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The map label for this gene is zwf [H]

Identifier: 148827750

GI number: 148827750

Start: 1102365

End: 1103849

Strand: Reverse

Name: zwf [H]

Synonym: CGSHiGG_06065

Alternate gene names: 148827750

Gene position: 1103849-1102365 (Counterclockwise)

Preceding gene: 148827751

Following gene: 148827749

Centisome position: 58.49

GC content: 40.88

Gene sequence:

>1485_bases
ATGCAAACTGATAATAATTGTATCGTCATTTTTGGCGCGTCTGGTGACTTAACTCATCGTAAACTCATTCCAGCCCTTTA
TAATCTCTACAAAATCGGGCGTTTGAGTGAAAATTTTTCCGTTCTTGGTGTTGCACGTTCTGACTTGAACGATGAAACTT
TCCGCAAAAAAATGCGTGAGGCGTTAATTCATAATGAAGAAACAACACCTGACACTTTAGATGCTTTCTGCTCTCATCTT
TATTATCAAGCAGTGAATACTTCGGATGCGCAAGATTACGGCAAACTTGTTCCACGCTTAGACGATCTTCACGATAAATA
TCAAACCTGTGGTAACACCCTTTACTATATGTCCACTCCACCAAGTCTCTATGGCGTGATTCCTGAGTGTTTGGCTGCAC
ATGGTTTAAATACGGAAGAATATGGCTGGAAACGTATTATCGTTGAAAAACCTTTTGGTTACGATGAAAAAACAGCGCAA
GCATTAGACGTACAAATCCACCGTTTCTTTGAAGAACACCAAATTTATCGTATCGACCATTATTTAGGTAAAGAAACCGT
TCAAAACTTGCTCGTATTACGTTTTTCAAATGGTTGGTTTGAACCGCTTTGGAACCGTAATTTCATTGATTATGTAGAAA
TTACTGGTGCAGAATCTATTGGCGTGGAAGAGCGCGGTGGCTATTATGATGGTTCTGGCGCAATGCGAGATATGTTCCAA
AACCATTTATTGCAAGTATTAGCAATGGTGGCAATGGAGCCGCCAGCGATTATTAACGCGAATTCAATGCGTGATGAAGT
TGCAAAAGTGATGCATAGTTTGCGTCCATTAACTTCGGAGGATATGGAGAATAACCTTGTTTTGGGTCAATACACTGCGG
CTGAAATTAACGGCAAAATGGAAAAAGGCTATCTAGAAGAAAAAGGTGTGCCTGCAGATTCTCGTACTGAAACCTACATC
TCATTGCGTTGTGAAATTGAAAACTGGCGTTGGGCTGGCGTGCCGTTCTATGTTCGTACGGGTAAACGCTTACCAGCTCG
TGTGACTGAAATTGTGATCCATTTTAAAACTACGCCACATCCTGTATTCAGCCAAAATGCACCAGAGAATAAATTGATTA
TTCGTATTCAACCTGATGAAGCTATTTCAATGCGTTTTGGTTTGAAGAAACCAGGTGCAGGTTTTGAGGCGAAAGAAGTA
TCAATGGATTTCCGTTATGCAGATTTAGCAGGCACGCAAGTATTAACCGCTTATGAACGTTTATTGTTGGATGCGATGAA
AGGCGATGCAACCTTGTTTGCTCGTACTGATGCTGTGCATGCTGCATGGAAATTTGTGCAACCGATTTTAGATTACAAAG
CGAATGGTGGTCGTATTCACGAATATGAAGCTGGCACTTGGGGGCCTGTTGCAGCTGATAAATTAATCGCAAAACAAGGC
AAAGTGTGGCGTAAACCAAGTGGATTGATGAAGAAAAAAGTTTAA

Upstream 100 bases:

>100_bases
GCGTTCTGTCTTTCAATTTAATTGATTGGTTCGATTGGTTTTTTTCTCTAGAATACGGCATTATTTTCGACATTACTCGG
AAGCCGAATAAGGAATAATT

Downstream 100 bases:

>100_bases
CTAATCTAATGTAGGGTGGGCTTTAGCCCACCGATCTTACTAACATAATAAATTGTGGGCTAAAGTCCAACGGAAAATCA
ATGAACTATATCAGCTTCCC

Product: glucose-6-phosphate 1-dehydrogenase

Products: NA

Alternate protein names: G6PD [H]

Number of amino acids: Translated: 494; Mature: 494

Protein sequence:

