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The map label for this gene is pgl [H]

Identifier: 148827749

GI number: 148827749

Start: 1101586

End: 1102284

Strand: Reverse

Name: pgl [H]

Synonym: CGSHiGG_06060

Alternate gene names: 148827749

Gene position: 1102284-1101586 (Counterclockwise)

Preceding gene: 148827750

Following gene: 148827748

Centisome position: 58.41

GC content: 38.77

Gene sequence:

>699_bases
ATGAACTATATCAGCTTCCCAACTGCTCAACATGCAGTCGATAAAATTGCACAAGAATTTGTGATTTATAGTCAATTAAA
TCATCCCGTACATATTTCCCTTTCTGGTGGTTCAACGCCTAAGTTATTATTTAAAACCCTAGCTAAATCACCTTATGCTG
AACAAATTAACTGGAAAAATCTGCATTTTTGGTGGGGAGATGATCGTATGGTTCCGCCATCTGATCCTGAAAGTAACTAT
GGCGAAGTGCAAAAACTTTTATTCGATCATATTCAAATTCCAACGGAAAATATCCATCGAATTCGTGGTGAAAATGAACC
GCACTTTGAACTAAAACACTTCGAAGAAGAATTAAGTGCGGTCATTCCAAACGGTGTTTTTGATTGGATTATTTTAGGCA
TGGGAACAGACGGTCATACCGCTTCTCTCTTCCCACATCAAACTAATTTTGATGATGAAAACCTAGCTGTCATTGCTAAG
CATCCTGAAAGTGGTCAAATTCGCATTTCTAAAACAGCCAAACTCATTGAACAAGCCAAACGCATTACCTATTTGGTCAC
TGGCGAAAGCAAAGCGGATATTTTAAAAGAAATTCAAACTACCCCAGCAGAAAACTTGCCTTATCCCGCTGCAAAAATTA
AAGCAAAAAATGGGGTGACGGAGTGGTACTTAGACAAAGCAGCGGCAAGGCTTCTCTAA

Upstream 100 bases:

>100_bases
TGATGAAGAAAAAAGTTTAACTAATCTAATGTAGGGTGGGCTTTAGCCCACCGATCTTACTAACATAATAAATTGTGGGC
TAAAGTCCAACGGAAAATCA

Downstream 100 bases:

>100_bases
TGGAAATTTTAGCTCATATTTTAACTTGCACTTGTCCCCCTTGAACATTTCTACATTCTCTATTTAGAAATGTTCACCAT
TGAAAGCAAAAGTGGTGTTC

Product: 6-phosphogluconate dehydrogenase

Products: NA

Alternate protein names: 6PGL [H]

Number of amino acids: Translated: 232; Mature: 232

Protein sequence:

>232_residues
MNYISFPTAQHAVDKIAQEFVIYSQLNHPVHISLSGGSTPKLLFKTLAKSPYAEQINWKNLHFWWGDDRMVPPSDPESNY
GEVQKLLFDHIQIPTENIHRIRGENEPHFELKHFEEELSAVIPNGVFDWIILGMGTDGHTASLFPHQTNFDDENLAVIAK
HPESGQIRISKTAKLIEQAKRITYLVTGESKADILKEIQTTPAENLPYPAAKIKAKNGVTEWYLDKAAARLL

Sequences:

>Translated_232_residues
MNYISFPTAQHAVDKIAQEFVIYSQLNHPVHISLSGGSTPKLLFKTLAKSPYAEQINWKNLHFWWGDDRMVPPSDPESNY
GEVQKLLFDHIQIPTENIHRIRGENEPHFELKHFEEELSAVIPNGVFDWIILGMGTDGHTASLFPHQTNFDDENLAVIAK
HPESGQIRISKTAKLIEQAKRITYLVTGESKADILKEIQTTPAENLPYPAAKIKAKNGVTEWYLDKAAARLL
>Mature_232_residues
MNYISFPTAQHAVDKIAQEFVIYSQLNHPVHISLSGGSTPKLLFKTLAKSPYAEQINWKNLHFWWGDDRMVPPSDPESNY
GEVQKLLFDHIQIPTENIHRIRGENEPHFELKHFEEELSAVIPNGVFDWIILGMGTDGHTASLFPHQTNFDDENLAVIAK
HPESGQIRISKTAKLIEQAKRITYLVTGESKADILKEIQTTPAENLPYPAAKIKAKNGVTEWYLDKAAARLL

