF
GGLEAAFLWVIVLGIYWDKANAYGALSSMIIGLGSYILLTQLGIKLFNFHQIVPSLVFGLIAFLVGNKLGERRIEKTQLK
VTAL

Sequences:

>Translated_484_residues
MNLGIILPLIIYLTFVFGAAIFAYVKRTKGDFLTEYYVGNRSMTGFVLAMTTASTYASASSFVGGPGAAYKYGLGWVLLA
MIQVPVVWLALGALGKKFALLSRETNALTINDLFFYRYKNKYLVWLSSLALLLAFFAAMTVQFIGGARLLETTIGISYTQ
ALLLFALTVGIYTFIGGFRAVVLTDTIQGTVMIFGTIILLIGTIYALGGVESAVNKLTEIDPDLVTPYGPNGMLDFQFMA
SFWILVCFGVVGLPHTAVRCMAFKDSKALHRGMLIGTIVLSIIMLGMHLAGALGRAVIPNLTVSDQVIPTLMIKVLPPIV
AGIFLAAPMSAIMSTIDAQLIQSSSIFVKDLYLSAKPEAAKNEKKVSYFSSIITLILTALLIFAALNPPDMIIWLNLFAF
GGLEAAFLWVIVLGIYWDKANAYGALSSMIIGLGSYILLTQLGIKLFNFHQIVPSLVFGLIAFLVGNKLGERRIEKTQLK
VTAL
>Mature_484_residues
MNLGIILPLIIYLTFVFGAAIFAYVKRTKGDFLTEYYVGNRSMTGFVLAMTTASTYASASSFVGGPGAAYKYGLGWVLLA
MIQVPVVWLALGALGKKFALLSRETNALTINDLFFYRYKNKYLVWLSSLALLLAFFAAMTVQFIGGARLLETTIGISYTQ
ALLLFALTVGIYTFIGGFRAVVLTDTIQGTVMIFGTIILLIGTIYALGGVESAVNKLTEIDPDLVTPYGPNGMLDFQFMA
SFWILVCFGVVGLPHTAVRCMAFKDSKALHRGMLIGTIVLSIIMLGMHLAGALGRAVIPNLTVSDQVIPTLMIKVLPPIV
AGIFLAAPMSAIMSTIDAQLIQSSSIFVKDLYLSAKPEAAKNEKKVSYFSSIITLILTALLIFAALNPPDMIIWLNLFAF
GGLEAAFLWVIVLGIYWDKANAYGALSSMIIGLGSYILLTQLGIKLFNFHQIVPSLVFGLIAFLVGNKLGERRIEKTQLK
VTAL

Specific function: Catalyzes the sodium-dependent uptake of extracellular pantothenate

COG id: COG4145

COG function: function code H; Na+/panthothenate symporter

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family

Homologues:

Organism=Homo sapiens, GI310128183, Length=452, Percent_Identity=29.4247787610619, Blast_Score=129, Evalue=4e-30,
Organism=Homo sapiens, GI14140236, Length=480, Percent_Identity=21.4583333333333, Blast_Score=78, Evalue=2e-14,
Organism=Homo sapiens, GI4507033, Length=412, Percent_Identity=23.7864077669903, Blast_Score=73, Evalue=6e-13,
Organism=Homo sapiens, GI110835708, Length=471, Percent_Identity=23.5668789808917, Blast_Score=69, Evalue=1e-11,
Organism=Escherichia coli, GI87082237, Length=479, Percent_Identity=63.2567849686848, Blast_Score=606, Evalue=1e-174,
Organism=Escherichia coli, GI1787251, Length=478, Percent_Identity=28.6610878661088, Blast_Score=152, Evalue=5e-38,
Organism=Escherichia coli, GI1790113, Length=455, Percent_Identity=23.2967032967033, Blast_Score=77, Evalue=3e-15,
Organism=Escherichia coli, GI1790503, Length=459, Percent_Identity=23.0936819172113, Blast_Score=70, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PANF_HAEIN (P44963)

Other databases:

- EMBL:   L42023
- PIR:   H64105
- RefSeq:   NP_439137.1
- GeneID:   950256
- GenomeReviews:   L42023_GR
- KEGG:   hin:HI0975
- TIGR:   HI_0975
- HOGENOM:   HBG352968
- OMA:   AIIPDLT
- ProtClustDB:   PRK09442
- BioCyc:   HINF71421:HI_0975-MONOMER
- InterPro:   IPR011849
- InterPro:   IPR001734
- InterPro:   IPR018212
- InterPro:   IPR019900
- PANTHER:   PTHR11819
- TIGRFAMs:   TIGR02119
- TIGRFAMs:   TIGR00813

Pfam domain/function: PF00474 SSF

EC number: NA

Molecular weight: Translated: 52502; Mature: 52502

Theoretical pI: Translated: 9.72; Mature: 9.72

Prosite motif: PS00456 NA_SOLUT_SYMP_1; PS00457 NA_SOLUT_SYMP_2; PS50283 NA_SOLUT_SYMP_3

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x12edfc6c)-; HASH(0x1296a5fc)-; HASH(0x1213744c)-; HASH(0x12939b94)-; HASH(0x132bf474)-; HASH(0x1368f068)-; HASH(0x123b9a90)-; HASH(0x13776960)-; HASH(0x133dd790)-; HASH(0x126ef6c8)-; HASH(0x13581538)-; HASH(0x13317c60)-;

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLGIILPLIIYLTFVFGAAIFAYVKRTKGDFLTEYYVGNRSMTGFVLAMTTASTYASAS
CCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHEECCCCCCEEEEEEEHHHHHHHHH
SFVGGPGAAYKYGLGWVLLAMIQVPVVWLALGALGKKFALLSRETNALTINDLFFYRYKN
HCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEHEEEEEECC
KYLVWLSSLALLLAFFAAMTVQFIGGARLLETTIGISYTQALLLFALTVGIYTFIGGFRA
CHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHE
VVLTDTIQGTVMIFGTIILLIGTIYALGGVESAVNKLTEIDPDLVTPYGPNGMLDFQFMA
EEEECCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHH
SFWILVCFGVVGLPHTAVRCMAFKDSKALHRGMLIGTIVLSIIMLGMHLAGALGRAVIPN
HHHHHHHHHHHCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
LTVSDQVIPTLMIKVLPPIVAGIFLAAPMSAIMSTIDAQLIQSSSIFVKDLYLSAKPEAA
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEHHEECCCCCCC
KNEKKVSYFSSIITLILTALLIFAALNPPDMIIWLNLFAFGGLEAAFLWVIVLGIYWDKA
CCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHCCC
NAYGALSSMIIGLGSYILLTQLGIKLFNFHQIVPSLVFGLIAFLVGNKLGERRIEKTQLK
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHEE
VTAL
EECH
>Mature Secondary Structure
MNLGIILPLIIYLTFVFGAAIFAYVKRTKGDFLTEYYVGNRSMTGFVLAMTTASTYASAS
CCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHEECCCCCCEEEEEEEHHHHHHHHH
SFVGGPGAAYKYGLGWVLLAMIQVPVVWLALGALGKKFALLSRETNALTINDLFFYRYKN
HCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEHEEEEEECC
KYLVWLSSLALLLAFFAAMTVQFIGGARLLETTIGISYTQALLLFALTVGIYTFIGGFRA
CHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHE
VVLTDTIQGTVMIFGTIILLIGTIYALGGVESAVNKLTEIDPDLVTPYGPNGMLDFQFMA
EEEECCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHH
SFWILVCFGVVGLPHTAVRCMAFKDSKALHRGMLIGTIVLSIIMLGMHLAGALGRAVIPN
HHHHHHHHHHHCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
LTVSDQVIPTLMIKVLPPIVAGIFLAAPMSAIMSTIDAQLIQSSSIFVKDLYLSAKPEAA
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEHHEECCCCCCC
KNEKKVSYFSSIITLILTALLIFAALNPPDMIIWLNLFAFGGLEAAFLWVIVLGIYWDKA
CCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHCCC
NAYGALSSMIIGLGSYILLTQLGIKLFNFHQIVPSLVFGLIAFLVGNKLGERRIEKTQLK
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHEE
VTAL
EECH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Na (I) [Periplasm]; pantothenate [Periplasm] [C]

Specific reaction: Na (I) [Periplasm] + pantothenate [Periplasm] = Na (I) [Cytoplasm] + pantothenate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800