>494_residues
MQTDNNCIVIFGASGDLTHRKLIPALYNLYKIGRLSENFSVLGVARSDLNDETFRKKMREALIHNEETTPDTLDAFCSHL
YYQAVNTSDAQDYGKLVPRLDDLHDKYQTCGNTLYYMSTPPSLYGVIPECLAAHGLNTEEYGWKRIIVEKPFGYDEKTAQ
ALDVQIHRFFEEHQIYRIDHYLGKETVQNLLVLRFSNGWFEPLWNRNFIDYVEITGAESIGVEERGGYYDGSGAMRDMFQ
NHLLQVLAMVAMEPPAIINANSMRDEVAKVMHSLRPLTSEDMENNLVLGQYTAAEINGKMEKGYLEEKGVPADSRTETYI
SLRCEIENWRWAGVPFYVRTGKRLPARVTEIVIHFKTTPHPVFSQNAPENKLIIRIQPDEAISMRFGLKKPGAGFEAKEV
SMDFRYADLAGTQVLTAYERLLLDAMKGDATLFARTDAVHAAWKFVQPILDYKANGGRIHEYEAGTWGPVAADKLIAKQG
KVWRKPSGLMKKKV

Sequences:

>Translated_494_residues
MQTDNNCIVIFGASGDLTHRKLIPALYNLYKIGRLSENFSVLGVARSDLNDETFRKKMREALIHNEETTPDTLDAFCSHL
YYQAVNTSDAQDYGKLVPRLDDLHDKYQTCGNTLYYMSTPPSLYGVIPECLAAHGLNTEEYGWKRIIVEKPFGYDEKTAQ
ALDVQIHRFFEEHQIYRIDHYLGKETVQNLLVLRFSNGWFEPLWNRNFIDYVEITGAESIGVEERGGYYDGSGAMRDMFQ
NHLLQVLAMVAMEPPAIINANSMRDEVAKVMHSLRPLTSEDMENNLVLGQYTAAEINGKMEKGYLEEKGVPADSRTETYI
SLRCEIENWRWAGVPFYVRTGKRLPARVTEIVIHFKTTPHPVFSQNAPENKLIIRIQPDEAISMRFGLKKPGAGFEAKEV
SMDFRYADLAGTQVLTAYERLLLDAMKGDATLFARTDAVHAAWKFVQPILDYKANGGRIHEYEAGTWGPVAADKLIAKQG
KVWRKPSGLMKKKV
>Mature_494_residues
MQTDNNCIVIFGASGDLTHRKLIPALYNLYKIGRLSENFSVLGVARSDLNDETFRKKMREALIHNEETTPDTLDAFCSHL
YYQAVNTSDAQDYGKLVPRLDDLHDKYQTCGNTLYYMSTPPSLYGVIPECLAAHGLNTEEYGWKRIIVEKPFGYDEKTAQ
ALDVQIHRFFEEHQIYRIDHYLGKETVQNLLVLRFSNGWFEPLWNRNFIDYVEITGAESIGVEERGGYYDGSGAMRDMFQ
NHLLQVLAMVAMEPPAIINANSMRDEVAKVMHSLRPLTSEDMENNLVLGQYTAAEINGKMEKGYLEEKGVPADSRTETYI
SLRCEIENWRWAGVPFYVRTGKRLPARVTEIVIHFKTTPHPVFSQNAPENKLIIRIQPDEAISMRFGLKKPGAGFEAKEV
SMDFRYADLAGTQVLTAYERLLLDAMKGDATLFARTDAVHAAWKFVQPILDYKANGGRIHEYEAGTWGPVAADKLIAKQG
KVWRKPSGLMKKKV

Specific function: Pentose phosphate pathway; first step. [C]

COG id: COG0364

COG function: function code G; Glucose-6-phosphate 1-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucose-6-phosphate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI109389365, Length=485, Percent_Identity=39.7938144329897, Blast_Score=340, Evalue=2e-93,
Organism=Homo sapiens, GI108773793, Length=485, Percent_Identity=39.7938144329897, Blast_Score=340, Evalue=2e-93,
Organism=Homo sapiens, GI52145310, Length=490, Percent_Identity=28.9795918367347, Blast_Score=164, Evalue=2e-40,
Organism=Escherichia coli, GI1788158, Length=492, Percent_Identity=43.6991869918699, Blast_Score=404, Evalue=1e-114,
Organism=Caenorhabditis elegans, GI17538218, Length=488, Percent_Identity=38.7295081967213, Blast_Score=330, Evalue=9e-91,
Organism=Saccharomyces cerevisiae, GI6324088, Length=488, Percent_Identity=34.2213114754098, Blast_Score=288, Evalue=2e-78,
Organism=Drosophila melanogaster, GI24643352, Length=471, Percent_Identity=36.9426751592357, Blast_Score=295, Evalue=5e-80,
Organism=Drosophila melanogaster, GI24643350, Length=471, Percent_Identity=36.9426751592357, Blast_Score=295, Evalue=6e-80,
Organism=Drosophila melanogaster, GI221513548, Length=484, Percent_Identity=30.5785123966942, Blast_Score=224, Evalue=8e-59,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001282
- InterPro:   IPR019796
- InterPro:   IPR022675
- InterPro:   IPR022674
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02781 G6PD_C; PF00479 G6PD_N [H]