Specific function: Hydrolysis of 6-phosphogluconolactone to 6- phosphogluconate [H]

COG id: COG0363

COG function: function code G; 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily [H]

Homologues:

Organism=Homo sapiens, GI52145310, Length=207, Percent_Identity=37.6811594202899, Blast_Score=137, Evalue=9e-33,
Organism=Homo sapiens, GI6912586, Length=211, Percent_Identity=33.175355450237, Blast_Score=98, Evalue=6e-21,
Organism=Caenorhabditis elegans, GI115533058, Length=216, Percent_Identity=30.0925925925926, Blast_Score=96, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI115533060, Length=216, Percent_Identity=30.0925925925926, Blast_Score=96, Evalue=1e-20,
Organism=Saccharomyces cerevisiae, GI6324362, Length=215, Percent_Identity=32.093023255814, Blast_Score=92, Evalue=5e-20,
Organism=Saccharomyces cerevisiae, GI6321687, Length=232, Percent_Identity=28.448275862069, Blast_Score=92, Evalue=7e-20,
Organism=Saccharomyces cerevisiae, GI6319918, Length=216, Percent_Identity=31.9444444444444, Blast_Score=90, Evalue=3e-19,
Organism=Saccharomyces cerevisiae, GI6321957, Length=209, Percent_Identity=28.2296650717703, Blast_Score=84, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24641119, Length=203, Percent_Identity=29.5566502463054, Blast_Score=77, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005900
- InterPro:   IPR006148 [H]

Pfam domain/function: PF01182 Glucosamine_iso [H]

EC number: =3.1.1.31 [H]

Molecular weight: Translated: 26278; Mature: 26278

Theoretical pI: Translated: 6.44; Mature: 6.44

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNYISFPTAQHAVDKIAQEFVIYSQLNHPVHISLSGGSTPKLLFKTLAKSPYAEQINWKN
CCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHCCCCHHCCCCCE
LHFWWGDDRMVPPSDPESNYGEVQKLLFDHIQIPTENIHRIRGENEPHFELKHFEEELSA
EEEEECCCCCCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHCCCCCCCHHHHHHHHHHHH
VIPNGVFDWIILGMGTDGHTASLFPHQTNFDDENLAVIAKHPESGQIRISKTAKLIEQAK
HCCCCCEEEEEEEECCCCCEEEECCCCCCCCCCCEEEEEECCCCCCEEEHHHHHHHHHHH
RITYLVTGESKADILKEIQTTPAENLPYPAAKIKAKNGVTEWYLDKAAARLL
HEEEEEECCCHHHHHHHHHCCCCCCCCCCHHHEECCCCCHHHHHHHHHHHCC
>Mature Secondary Structure
MNYISFPTAQHAVDKIAQEFVIYSQLNHPVHISLSGGSTPKLLFKTLAKSPYAEQINWKN
CCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHCCCCHHCCCCCE
LHFWWGDDRMVPPSDPESNYGEVQKLLFDHIQIPTENIHRIRGENEPHFELKHFEEELSA
EEEEECCCCCCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHCCCCCCCHHHHHHHHHHHH
VIPNGVFDWIILGMGTDGHTASLFPHQTNFDDENLAVIAKHPESGQIRISKTAKLIEQAK
HCCCCCEEEEEEEECCCCCEEEECCCCCCCCCCCEEEEEECCCCCCEEEHHHHHHHHHHH
RITYLVTGESKADILKEIQTTPAENLPYPAAKIKAKNGVTEWYLDKAAARLL
HEEEEEECCCHHHHHHHHHCCCCCCCCCCHHHEECCCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9020051 [H]