EC number: =1.1.1.49 [H]

Molecular weight: Translated: 56158; Mature: 56158

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: PS00069 G6P_DEHYDROGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQTDNNCIVIFGASGDLTHRKLIPALYNLYKIGRLSENFSVLGVARSDLNDETFRKKMRE
CCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCHHHHHHHHHH
ALIHNEETTPDTLDAFCSHLYYQAVNTSDAQDYGKLVPRLDDLHDKYQTCGNTLYYMSTP
HHHCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCHHHHHHHHHHHCCEEEEECCC
PSLYGVIPECLAAHGLNTEEYGWKRIIVEKPFGYDEKTAQALDVQIHRFFEEHQIYRIDH
CHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHCCEEEHHH
YLGKETVQNLLVLRFSNGWFEPLWNRNFIDYVEITGAESIGVEERGGYYDGSGAMRDMFQ
HHCHHHHHHEEEEEECCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCEECCCHHHHHHHH
NHLLQVLAMVAMEPPAIINANSMRDEVAKVMHSLRPLTSEDMENNLVLGQYTAAEINGKM
HHHHHHHHHHHCCCCCEEECCHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEEHHHHCCCH
EKGYLEEKGVPADSRTETYISLRCEIENWRWAGVPFYVRTGKRLPARVTEIVIHFKTTPH
HCCCHHHCCCCCCCCCCEEEEEEEEECCCEECCCCEEEECCCCCCCCEEEEEEEEECCCC
PVFSQNAPENKLIIRIQPDEAISMRFGLKKPGAGFEAKEVSMDFRYADLAGTQVLTAYER
CCCCCCCCCCEEEEEECCCCCEEHEECCCCCCCCCCHHHEEECEEEHHHCCHHHHHHHHH
LLLDAMKGDATLFARTDAVHAAWKFVQPILDYKANGGRIHEYEAGTWGPVAADKLIAKQG
HHHHHHCCCEEEEEECHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCHHHHHHHHHCC
KVWRKPSGLMKKKV
CCCCCCCCHHHCCC
>Mature Secondary Structure
MQTDNNCIVIFGASGDLTHRKLIPALYNLYKIGRLSENFSVLGVARSDLNDETFRKKMRE
CCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCHHHHHHHHHH
ALIHNEETTPDTLDAFCSHLYYQAVNTSDAQDYGKLVPRLDDLHDKYQTCGNTLYYMSTP
HHHCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCHHHHHHHHHHHCCEEEEECCC
PSLYGVIPECLAAHGLNTEEYGWKRIIVEKPFGYDEKTAQALDVQIHRFFEEHQIYRIDH
CHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHCCEEEHHH
YLGKETVQNLLVLRFSNGWFEPLWNRNFIDYVEITGAESIGVEERGGYYDGSGAMRDMFQ
HHCHHHHHHEEEEEECCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCEECCCHHHHHHHH
NHLLQVLAMVAMEPPAIINANSMRDEVAKVMHSLRPLTSEDMENNLVLGQYTAAEINGKM
HHHHHHHHHHHCCCCCEEECCHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEEHHHHCCCH
EKGYLEEKGVPADSRTETYISLRCEIENWRWAGVPFYVRTGKRLPARVTEIVIHFKTTPH
HCCCHHHCCCCCCCCCCEEEEEEEEECCCEECCCCEEEECCCCCCCCEEEEEEEEECCCC
PVFSQNAPENKLIIRIQPDEAISMRFGLKKPGAGFEAKEVSMDFRYADLAGTQVLTAYER
CCCCCCCCCCEEEEEECCCCCEEHEECCCCCCCCCCHHHEEECEEEHHHCCHHHHHHHHH
LLLDAMKGDATLFARTDAVHAAWKFVQPILDYKANGGRIHEYEAGTWGPVAADKLIAKQG
HHHHHHCCCEEEEEECHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCHHHHHHHHHCC
KVWRKPSGLMKKKV
CCCCCCCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]